• The Korean Journal of Applied Statistics
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• v.28 no.2
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• pp.175-188
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• 2015

This study is about estimation methods for the population pharmacokinetic and pharmacodymic model. This is a nonlinear mixed effect model, and it is difficult to find estimates of parameters because of nonlinearity. In this study, we examined theoretical background of various estimation methods provided by NONMEM, which is the most widely used software in the pharmacometrics area. We focused on estimation methods using a stochastic sampling approach - IMP, IMPMAP, SAEM and BAYES. The SAEM method showed the best performance among methods, and IMPMAP and BAYES methods showed slightly less performance than SAEM. The major obstacle to a stochastic sampling approach is the running time to find solution. We propose new approach to find more precise initial values using an ITS method to shorten the running time.

• Journal of applied mathematics & informatics
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• v.20 no.1_2
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• pp.119-132
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• 2006

This paper presents an approach for using right-truncated exponentially distributed random variables to model activity times in stochastic activity networks. The advantages of using the right-truncated exponential distribution are discussed. The moments of a project completion time using the proposed distribution are derived and compared with other estimated moments in literature.

• Journal of the Chungcheong Mathematical Society
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• v.29 no.2
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• pp.337-346
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• 2016

Within white noise approach, we study the existence and uniqueness of the solution of an initial value problem for generalized white noise functionals, and then as a corollary we discuss the linear stochastic differential equation associated with a convolution of white noise functionals.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1991.10a
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• pp.147-159
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• 1991

Stochastic convexity(concvity) of a stochastic process is a very useful concept for various stochastic optimization problems. In this study we first establish stochastic convexity of a certain class of Markov additive processes through the probabilistic construction based on the sample path approach. A Markov additive process is obtained by integrating a functional of the underlying Markov process with respect to time, and its stochastic convexity can be utilized to provide efficient methods for optimal design or for optimal operation schedule of a wide range of stochastic systems. We also clarify the conditions for stochatic monotonicity of the Markov process, which is required for stochatic convexity of the Markov additive process. This result shows that stochastic convexity can be used for the analysis of probabilistic models based on birth and death processes, which have very wide application area. Finally we demonstrate the validity and usefulness of the theoretical results by developing efficient methods for the optimal replacement scheduling based on the stochastic convexity property.

• Journal of the Korean Operations Research and Management Science Society
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• v.16 no.1
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• pp.76-88
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• 1991

Stochastic convexity (concavity) of a stochastic process is a very useful concept for various stochastic optimization problems. In this study we first establish stochastic convexity of a certain class of Markov additive processes through probabilistic construction based on the sample path approach. A Markov additive process is abtained by integrating a functional of the underlying Markov process with respect to time, and its stochastic convexity can be utilized to provide efficient methods for optimal design or optimal operation schedule wide range of stochastic systems. We also clarify the conditions for stochastic monotonicity of the Markov process. From the result it is shown that stachstic convexity can be used for the analysis of probabilitic models based on birth and death processes, which have very wide applications area. Finally we demonstrate the validity and usefulness of the theoretical results by developing efficient methods for the optimal replacement scheduling based on the stochastic convexity property.

• Advances in aircraft and spacecraft science
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• v.7 no.5
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• pp.405-423
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• 2020

Non-linear energy sink (NES) is an emerging passive absorber able to mitigate the dynamic response of structures without any external energy supply, resonating with all the modes of the primary structure to control. However, its inherent non-linearities hinder its large-scale use and leads to complicated design procedures. For this purpose, an approximate design approach is herein proposed in a stochastic framework. Since loads are random in nature, the stochastic analysis of non-linear systems may be performed by means of computational intensive techniques such as Monte Carlo simulations (MCS). Alternatively, the Stochastic Linearisation (SL) technique has proven to be an effective tool to investigate the performance of different passive control systems under random loads. Since controlled systems are generally non-classically damped and most of SL algorithms operate recursively, the computational burden required is still large for those problems that make intensive use of SL technique, as optimal design procedures. Herein, a procedure to speed up the Stochastic Linearisation technique is proposed by avoiding or strongly reducing numerical evaluations of response statistics. The ability of the proposed procedure to effectively reduce the computational effort and to reliably design the NES is showed through an application on a well-known case study related to the vibrations mitigation of an aircraft wing.

• International Journal of Control, Automation, and Systems
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• v.5 no.4
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• pp.355-363
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• 2007

The paper deals with the Kalman stochastic filtering problem for linear continuous-time systems with both instantaneous and time-delayed measurements. Different from the standard linear system, the system state is corrupted by multiplicative white noise, and the instantaneous measurement and the delayed measurement are also corrupted by multiplicative white noise. A new approach to the problem is presented by using projection formulation and reorganized innovation analysis. More importantly, the proposed approach in the paper can be applied to solve many complicated problems such as stochastic $H_{\infty}$ estimation, $H_{\infty}$ control stochastic system with preview and so on.

• Water for future
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• v.4 no.1
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• pp.51-58
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• 1971

Hydrologic data serve as an input to the water resources system. An adequate analysis of hydrologic data is one of the most important steps in the planning of the water resources development program. The natural hydrologic processes, which produce the hydrologic data, are truely 'stochastic' in the sense that natural hydrologic phenomena change with time in accordance with the law of probability as well as with sequential relationship between their occurrences. Therefore, the stochastic approach to the analysis of hydrologic data has become more popular in recent years than the conventional deterministic or probabilistic approach. This paper reviews the mathematical models which can adequately simulate the stochastic behavior of the hydrologic characteristics of a hydrologic system. The actual application of these models in the analysis of hydrologic records(precipipitation and runoff records in particular) is also presented.

• Korean Management Science Review
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• v.28 no.2
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• pp.17-29
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• 2011

The purpose of this paper is to schedule elective surgery patients using a stochastic programming approach and to illustrate how operating room utilization behaves when a decision-maker varies costs associated with utilization. Because of the uncertainty in surgery durations, the underage and overage costs that a decision-maker considers plays an important role in allocating surgery cases into available operating room capacity. We formulate the problem as a stochastic mixed integer programming and propose a sampling-based approximation method for a computational purpose. Newsvendor model is employed to explain the results from numerical experiments that are conducted with the actual data from a hospital. The results show that the operating room utilization is more sensitive when the unit overtime cost is relatively larger than the unit cost for underutilized time.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1994.10a
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• pp.653-657
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• 1994

A symbolic performance analysis approach for flexible for manufactring systems (FMS) can be formulated based on the integration of Petri Nets (PN) and moment generating function (MGF) concept. In this method, generalized stochastic Petri Nets are used to define performance models for FMS, then MGF nased approach for evaluating stochastic PN is used to derive performance parameters of PN, and finally system performance is calculated. A GSPN model of machine cell is shown to illustrate the proposed method for evaluating such performance indices as production rate, utilization, work-in-process and lead time. The major advantage of this method over existing performance evaluation of FMS is the ability to compute symbolic solutions for performance. Finally future research toward automating performance measure for GSPN models of FMS is discussed.