• Structural Engineering and Mechanics
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• 제36권5호
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• pp.625-642
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• 2010

The Integrated Force Method (IFM) is a novel matrix formulation developed for analyzing the civil, mechanical and aerospace engineering structures. In this method all independent/internal forces are treated as unknown variables which are calculated by simultaneously imposing equations of equilibrium and compatibility conditions. This paper presents a new 12-node serendipity quadrilateral plate bending element MQP12 for the analysis of thin and thick plate problems using IFM. The Mindlin-Reissner plate theory has been employed in the formulation which accounts the effect of shear deformation. The performance of this new element with respect to accuracy and convergence is studied by analyzing many standard benchmark plate bending problems. The results of the new element MQP12 are compared with those of displacement-based 12-node plate bending elements available in the literature. The results are also compared with exact solutions. The new element MQP12 is free from shear locking and performs excellent for both thin and moderately thick plate bending situations.

• 한국환경보건학회지
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• 제22권4호
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• pp.91-101
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• 1996

Exposure indices are important tools which enable scientists to reliably predict and detect exposures to xenobiotics and resultant cell injury. Since the de novo synthesis of stress proteins can be detected early after exposure to some agents, analysis of toxicant-induced changes in gene expression, i.e. alterations in patterns of protein synthesis, may be useful to develop as biomarkers of exposure and toxicity. The acute and chronic effects of cadmium(Cd, $CdCl_2$ 20 mg/kg) on Wistar male rats were evaluated concerning cadmium contents, tissues enzyme activity, HSP expression. The results of the study were as follows: 1. Less cadmium was absorbed through the digestive tracts, but the ratio of contents in renal to hepatic cadmium was higher at 8 weeks after treatment. 2. ALT(alanine aminotransferase), AST(aspartate aminotransferase), glucose, BUN(blood urea nitrogen), creatinine, the key indices of the clinical changes in hepatic and renal function were significantly changed by the cadmium treatment after 1 week in liver, after 4 weeks in kidney. 3. Enhanced synthesis of 70 KDa relative molecular mass proteins were detected in 2 hours after cadmium exposure, with maximum activity occurring at 8~48 hours. Induction of $HSP_{70}$ was evident at proximal tubules and glomeruli in kidney. Testicular cells produced enough HSP to be detected normally. From the above results, it could be concluded that $HSP_{70}$ induction by the cadmium treatment was a rapid reaction to indicate the exposure of xenobiotics.

• Safety and Health at Work
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• 제8권4호
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• pp.327-328
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• 2017

Despite provision of drinking water as the most common method of occupational heat stress prevention, there remains confusion in hydration messaging to workers. During work site interactions in a hot and humid climate, workers commonly report being informed to consume tepid fluids to accelerate rehydration. When questioned on the evidence supporting such advice, workers typically cite that fluid absorption is delayed by ingestion of chilled beverages. Presumably, delayed absorption would be a product of fluid delivery from the gut to the intestines, otherwise known as gastric emptying. Regulation of gastric emptying is multifactorial, with gastric volume and beverage energy density the primary factors. If gastric emptying is temperature dependent, the impact of cooling is modest in both magnitude and duration (${\leq}5$ minutes) due to the warming of fluids upon ingestion, particularly where workers have elevated core temperature. Given that chilled beverages are most preferred by workers, and result in greater consumption than warm fluids during and following physical activity, the resultant increased consumption of chilled fluids would promote gastric emptying through superior gastric volume. Hence, advising workers to avoid cool/cold fluids during rehydration appears to be a misinterpretation of the research. More appropriate messaging to workers would include the thermal benefits of cool/cold fluid consumption in hot and humid conditions, thereby promoting autonomy to trial chilled beverages and determine personal preference. In doing so, temperature-based palatability would be maximized and increase the likelihood of workers maintaining or restoring hydration status during and after their work shift.

• Wind and Structures
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• 제32권4호
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• pp.371-391
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• 2021

Tornadoes are the most devastating meteorological natural hazards. Many empirical and theoretical numerical models of tornado vortex have been proposed, because it is difficult to carry out direct measurements of tornado velocity components. However, most of existing numerical models fail to explain the physical structure of tornado vortices. The present paper proposes a new empirical numerical model for a tornado vortex, and its load effects on a low-rise and a tall building are calculated and compared with those for existing numerical models. The velocity components of the proposed model show clear variations with radius and height, showing good agreement with the results of field measurements, wind tunnel experiments and computational fluid dynamics. Normal stresses in the columns of a low-rise building obtained from the proposed model show intermediate values when compared with those obtained from existing numerical models. Local forces on a tall building show clear variation with height and the largest local forces show similar values to most existing numerical models. Local forces increase with increasing turbulence intensity and are found to depend mainly on reference velocity Uref and moving velocity Umov. However, they collapse to one curve for the same normalized velocity Uref / Umov. The effects of reference radius and reference height are found to be small. Resultant fluctuating force of generalized forces obtained from the modified Rankine model is considered to be larger than those obtained from the proposed model. Fluctuating force increases as the integral length scale increases for the modified Rankine model, while they remain almost constant regardless of the integral length scale for the proposed model.

• Journal of Microbiology and Biotechnology
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• 제32권12호
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• pp.1547-1552
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• 2022

β-Amyrin is a pentacyclic triterpene widely distributed in leaves and stems worldwide. The ability of β-amyrin to induce the production of reactive oxygen species (ROS) in microorganisms suggests its potential as an antimicrobial agent. Thus, this study aimed to elucidate the antibacterial mode of action of β-amyrin. We treated Escherichia coli cells with β-amyrin and found that it triggered ROS accumulation. Excessive stress caused by ROS, particularly hydroxyl radicals, induces glutathione (GSH) dysfunction. GSH protects cells from oxidative and osmotic stresses; thus, its dysfunction leads to membrane depolarization. The resultant change in membrane potential leads to the release of apoptotic proteins, such as caspases. The activated caspases-like protein promotes the cleavage of DNA into single strands, which is a hallmark of apoptosis-like death in bacteria. Apoptotic cells usually undergo events such as DNA fragmentation and phosphatidylserine exposure, differentiating them from necrotic cells, and the cells treated with β-amyrin in this study were positive for annexin V and negative for propidium iodide, indicating apoptosis-like death. In conclusion, our findings suggest that the antibacterial mode of action of β-amyrin involves the induction of ROS, which resulted in apoptosis-like death in E. coli.

• Nuclear Engineering and Technology
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• 제55권8호
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• pp.2823-2834
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• 2023

Austenitic stainless steel welds (ASSWs) of nuclear components undergo aging-related degradations caused by high temperature and neutron radiation. Since irradiation leads to the change of material characteristics, relevant quantification is important for long-term operation, but limitations exist. Although ion irradiation is utilized to emulate neutron irradiation, its penetration depth is too shallow to measure bulk properties. In this study, a systematic approach was suggested to estimate mechanical properties of ion irradiated 308 ASSW. First of all, weld specimens were irradiated by 2 MeV proton to 1 and 10 dpa. Microstructure evolutions due to irradiation in δ-ferrite and austenite phases were characterized and micropillar compression tests were performed. In succession, dislocation density based stress-strain (S-S) relationships and quantification models of irradiation defects were adopted to define phases in finite element analyses. Resultant microscopic S-S curves were compared to verify material parameters. Finally, macroscopic behaviors were calculated by multiscale simulations using real microstructure based representative volume element (RVE). Validity of the approach was verified for the unirradiated specimens such that the estimated S-S curves and 0.2% offset yield strengths (YSs) which was 363.14 MPa were in 10% agreement with test. For irradiated specimens, the estimated YS were 917.41 MPa in 9% agreement.

• 대한치과보철학회지
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• 제33권4호
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• pp.780-806
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• 1995

The purpose of this study was to describe the application of 3D finite element analysis to determine resultant stresses on the bone anchored fixed prosthesis, implants and supporting bone of the mandible according to fixture numbers and load conditions. 4 or 6 fixtures and the bone anchored fixed prosthesis were placed in 3D finite element mandibular arch model which represents an actual mandibular skull. A $45^{\circ}$ diagonal load of 10㎏ was labiolingually applied in the center of the prosthesis(P1). A $45^{\circ}$ diagonal load of 20㎏ was buccolingually applied at the location of the 10mm or 20mm cantilever posterior to the most distal implant(P2 or P3). The vertical distribution loads were applied to the superior surfaces of both the right and the left 20mm cantilevers(P4). In order that the boundary conditions of the structure were located to the mandibular ramus and angle, the distal bone plane was to totally fixed to prevent rigid body motion of the entire model. 3D finite element analysis was perfomed for stress distribution and deflection on implants and supporting bone using commercial software(ABAQUS program. for Sun-SPARC Workstation. The results were as follows : 1. In all conditions of load, the hightest tensile stresses were observed at the metal lates of prostheses. 2. The higher tensile stresses were observed at the diagonal loads rather than the vertical loads 3. 6-implants cases were more stable than 4-implants cases for decreasing bending and torque under diagonal load on the anterior of prosthesis. 4. From a biomechanical perspective, high stress developed at the metal plate of cantilever-to-the most distal implant junctions as a consequence of loads applied to the cantilever extension. 5. Under diagonal load on cantilever extension, the 6-implants cases had a tendency to reduce displacement and to increase the reaction force of supporting point due to increasing the bendign stiffness of the prosthesis than 4-implants cases. 6. Under diagonal load on cantilever extension, the case of 10mm long cantilever was more stable than that of 20mm long cnatilever in respect of stress distribution and displacement. 7. When the ends of 10mm or 20mm long cantilever were loaded, the higher tensile stress was observed at the second most distal implant rather than the first most distal implant. 8. The 6-implants cases were more favorable about prevention of screw loosening under repeated loadings because 6-implants cases had smaller deformation and 4-implants cases had larger deformation.

• 한국전산구조공학회논문집
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• 제29권6호
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• pp.529-538
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• 2016

멱 법칙 및 S 형상 함수를 이용한 점진기능재료(FGM) 판의 정적 및 동적해석을 위해 단순화된 전단변형이 고려된 이론을 정식화 하여 동적 평형방정식을 유도하였다. 단순화된 전단변형 이론은 전단보정계수가 필요없으며 수직 전단변형률과 전단응력의 곡선분포를 고려하였고 판의 상부와 하부에서 0이 된다는 조건을 만족한다. 또한 4개의 변수만으로 평형방정식이 유도되고 합응력, 평형방정식 그리고 경계조건이 고전적 이론과 유사한 형태를 가지게 된다. 점진기능재료의 형태는 멱 법칙 및 S 형상 함수로 두께방향으로 변화가 고려된다. Hamilton 원리를 이용하여 동적 평형방정식을 유도하였고 Winkler-Pasternak 탄성지반 모델을 적용하였다. 단순지지된 점진기능재료 판의 정적 및 자유진동 응답을 계산하였고 비교하였다. 본 연구에서 제시한 결과는 참고문헌과 비교하여 정확하고 관련성을 가진다. 거듭제곱 지수, 탄성지반 계수 그리고 폭-두께비의 변화에 따른 정적 및 자유진동 해석결과를 제시하였다.

• 한국전산구조공학회논문집
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• 제22권6호
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• pp.617-625
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• 2009

본 연구에서는 MgO를 첨가하여 자기팽창을 유도하는 화학적 프리스트레싱 기법(chemically prestressing method)으로 균열을 제어하는 방법을 다루고자 한다. 수화열에 의한 온도변형 및 수축과 같은 콘크리트의 필연적인 체적변화는 시공 중 균열을 발생시키고, 이는 장기적인 콘크리트의 내구성 및 사용성을 저하시키는 주요 요인으로 작용한다. 시공 중 발생하는 균열을 제어하기 위하여 본 연구는 MgO 콘크리트의 팽창 특성을 모델링하고 콘크리트의 단면 내 온도분포로부터 온도응력 및 자기팽창 응력을 평가하는 3차원 유한요소해석 프로그램을 개발하였다. 개발된 해석프로그램은 온도의존적 자기팽창량과 팽창응력을 검증하였고, 예제 해석을 통하여 MgO 팽창 여부에 따른 잔류응력(residual stress)의 변화 양상을 비교, 분석하였다. 저온에서 소성한 MgO를 혼입하여 제조한 장기팽창성 콘크리트는 온도의존적 특성을 보이고 수년에 걸쳐 발생하는 경향을 보이므로, 장기적으로 높은 온도가 유지되는 매스콘크리트 구조물의 온도균열을 제어하는데 가장 유용하게 적용될 수 있을 것으로 사료된다.

• 감성과학
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• 제24권4호
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• pp.39-52
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• 2021

본 연구의 목적은 코로나바이러스 유행이 대학생들의 불안, 우울, 공포 및 스트레스와 같은 부정정서에 미치는 영향을 알아보는 것이다. J대학교에 재학 중인 대학생을 대상으로 인터뷰를 실시하였으며, 시간에 따라 부정정서의 변화 양상을 살펴보고자 2019년 3월, 2020년 3월, 2020년 11월 세 시기를 측정하였다. 조사 시점이 2020년 11월로, 2019년 3월과 2020년 3월에 겪었던 정서 기억 회상을 돕기 위해 연구 참여자에게 당시 겪었을 법한 상황에 대한 구조화된 인터뷰 질문을 하고 답변에 대한 요약정리를 하도록 요청하였다. 세 시기의 부정정서에 차이가 있는지 살펴보기 위해 반복측정 변량분석을 실시하였고, 부정정서의 변화 양상을 살펴보기 위해 다항식 추세 분석을 실시하였다. 연구 결과 세 시기의 부정정서에 차이가 있었으며, 2019년과 비교하여 2020년 3월에 대학생들이 우울, 불안, 공포 및 스트레스를 더 느끼고 있었으며, 이러한 부정정서가 2020년 11월까지 지속되었음을 알 수 있었다. 이러한 결과는 코로나바이러스의 영향이 지속되고 있는 현재에도 대학생들이 부정정서를 겪을 수 있음을 시사한다. 본 연구의 결과는 코로나바이러스 유행 상황에서 대학생이 겪을 수 있는 부정정서의 양상을 나타내며, 결과를 바탕으로 대학생을 위한 스트레스 관리 지침 및 심리 상담과 같은 심리지원체계 제공의 필요성이 제시되었다.