• 대한기계학회논문집A
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• 제30권5호
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• pp.602-608
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• 2006

Vehicle components such as lower control arm are usually affected by heat during the welding process. As a result, residual stress is generated, which has much effect on mechanical performances such as crashworthiness and durability. In this study, the residual stress in lower control arm has been measured by the x-ray diffraction method and been analyzed by finite element methods. Heat transfer during seam weld process has been calculated and used in calculating thermal deformation with temperature dependent material properties. High residual stress has been found at vertical wall both by measurement and simulation. The simulation also showed the residual stress re-distribution when the component is subjected to cyclic loading condition.

• Journal of Welding and Joining
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• 제21권5호
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• pp.561-567
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• 2003

For construction of I-beam steel structures, a fillet welding is one of the main manufacturing process. However, this welding process cause some problems associated with welding residual stress and welding deformation that are harmful to the safety of structures. Accordingly, this study clarified the creation mechanism of the welding deformation on I-beam steel structure from the experimental results given by the FEM method. To prevent or minimize the longitudinal bending deformation, first of all, a field supervision is necessary to observe the optimal groove design. Secondly, the welding order for cooling weld zone is needed.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 추계학술대회논문집
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• pp.252-252
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• 2004

• Mycobiology
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• 제51권5호
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• pp.372-378
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• 2023

Lkh1, a LAMMER kinase homolog in the fission yeast Schizosaccharomyces pombe, acts as a negative regulator of filamentous growth and flocculation. It is also involved in the response to oxidative stress. The lkh1-deletion mutant displays slower cell growth, shorter cell size, and abnormal DNA content compared to the wild type. These phenotypes suggest that Lkh1 controls cell size and cell cycle progression. When we performed microarray analysis using the lkh1-deletion mutant, we found that only four of the up-regulated genes in the lkh1-deletion were associated with the cell cycle. Interestingly, all of these genes are regulated by the Mlu1 cell cycle box binding factor (MBF), which is a transcription complex responsible for regulating the expression of cell cycle genes during the G1/S phase. Transcription analyses of the MBF-dependent cell-cycle genes, including negative feedback regulators, confirmed the up-regulation of these genes by the deletion of lkh1. Pull-down assay confirmed the interaction between Lkh1 and Yox1, which is a negative feedback regulator of MBF. This result supports the involvement of LAMMER kinase in cell cycle regulation by modulating MBF activity. In vitro kinase assay and NetPhosK 2.0 analysis with the Yox1T40,41A mutant allele revealed that T40 and T41 residues are the phosphorylation sites mediated by Lkh1. These sites affect the G1/S cell cycle progression of fission yeast by modulating the activity of the MBF complex.

• Coupled systems mechanics
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• 제8권3호
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• pp.273-287
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• 2019

Elastoplastic analysis of an annular disc, being fully constrained on its outer rim and interacting with a purely elastic inclusion perfectly bonded with its inner rim, is conducted to study its plastic deformation and residual stress under thermal cycles. The system is termed the composite disc. Quasi-static plane-strain deformation is assumed, and the von Mises yield criterion with or without the Ludwik hardening rule is adopted in our finite element calculations. Effects of multiple material properties simultaneously being temperature dependent on the plastic behavior of the composite disc are considered. Residual stress is analyzed from a complete loading and unloading cycle. Results are discussed for various inclusion radii. It is found that when temperature dependent material properties are considered, the maximum residual stress may be greater than the maximum stress inside the disc at the temperature-loaded state due to lower temperature having larger yield stress. Temperature independent material properties overestimate stresses inside materials, as well as the elastic irreversible temperature and plastic collapse temperature.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.98-103
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• 2008

This paper is to discuss distribution of welding residual stresses of a ferritic low alloy steel nozzle with dissimilar metal weld using Alloy 82/182. Two dimensional (2D) thermo-mechanical finite element analyses are carried out to simulate multi-pass welding process on the basis of the detailed and fabrication data. On performing the welding analysis generally, the characteristics on the heat input and heat transfer of weld are affected on the weld residual stress analyses. Thermal analyses in the welding heat cycle process is very important process in weld residual stress analyses. Therefore, heat is rapidly input to the weld pass material, using internal volumetric heat generation, at a rate which raises the peak weld metal temperature to $2200^{\circ}C$ and the base metal adjacent to the weld to about $1400^{\circ}C$. These are approximately the temperature that the weld metal and surrounding base materials reach during welding. Also, According to the various ways of appling the weld heat source, the predicted residual stress results are compared with measured axial, hoop and radial through-wall profiles in the heat affected zone of test component. Also, those results are compared with those of full 3-dimensional simulation.

• 대한기계학회논문집
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• 제18권2호
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• pp.271-277
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• 1994

The fatigue crack opening behavior is analyzed using finite element method. Because extremely fine mesh subdivision is required when using constant stress constant strain triangular element, this study uses conventional two dimensional eight node isoparametric elements. Since plasitc zone size is similar to crack propagating length per each load cycle because of relatively large element size, a new analysis model that a crack propagates every two load cycle is suggested. the opening load and crack opening displacement can be obtained accurately by this method.

• Toxicological Research
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• 제21권1호
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• pp.77-85
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• 2005

Cadmium is an environmental pollutant exposed from contaminated foods or cigarette smoking and known to cause oxidative damage in organs. We investigated the cadmium-induced apoptosis and cell arrest in human breast cancer cells, MCF-7 cells and MDA-MB-231 cells. Obvious apoptotic cell death was shown in CdCl₂ 100 μM treatment for 12 hr, which were determined by DAPI staining and flow cytometric analysis. In cell cycle analysis, MCF-7 cells and MDA-MB-231 cells were arrested in S phase and G2/M phase respectively. These could be explained by the induction of cell cycle inhibitory protein, p21/sup Waf1/Cip1/ and p27/sup Kip1/, expression and reduction of cyclin/Cdk complexes in both cell lines. The decreased expression of cyclin A and Cdk2 in MCF-7 cells and cyclin B1 and Cdc2 in MDA-MB-231 cells were consistent with the flow cytometric observation. p-ERK expression was increased dose-dependent manner in both cell lines. It suggests that ERK MAPK pathway are involved in cadmium-induced cell cycle arrest and apoptosis. Moreover, cotreatment of zinc (100 μM, 12 hr) recovered the cadmium-induced cell arrest in both cells, which shows cadmium-induced oxidative stress mediates apoptosis and cell cycle arrest in human breast cancer cells.

• 한국전기전자재료학회논문지
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• 제21권5호
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• pp.434-439
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• 2008

Silver pastes as the outer electrodes have been prepared using Pb-free glass frits with different content of $Bi_2O_3$ and the effects of glass composition on the degradation behaviors of the Ag electrodes were investigated using the change of adhesion between Ag electrode and alumina substrate with thermal cycle stress. Low adhesion and high surface resistance were observed in Ag electrode using glass frit with a $Bi_2O_3$ content of 60 wt%, owing to the open microstructure formed at the firing temperature of $600^{\circ}C$. When the $Bi_2O_3$ was increased to 80 wt% in the glass frit, the Ag electrodes had a dense microstructure with high adhesion and a low surface resistance. Delamination of the Ag electrodes was a major failure mode under thermal cycle stress and this was attributed to residual stress due to the thermal expansion mismatch between the Ag electrode and the alumina substrate.

• 한국생산제조학회지
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• 제20권5호
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• pp.528-534
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• 2011

This study analyzes thermal stress and durability fatigue on the modelling of EGR valve. In case of 10% opening at its inlet, the minimum temperature gets cool as 3 times as inlet temperature. The maximum equivalent stress becomes lowest as the value of $2.6274{\times}109$ Pa and fatigue life becomes highest as 23.657 Cycle. But the minimum temperature gets cool as 2.2 times as inlet temperature in case of 50% opening at its inlet. The equivalent stress becomes higher and fatigue life becomes lower than in case of 10% opening. In case of 100% opening at its inlet, the minimum temperature gets cool as 0.2 times as inlet temperature. The equivalent stress becomes lower and fatigue life becomes higher than in case of 50% opening. Maximum equivalent stress and total deformation are shown at the closing of EGR valve by the pressure of inflow gas. The structural analysis result of this study can be effectively utilized with the design of EGR valve by investigating prevention and durability against its damage.