• Title/Summary/Keyword: Statistical hypothesis testing

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Comparison of methods for the proportion of true null hypotheses in microarray studies

  • Kang, Joonsung
    • Communications for Statistical Applications and Methods
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    • v.27 no.1
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    • pp.141-148
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    • 2020
  • We consider estimating the proportion of true null hypotheses in multiple testing problems. A traditional multiple testing rate, family-wise error rate is too conservative and old to control type I error in multiple testing setups; however, false discovery rate (FDR) has received significant attention in many research areas such as GWAS data, FMRI data, and signal processing. Identify differentially expressed genes in microarray studies involves estimating the proportion of true null hypotheses in FDR procedures. However, we need to account for unknown dependence structures among genes in microarray data in order to estimate the proportion of true null hypothesis since the genuine dependence structure of microarray data is unknown. We compare various procedures in simulation data and real microarray data. We consider a hidden Markov model for simulated data with dependency. Cai procedure (2007) and a sliding linear model procedure (2011) have a relatively smaller bias and standard errors, being more proper for estimating the proportion of true null hypotheses in simulated data under various setups. Real data analysis shows that 5 estimation procedures among 9 procedures have almost similar values of the estimated proportion of true null hypotheses in microarray data.

k-Sample Rank Procedures for Ordered Location-Scale Alternatives

  • Park, Hee-Moon
    • Journal of Korean Society for Quality Management
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    • v.22 no.2
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    • pp.166-176
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    • 1994
  • Some rank score tests are proposed for testing the equality of all sampling distribution functions against ordered location-scale alternatives in k-sample problem. Under the null hypothesis and a contiguous sequence of ordered location-scale alternatives, the asymptotic properties of the proposed test statistics are investigated. Also, the asymptotic local powers are compared with each others. The results show that the proposed tests based on the Hettmansperger-Norton type statistic are more powerful than others for the general ordered location-scale alternatives. However, the Shiraishi's tests based on the sum of two Bartholomew's rank analogue statistics are robust.

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A Study on the Two Equal Tail Critical Region for the Testing Statistical Hypothesis (통계적 가설검정에 있어서의 등측기각역에 관한 고찰)

  • 김광섭
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.5 no.7
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    • pp.25-27
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    • 1982
  • In most introductory statistics courses and text, the two equal tail test is presented without justification. In the present paper, the two equal tail critical region will be discussed in the light of unbiasedness with some test examples for the mean and the variance based on the random sample $X_1$, $X_2$,....$X_n$ from N($\mu$, $\delta^2$) using only elementary mathematics.

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Reproducibility of Hypothesis Testing and Confidence Interval (가설검정과 신뢰구간의 재현성)

  • Huh, Myung-Hoe
    • The Korean Journal of Applied Statistics
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    • v.27 no.4
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    • pp.645-653
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    • 2014
  • P-value is the probability of observing a current sample and possibly other samples departing equally or more extremely from the null hypothesis toward postulated alternative hypothesis. When p-value is less than a certain level called ${\alpha}$(= 0:05), researchers claim that the alternative hypothesis is supported empirically. Unfortunately, some findings discovered in that way are not reproducible, partly because the p-value itself is a statistic vulnerable to random variation. Boos and Stefanski (2011) suggests calculating the upper limit of p-value in hypothesis testing, using a bootstrap predictive distribution. To determine the sample size of a replication study, this study proposes thought experiments by simulating boosted bootstrap samples of different sizes from given observations. The method is illustrated for the cases of two-group comparison and multiple linear regression. This study also addresses the reproducibility of the points in the given 95% confidence interval. Numerical examples show that the center point is covered by 95% confidence intervals generated from bootstrap resamples. However, end points are covered with a 50% chance. Hence this study draws the graph of the reproducibility rate for each parameter in the confidence interval.

Bootstrap inference for covariance matrices of two independent populations (두 독립 모집단의 공분산 행렬에 대한 붓스트랩 추론)

  • 김기영;전명식
    • The Korean Journal of Applied Statistics
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    • v.4 no.1
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    • pp.1-11
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    • 1991
  • It is of great interest to consider the homogeniety of covariance matrices in MANOVA of discriminant analysis. If we lock at the problem of testing hypothesis, H : $\Sigma_1 = \Sigma_2$ from an invariance point of view where $\Sigma_i$ are the covariance matrix of two independent p-variate distribution, the testing problem is invariant under the group of nonsingular transformations and the hypothesis becomes H : $\delta_1 = \delta_2 = \cdots = \delta_p = 1$ where $\delta = (\delta_1, \delta_2, \cdots, \delta_p)$ is a vector of latent roots of $\Sigma$. Bias-corrected estimators of eigenvalues and sampling distribution of the test statistics proposed are obtained. Pooled-bootstrap method also considered for Bartlett's modified likelihood ratio statistics.

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The Limit Distribution of an Invariant Test Statistic for Multivariate Normality

  • Kim Namhyun
    • Communications for Statistical Applications and Methods
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    • v.12 no.1
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    • pp.71-86
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    • 2005
  • Testing for normality has always been an important part of statistical methodology. In this paper a test statistic for multivariate normality is proposed. The underlying idea is to investigate all the possible linear combinations that reduce to the standard normal distribution under the null hypothesis and compare the order statistics of them with the theoretical normal quantiles. The suggested statistic is invariant with respect to nonsingular matrix multiplication and vector addition. We show that the limit distribution of an approximation to the suggested statistic is representable as the supremum over an index set of the integral of a suitable Gaussian process.

The Limit Distribution and Power of a Test for Bivariate Normality

  • Kim, Namhyun
    • Communications for Statistical Applications and Methods
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    • v.9 no.1
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    • pp.187-196
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    • 2002
  • Testing for normality has always been a center of practical and theoretical interest in statistical research. In this paper a test statistic for bivariate normality is proposed. The underlying idea is to investigate all the possible linear combinations that reduce to the standard normal distribution under the null hypothesis and compare the order statistics of them with the theoretical normal quantiles. The suggested statistic is invariant with respect to nonsingular matrix multiplication and vector addition. We show that the limit distribution of an approximation to the suggested statistic is represented as the supremum over an index set of the integral of a suitable Gaussian Process. We also simulate the null distribution of the statistic and give some critical values of the distribution and power results.

Derivation and Implementation of Statistical Difference and Practical Equivalence Models in the Quality Improvement Processes (품질개선 프로세스에서 통계적 차이와 실제적 동등성 모형의 유도 및 적용방안)

  • Choi, Sung-Woon
    • Journal of the Korea Safety Management & Science
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    • v.12 no.2
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    • pp.217-223
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    • 2010
  • The research proposes the complementary methodology using integrated hypothesis testing and confidence interval models that can be identified the statistical difference and practical equivalence. The models developed in this study can be used in the quality improvement processes such as QC story 15 steps. For the expressions of CI4LSD(Confidence Interval for Least Significant Difference) and CI4TOST(Confidence Interval for Two One-Sided Tests) are simple, quality practioners can efficiently handle them. CI4TOST models as a complement can be applied when CI4LSD models are influenced by sample size and precision.

Statistical Tests for Edg Detection (에지 검출을 위한 통계적 검정법)

  • Im, Dong-Hun;Seong, Sin-Hui
    • The Transactions of the Korea Information Processing Society
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    • v.7 no.3
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    • pp.1021-1024
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    • 2000
  • In this paper we describe a nonparametric Wilcoxon test and a parametric Z test based on statistical hypothesis testing for the detection of edges. We use the threshold determined by specifying significance level $\alpha$, while Bovik, Huang and Munson[4] consider the range of possible values of test statistics for the threshold. From the experimental results of edge detection, the Z method performs sensitively to the noisy image, while the Wilcoxon method is robust over both noisy nd noise-free images. Comparison with our statistical tests and Sobel operator shows that our tests perform more effectively in both noisy and noise-free images.

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An Automatic Segmentation Method for Video Object Plane Generation (비디오 객체 생성을 위한 자동 영상 분할 방법)

  • 최재각;김문철;이명호;안치득;김성대
    • Journal of Broadcast Engineering
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    • v.2 no.2
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    • pp.146-155
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    • 1997
  • The new video coding standard Iv1PEG-4 is enabling content-based functionalities. It requires a prior decomposition of sequences into video object planes (VOP's) so that each VOP represents moving objets. This paper addresses an image segmentation method for separating moving objects from still background (non-moving area) in video sequences using a statistical hypothesis test. In the proposed method. three consecutive image frames are exploited and a hypothesis testing is performed by comparing two means from two consecutive difference images. which results in a T-test. This hypothesis test yields a change detection mask that indicates moving areas (foreground) and non-moving areas (background), Moreover. an effective method for extracting

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