• The Korean journal of helicobacter and upper gastrointestinal research
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• v.18 no.3
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• pp.162-167
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• 2018

Cancer specimens obtained via surgical resection or biopsy are generally used to understand tumor-associated alterations; however, those approaches cannot always be performed because of their invasive nature, and they may fail to reflect current tumor dynamics and drug sensitivity, which may change during the therapeutic process. Therefore, many research groups have focused on developing a non-invasive biomarker with the ability to monitor tumor dynamics. Circulating tumor cells (CTCs) are metastatic cells released from the primary tumor into the bloodstream. Hematogenous spreading of CTCs is a crucial step in the metastatic cascade, which leads to the formation of overt metastases. CTCs have attracted considerable attention because of their easy accessibility and their superiority over conventional tumor markers. Detecting CTCs is considered a valuable modality to determine prognosis and monitor response to systemic therapies in patients with gastric cancer. Moreover, molecular analyses of CTCs may provide important biological information for individual patients with cancer, which may lead to the development of personalized cancer treatment. In this article, we review potential roles and clinical applications of CTCs in patients with gastric cancer.

• Journal of Advanced Marine Engineering and Technology
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• v.29 no.7
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• pp.769-778
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• 2005

The velocity and pressure fields of a ship's Weis-Fogh type propulsion mechanism are studied in this paper using an advanced vortex method. The wing (NACA0010 airfoil) and channel are approximated by source and vortex panels. and free vortices are introduced away from the body surfaces. The viscous diffusion of fluid is represented using the core-spreading model to the discrete vortices. The velocity is calculated on the basis of the generalized Biot-Savart law and the pressure field is calculated from an integral, based on the instantaneous velocity and vorticity distributions in the flow field. Two-dimensional unsteady viscous flow calculations of this propulsion mechanism are shown. and the calculated results agree qualitatively with the measured thrust and drag due to un-modeled large fluctuations in the measured data.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.1407-1412
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• 2004

The velocity and pressure fields of a ship's propulsion mechanism of Weis-Fogh type are studied by advanced vortex method. The wing of NACA0010 type and the channel are approximated by a finite of source and vortex panels, and the free vortices are introduced from the surface of their bodies. The viscous diffusion of fluid is represented by the core-spreading method. The velocity field is calculated on the basis of Biot-Savart law and the pressure field is calculated from the integration equation formulated by Uhlman. The flow fields of this propulsion mechanism are unsteady and complex, but the flow fields are clarified by numerical simulation.

• 한국전산유체공학회:학술대회논문집
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• 2005.10a
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• pp.305-310
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• 2005

The velocity and pressure fields of a ship's propulsion mechanism of the Weis-Fogh type, in which a airfoil moves reciprocally in a channel, are studied in this paper using the advanced vortex method. The airfoil and the channel are approximated by a finite number of source and vortex panels, and the free vortices are introduced from the body surfaces. The viscous diffusion of fluid is represented using the core-spreading model to the discrete vortices. The velocity is calculated on the basis of the generalized Biot-Savart low and the pressure field is calculated from integrating the equation given by the instantaneous velocity and vorticity fields. Two-dimensional unsteady viscose flows of this propulsion mechanism are numerically clarified, and the calculated results agree well with the experimental ones.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.431-436
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• 2010

Recently, several open source codes for computational fluid dynamics (CFD) have been emerged and are spreading fast. Our group has chosen OpenFOAM as a platform to develop our own in-house code. In this paper, we would like to share the information on the codes and what we have experienced so far. We introduce several features of OpenFOAM, which include the performance compared with commercial packages, estimation for current user population and our own prospect for future improvement in performance and growth in user population. In addition, we briefly introduce our experience gained in embedding the level set method into the OpenFOAM.

• Journal of computational fluids engineering
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• v.15 no.3
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• pp.46-53
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• 2010

Recently, several open source codes for computational fluid dynamics (CFD) have been introduced and are spreading fast. Our group has chosen the OpenFOAM as a platform to develop our own in-house code. In this brief review, we would like to share the information on the codes and what we have experienced so far. We introduce several features of OpenFOAM, which include the performance compared with commercial packages, estimation for current user population, and our own prospect for future improvement in performance and growth in user population. In addition, we briefly introduce our experience gained in embedding the level set method into the OpenFOAM.

• Journal of the Korean Mathematical Society
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• v.51 no.4
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• pp.703-719
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• 2014

This paper is concerned with the traveling wave solutions of nonlocal dispersal models with nonlocal delays. The existence of traveling wave solutions is investigated by the upper and lower solutions, and the asymptotic behavior of traveling wave solutions is studied by the idea of contracting rectangles. To illustrate these results, a delayed competition model is considered by presenting the existence and nonexistence of traveling wave solutions, which completes and improves some known results. In particular, our conclusions can deal with the traveling wave solutions of evolutionary systems which admit large time delays reflecting intraspecific competition in population dynamics and leading to the failure of comparison principle in literature.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.23 no.6
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• pp.651-657
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• 2010

Solute transport through a groove is affected by its vortices. Our laboratory and numerical experiments of dye transport through a single axisymmetric groove reveal evidence of enhanced spreading and mixing by the vortex, i.e., a new kind of dispersion called here the vortex dispersion. The uptake and release of contaminants by vortices in porous media is affected by the flow Reynolds number. The larger the flow Reynolds number, the larger is the vortex dispersion, and the larger is the mass-transfer rate between the mobile zone and the vortex. The long known dependence of the mass-transfer rate between the mobile and "immobile" zones in porous media on flow velocity can be explained by the presence of vortices in the "immobile" zone and their uptake and release of contaminants.

• Journal of Mechanical Science and Technology
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• v.20 no.8
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• pp.1248-1255
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• 2006

The velocity and pressure fields of a ship's propulsion mechanism of the Weis-Fogh type, in which a airfoil moves reciprocally in a channel, are studied in this paper using the advanced vortex method. The airfoil and the channel are approximated by a finite number of source and vortex panels, and the free vortices are introduced from the body surfaces. The viscous diffusion of fluid is represented using the core-spreading model to the discrete vortices. The velocity is calculated on the basis of the generalized Biot-Savart law and the pressure field is calculated from integrating the equation given by the instantaneous velocity and vorticity fields. Two-dimensional unsteady viscose flows of this propulsion mechanism are numerically clarified, and the calculated results agree well with the experimental ones.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.551-555
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• 2010

Electrowetting is a versatile tool to handle tiny droplets and forms a backbone of digital microfluidics. Numerical analysis is necessary to fully understand the dynamics of electrowetting, especially in designing electrowetting-based devices, such as liquid lenses and reflective displays. We developed a numerical method to analyze the general contact-line problems, incorporating dynamic contact angle models. The method is based on the conservative level set method to capture the interface of two fluids without loss of mass. We applied the method to the analysis of spreading process of a sessile droplet for step input voltages and oscillation of the droplet for alternating input voltages in electrowetting. The result was compared with experimental data. It is shown that contact line friction significantly affects the contact line motion and the oscillation amplitude. The pinning process of contact line was well represented by including the hysteresis effect in the contact angle models. In level set method, in the mean time, material properties are made to change smoothly across an interface of two materials with different properties by introducing an interpolation or smoothing scheme. So far, the weighted arithmetic mean (WAM) method has been exclusively adopted in level set method, without complete assessment for its validity. We viscosity, thermal conductivity, electrical conductivity, and permittivity, can be an alternative. I.e., the WHM gives more accurate results than the WAM method in certain circumstances. The interpolation scheme should be selected considering various characteristics including type of property, ratio of property of two fluids, geometry of interface, and so on.