• 천문학회보
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• 제39권1호
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• pp.70.2-70.2
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• 2014

We developed a three-dimensional (3D) magnetohydrodynamic (MHD) simulation code to reproduce the structure of a solar wind and the propagation of a coronal mass ejection (CME) through it. This code is constructed by a finite volume method based on a total variation diminishing (TVD) scheme using an unstructured grid system (Tanaka 1994). The grid system can avoid the singularity arising in the spherical coordinate system. In this study, we made an improvement of the code focused on the propagation of a CME through a solar wind, which extends a previous work done by Nakamizo et al. (2009). We first reconstructed a solar wind in a steady state from physical values obtained at 50 solar radii away from the Sun via an MHD tomography applied to interplanetary scintillation (IPS) data (Hayashi et al. 2003). We selected CR2057 and inserted a spheromak-type CME (Kataoka et al. 2009) into a reconstructed solar wind. As a result, we found that our simulation well captures the velocity, temperature and density profiles of an observed solar wind. Furthermore, we successfully reproduce the general characteristics of an interplanetary coronal mass ejection (ICME) obtained by the Helios 1/2 spacecraft (R. J. FORSYTH et al. 2006).

• 한국정보과학회논문지:데이타베이스
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• 제30권5호
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• pp.464-475
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• 2003

웹상의 이미지 데이타베이스들은 자치성과 이질성이라는 두 가지 다른 특성을 갖고 있다. 즉 독립적으로 만들어지고 유지되며 질의 처리 방법이 서로 다르다. 분산된 이미지 데이타베이스들에 대한 내용기반 검색에서, 메타 서버의 유사성 측정함수에 대하여 서로 다른 지역 유사성 측정 함수를 갖는 데이터베이스들로부터 주어진 질의 객체와 유사한 객체들을 찾는 능력을 갖는 것은 중요하다. 현재까지, 동일한 유사성 측정 함수들을 사용하는 이미지 데이타베이스들을 선택하는 방법에 대하여 많은 연구가 진행되었으나 이미지 데이타베이스들이 다른 유사성 측정함수를 사용하는 경우에 대한 연구는 없었다. 본 논문에서는 웹상의 많은 이질적인 이미지 데이타베이스들 중 질의에 유사한 객체들을 보다 많이 가지고 있는 데이타베이스들을 찾는 문제를 다룬다. 데이타베이스들의 순위는 이미지 데이타베이스들의 압축된 히스토그램 정보와 적은 수의 표본 객체들을 사용하는 복합 추정에 기반을 두고 있다. 구형 영역 질의에 대한 선택률을 추정하기 위하여 히스토그램 정보를 사용하며, 유사성 측정 함수의 차이로 인한 선택률 오차를 보정하기 위하여 표본 객체들을 이용한다. 많은 수의 이미지 데이타에 대한 상세한 실험은 제안된 방법이 이질적인 분산 환경에서 효율적임을 보여준다.

• Journal of Pharmaceutical Investigation
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• 제38권2호
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• pp.119-126
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• 2008

Solid dispersions of poorly water-soluble drug, sibutramine, were prepared with hydrophilic polymer, poly-N-vinylpyrrolidone (PVP), hydroxypropylmethylcellulose (HPMC) and organic acid, citric acid, to improve the solubility of drug. Physicochemical variation and shape of microsphere were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and Fourier-transform infrared spectroscopy (FT-IR). Microspheres containing additives showed more spherical shape than non additive microspheres. In vitro release behavior of microspheres presented at simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). The solid dispersion form transformed the drug into an amorphous state and dramatically improved its dissolution rate. These data suggest that the solid dispersion technique is an effective approach for developing the appetite depressant drug products and various pharmaceutical excipients are able to control the release behaviors.

• Korean Chemical Engineering Research
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• 제59권4호
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• pp.493-502
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• 2021

We prepared and investigated a biosynthesized nanoparticulate system with high adsorption and release capacity of letrozole. Silver nanoparticles (AgNPs) were biosynthesized using olive leaf extract. Cysteine was capped AgNPs to increase the adsorption capacity and suitable interaction between nanoparticles and drug. Morphology and size of nanoparticles were confirmed using transmission electron microscopy (TEM). Nanoparticles were spherical with an average diameter of less than 100 nm. Cysteine capping was successfully confirmed by Fourier transform infrared resonance (FTIR) spectroscopy and elemental analysis (CHN). Also, the factors of letrozole adsorption were optimized and the linear and non-linear forms of isotherms and kinetics were studied. Confirmation of the adsorption data of letrozole by cysteine capped nanoparticles in the Langmuir isotherm model indicated the homogeneous binding site of modified nanoparticles surface. Furthermore, the adsorption rate was kinetically adjusted to the pseudo-second-order model, and a high adsorption rate was observed, indicating that cysteine coated nanoparticles are a promising adsorbent for letrozole delivery. Finally, the kinetic release profile of letrozole loaded modified nanoparticles in simulated gastric and intestinal buffers was studied. Nearly 40% of letrozole was released in simulated gastric fluid with pH 1.2, in 30 min and the rest of it (60%) was released in simulated intestinal fluid with pH 7.4 in 10 h. These results indicate the efficiency of the cysteine capped AgNPs for adsorption and release of drug letrozole for breast cancer therapy.

• Yonsei Medical Journal
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• 제59권9호
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• pp.1115-1122
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• 2018

Purpose: To investigate biomechanical properties of the cornea using a dynamic Scheimpflug analyzer according to age. Materials and Methods: In this prospective, cross-sectional, observational study, participants underwent ophthalmic investigations including corneal biomechanical properties, keratometric values, intraocular pressure (IOP), and manifest refraction spherical equivalent (MRSE). We determined the relationship of biomechanical parameters and ocular/systemic variables (participant's age, MRSE, IOP, and mean keratometric values) by piecewise regression analysis, association of biomechanical parameters with variables by Spearman's correlation and stepwise multiple regression analyses, and reference intervals (RI) by the bootstrap method. Results: This study included 217 eyes of 118 participants (20-81 years of age). Piecewise regression analysis between Corvis-central corneal thickness (CCT) and participant's age revealed that the optimal cut-off value of age was 45 years. No clear breakpoints were detected between the corneal biomechanical parameters and MRSE, IOP, and mean keratometric values. Corneal velocity, deformation amplitude, radius, maximal concave power, Corvis-CCT, and Corvis-IOP exhibited correlations with IOP, regardless of age (all ages, 20-44 years, and over 44 years). With smaller deformation amplitude and corneal velocity as well as increased CorvisIOP and Corvis-CCT, IOP became significantly increased. We provided the results of determination of confidence interval from RI data using bootstrap method in three separate age groups (all ages, 20-44 years, and over 44 years). Conclusion: We demonstrated multiple corneal biomechanical parameters according to age, and reported that the corneal biomechanical parameters are influenced by IOP.

• Nuclear Engineering and Technology
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• 제54권7호
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• pp.2367-2375
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• 2022

In this work, we propose a new mechanistic model for the treatment of helium behaviour at the grain boundaries in oxide nuclear fuel. The model provides a rate-theory description of helium inter-granular behaviour, considering diffusion towards grain edges, trapping in lenticular bubbles, and thermal resolution. It is paired with a rate-theory description of helium intra-granular behaviour that includes diffusion towards grain boundaries, trapping in spherical bubbles, and thermal re-solution. The proposed model has been implemented in the meso-scale software designed for coupling with fuel performance codes SCIANTIX. It is validated against thermal desorption experiments performed on doped UO₂ samples annealed at different temperatures. The overall agreement of the new model with the experimental data is improved, both in terms of integral helium release and of the helium release rate. By considering the contribution of helium at the grain boundaries in the new model, it is possible to represent the kinetics of helium release rate at high temperature. Given the uncertainties involved in the initial conditions for the inter-granular part of the model and the uncertainties associated to some model parameters for which limited lower-length scale information is available, such as the helium diffusivity at the grain boundaries, the results are complemented by a dedicated uncertainty analysis. This assessment demonstrates that the initial conditions, chosen in a reasonable range, have limited impact on the results, and confirms that it is possible to achieve satisfying results using sound values for the uncertain physical parameters.

• Advances in nano research
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• 제12권5호
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• pp.529-547
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• 2022

Graphene is one of the strongest, stiffest, and lightest nanoscale materials known to date, making it a potentially viable and attractive candidate for developing lightweight structural composites to prevent high-velocity ballistic impact, as commonly encountered in defense and space sectors. In-plane twist in bilayer graphene has recently revealed unprecedented electronic properties like superconductivity, which has now started attracting the attention for other multi-physical properties of such twisted structures. For example, the latest studies show that twisting can enhance the strength and stiffness of graphene by many folds, which in turn creates a strong rationale for their prospective exploitation in high-velocity impact. The present article investigates the ballistic performance of twisted bilayer graphene (tBLG) nanostructures. We have employed molecular dynamics (MD) simulations, augmented further by coupling gaussian process-based machine learning, for the nanoscale characterization of various tBLG structures with varying relative rotation angle (RRA). Spherical diamond impactors (with a diameter of 25Å) are enforced with high initial velocity (V_i) in the range of 1 km/s to 6.5 km/s to observe the ballistic performance of tBLG nanostructures. The specific penetration energy (E_p^*) of the impacted nanostructures and residual velocity (V_r) of the impactor are considered as the quantities of interest, wherein the effect of stochastic system parameters is computationally captured based on an efficient Gaussian process regression (GPR) based Monte Carlo simulation approach. A data-driven sensitivity analysis is carried out to quantify the relative importance of different critical system parameters. As an integral part of this study, we have deterministically investigated the resonant behaviour of graphene nanostructures, wherein the high-velocity impact is used as the initial actuation mechanism. The comprehensive dynamic investigation of bilayer graphene under the ballistic impact, as presented in this paper including the effect of twisting and random disorder for their prospective exploitation, would lead to the development of improved impact-resistant lightweight materials.

• Advances in materials Research
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• 제11권3호
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• pp.225-235
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• 2022

It includes the synthesis of pristine ZnO nanoparticles and a series of Ag-doped zinc oxide nanoparticles was carried out by reflux method by varying the amount of silver (1, 3, 5, 7 and 9% by mol.). The morphology of these nanoparticles was investigated by SEM, XRD and FT-IR techniques. These techniques show that synthesized particles are homogenous spherical nanoparticles having an average particle size of about 50-100 nm along with some agglomeration. The photocatalytic activity of the ZnO nanoparticles and Ag doped ZnO nanoparticles were investigated via photodegradation of methylene blue (MB) as a standard dye. The data from the photocatalytic activity of these nanoparticles show that 7% Ag-doped ZnO nanoparticles exhibit much enhanced photocatalytic activity as compared to pristine ZnO nanoparticles and other percentages of Ag-doped ZnO nanoparticles. Furthermore, 7% Ag-doped ZnO was made composites with sulfur-doped graphitic carbon nitride by physical mixing method and a series of nanocomposites were made (3.5, 7.5, 25, 50, 75% by weight). It was observed that the 25% composites exhibited better photocatalytic performance than pristine S-g-C 3 N 4 and pure 7% Ag-doped ZnO. Tauc's plot also supports the photodegradation results.

• The Journal of Advanced Prosthodontics
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• 제16권2호
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• pp.91-104
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• 2024

PURPOSE. The objectives of the current study were to estimate the influence of self-reinforced hollow structures with a graded density on the dimensional accuracy, weight, and mechanical properties of Co-Cr objects printed with the direct metal laser sintering (DMLS) technique. MATERIALS AND METHODS. Sixty-five dog-bone samples were manufactured to evaluate the dimensional accuracy of printing, weight, and tensile properties of DMLS printed Co-Cr. They were divided into Group 1 (control) (n = 5), Group 2, 3, and 4 with incorporated hollow structures based on (spherical, elliptical, and diamond) shapes; they were subdivided into subgroups (n = 5) according to the volumetric reduction (10%, 15%, 20% and 25%). Radiographic imaging and microscopic analysis of the fractographs were conducted to validate the created geometries; the dimensional accuracy, weight, yield tensile strength, and modulus of elasticity were calculated. The data were estimated by one-way ANOVA and Duncan's tests at P < .05. RESULTS. The accuracy test showed an insignificant difference in the x, y, z directions in all printed groups. The weight was significantly reduced proportionally to the reduced volume fraction. The yield strength and elastic modulus of the control group and Group 2 at 10% volume reduction were comparable and significantly higher than the other subgroups. CONCLUSION. The printing accuracy was not affected by the presence or type of the hollow geometry. The weight of Group 2 at 10% reduction was significantly lower than that of the control group. The yield strength and elastic modulus of the Group 2 at a 10% reduction showed means equivalent to the compact objects and were significantly higher than other subgroups.

• 한국정보과학회논문지:소프트웨어및응용
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• 제36권11호
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• pp.936-946
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• 2009

그래프 컷(graph cuts) 방법은 주어진 사전정보와 각 픽셀간의 유사도를 나타내는 데이터 항(data term)과 이웃하는 픽셀간의 유사도를 나타내는 스무드 항(smoothness term)으로 구성된 에너지 함수를 전역적으로 최소화하는 방법으로, 최근 영상 분할에 많이 이용되고 있다. 기존 그래프 컷 기반의 영상 분할 방법에서 데이터 항을 설정하기 위해 GMM(Gaussian mixture model)을 주로 이용하였으며, 평균과 공분산을 각 클래스를 위한 사전정보로 이용하였다. 이 때문에 클래스의 모양이 초구(hyper-sphere) 또는 초타원(hyper-ellipsoid)일 때만 좋은 성능을 보이는 단점이 있다. 다양한 클래스의 모양에서 좋은 성능을 보이기 위해, 본 논문에서는 mean shift 분석 방법을 이용한 그래프 컷 기반의 자동 영상분할 방법을 제안한다. 데이터 항을 설정하기 위해 $L^*u^*{\upsilon}^*$ 색상공간에서 임의로 선택된 초기 mean으로부터 밀도가 높은 지역인 모드(mode)로 이동하는 mean의 집합들을 사전정보로 이용한다. Mean shift 분석 방법은 군집화에서 좋은 성능을 보이지만, 오랜 수행시간이 소요되는 단점이 있다. 이를 해결하기 위해 특징공간을 3차원 격자로 변형하였으며, mean의 이동은 격자에서 모든 픽셀이 아닌 3차원 윈도우내의 1차원 모멘트(moment)를 이용한다. 실험에서 GMM을 이용한 그래프 컷 기반의 영상분할 방법과 최근 많이 이용되고 있는 mean shift와 normalized cut기반의 영상분할 방법을 제안된 방법과 비교하였으며, Berkeley dataset을 기반으로 앞의 세 가지 방법보다 좋은 성능을 보였다.