• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.1
• /
• pp.167-174
• /
• 2014

Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore investigated the effects of barbigerone on all three in the B16F10 tumor model established in both zebrafish and mouse models, and explored underlying molecular mechanisms. In vitro, barbigerone inhibited B16F10 cell proliferation, survival, migration and invasion and suppressed human umbilical vascular endothelial cell migration, invasion and tube formation in concentration-dependent manners. In the transgenic zebrafish model, treatment with $10{\mu}M$ barbigerone remarkably inhibited angiogenesis and tumor-associated angiogenesis by reducing blood vessel development more than 90%. In vivo, barbigerone significantly suppressed angiogenesis as measured by H and E staining of matrigel plugs and CD31 staining of B16F10 melanoma tumors in C57BL/6 mice. Furthermore, it exhibited highly potent activity at inhibiting tumor growth and metastasis to the lung of B16F10 melanoma cells injected into C57BL/6 mice. Western blotting revealed that barbigerone inhibited phosphorylation of AKT, FAK and MAPK family members, including ERK, JNK, and p38 MAPKs, in B16F10 cells mainly through the MEK3/6/p38 MAPK signaling pathway. These findings suggested for the first time that barbigerone could inhibit tumor-angiogenesis, tumor growth and lung metastasis via downregulation of the MEK3/6/p38 MAPK signaling pathway. The findings support further investigation of barbigerone as a potential anti-cancer drug.

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.47 no.5
• /
• pp.74-80
• /
• 2010

Speech and audio codecs have been developed based on different type of coding technologies since they have different characteristics of signal and applications. In harmony with a convergence between broadcasting and telecommunication system, international organizations for standardization such as 3GPP and ISO/IEC MPEG have tried to compress and transmit multimedia signals using unified codecs. MPEG recently initiated an activity to standardize the USAC (Unified speech and audio coding). However, USAC RM (Reference model) software has been problematic since it has a complex hierarchy, many useless source codes and poor quality of the encoder. To solve these problems, this paper introduces a new RM software designed with an open source paradigm. It was presented at the MPEG meeting in April, 2010 and the source code was released in June.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.7
• /
• pp.3113-3118
• /
• 2012

Introduction: Cancer is the second cause of death in Kuwaiti people after cardiovascular diseases. This study is the first in the country to describe epidemiological measures related to cancer in this population. Methods: Data obtained from the Kuwait cancer registry included all Kuwaiti patients between years 2000-2009. Analyses were conducted using age-specific rates, the age-standardization-direct method, 95% confidence intervals (95% CI), cumulative risk by the age of 74 years, limited-duration prevalence, mortality and forecasting to year 2029. Results: It was noted that the commonest cancer sites were colorectal with an age standardized incidence rate (ASIR) of 16.1/100,000 in males and breast (49.4/100,000) in the female population. The trend of cancer incidence (1974-2009) showed no statistically significant change. First causes of death due to cancer were female breast 8(6.4-9.6)/100,000 and lung (males) 8.1/100,000 (6.6-10.0). The risk of developing cancer by the age of 74 was 13.4% (1/8) and 14.3% (1/7) in males and females respectively, and the risk of dying from cancer in the same age group was 1/17 and 1/23. By the end of 2009, prevalent cases represented 0.52% of the Kuwaiti population. In the year 2029, the total number of cancer cases is expected to reach 1200 cases compared to 889 cases in 2009. Conclusions and recommendations: The most common cancers in Kuwait (breast, colorectal and lung) are largely preventable. Prompt and effective interventional prevention programs that vigorously involve diet, anti-smoking and physical activity for both sexes are urgently required.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2008.10a
• /
• pp.685-688
• /
• 2008

A Next Generation Network (NGN) is a packet-based network able to provide services including Telecommunication Services and able to make use of multiple broadband, QoS-enabled transport technologies and in which service-related functions are independent from underlying transport-related technologies. It offers unrestricted access by users to different service providers. It supports generalized mobility which will allow consistent and ubiquitous provision of services to users in this paper. we describe the trend of standardization activity related with open services environment capabilities which had been finally approved at September 2008 in ITU-T. ITU-T SG13 is responsible for studies relating to the architecture, evolution and convergence of next generation networks including frameworks and functional architectures, signalling requirements for NGN.

• Journal of Broadcast Engineering
• /
• v.18 no.2
• /
• pp.319-322
• /
• 2013

Image retrieval research activity has moved its focus from global descriptors to local descriptors of feature point such as SIFT. MPEG is Currently working on standardization of effective coding of location and local descriptors of feature point in the context mobile based image search driven application in the name of MPEG-7 CDVS (Compact Descriptor for Visual Search). The extracted feature points consist of two parts, location information and Descriptor. For efficient image retrieval, we proposed a novel method that is gradual block-based efficient lossy location coding to compress location information according to distribution in images. From experimental result, the number of average bits per feature point reduce 5~6% and the accuracy rate keep compared to state of the art TM 3.0.

• Journal of Life Science
• /
• v.19 no.1
• /
• pp.138-146
• /
• 2009

Garlic (Allium sativum) are an agronomically important genus because of their sulfur flavour components. The majority of the volatiles flavour principles are generated through the enzymatic hydrolysis of the non-volatile organosulfur compounds. However, these compounds may be possible sources of new novel bioacuve and therapeutic principles. Garlic has strong antioxidant activity, and epidemiological studies support the fad that diets rich of garlic may prevent some of the chronic diseases. The health cares of garlic likely arise from a wide variety of components, which may work synergistically. The chemical changes of garlic composition makes it plausible that a variation in processing can lead to acquisition of differential chemical compositions of garlic products. Especially highly unstable allicin can easily disappear during processing and are quickly transformed into a various organosulfur compounds. Various supplements of garlic, particularly aged garlic extract (AGE), are known to possess a promising antioxidant potential and are effective in prevention of chronic diseases because of the bioactive constituents. Although all of active ingredients of AGE are not elucidated, water-soluble components of AGE, including S-allylcysteine, S-allylmercaptane, steroid saponins, tetrahydro-${\beta}$-carboline derivatives, and fructosyl-arginine, appears to be associated with the pharmacological effects of AGE. Consequently, the allicin free garlic components such as S-allylcysteine, S-allylmercaptane, steroid saponins, tetrahydro-${\beta}$-carboline derivatives, and fructosyl-arginine can be applicable to standardization of the quality of commercial garlic products. This review provides an insight into garlic's biomarkers and presents evidence that they may either prevent or delay chronic disease associated with aging.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.3 no.4
• /
• pp.335-340
• /
• 2005

The forward dissolution rate of a borosilicate waste glass was determined as an interlaboratory study(ILS) testing program for the evaluation of precision in the measurement of the dissolution rate or a waste glass using a single-pass flow-through(SPFT) test, whose conducting practice has been written for standardization through American Society for Testing and Materials (ASTM). A simulated low-activity waste glass powder with a size of 100/200 mesh was dissolved by lithium buffer solution (pH=10) at 70? under Ar atmosphere. By plotting the dissolution rates as a function of silicon and boron concentration in eluate, the forward dissolution rate of the glass was obtained as about $2.7\times10^{-5}g{\cdot}m{\cdot}s^{-1}$ in our laboratory.

• The Journal of the Korea Contents Association
• /
• v.17 no.1
• /
• pp.728-739
• /
• 2017

This study has a purpose that comes up with a practical direction of training program about a cultivating vocational competence to older adults for living an independent life including a social, economic, and emotional base. The aged people suffered from a employment uncertainty because the aged people's job opportunity is just opened to unskilled works and not related with a regular lifelong educational program. In this study, the direction of program for cultivating vocational competence should be expanded and standardized. Also, there are less social agreement about older adult's cultivating vocational competence has a meaning above the purpose with economic activity. And the program should related with the employment. The direction of program for cultivating vocational competence to older adult should be the expansion and standardization of program. and should have the opportunity of sympathy about older adult's physical and social problem.

• The Journal of Korean Medicine
• /
• v.18 no.1
• /
• pp.187-197
• /
• 1997

Major separation for the active ingredients and characterization of chemical properties in conjunction with screening test on animal were performed in order to analyze and standardize Ligustici Rhizoma or Angelicae Tenuissimae Radix as an important oriental herbal medicine for antiphlogistic or an important oriental herbal medicine for antiphlogistic or an anodyne. Furthermore the structure, composition and contents of ingredients for essential oil in Angelicae Tenuissimae Radix(Suckpo, Korea) were determined by means of Ge/MS followed by screening test on Z-ligustilide(82%) known as major ingredient as well as butylidenephthalide collected by HPLC with normal phase semiprep-column. The total active ingredient in Ligustici Rhizoma from China or Angelicae Tenuissimae harvested at Choonyang(Kyungnam, Korea), Jungsun(Kangwon, Korea), Suckpo(Kyungnam Korea), Youngchun(Kyungnam, Korea) have been determined showing higher abundant for three times on the product in Korea compared to that in China. In addition, the major component in Ahgelicae Tebyussunae Radux extract was found to be Z-ligustilide(70-80%) which is very different from that in Ligustici Rhizoma senkyunolide(39%) as major species. For screening test of Ligustici Rhizoma or Angelicae Tenuissimae Radix extracts toward the target animal, the efficiency has been shown the similarity on both extracts. Taking into account the level of ingredient, the total efficiency may be three times higher on Angelicae Tenuissimae Radix in Korea compared to Ligustici Rhizoma in China. As a result of present study, it is preferable to distinguish between Ligustici Rhizoma and Angelicae Tenuissimae Radix for better usage of oriental herbal medicine because of very different composition and abundant in spite of their similar screening effect.

• Journal of Home Health Care Nursing
• /
• v.5
• /
• pp.32-46
• /
• 1998

Cancer is a leading cause of death, and the number of cancer patients is increasing in Korea. The needs for the home care of cancer patients are increasing recently, but the standardized home care protocols are not developed yet. This study was designed to develop nursing assessment -intervention algorithms for the cancer chemotherapy patients at home. These algorithms suggest guidelines when we assess the patient's condition, and find appropriate nursing interventions, so that standardization and quality control of home care can be attained. The algorithms were processed by yes-no tree. Eleven common problems of cancer chemotherapy patients were identified by the literature review and oncology nurses' experience. These were digestive dysfunction, pain, fatigue, infection, respiratory difficulties, activity intolerance, hemorrhage, sensory disorder, edema, skin problem, and mucosal problem. The algorithm needs to be validated and modified by using for the cancer chemotherapy patients at home.