• The Korea Journal of Herbology
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• v.24 no.1
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• pp.89-98
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• 2009

Objectives : The purpose of this study was to evaluate effects of processed sulfur with red ginseng on streptozotocin(STZ) induced diabetic rats for expansion of processed sulfur internal application. Methods : We prepared red ginseng with non processed sulfur extracts(GS), red ginseng with processed sulfur I extracts(GPS I) and red ginseng with processed sulfur II extracts(GPS II). In the present study, we examined about contents of crdue saponin, antioxidant activity, $\alpha$-glucosidase inhibitory activity, and effects of STZ induced diabetic rats. Results : Contents of crude saponin increased by processed sulfur, and GPS II was shown highest contents in crude saponin and sulfur compared with another groups. Electron donating ability of GPS II was shown highest activity compared with GS and GPS I, SOD-like activity showed same tendency as electron donating ability at 1 $mg/m\ell$ concentration. Inhibitory activity of $\alpha$-glucosidase was approximately same level in acarbose and GPS II. Blood glucose level of GPS II group was decreased 18.34% compared with DC(diabetes control) group and maintained stability range in glucose level. but GS and GPS I showed high level compared to GPS II. Serum triglycerides concentration also showed lowest level in GPS II. The activity of ALT, AST and ALP was shown high level in diabetic induced groups, and lowest level in GPS II. Creatinine was shown non-significantly difference in each groups and GPS II was shown lowest level in BUN. Conclusions : These results suggested that processed sulfur with red ginseng have improvement effects on diabetes and internal application of processed sulfur with red ginseng have no specific toxicity in liver and kidney.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.1
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• pp.17-27
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• 2023

A study was performed to increase skin permeation of tocopheryl acetate, an oil-soluble component among tocopheryl acetate, salicylic acid, and niacinamide, which are the active ingredients of the anti-hair loss toner. As a method of transparently solubilizing tocopheryl acetate while containing salicyl acid and niacinamide, we used a swollen micelle structure that increased the size of the micelle formed by the aggregation of surfactants. The prepared swollen micelle solution contains three kinds of active ingredients, and poloxamer 407 and octyldodeceth-16 were used as surfactants to increase transparent properties and stability. In addition, isostearic acid was used as a co-surfactant to increase the size of micelles. To evaluate the physical properties of the prepared swollen micelles, turbidity at room temperature (25 ℃) was measured. The Franz diffusion cell method was used to evaluate the skin permeation rate of tocopheryl acetate among the hair-loss prevention components contained in swollen micelles. After 24 h, tocopheryl acetate showed a 6-fold improvement in skin permeation compared to the control group. Therefore, it can be seen that the swollen micelles developed in this study can be applied to hair-loss prevention products or solubilized formulations of various functional cosmetics.

• Journal of the Korea Knowledge Information Technology Society
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• v.13 no.3
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• pp.327-339
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• 2018

This study is on the elderly people's use and experience of pet robots (companion robots). Applying companion robots for the elderly's daily lives can enhance their quality of life. Leisure is main activity of the elderly who are out of work. Therefore, the quality and diversity of leisure can affect the quality of their life. Companion Robots could provide them with more advanced and interesting experiences. Around the world, population aging becomes one of the most important trends in each country. The social and economic burden of aging is serious challenge on sustainability of the world, including S. Korea. The authors examine use of Companion Robots for elderly (from 50 years old to 90 years old). In this experiment, the authors study and measure many factors including system quality, interface quality, displeasure, enjoyment, willingness to reuse, perception on new technology. In regression analysis, intimacy(t=-2.006, p<.05) is significant factor on displeasure of Companion Robot. In another regression, displeasure of Companion Robot (independent variable) is significant factor on enjoyment(t=-3.327, p<.01) and willingness to reuse(t=-2.636, p<.01). Therefore, when elderly one feels less displeasure of Companion Robot, he/she feels more enjoyment and willingness to reuse. As a result, the elderly who don't familiar to new technology could improve quality of life and leisure activity by using companion robot.

• The Korea Journal of Herbology
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• v.38 no.6
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• pp.1-27
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• 2023

Objectives : To investigate the modern research achievements of agarwood and its association with the efficacy of herbal medicine based on the in vivo and in vitro activities of volatile compounds detected in agarwood. Methods : Databases such as PubMed and ScienceOn were searched for medicinal in vivo and in vitro activity studies on agarwood. They were categorized into "medicine and pharmacy" and "others not related to medicine and pharmacy," and the studies on medicine and pharmacy were organized according to active efficacy. The efficacy and virtue of agarwood as identified in the book (or herbal medicine/herbology) corresponded to modern medical terms and diseases in reference to the . Separately, the Gas Chromatography & Mass spectrometer (GC-MS) analysis results of agarwood from a total of 5 production areas of Aquilaria crassna from Vietnam, Indonesia, Malaysia, Myanmar, and Cambodia as identified in previous studies were consulted to search for research papers on the medicinal activity of the 13 compounds of the aromatic sesquiterpene family detected in agarwood, and they were categorized according to topic. Results : There were 123 studies on the medicinal activity of agarwood. Overall, 46 studies on single extracts of agarwood reported activities such as improving mental health, including anti-anxiety and stability, and antiallergic, antioxidant, antibacterial, and digestive system protective effects. In total, 59 papers on the activities of single compounds isolated from agarwood reported anti-inflammatory and mental health benefits. Separately, 13 compounds detected in agarwood, such as α-agarofuran and β-caryophyllene, were reported by 110 studies to have anticancer, stabilizing, antibacterial, and anti-inflammatory activities. There were also papers on the cultivation methods and resin formation conditions of agarwood trees unrelated to the efficacy of herbal medicine. Conclusion : Among the pharmacological papers, a total of 57 papers corresponded to the effects of agarwood in traditional herbal medicine, including 33 papers related to agarwood extracts and 24 papers analyzing 8 types of sesquiterpenes, such as β-caryophyllene and cedrol, from previous studies. Based on the research findings of each paper, it was possible to correlate the effects of agarwood in traditional herbal medicine with the achievements of modern pharmacological research. In addition, further research is anticipated in new areas related to traditional herbal medicine, including the improvement of mental health such as anti-depression, as well as activities related to anticancer, antioxidant, and hair growth.

• Journal of the Korean Geotechnical Society
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• v.39 no.11
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• pp.7-22
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• 2023

In January 2022, a new legislation was enforced to enhance the safety of underground construction. Consequently, a comprehensive assessment of underground safety is now an integral part of the planning process, including an evaluation of its impact. Ensuring the stability of temporary retaining walls during underground excavation has become paramount, prompting a heightened focus on the assessment of underground safety. This study delves into the analysis of the Multi-axis Flat Continuous Soil Cement Wall retaining wall (MFS) construction method. This method facilitates the expansion of wall thickness in the ground and provides flexibility in selecting and spacing H-piles. Through laboratory model tests, we scrutinized the load-displacement behavior of the wall, varying the H-pile installation intervals using the MFS method. Additionally, a 3-dimensional numerical analysis was conducted to explore the influence of H-pile installation intervals and sizes on the load for different thicknesses of the MFS retaining wall. The displacement analysis yielded the calculation of the height of the arching effect acting on the wall. To further our understanding, a design method was introduced, quantitatively analyzing the results of axial force and shear force acting on the wall. This involved applying the maximum arching height, calculated by the MFS method, to the existing member force review method. The axial force and shear force, contingent on the H-pile installation interval and size applied to the MFS retaining wall, demonstrated a reduction effect ranging from 24.6% to 62.9%.

• Journal of the Korean GEO-environmental Society
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• v.24 no.12
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• pp.53-60
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• 2023

Recently, along with the improvement of high-speed rail and road design speed, the proportion of tunnel construction work is increasing proportionally. In particular, the construction of long tunnels is rapidly increasing due to the mountainous terrain of our country. In this way, due to the trend of tunnels becoming longer, it is difficult to design and construct tunnels by avoiding fault zones. In the case of tunnel construction in mountainous areas, ground investigation is often difficult even during design due to the topographical conditions, making precise ground investigation difficult, and as a result, the upper part of the tunnel is damaged during tunnel construction. When fault zones, which are vulnerable to weathering, exist, the stability of the tunnel during excavation is directly affected by the fault zone distribution, strength characteristics, and groundwater distribution range. In particular, when a fault zone is distributed in the upper part of a tunnel, damage such as tunnel collapse and excessive displacement may occur, and in order to prevent this in advance, countermeasures must be established through analysis of similar cases. Therefore, in this study, when a large-scale fault zone exists in the upper part of a tunnel, the relationship and characteristics of damage to the tunnel structure were analyzed.

• Journal of Korea Water Resources Association
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• v.56 no.spc1
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• pp.1059-1069
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• 2023

Dam-break flow occurs when an elevated dam suddenly collapses, resulting in the catastrophic release of rapid and uncontrolled impounded water. This study compares laminar and turbulent closure models for simulating three-dimensional dam-break flows using OpenFOAM. The Reynolds-Averaged Navier-Stokes (RANS) model, specifically the k-ε model, is employed to capture turbulent dissipation. Two scenarios are evaluated based on a laboratory experiment and a modified multi-layered block obstacle scenario. Both models effectively represent dam-break flows, with the turbulent closure model reducing oscillations. However, excessive dissipation in turbulent models can underestimate water surface profiles. Improving numerical schemes and grid resolution enhances flow recreation, particularly near structures and during turbulence. Model stability is more significantly influenced by numerical schemes and grid refinement than the use of turbulence closure. The k-ε model's reliance on time-averaging processes poses challenges in representing dam-break profiles with pronounced discontinuities and unsteadiness. While simulating turbulence models requires extensive computational efforts, the performance improvement compared to laminar models is marginal. To achieve better representation, more advanced turbulence models like Large Eddy Simulation (LES) and Direct Numerical Simulation (DNS) are recommended, necessitating small spatial and time scales. This research provides insights into the applicability of different modeling approaches for simulating dam-break flows, emphasizing the importance of accurate representation near structures and during turbulence.

• Journal of Korean Tunnelling and Underground Space Association
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• v.25 no.6
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• pp.469-478
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• 2023

The deep tunnel in urban area is a future-oriented construction plan that allows the above-ground space to be used as an eco-friendly park and transportation infrastructure to be constructed in the underground space. However, tunnel construction is often depicted as to cause ground collapse in some media and movies. In fact, while the construction of a deep tunnel in the urban area is underway, the project face with difficulties due to opposition complaints from residents near the route. In this study, we sought to identify perceptions on deep space development and citizen concerns through a public opinion survey regarding deep tunnels. By analyzing laws relevant with the promotion of deep tunnel construction, we reviewed the possibility of public engagement at each stage of the construction and investigated separated surface rights related to compensation for underground space. Through the results of the public opinion survey, it was identified that the concerns of citizens were problems that current technology could solve. Citizen's concerns were improved into a system that confirmed the stability of tunnel construction through public participation, and improvement measures were presented to encourage cooperation from those concerned regarding the establishment of divided superficies.

• Journal of Dental Rehabilitation and Applied Science
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• v.39 no.4
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• pp.260-266
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• 2023

The concept of 'Implant Supracrestal Complex (ISC)' was introduced as a way to determine the impact of implant prosthetic design form on both short-term clinical outcomes and the long-term prognosis of bone and soft tissues around the implant. Implant-prosthesis-abutment complex design forms, such as implant-abutment design, junction, and location, can have important implications for the stable and healthy long-term maintenance of the tissues around the implant. In this case, a customized concave abutment and a prosthesis with an emergence angle of about 30 degrees were restored to a patient suffering from chronic soft tissue inflammation and pain after restoration of an implant prosthesis. It was confirmed that the new prosthesis improved complications by allowing sufficient bone and soft tissue space, achieved appropriate soft tissue sealing, and maintained the long-term stability of the implant.

• Korean Journal of Radiology
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• v.23 no.11
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• pp.1067-1077
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• 2022

Objective: To determine whether Sonazoid-enhanced ultrasound (SZUS) was noninferior to SonoVue-enhanced ultrasound (SVUS) in diagnosing hepatocellular carcinoma (HCC) using the same diagnostic criteria. Materials and Methods: This prospective, single-center, noninferiority study (NCT04847726) enrolled 105 at-risk participants (71 male; mean age ± standard deviation, 63 ± 11 years; range, 26-86 years) with treatment-naïve solid hepatic nodules (≥ 1 cm). All participants underwent same-day SZUS (experimental method) and SVUS (control method) for one representative nodule per participant. Images were interpreted by three readers (the operator and two independent readers). All malignancies were diagnosed histopathologically, while the benignity of other lesions was confirmed by follow-up stability or pathology. The primary endpoint was per-lesion diagnostic accuracy for HCC pooled across three readers using the conventional contrast-enhanced ultrasound diagnostic criteria, including arterial phase hyperenhancement followed by mild (assessed within 2 minutes after contrast injection) and late (≥ 60 seconds with a delay of 5 minutes) washout. The noninferiority delta was -10%p. Furthermore, different time delays were compared as washout criteria in SZUS, including delays of 2, 5, and > 10 minutes. Results: A total of 105 lesions (HCCs [n = 61], non-HCC malignancies [n = 19], and benign [n = 25]) were evaluated. Using the 5-minutes washout criterion, per-lesion accuracy of SZUS pooled across the three readers (72.4%; 95% confidence interval [CI], 64.1%-79.3%) was noninferior to that of SVUS (71.4%; 95% CI, 63.1%-78.6%), meeting the statistical criterion for non-inferiority (difference of 0.95%p; 95% CI, -3.8%p-5.7%p). The arterial phase hyperenhancement combined with the 5-minutes washout criterion showed the same sensitivity as that of the > 10-minutes criterion (59.0% vs. 59.0%, p = 0.989), and the specificities were not significantly different (90.9% vs. 86.4%, p = 0.072). Conclusion: SZUS was noninferior to SVUS for diagnosing HCC in at-risk patients using the same diagnostic criteria. No significant improvement in HCC diagnosis was observed by extending the washout time delay from 5 to 10 minutes.