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Trans-disciplinary Approach to Molecular Modeling and Experiment in PDP Materials

  • Takaba, Hiromitsu;Serizawa, Kazumi;Onuma, Hiroaki;Kikuchi, Hiromi;Suzuki, Ai;Sahnoun, Riadh;Koyama, Michihisa;Tsuboi, Hideyuki;Hatakeyama, Nozomu;Endou, Akira;Carpio, Carlos A. Del;Kubo, Momoji;Kajiyama, Hiroshi;Miyamoto, Akira
    • 한국정보디스플레이학회:학술대회논문집
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    • 2008.10a
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    • pp.1441-1444
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    • 2008
  • We developed ultra-accelerated quantum chemical molecular dynamics and spectroscopic characterization simulators for development of PDP materials. By combination of these simulators, realistic structure of PDP materials is drawn on the computer. Furthermore, based on the structures, various properties such as cathode luminescence spectrum and secondary electron emission, is successfully evaluated. The strategy of "Experiment integrated Computational Chemistry" using developed simulators will presented that has the potential in being powerful tool for designing the PDP materials.

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Study on Flame Oscillations in Laminar Lift-off Butane Flames Diluted with Nitrogen (질소 희석된 부탄 부상화염에 있어서 화염진동에 관한 연구)

  • Yoon, Sung-Hwan;Park, Jeong;Kwon, Oh-Boong;Kim, Jeong-Soo
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.34 no.7
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    • pp.729-738
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    • 2010
  • The characteristics of lifted butane flames diluted with nitrogen have been investigated experimentally in order to elucidate the mechanism of individual flame oscillation modes. Flame oscillations in laminar free-jet lift-off flames are classified into the following five regimes: a stabilized lift-off regime (I), a heat-loss-induced oscillation (II), a buoyancy-induced oscillation along with a heat-loss-induced oscillation (III), a combined form of an oscillation prior to blow-out and a heat-loss-induced oscillation (IV), and a combination of an oscillation prior to blow-out and a buoyancy-induced oscillation along with a heat-loss-induced oscillation (V). The characterization of the individual flame oscillations modes are presented and discussed using Strouhal numbers and their relevant parameters by the analysis of the power spectrum for temporal variation of the lift-off height.

Microchips and their Significance in Isolation of Circulating Tumor Cells and Monitoring of Cancers

  • Sahmani, Mehdi;Vatanmakanian, Mousa;Goudarzi, Mehdi;Mobarra, Naser;Azad, Mehdi
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.3
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    • pp.879-894
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    • 2016
  • In micro-fluid systems, fluids are injected into extremely narrow polymer channels in small amounts such as micro-, nano-, or pico-liter scales. These channels themselves are embedded on tiny chips. Various specialized structures in the chips including pumps, valves, and channels allow the chips to accept different types of fluids to be entered the channel and along with flowing through the channels, exert their effects in the framework of different reactions. The chips are generally crystal, silicon, or elastomer in texture. These highly organized structures are equipped with discharging channels through which products as well as wastes of the reactions are secreted out. A particular advantage regarding the use of fluids in micro-scales over macro-scales lies in the fact that these fluids are much better processed in the chips when they applied as micro-scales. When the laboratory is miniaturized as a microchip and solutions are injected on a micro-scale, this combination makes a specialized construction referred to as "lab-on-chip". Taken together, micro-fluids are among the novel technologies which further than declining the costs; enhancing the test repeatability, sensitivity, accuracy, and speed; are emerged as widespread technology in laboratory diagnosis. They can be utilized for monitoring a wide spectrum of biological disorders including different types of cancers. When these microchips are used for cancer monitoring, circulatory tumor cells play a fundamental role.

Purification of Glucose Oxidase by Affinity Chromatography and Its Characterization (친화성 크로마토그래피를 이용한 글루코오스 옥시다아제의 정제와 효소특성)

  • Ko Jung Hwan;Byun Si Myung
    • Journal of the Korean Chemical Society
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    • v.23 no.3
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    • pp.165-174
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    • 1979
  • A purification technique of glucose oxidase was developed. Using the gluconyl-${\omega}$-aminohexyl Sepharose affinity chromatography, it was partially purified 14.6 folds with 79.7% yield. With the combination of the affinity chromatography and Sepharose 6B gel filtration, the enzyme was purified 27.2 folds from the broth with 74.1% yield. The final purified preparation showed 90.83 U of glucose oxidase activity per mg of protein and a single band by 7% polyacrylamide gel electrophoresis. The absorption spectrum and substrate specificity of the enzyme were studied and the fianal preparation showed the optimal pH between 5.6 and 6.0, the optimal temperature at $40^{\circ}C$, $8.5{\times}10^{-3}M$ of $K_m$ for D-glucose, and 3.43 kcal/mole of the activation energy.

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APPLICATION OF A DUAL-ENERGY MONOCHROMATIC XRAY CT ALGORITHM TO POLYCHROMATIC X-RAY CT: A FEASIBILITY STUDY

  • Chang, S.;Lee, H.K.;Cho, G.
    • Nuclear Engineering and Technology
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    • v.44 no.1
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    • pp.61-70
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    • 2012
  • In this study, a simple post-reconstruction dual-energy computed tomography (CT) method is proposed. A dual-energy CT algorithm for monochromatic x-rays was adopted and applied to the dual-energy CT of polychromatic x-rays by assigning a representative mono-energy. The accuracy of algorithm implementation was tested with mathematical phantoms. To test the sensitivity of this algorithm to the inaccuracy of representative energy value in energy values, a simulation study was performed with mathematical phantom. To represent a polychromatic x-ray energy spectrum with a single-energy, mean energy and equivalent energy were used, and the results were compared. The feasibility of the proposed method was experimentally tested with two different micro-CTs and a test phantom made of polymethyl methacrylate (PMMA), water, and graphite. The dual-energy calculations were carried out with CT images of all possible energy pairs among 40, 50, 60, 70, and 80 kVp. The effective atomic number and the electron density values obtained from the proposed method were compared with theoretical values. The results showed that, except the errors in the effective atomic number of graphite, most of the errors were less than 10 % for both CT scanners, and for the combination of 60 kVp and 70 kVp, errors less than 6.0 % could be achieved with a Polaris 90 CT. The proposed method shows simplicity of calibration, demonstrating its practicality and feasibility for use with a general polychromatic CT.

Foliar Application of the Fungicide Pyraclostrobin Reduced Bacterial Spot Disease of Pepper (Fungicide pyraclostrobin의 고추 세균점무늬병 예방효과)

  • Kang, Beom Ryong;Lee, Jang Hoon;Kim, Young Cheol
    • Research in Plant Disease
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    • v.24 no.1
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    • pp.59-65
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    • 2018
  • Pyraclostrobin is a broad-spectrum fungicide that inhibits mitochondrial respiration. However, it may also induce systemic resistance effective against bacterial and viral diseases. In this study, we evaluated whether pyraclostrobin enhanced resistance against the bacterial spot pathogen, Xanthomonas euvesicatora on pepper (Capsicum annuum). Although pyraclostrobin alone did not suppressed the in vitro growth of X. euvesicatoria, disease severity in pepper was significantly lower by 69% after treatments with pyraclostrobin alone. A combination of pyraclostrobin with streptomycin reduced disease by over 90% that of the control plants. The preventive control of the pyraclostrobin against bacterial spot was required application 1-3 days before pathogen inoculation. Our findings suggest that the fungicide pyraclostrobin can be used with a chemical pesticide to control bacterial leaf spot diseases in pepper.

DEEP-South: The Progress Report

  • Moon, Hong-Kyu;Kim, Myung-Jin;Park, Jintae;JeongAhn, Youngmin;Yang, Hongu;Lee, Hee-Jae;Kim, Dong-Heun;Roh, Dong-Goo;Choi, Young-Jun;Yim, Hong-Suh;Lee, Sang-Min;Kwak, SungWon
    • The Bulletin of The Korean Astronomical Society
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    • v.43 no.1
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    • pp.42.1-42.1
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    • 2018
  • Deep Ecliptic Patrol of the Southern Sky (DEEP-South) observation is being made during the off-season for exoplanet survey, using Korea Microlensing Telescope Network (KMTNet). An optimal combination of its prime focus optics and the 0.3 billion pixel CCD provides a four square degrees field of view with 0.4 arcsec/pixel plate scale which is also best suited for small body studies. Normal operation of KMTNet started in October 2015, and a significant portion of the allocated telescope time for DEEP-South is dedicated to targeted observation, Opposition Census (OC), of near-Earth asteroids for physical and taxonomic characterization. This is effectively achieved through multiband, time series photometry using Johnson-Cousins BVRI filters. Uninterrupted monitoring of the southern sky with KMTNet is optimized for spin characterization of a broad spectrum of asteroids ranging from the near-Earth space to the main-belt, including binaries, asteroids with satellites, slow/fast- and non-principal axis-rotators, and thus is expected to facilitate the debiasing of previously reported lightcurve observations. Our software subsystem consists of an automated observation scheduler, a pipelined data processing system for differential photometry, and an easy-to-use lightcurve analysis toolkit. Lightcurves, spin periods and provisional determination of class of asteroids to which the lightcurve belongs will be presented, using the dataset from first year operation of KMTNet. Our new taxonomic classification scheme for asteroids will also be summarized.

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Production and Process Monitoring of 5-Aminolevulinic Acid (ALA) by Recombinant E. coli II. process Monitoring by a 2-Dimensional Fluorescence Sensor (유전자 재조합 대장균에 의만 5-Aminolevulinic Acid (ALA)의 생산 및 공정 모니터링 II. 2차원 형광센서에 의안 공정 모니터링)

  • 이종일;정상윤;임용식;정상욱
    • KSBB Journal
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    • v.19 no.1
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    • pp.27-32
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    • 2004
  • 2-Dimensional fluorescence sensor has a wide range of excitation and emission wavelengths, that some biogenic fluorphors in a biological process can be monitored simultaneously. The production processes of 5-aminolevulinic aicd (ALA) by recombinant E. coli BL21 (DE3) pLysS harboring plasmid pFLS45 were on-line monitored by a 2-dimensional fluorescence sensor The characteristics of fluorescence spectrum was dependent upon physical and biological factors of a bioprocess such as culture pH, cell mass etc. Some off-line data were correlated to the fluorescence intensity well, which was monitored at some combination of excitation and emission wavelengths by the 2-dimensional fluorescence sensor.

Feasibility of Determining the Ripeness of Strawberry Fruit Flesh by Fourier Transform Infrared Spectroscopy (Fourier 변환 적외선 분광분석법에 의한 딸기 과육의 성숙도 측정 가능성)

  • Min, Sung-Ran;Kwak, Chul-Won;Kim, Suk-Weon;Jeong, Won-Joong;Chung, Hwa-Jee;Choi, Pil-Son;Ko, Suk-Min;Park, Sang-Kyu;Chung, Hoe-Il;Liu, Jang, R.
    • Journal of Plant Biotechnology
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    • v.33 no.4
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    • pp.277-281
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    • 2006
  • Fourier transform - infrared spectroscopy (FT-IR) provides biochemical profiles containing overlapping signals from a majority of the compounds that are present when whole cell extracts are analyzed. We attempted to determine the ripeness of strawberry fruit flesh by FT-IR. Fruit ripeness was divided into four developmental stages based on fruit skin color: 'yellow-green', 'pink-green', 'pink', and 'red' stages. Principal component analysis of FT-IR data of inside fruit flesh extracts clustered samples of four different developmental stages into three discrete groups: (1) 'yellow-green' group, (2) 'pink-green' group, and (3) 'pink' and 'red' group. The most remarkable difference between four different developmental stages was found in the carbohydrate fingerprint region $(1,000-1,100cm^{-1})$ of the FT-IR spectrum, indicating that differences in carbohydrate compounds represented the ripeness of strawberry fruit. Overall results indicate that FT-IR in combination with PCA enables discrimination of the ripeness of strawberry fruit flesh.

Effects of HP228 on Analgesia Alone or in Combination with Morphine (새로운 해열, 진통, 소염제인 HP228의 단독 또는 Morphine과의 병용투여가 제통효과에 미치는 영향)

  • Lee, Seung-Gu;Lee, Seung-Hoon;Kim, Tae-Sung;Kim, Hyun-Soo;Kim, Kwang-Min
    • The Korean Journal of Pain
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    • v.12 no.1
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    • pp.64-69
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    • 1999
  • Background: The new drug HP228 is a cytokine restraining agent with a broad spectrum of anti-inflammatory, analgesic, and antipyretic activity. Six healthy, adult, male volunteers were studied to determine the independent and interactive effects of HP228 and morphine on pain perception. Methods: Two groups of stimuli were applied to each volunteers before drug administration as control, 20 min after morphine and HP228 administration, and 20 min after combined administration of these two drugs. Two adhesive electrically-conducting pads were applied on opposite sides of the arm approximately 8 cm apart. The electrode were connected to an electrical impulse generator and 50 Hz 1 msec pulses of incrementally increasing intensity were delivered at 1 sec intervals. The analgesic endpoints were the current intensity (mA) at which the subject first detected the stimulus (THRESH), the intensity at which the stimulus was first idenfied as being painful (PAIN), and the intensity at which the subject requested that the stimulus be terminated due to discomfort (LIMIT). A second series of stimuli were applied immediately thereafter using 1-sec duration 50 Hz tetanus pulses with increasing intensities at 2~5 sec intervals. Results: There were significant differences between drug treatments (Morphine, HP228, HP228/Morphine) and control (No drugs) in any of the measurements (PAIN, LIMIT) except THRESH with the twitch and tetanus test. Conclusions: The data suggests that HP228 is an analgesic, but it does not appear to interact with morphine in an additive manner.

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