• 생명과학회지
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• 제18권6호
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• pp.796-803
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• 2008

알츠하이머 질환은 신경퇴행성질환으로 노령인구에서 뿐만 아니라 $30{\sim}60$세 사이에서도 상염색체성우성형으로 발생하여 사회문제로 대두되고 있으며 발병기전도 명확하게 규명되지 않은 상태이다. 따라서 이 연구에서는 hAPP695sw 돌연변이를 neuron-specific enolase (NSE) 유전자의 프로모터 조절 하에 연결시킨 융합 유전자(pNSE/APP695sw fusion gene)를 과 발현시킨 알츠하이머 질환 모델생쥐를 대상으로 16주간 지구성 운동에 따른 알츠하이머 질환 모델생쥐의 인지능력의 변화와 주병변인 $A{\beta}-42$ 단백질과 함께 GLUT-1, BDNF, HSP-70 단백질의 발현량을 분석하였다. 그 결과 지구성 운동은 APPsw 알츠하이머 질환 모델생쥐의 인지능력을 개선시키는데 긍정적인 영향을 미친 것으로 나타났으며 이러한 인지능력의 개선은 알츠하이머 질환의 주 병변인 뇌의 $A{\beta}-42$ 감소뿐만 아니라 BDNF, GLUT-1과 HSP-70 단백질의 발현 증가와 관련이 있음을 확인하였다. 따라서 지구성 운동은 약물 처치 이외에 알츠하이머 질환을 예방하거나 지연시킬 수 있는 전략적인 방법으로 활용할 수 있음을 알 수 있다.

• Journal of the Korean Wood Science and Technology
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• 제35권6호
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• pp.13-22
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• 2007

주요 조림수종으로 도입 식재된 리기다소나무의 고부가가치 이용을 위한 구조용 집성재 이용 가능성을 검토하고, 이에 적합한 기술을 개발하기 위하여 본 연구를 수행하였다. 국산 리기다소나무 제재목의 기계응력등급은 대부분 E7에서 E9등급으로 집성재 제조에는 다소 불량한 것으로 나타났다. 반면 단일수종 및 혼합수종 구조용 집성재 제조에 필수적인 리기다소나무 및 낙엽소 판재의 접착성을 평가한 결과 전단접착력, 목파율, 침지 및 삶음박리율 모두 KS기준 이상으로 나타났다. 리기다소나무 단일수종 집성재의 휨성능을 측정해본 결과 휨강도는 KS의 집성재 강도등급에 따른 휨성능 합격기준을 만족한 반면 휨 탄성계수는 기준에 다소 못 미치는 결과를 나타내었다. 그러나 낙엽송 층재와의 혼합구성을 통해 리기다소나무 집성재의 휨성능(휨강도와 휨탄성계수)을 20% 향상시킬 수 있었으며, 층재 구성방법에 있어서는 판재의 탄성계수가 높고 품질이 우수한 낙엽송 층재를 외층에 배치하는 방법이 보다 효과적인 것으로 확인되었다. 결론적으로 리기다소나무의 부가가치 증진을 위한 구조용 집성재 이용은 그 가능성이 매우 컸다.

• Journal of Microbiology and Biotechnology
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• 제18권1호
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• pp.15-22
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• 2008

Four series (S, M, R, and W) of Alternaria longipes isolates were obtained based on consecutive selection with Dimethachlon (Dim) and ultraviolet irradiation. These isolates were then characterized according to their tolerance to Dim, sensitivity to osmotic stress, and phenotypic properties. All the selected Dim-resistant isolates showed a higher osmosensitivity than the parental strains, and the last generation was more resistant than the first generation in the M, R, and W series. In addition, the changes in the Dim resistance and osmotic sensitivity were not found to be directly correlated, and no distinct morphologic characteristics were found among the resistant and sensitive isolates, with the exception of the resistant isolate K-11. Thus, to investigate the molecular basis of the fungicide resistance, a group III two-component histidine kinase (HK) gene, AlHK1, was cloned from nineteen A. longipes isolates. AlHK1p was found to be comprised of a six 92-amino-acid repeat domain (AARD), HK domain, and response regulator domain, similar to the Os-1p from Neurospora crassa. A comparison of the nucleotide sequences of the AlHK1 gene from the Dim-sensitive and -resistant isolates revealed that all the resistant isolates contained a single-point mutation in the AARD of AlHK1p, with the exception of isolate K-11, where the AlHK1p contained a deletion of 107 amino acids. Moreover, the AlHK1p mutations in the isolates of each respective series involved the same amino acid substitution at the same site, although the resistance levels differed significantly in each series. Therefore, these findings suggested that a mutation in the AARD of AlHK1p was not the sole factor responsible for A. longipes resistance to dicarboximide fungicides.

• 대한한의학방제학회지
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• 제22권1호
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• pp.13-32
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• 2014

Objectives : Until now the study of Cnidii Rhizoma, hemorrhage, brain waves, such as ischemic brain injury, analgesic, effect overcome of the stress from pregnancy melanin formation and inhibiting effects skin whitening have been published regarding this article. Cnidii Rhizoma demonstrates its different abilities depending on the characteristics. This paper reported that effect of Cnidii Rhizoma in Dongeuibogam blended prescriptions as main medicine. In addition, by analyzing data, we studied about utilizing of Cnidii Rhizoma. Methods : Cnidii Rhizoma in Dongeuibogam Prescriptions as the main ingredient was built with database of 202 prescriptions. Thus analyzed data was summarized in detail.(Table-1) If there is no difference in the title of the prescription but in other case the configuration information is different, formulations 1 and 2 were divided by the table. Results : The following results were reached through investigations on the prescriptions usikng Cnidii Rhizoma as a key component. 1. Prescriptions taking Cnidii Rhizoma as a monarch drug are utilized for 40 therapeutic purposes. In particular, 12.3% of prescriptions appear in the chapter of head, and 10.8% of those appear in the chapter of women, and 9.4% of eye, 8.9% of child, 6.4% of wind disease respectively. 2. Prescriptions utilizing Cnidii Rhizoma as the main ingredient are used in the treatment of headache, dizziness and pregnancy hemorrhage fetal movement, premature birth and they are also used for treating 131 different types of disease. 3. The dosage of Cnidii Rhizoma in formulas is from 2pun(about 0.75g) to 5don(nearly 18.75g), however 1don(nearly 3.75g) has been taken the most for clinical application. 4. We find out that according to herbs or prescriptions, Cnidii Rhizoma has a variety of functions such as ascending & descending of energy. Samultang is the most useful base prescription which used the Cnidii Rhizoma as the main component. Conclusion : These results suggest that, Cnidii Rhizoma once-amount use (don nearly 3.75g) 4g in head, gynecology, ophthalmology, pediatrics and paralysis disease associated with oriental medicine resource development can be considered to be widely used These results suggest that Cnidii Rhizoma was used most with 1 don(4g) and can be widely used for the resource development to the disease such as brain, gynecology, ophthalmologhy, pediatrics and wind-associated symptoms.

• Journal of the Korean Wood Science and Technology
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• 제37권3호
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• pp.184-191
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• 2009

삼나무 원목은 제주도를 중심으로 점차 생산량이 증가하고 있으나, 옹이 등의 결함으로 인하여 목재자원으로서의 가치가 낮게 평가되고 있다. 본 연구에서는 삼나무에 대한 고부가가치의 새로운 용도 창출을 목적으로 구조용 집성재 이용 가능성을 확인하였다. 먼저 삼나무 제재목의 기계응력등급을 조사한 결과 국내의 다른 주요 침엽수종에 비해서는 다소 불량하지만 KS에 적합한 집성재 적층 구성에는 무리가 없는 것으로 확인되었다. 또한 집성재 제조에 필수적인 접착성 및 접착내구성에 있어서도 우수한 성능을 나타내었다. 그러나 집성재의 구조 성능을 평가한 결과, 휨 탄성계수가 KS의 기준에 다소 미달하는 결과를 나타내어 집성재의 강성 보강을 위한 추가적인 검토가 요구되었다.

• Journal of Mechanical Science and Technology
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• 제18권5호
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• pp.770-779
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• 2004

This paper describes the micro cutting of wear resistant tungsten carbides using PCD (Poly-Crystalline Diamond) cutting tools in performance with SEM (Scanning Electron Microscope) direct observation method. Turning experiments were also carried out on this alloy (V50) using a PCD cutting tool. One of the purposes of this study is to describe clearly the cutting mechanism of tungsten carbides and the behavior of WC particles in the deformation zone in orthogonal micro cutting. Other purposes are to achieve a systematic understanding of machining characteristics and the effects of machining parameters on cutting force, machined surface and tool wear rates by the outer turning of this alloy carried out using the PCD cutting tool during these various cutting conditions. A summary of the results are as follows: (1) From the SEM direct observation in cutting the tungsten carbide, WC particles are broken and come into contact with the tool edge directly. This causes tool wear in which portions scrape the tool in a strong manner. (2) There are two chip formation types. One is where the shear angle is comparatively small and the crack of the shear plane becomes wide. The other is a type where the shear angle is above 45 degrees and the crack of the shear plane does not widen. These differences are caused by the stress condition which gives rise to the friction at the shear plane. (3) The thrust cutting forces tend to increase more rapidly than the principal forces, as the depth of cut and the cutting speed are increased preferably in the orthogonal micro cutting. (4) The tool wear on the flank face was larger than that on the rake face in the orthogonal micro cutting. (5) Three components of cutting force in the conventional turning experiments were different in balance from ordinary cutting such as the cutting of steel or cast iron. Those expressed a large value of thrust force, principal force, and feed force. (6) From the viewpoint of high efficient cutting found within this research, a proper cutting speed was 15 m/min and a proper feed rate was 0.1 mm/rev. In this case, it was found that the tool life of a PCD tool was limited to a distance of approximately 230 m. (7) When the depth of cut was 0.1 mm, there was no influence of the feed rate on the feed force. The feed force tended to decrease, as the cutting distance was long, because the tool was worn and the tool edge retreated. (8) The main tool wear of a PCD tool in this research was due to the flank wear within the maximum value of $V_{max}$ being about 260 $\mu\textrm{m}$.

• 한국직업건강간호학회지
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• 제13권2호
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• pp.104-117
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• 2004

Objectives: To propose the basic data for the development of the optimum health promotion program (HPP) for the workers in a petrochemical industry complex. Methods: The subjects were 553 workers who worked at the six plants in a petrochemical industry complex. From February to March 2003, questionnaire survey was conducted by the nurses with occupational health specialty about the life styles, interests, self-cognitions, practices of health behavior, subjective symptoms thought to be related the working environments, burden to the own health, needs and intentions to participation of the HPP. Data analysis was done using SPSS program (ver 10.0) with ${\alpha}=0.05$ of statistical significance. Results: The mean age and tenure of the subjects were 39.7 years and 14.2 years, respectively, and proportion of smokers was around 50%. Two of third (66%) satisfied their own job, and 58% recognized themselves healthy. The most frequent health behavior were exercise (60%) and regular health check (87%) in individual and job based, respectively. About half of them (58%) had at least one of the symptoms thought to be related the working environments, and the most frequent one was odor (21%). These symptoms were more frequent in case of the shorter career. The needs of HPP was relatively higher in exercise (66%), cancer prevention (51%), stress control (47%), and intention to participation was also the highest in exercise (64%). Job satisfaction was higher in case of the higher interests and cognitions to their own health, and thought that the ownership's interest to workers' health be high (p<0.01), but no associations with the subjective symptoms. The mean level of burden to the own health were $14.1{\pm}13.9$ of physical, $11.7{\pm}13.6$ of emotional, $9.1{\pm}10.7$ of behavioral as out of one hundred. They felt the more burden in case of office workers, the lower interests and cognitions to their own health, the lower satisfaction to their job, the frequent drinking group, and complained the subjective symptoms (p<0.05). Abnormal results of the regular health check was higher in the frequent drinking group (p=0.083). Conclusions: For the optimum HPP for the workers in the petrochemical complex, the ownership's interest to workers' health would be enhanced, and the priority would be focused on exercise and drinking habits control.

• Asian-Australasian Journal of Animal Sciences
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• 제12권2호
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• pp.174-179
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• 1999

The effect of a chronic inflammation (cell-mediated immune response) on energy metabolism and growth performance was assessed in weanling piglets. Twenty four barrows of 4 wk of age were assigned to one of two immunization treatments : Control group [CON: immunized with Incomplete Freund's Adjuvant (lFA)] or Immunization group [IMMU: immunized with Complete Freund's Adjuvant (CFA)]. On d0, piglets were weaned and subcutaneously immunized at the medial side of the femur with 2 ml of IFA or CFA, respectively. Energy and nitrogen balances were measured per group during 13-d balance period, and total $(HP_{tot})$, activity-related ($(HP_{act})$) and non-activity-related $(HP_{cor})$ heat production were determined every 9-min by indirect calorimetry. Ig total titers to Mycobacterium butyricum, which is present in CFA, were higher (p<0.01) in IMMU than in CON on d13 (2.5 vs 1.8) and d20 (2.9 vs 1.8) after immunization. There were no differences (p>0.10) between treatments in rectal temperature, performance, feed intake, and availability and partitioning of energy during the balance period. Average daily feed intake was numerically higher in IMMU than in CON (0.34 vs 0.32 kg/d), but there was no difference (p>0.10) in metabolizability of the dietary energy between treatments. $HP_{act}/HP_{tot}$ was 16.24 and 16.89%, and retained energy was 251 and 268 $268\;kJ{\cdot}kg^{0.75}{\cdot}d^{-1}$ for CON and IMMU, respectively. Numerically, maintenance requirement of IMMU was even lower than that of CON $(419\;vs\;427\;kJ{\cdot}kg^{0.75}{\cdot}d^{-1})$. The present study suggests that a chronic inflammation has no effect on energy metabolism and growth performance, in spite of the difference in systemic antibody responses. The reason was considered to be due to locally induced immune response, resulting from the possible encapsulation at the site of injection, and/or to a low systemic immune stress which is within a functionally acceptable physiological range for the piglets.

• 한국산림과학회지
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• 제101권1호
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• pp.130-137
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• 2012

본 연구는 산지계류의 자연친화적 복원을 위해 산지 계류 특성에 적합한 안정성과 구조를 가지면서 계안 보호 및 복원이 가능하도록 식생기반재 돌망태 공법을 개발하고, 개발 공법의 치수안정성, 생태계 구조 및 기능, 경관에 대한 모니터링을 통해 공법의 효능을 평가하는데 그 목적이 있다. 본 보에서는 개발된 계류복원을 위한 식생기 반재 돌망태 공법 중 식생기반재 돌망태 옹벽 공법의 사면안정효과를 중심으로 개발 공법의 효능을 정리, 보고하였다. 개발된 식생기반재 돌망태 옹벽의 표준형태는 배면이 수직인 사다리꼴 상자이며, 전면에 경사각 $60^{\circ}{\sim}65^{\circ}$의 비탈면을 조성하여 식생의 상향 생육이 가능하도록 조치하였다. 식생기반재 돌망태 옹벽의 수리학적 안정성 분석 결과 식생으로 피복되었을 때 가장 높은 한계전단응력을 가지는 것으로 나타났으며, 많은 유량에서도 안정된 계안보호효과를 발휘하는 것으로 분석되었다. 또한, 식생기반재 돌망태 옹벽의 활동 및 전도에 대한 안정 해석 결과 적정 안전계수 1.5를 훨씬 상회하는 것으로 나타나 본 연구에서 시공한 식생기반재 돌망태 옹벽은 활동 및 전도에 대한 안정성을 가지는 것으로 분석되었다.

• 한국산학기술학회논문지
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• 제22권3호
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• pp.138-147
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• 2021

본 연구는 우리나라 간호사의 건강증진행위 측정을 위한 검증된 도구가 부족한 실정으로 간호사의 간호환경 특성을 반영하면서 그 사용이 검증된 도구 개발이 필요함에 따라 한국 간호사의 건강증진행위 측정도구를 개발하는 것을 목적으로 한다. 본 연구는 2019년 1월부터 12월까지 간호사 총 530명을 대상으로 실시하였으며 연구방법으로는 문헌 고찰 및 포커스 그룹 면담을 실시하고, 타당성과 신뢰성을 측정하기 위해 데이터 분석을 하였으며, IMB(Information-Motivation-Behavioral Skills) 모델을 적용하여 개념 틀을 구성하였다. 그 결과 간호사로서의 자아개념(2 문항), 병원생활관리(4 문항), 건강에 대한 지식 및 정보(5 문항), 신체적·정신적 스트레스관리(3 문항), 근무적응(2 문항)의 5가지 요인 16 문항으로 도출되었다. 모델 적합도는 346.23 (��<.001), PNFI는 .60, PCFI는 .63으로 허용 기준을 충족했으며 RMSEA는 .10이었다. GFI .88, CFI .85, IFI .85는 기준치에 적합한 것으로 확인되었다. 모든 항목은 Cronbach의 �� .85로 안정적인 신뢰성을 확보하였다. 본 연구에서 개발 한 간호사의 건강증진행위 측정도구는 간호 실무 측면에서 간호사의 건강 증진 행동을 측정하는 도구로 사용될 것이며 간호사의 건강 증진 행동을 폭넓게 이해하는 데 도움이 될 것이다.