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http://dx.doi.org/10.7314/APJCP.2016.17.3.879

Microchips and their Significance in Isolation of Circulating Tumor Cells and Monitoring of Cancers  

Sahmani, Mehdi (Department of Clinical Biochemistry, Cellular and Molecular Research Center, Qazvin University of Medical Sciences)
Vatanmakanian, Mousa (Department of Hematology, Faculty of Allied Medicine, Tehran University of Medical Sciences)
Goudarzi, Mehdi (Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Science)
Mobarra, Naser (Stem cell Research Center, Department of Biochemistry, School of Medicine, Golestan University of Medical Sciences)
Azad, Mehdi (Department of Medical laboratory sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.3, 2016 , pp. 879-894 More about this Journal
Abstract
In micro-fluid systems, fluids are injected into extremely narrow polymer channels in small amounts such as micro-, nano-, or pico-liter scales. These channels themselves are embedded on tiny chips. Various specialized structures in the chips including pumps, valves, and channels allow the chips to accept different types of fluids to be entered the channel and along with flowing through the channels, exert their effects in the framework of different reactions. The chips are generally crystal, silicon, or elastomer in texture. These highly organized structures are equipped with discharging channels through which products as well as wastes of the reactions are secreted out. A particular advantage regarding the use of fluids in micro-scales over macro-scales lies in the fact that these fluids are much better processed in the chips when they applied as micro-scales. When the laboratory is miniaturized as a microchip and solutions are injected on a micro-scale, this combination makes a specialized construction referred to as "lab-on-chip". Taken together, micro-fluids are among the novel technologies which further than declining the costs; enhancing the test repeatability, sensitivity, accuracy, and speed; are emerged as widespread technology in laboratory diagnosis. They can be utilized for monitoring a wide spectrum of biological disorders including different types of cancers. When these microchips are used for cancer monitoring, circulatory tumor cells play a fundamental role.
Keywords
Microchips; cancer; circulating tumor cells; monitoring;
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1 Hur SC, Henderson-MacLennan NK, McCabe ER, et al (2011). Deformability-based cell classification and enrichment using inertial microfluidics. Lab Chip, 11, 912-20.   DOI
2 Kang JH, Krause S, Tobin H, et al (2012). A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. Lab Chip, 12, 2175-81.   DOI
3 Kanwar SS, Dunlay CJ, Simeone DM, et al (2014). Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes. Lab Chip, 14, 1891-900.   DOI
4 Kartalov EP, Zhong JF, Scherer A, et al (2006). High-throughput multi-antigen microfluidic fluorescence immunoassays. Biotechniques, 40, 85-90.   DOI
5 Kim H, Lee S, Lee JH, et al (2015). Integration of a microfluidic chip with a size-based cell bandpass filter for reliable isolation of single cells. Lab Chip, 15, 4128-32.   DOI
6 Kim YJ, Koo GB, Lee JY, et al (2014). A microchip filter device incorporating slit arrays and 3-D flow for detection of circulating tumor cells using CAV1-EpCAM conjugated microbeads. Biomaterials, 35, 7501-10.   DOI
7 Kuo JS, Chiu DT (2011). Disposable microfluidic substrates: transitioning from the research laboratory into the clinic. Lab Chip, 11, 2656-65.   DOI
8 Kuo JS, Zhao Y, Schiro PG, et al (2010). Deformability considerations in filtration of biological cells. Lab Chip, 10, 837-42.   DOI
9 Li Y, Zheng Q, Bao C, et al (2015). Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res, 25, 981-4.   DOI
10 Lianidou ES, Markou A, Strati A (2015). The Role of CTCs as Tumor Biomarkers. Adv Exp Med Biol, 867, 341-67.   DOI
11 Liu RH, Yang J, Lenigk R, et al (2004). Self-contained, fully integrated biochip for sample preparation, polymerase chain reaction amplification, and DNA microarray detection. Anal Chem, 76, 1824-31.   DOI
12 Mach AJ, Adeyiga OB, Di Carlo D (2013). Microfluidic sample preparation for diagnostic cytopathology. Lab Chip, 13, 1011-26.   DOI
13 Maheswaran S, Haber DA (2010). Circulating tumor cells: a window into cancer biology and metastasis. Curr Opin Genet Dev, 20, 96-9.   DOI
14 Maheswaran S, Sequist LV, Nagrath S, et al (2008). Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med, 359, 366-77.   DOI
15 Mair DA, Geiger E, Pisano AP, et al (2006). Injection molded microfluidic chips featuring integrated interconnects. Lab Chip, 6, 1346-54.   DOI
16 Marques MP, Fernandes P (2011). Microfluidic devices: useful tools for bioprocess intensification. Molecules, 16, 8368-401.   DOI
17 Meng S, Tripathy D, Shete S, et al (2004). HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci U S A, 101, 9393-8.   DOI
18 Meng S, Tripathy D, Shete S, et al (2006). uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues. Proc Natl Acad Sci U S A, 103, 17361-5.   DOI
19 Minhas H (2015). Developing the Lab on a Chip-microTAS community. Lab Chip, 15, 15-6.   DOI
20 Moon HS, Kwon K, Kim SI, et al (2011). Continuous separation of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP). Lab Chip, 11, 1118-25.   DOI
21 Mrksich M, Whitesides GM (1996). Using self-assembled monolayers to understand the interactions of man-made surfaces with proteins and cells. Annu Rev Biophys Biomol Struct, 25, 55-78.   DOI
22 Muluneh M, Issadore D (2014). Microchip-based detection of magnetically labeled cancer biomarkers. Adv Drug Deliv Rev, 66, 101-9.   DOI
23 Munro NJ, Snow K, Kant JA, et al (1999). Molecular diagnostics on microfabricated electrophoretic devices: from slab gel- to capillary- to microchip-based assays for T- and B-cell lymphoproliferative disorders. Clin Chem, 45, 1906-17.
24 Myung JH, Launiere CA, Eddington DT, et al (2010). Enhanced tumor cell isolation by a biomimetic combination of E-selectin and anti-EpCAM: implications for the effective separation of circulating tumor cells (CTCs). Langmuir, 26, 8589-96.   DOI
25 Nagrath S, Sequist LV, Maheswaran S, et al (2007). Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature, 450, 1235-9.   DOI
26 Nandi P, Lunte SM (2009). Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: a review. Anal Chim Acta, 651, 1-14.   DOI
27 Ng AH, Wheeler AR (2015). Next-generation microfluidic point-of-care diagnostics. Clin Chem, 61, 1233-4.   DOI
28 Nge PN, Rogers CI, Woolley AT (2013). Advances in microfluidic materials, functions, integration, and applications. Chem Rev, 113, 2550-83.   DOI
29 Nind F (1999). Microchip identification. Vet Rec, 145, 532.
30 Pantel K, Brakenhoff RH, Brandt B (2008). Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer, 8, 329-40.   DOI
31 Pappalardo PA, Bonner R, Krizman DB, et al (1998). Microdissection, microchip arrays, and molecular analysis of tumor cells (primary and metastases). Semin Radiat Oncol, 8, 217-23.   DOI
32 Payne RE, Yague E, Slade MJ, et al (2009). Measurements of EGFR expression on circulating tumor cells are reproducible over time in metastatic breast cancer patients. Pharmacogenomics, 10, 51-7.   DOI
33 Ratajczak J, Wysoczynski M, Hayek F, et al (2006). Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia, 20, 1487-95.   DOI
34 Reyes DR, Iossifidis D, Auroux PA, et al (2002). Micro total analysis systems. 1. Introduction, theory, and technology. Anal Chem, 74, 2623-36.   DOI
35 Saliba AE, Saias L, Psychari E, et al (2010). Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays. Proc Natl Acad Sci U S A, 107, 14524-9.   DOI
36 Sato K, Tokeshi M, Kimura H, et al (2001). Determination of carcinoembryonic antigen in human sera by integrated bead-bed immunoassay in a microchip for cancer diagnosis. Anal Chem, 73, 1213-8.   DOI
37 Sato K, Yamanaka M, Takahashi H, et al (2002). Microchip-based immunoassay system with branching multichannels for simultaneous determination of interferon-gamma. Electrophoresis, 23, 734-9.   DOI
38 Seemann R, Brinkmann M, Pfohl T, et al (2012). Droplet based microfluidics. Rep Prog Phys, 75, 016601.   DOI
39 Seigneuric R, Markey L, Nuyten DS, et al (2010). From nanotechnology to nanomedicine: applications to cancer research. Curr Mol Med, 10, 640-52.   DOI
40 Sheng W, Ogunwobi OO, Chen T, et al (2014). Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip. Lab Chip, 14, 89-98.   DOI
41 Sin ML, Gao J, Liao JC, et al (2011). System Integration - A Major Step toward Lab on a Chip. J Biol Eng, 5, 6.   DOI
42 Smith RJ (1984). Pentagon hit by new microchip troubles. Science, 226, 953.
43 Stathopoulou A, Gizi A, Perraki M, et al (2003). Real-time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system. Clin Cancer Res, 9, 5145-51.
44 Stott SL, Hsu CH, Tsukrov DI, et al (2010). Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A, 107, 18392-7.   DOI
45 Taylor DD, Gercel-Taylor C (2005). Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer, 92, 305-11.   DOI
46 Tian H, Jaquins-Gerstl A, Munro N, et al (2000). Single-strand conformation polymorphism analysis by capillary and microchip electrophoresis: a fast, simple method for detection of common mutations in BRCA1 and BRCA2. Genomics, 63, 25-34.   DOI
47 Tsujiura M, Ichikawa D, Komatsu S, et al (2010). Circulating microRNAs in plasma of patients with gastric cancers. Br J Cancer, 102, 1174-9.   DOI
48 Van Loo P, Voet T (2014). Single cell analysis of cancer genomes. Curr Opin Genet Dev, 24, 82-91.   DOI
49 Vidi PA, Leary JF, Lelievre SA (2013). Building risk-on-achip models to improve breast cancer risk assessment and prevention. Integr Biol, 5, 1110-8.   DOI
50 Wang C, Ye M, Cheng L, et al (2015). Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes. Biomaterials, 54, 55-62.   DOI
51 Wang J, Chen J, Sen S (2016). MicroRNA as Biomarkers and Diagnostics. J Cell Physiol, 231, 25-30.   DOI
52 Whitesides GM (2006). The origins and the future of microfluidics. Nature, 442, 368-73.   DOI
53 Whitesides GM, Ostuni E, Takayama S, et al (2001). Soft lithography in biology and biochemistry. Annu Rev Biomed Eng, 3, 335-73.   DOI
54 Wu A, Wang L, Jensen E, et al (2010). Modular integration of electronics and microfluidic systems using flexible printed circuit boards. Lab Chip, 10, 519-21.   DOI
55 Xi L, Nicastri DG, El-Hefnawy T, et al (2007). Optimal markers for real-time quantitative reverse transcription PCR detection of circulating tumor cells from melanoma, breast, colon, esophageal, head and neck, and lung cancers. Clin Chem, 53, 1206-15.   DOI
56 Yang J, Vykoukal J, Noshari J, et al (2000). Dielectrophoresis-Based Microfluidic Separation and Detection Systems. Int J Adv Manuf Syst, 3, 1-12.
57 Yang J, Weinberg RA (2008). Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell, 14, 818-29.   DOI
58 Zhang P, Sun C, Zhang R, et al (2013). A novel and facile microchip based on nitrocellulose membrane toward efficient capture of circulating tumor cells. Se Pu, 31, 518-21 (in Chinese).
59 Zhang Z, Nagrath S (2013). Microfluidics and cancer: are we there yet? Biomed Microdevices, 15, 595-609.   DOI
60 Zhao L, Lu YT, Li F, et al (2013). High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing. Adv Mater, 25, 2897-902.   DOI
61 Zheng S, Lin H, Liu JQ, et al (2007). Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells. J Chromatogr A, 1162, 154-61.   DOI
62 Zheng S, Lin HK, Lu B, et al (2011). 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood. Biomed Microdevices, 13, 203-13.   DOI
63 Zubritsky E (1999). Science: microchip gets a tip. Anal Chem, 71, 590-1
64 Allan AL, Keeney M (2010). Circulating tumor cell analysis: technical and statistical considerations for application to the clinic. J Oncol, 2010, 426218.
65 Aitman TJ (2001). DNA microarrays in medical practice. BMJ, 323, 611-5.   DOI
66 Alexis F, Rhee JW, Richie JP, et al (2008). New frontiers in nanotechnology for cancer treatment. Urol Oncol, 26, 74-85.   DOI
67 Alizadeh AA, Eisen MB, Davis RE, et al (2000). Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature, 403, 503-11.   DOI
68 Allen-Mersh TG, McCullough TK, Patel H, et al (2007). Role of circulating tumour cells in predicting recurrence after excision of primary colorectal carcinoma. Br J Surg, 94, 96-105.   DOI
69 Azad M, Bakhshi Biniaz R, Goudarzi M, et al (2015). Short view of leukemia diagnosis and treatment in iran. Int J Hematol Oncol Stem Cell Res, 9, 88-94.
70 Backhouse CJ, Crabtree HJ, Glerum DM (2002). Frontal analysis on a microchip. Analyst, 127, 1169-75.   DOI
71 Bean P (2001). Biochips 2001: the second-generation chip for the clinic. Am Clin Lab, 20, 11-2.
72 Bhagat AA, Hou HW, Li LD, et al (2011). Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation. Lab Chip, 11, 1870-8.   DOI
73 Chen CL, Chen KC, Pan YC, et al (2011a). Separation and detection of rare cells in a microfluidic disk via negative selection. Lab Chip, 11, 474-83.   DOI
74 Brivio M, Verboom W, Reinhoudt DN (2006). Miniaturized continuous flow reaction vessels: influence on chemical reactions. Lab Chip, 6, 329-44.   DOI
75 Brouzes E, Medkova M, Savenelli N, et al (2009). Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A, 106, 14195-200.   DOI
76 Bunger S, Zimmermann M, Habermann JK (2015). Diversity of assessing circulating tumor cells (CTCs) emphasizes need for standardization: a CTC Guide to design and report trials. Cancer Metastasis Rev, 34, 527-45.   DOI
77 Chen KC, Lee TP, Pan YC, et al (2011b). Detection of circulating endothelial cells via a microfluidic disk. Clin Chem, 57, 586-92.   DOI
78 Chiu TK, Lei KF, Hsieh CH, et al (2015). Development of a microfluidic-based optical sensing device for label-free detection of circulating tumor cells (CTCs) through their lactic acid metabolism. Sensors (Basel), 15, 6789-806.   DOI
79 Chuang WC, Lee HL, Chang PZ, et al (2010). Review on the modeling of electrostatic MEMS. Sensors (Basel), 10, 6149-71.   DOI
80 Cibilic D (2000). Microchip action. Aust Vet J, 78, 598.
81 de Bono JS, Attard G, Adjei A, et al (2007). Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor. Clin Cancer Res, 13, 3611-6.   DOI
82 den Toonder J (2011). Circulating tumor cells: the Grand Challenge. Lab Chip, 11, 375-7.   DOI
83 Di Carlo D, Wu LY, Lee LP (2006). Dynamic single cell culture array. Lab Chip, 6, 1445-9.   DOI
84 DeRisi J, Penland L, Brown PO, et al (1996). Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet, 14, 457-60.   DOI
85 Dharmasiri U, Balamurugan S, Adams AA, et al (2009). Highly efficient capture and enumeration of low abundance prostate cancer cells using prostate-specific membrane antigen aptamers immobilized to a polymeric microfluidic device. Electrophoresis, 30, 3289-300.   DOI
86 Dharmasiri U, Njoroge SK, Witek MA, et al (2011). High-throughput selection, enumeration, electrokinetic manipulation, and molecular profiling of low-abundance circulating tumor cells using a microfluidic system. Anal Chem, 83, 2301-9.   DOI
87 Dingwall R (1979). Are you ready for the microchip? Nurs Times, 75, 975-6.
88 Emmert-Buck MR, Bonner RF, Smith PD, et al (1996). Laser capture microdissection. Science, 274, 998-1001.   DOI
89 Fabian TK, Fejerdy P, Csermely P (2008). Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases. Curr Genomics, 9, 11-21.   DOI
90 Fey MF (2002). The impact of chip technology on cancer medicine. Ann Oncol, 13, 109-13.
91 Figeys D, Pinto D (2000). Lab-on-a-chip: a revolution in biological and medical sciences. Anal Chem, 72, 330A-5A.
92 Gleghorn JP, Pratt ED, Denning D, et al (2010). Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody. Lab Chip, 10, 27-9.   DOI
93 Guzman NA, Phillips TM (2011). Immunoaffinity capillary electrophoresis: a new versatile tool for determining protein biomarkers in inflammatory processes. Electrophoresis, 32, 1565-78.
94 Gomez-Sjoberg R, Leyrat AA, Pirone DM, et al (2007). Versatile, fully automated, microfluidic cell culture system. Anal Chem, 79, 8557-63.   DOI
95 Goodale D, Phay C, Postenka CO, et al (2009). Characterization of tumor cell dissemination patterns in preclinical models of cancer metastasis using flow cytometry and laser scanning cytometry. Cytometry A, 75, 344-55.
96 Gross A, Schoendube J, Zimmermann S, et al (2015). Technologies for Single-Cell Isolation. Int J Mol Sci, 16, 16897-919.   DOI
97 Helo P, Cronin AM, Danila DC, et al (2009). Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival. Clin Chem, 55, 765-73.   DOI
98 Holden C (1989). Engineers' nobel to microchip pioneers. Science, 246, 214.
99 Hosokawa M, Hayata T, Fukuda Y, et al (2010). Size-selective microcavity array for rapid and efficient detection of circulating tumor cells. Anal Chem, 82, 6629-35.   DOI
100 Huang F, Adelman J, Jiang H, et al (1999). Identification and temporal expression pattern of genes modulated during irreversible growth arrest and terminal differentiation in human melanoma cells. Oncogene, 18, 3546-52.   DOI
101 Hung LY, Chuang YH, Kuo HT, et al (2013). An integrated microfluidic platform for rapid tumor cell isolation, counting and molecular diagnosis. Biomed Microdevices, 15, 339-52.   DOI