The Effect of Exercise Training on Aβ-42, BDNF, GLUT-1 and HSP-70 Proteins in a NSE/ APPsw-transgenic Model for Alzheimer's Disease. |
Eum, Hyun-Sub
(Exercise Biochemistry Laboratory, Korea National Sport University)
Kang, Eun-Bum (Exercise Biochemistry Laboratory, Korea National Sport University) Lim, Yea-Hyun (Exercise Biochemistry Laboratory, Korea National Sport University) Lee, Jong-Rok (Exercise Biochemistry Laboratory, Korea National Sport University) Cho, In-Ho (Exercise Biochemistry Laboratory, Korea National Sport University) Kim, Young-Soo (Korea Institute of Sport Science) Chae, Kab-Ryoung (Division of Laboratory Animal Resources, and National Institute of Toxicological Research, Korea FDA) Hwang, Dae-Yean (College of National Resources & Life Science, Pusan National University) Kwak, Yi-Sub (Department of Physical Education, Dong-Eui University) Oh, Yoo-Sung (Department of Physical Education, Seoul City University) Cho, Joon-Yong (Exercise Biochemistry Laboratory, Korea National Sport University) |
1 | Rogaev, E. I., R. Sherrington, E. A. Rogaeva, G. Levesque, M. Ikeda, Y. Liang, H. Chi, C. Lin, K. Holman, T. Tsuda. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778 DOI ScienceOn |
2 | Adlard, P. A., V. M. Perreau, V. Pop and C. W. Cotman. 2005. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J. Neurosci. 25, 4217-4221 DOI ScienceOn |
3 | Chong, Z. Z., F. Li and K. Maiese. 2005. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog. Neurobiol. 75, 207-246 DOI ScienceOn |
4 | Ding, Y. H., J. Li, Y. Zhou, J. A. Rafols, J. C. Clark and Y. Ding. 2006. Cerebral angiogenesis and expression of angiogenic factors in aging rats after exercise. Curr. Neurovasc. Res. 3, 15-23 DOI ScienceOn |
5 | Hsiao, K., P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang and G. Cole. 1996. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274, 99-102 DOI ScienceOn |
6 | Hwang, D. Y., J. S. Cho, S. H. Lee, K. R. Chae, H. J. Lim, S. H. Min, S. J. Seo, Y. S. Song, C. W. Song, S. G. Paik, Y. Y. Sheen and Y. K. Kim. 2004. Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw. Exp. Neurol. 186, 20-32 DOI ScienceOn |
7 | Lazarov, O., J. Robinson, Y. P. Tang, I. S. Hairston, Z. Korade-Mirnics, V. M. Lee, L. B. Hersh, R. M. Sapolsky, K. Mirnics and S. S Sisodia. 2005. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 120, 701-713 DOI ScienceOn |
8 | Lee, V. M. and J. Q. Trojanowski. 1992. The disordered neuronal cytoskeleton in Alzheimer's disease. Curr. Opin. Neurobiol. 2, 653-656 DOI ScienceOn |
9 | Spirduso, W. W. 1983. Exercise and the Aging Brain. (The 1982 CH McCloy Research Lecture), pp. 208-218 |
10 | van Praag, H., G. Kempermann and F. H. Gage. 1999. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2, 266-270 DOI ScienceOn |
11 | Farkas, E. and P. G. Luiten. 2001. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 64, 575-611 DOI ScienceOn |
12 | Hager, K., A. Marahrens, M. Kenklies, P. Riederer and G. Munch. 2001. Alpha-lipoic acid as a new treatment option for Azheimer type dementia. Arch. Gerontol. Geriatr. 32, 275-282 DOI ScienceOn |
13 | Melling, C. W., D. B. Thorp, K. J. Milne, M. P. Krause and E. G. Noble. 2007. Exercise-mediated regulation of Hsp70 expression following aerobic exercise training. Am. J. Physiol. Heart Circ. Physiol. 293, H3692-3698 DOI ScienceOn |
14 | Russo-Neustadt, A. A., H. Alejandre, C. Garcia, A. S. Ivy and M. J. Chen. 2004. Hippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exercise. Neuropsychopharmacology 29, 2189-2199 DOI ScienceOn |
15 | Tanzi, R. E., D. M. Kovacs, T. W. Kim, R. D. Moir, S. Y. Guenette and W. Wasco, 1996. The gene defects responsible for familial Alzheimer's disease. Neurobiol. Dis. 3, 159-168 DOI ScienceOn |
16 | Yoo, B. C., S. H. Kim, N. Cairns, M. Fountoulakis and G. Lubec. 2001. Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease. Biochem. Biophys. Res. Commun. 280, 249-258 DOI ScienceOn |
17 | Horwood, N. and D. C. Davies. 1994. Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease. Virchows Arch. 425, 69-72 |
18 | Cho, J. Y., D. Y. Hwang, T. S. Kang, D. H. Shin, J. H. Hwang, C. H. Lim, S. H. Lee, H. J. Lim, S. H. Min, S. J. Seo, Y. S. Song, K. T. Nam, K. S. Lee, J. S. Cho and Y. K. Kim. 2003. Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease. J. Sports Sci. 21, 943-951 DOI ScienceOn |
19 | Black, J. E., K. R. Isaacs and W. T. Greenough. 1991. Usual vs. successful aging: some notes on experiential factors. Neurobiol. Aging 12, 325-328 DOI ScienceOn |
20 | Hock, C., K. Heese, C. Hulette, C. Rosenberg and U. Otten. 2000. Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch. Neurol. 57, 846-851 DOI ScienceOn |
21 | Xie, L., E. Helmerhorst, K. Taddei, B. Plewright, W. van Bronswijk and R. Martins. 2002. Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor. J. Neurosci. 22, RC221 DOI |
22 | Neeper, S. A., F. Gomez-Pinilla, J. Choi and C. W. Cotman. 1996. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 726, 49-56 DOI ScienceOn |
23 | Cotman, C. W., N. C. Berchtold and L. A. Christie. 2007. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 30, 464-472 DOI ScienceOn |
24 | Kumar, P., R. K. Ambasta, V. Veereshwarayya, K. M. Rosen, K. S. Kosik, H. Band, R. Mestril, C. Patterson and H. W. Querfurth. 2007. CHIP and HSPs interact with beta- APP in a proteasome-dependent manner and influence Abeta metabolism. Hum. Mol. Genet. 16, 848-864 DOI ScienceOn |
25 | Nichol, K. E., A. I. Parachikova and C. W. Cotman. 2007. Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav. Brain Res. 184, 124-132 DOI ScienceOn |
26 | Cotman, C. W. and N. C. Berchtold. 2002. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 25, 295-301 DOI ScienceOn |
27 | Wolf, S. A., G. Kronenberg, K. Lehmann, A. Blankenship, R. Overall, M. Staufenbiel and G. Kempermann. 2006. Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease. Biol. Psychiatry. 60, 1314-1323 DOI ScienceOn |
28 | Korea Institute and Social Affairs, 2007 |
29 | Hooijmans, C. R., C. Graven, P. J. Dederen, H. Tanila, T. van Groen and A. J. Kiliaan. 2007. Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice. Brain Res. 1181, 93-103 DOI ScienceOn |
30 | Blass, J. P. 2001. Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? J. Neurosci. Res. 66, 851-856 DOI ScienceOn |
31 | Yenari, M. A., J. Liu, Z. Zheng, Z. S. Vexler, J. E. Lee and R. G. Giffard. 2005. Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection. Ann. N.Y. Acad. Sci. 1053, 74-83 DOI ScienceOn |
32 | Choeiri, C., W. Staines and C. Messier. 2002. Immunohistochemical localization and quantification of glucose transporters in the mouse brain. Neuroscience 111, 19-34 DOI ScienceOn |