• Journal of the Korean Institute of Navigation
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• v.20 no.1
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• pp.59-79
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• 1996

Waterfront redevelopment is an element in the process of inner-city regeneration now widespread in many ports of the world. Academic interest in the processes involved has yielded a literature biased towards specific locations rather than towards the analysis of processes and issues. The redevelopment of urban waterfronts does not, of course, occur exclusively in port cities but is found as a continuous process in most places where settlement and water are juxtaposed, whether or not commercial port activity is or was present. Port cities, however, as a result of the concentration and juxtaposition of urban and maritime influences, generally present the major issues involved in waterfront redevelopment most clearly. In this context, the general aim is to explore Korean dimensions of waterfront redevelopment in a range of port cities in a context of inner-urban renewal; and a specific objective is to examine the views of decision-makers in Korean port cities on the processes involved by a questionnaire method. The focus is on comparative strategies, and in particular upon the factors affecting the balance between social goals and commercial interests. To test the response of four categories of decision-makers in Korean port cities on a number of issues perceived as underpinning the processes involved in waterfront redevelopment, four catergories of respondents-port authority representatives(PO), urban planners(UP), port specialists(PS) and city-government official(GO)-were asked to fill in a questionnaire form. In three out of ten cases, the overall result broadly confirmed the a priori expectation; in six cases the confirmation was partial; and in one other the view of respondent was generally contrary to those anticipated. In many, but by no means all, cases there was substantial agreement between the four categories of respondents, but the range of scores was generally much wider than expected.

• Genomics & Informatics
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• v.19 no.4
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• pp.40.1-40.11
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• 2021

Mutation signatures represent unique sequence footprints of somatic mutations resulting from specific DNA mutagenic and repair processes. However, their causal associations and the potential utility for genome research remain largely unknown. In this study, we performed PanCancer-scale correlative analyses to identify the genomic features associated with tumor mutation burdens (TMB) and individual mutation signatures. We observed that TMB was correlated with tumor purity, ploidy, and the level of aneuploidy, as well as with the expression of cell proliferation-related genes representing genomic covariates in evaluating TMB. Correlative analyses of mutation signature levels with genes belonging to specific DNA damage-repair processes revealed that deficiencies of NHEJ1 and ALKBH3 may contribute to mutations in the settings of APOBEC cytidine deaminase activation and DNA mismatch repair deficiency, respectively. We further employed a strategy to identify feature-driven, de novo mutation signatures and demonstrated that mutation signatures can be reconstructed using known causal features. Using the strategy, we further identified tumor hypoxia-related mutation signatures similar to the APOBEC-related mutation signatures, suggesting that APOBEC activity mediates hypoxia-related mutational consequences in cancer genomes. Our study advances the mechanistic insights into the TMB and signature-based DNA mutagenic and repair processes in cancer genomes. We also propose that feature-driven mutation signature analysis can further extend the categories of cancer-relevant mutation signatures and their causal relationships.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.792-799
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• 2003

As eTransformation and collaborative eCommerce have been on the rise, business processes between business partners are increasingly recognized as important assets that need to be integrated. These trends imply more complex and dynamic business processes should be considered in order to integrate related business organizations and business units. Moreover, these business processes are widely distributed across stakeholders. Therefore, there is a need for business process modeling that is usable, flexible and capable of integrating systems consistently across businesses and technology barriers. In this paper, a business process modeling methodology is introduced, which is based on top­do\W and model-driven approach utilizing OMG's MDA(Model-Driven Architecture) and UML profile for EDOC(Enterprise Distributed Object Computing). This provides the ability to model business process at all levels simultaneously, to combine business process models retaining their meaning, to use business process design patterns constraining the behavior of sub-processes, and to derive specific codes from a stable model as the underlying infrastructure shifts over time. In addition, we suggest some modifications of the meta-model for EDOC-Business Process Profile by adding new features in order to model business processes rigidly. This paper illustrates some examples of business process modeling and compares them with UML diagrams and IDEF models. The proposed methodology is implemented to develop a business process modeling tool.

• Journal of Korean Institute of Industrial Engineers
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• v.33 no.1
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• pp.1-10
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• 2007

The capabilities ofBusiness Process Management Systems (BPMS's) are continuously extended to increase theeffectiveness of the management and enactment of business processes. This paper identifies the challenge ofcase prediction, which for a specific case under the control of a BPMS deals with the estimation of the remaining time until it is completed. An accurate case prediction facility is a valuable tool for the operationalcontrol of business processes, as it enables the pre-active monitoring of time violations. Little research has beencarried out in this area and few commercial tools support case prediction. This paper lists the requirements onsuch a facility and sketches sonae directions to reach a solution. To illustrate the depth of the problem, a smallaspect of the problem is treated in more detail. It involves the complex relations between tasks and resources inbusiness processes, which makes an exact analytical approach mfeasible.

• 한국연소학회:학술대회논문집
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• 2004.11a
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• pp.225-230
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• 2004

Volatile organic compounds (VOCs) are low calorific value gases (LCVG) emitted from chemical processes such as painting booth, dye works and drying processes etc. Characteristics of VOCs are low calorific values less than 150 kcal/$m^3$, high activation energy for ignition and low energy output. These characteristics usually make combustion unstable and its treatment processes needs high-energy consumption, The cyclone combustion system is suitable for LCVG burning because it can recirculate energy through a high swirling flow to supply the activation energy for ignition, increases energy density to make a combustion temperature higher than usual swirl combustor and also increases mixing intensity, This research was conducted to develop optimized cyclone combustion system for thermal oxidation of VOCs. This research was executed to establish the effect of swirl number with respect to the combustion temperature and composition of exhausted gas in the specific combustor design.

• BMB Reports
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• v.44 no.2
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• pp.96-101
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• 2011

Calcineurin is a serine/threonine protein phosphatase controlled by $Ca^{2+}$ and calmodulin that has been implicated in various signaling pathways. Previously, we reported that calcineurin regulates coelomocyte endocytosis in Caenorhabditis elegans. So far, simple and powerful in vivo approaches have been developed to study various endocytic processes in C. elegans. Using these in vivo assays, we further analyzed the endocytic phenotypes of calcineurin mutants. We observed that the calcineurin mutants were defective in apical endocytosis in the intestine as well as synaptic vesicle recycling in the nerve cord. However, we found that calcineurin mutants displayed normal receptor-mediated endocytosis in oocytes. Therefore, our results suggest that calcineurin may regulate specific sets of endocytic processes in nematode.

• Proceedings of the Microbiological Society of Korea Conference
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• 2003.05a
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• pp.118-121
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• 2003

A method for detection and quantification of aceticlastic methanogens using a real-time PCR with a TaqMan probe was developed. Two sets of primers and probes targeting the family Methanosarcinaceae and Methanosaetaceae were designed by using the Ribosormal Database Project (RDP) II, and softwares for phylogenetic probe design and sequence analysis. Target-group specificity of each set of primers and probe was verified by testing DNAs isolated from pure cultures of 28 archaeal strains purchased from DSMZ. Cell numbers in the 28 archaeal cultures and in the samples from anaerobic processes were quantified using a real-time PCR with the sets of primers and probe. In conclusion, the real-time PCR assay was very specific for the corresponding target methanogenic family and was proved to be a powerful method for quantification of aceticlastic methanogens in anaerobic processes.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.11a
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• pp.330-333
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• 2000

Dimensional accuracy and surface quality are very important in rapid prototyping especially when the models are used for the production of tools. This paper presents the development of benchmarking part to investigate dimensional accuracy and surface finish. A new test part is designed to perform benchmarking of major rapid prototyping processes such as selective laser sintering, laminated object manufacturing, stereolithography apparatus, and fused deposition modeling. The test part design includes basic manufacturing features such as holes, walls, squares, cylinder and etc. In addition, the small features are included in order to evaluate the fine details that can be manufactured by a specific RP process. The CMM program that automatically measures different features in the test part is also developed. The evaluation of accuracy as well as surface roughness are discussed for major rapid prototyping processes.

• English Language & Literature Teaching
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• v.12 no.2
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• pp.127-152
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• 2006

For the past 20 years the process approach to writing has been popular in second language writing classrooms. However, there have been very few studies conducted in Korea with regard to the composing processes and the effects of proficiency on writers' usage. The present study attempts to begin to fill this gap. Three groups of college students with different writing proficiency participated in the study: the advanced group, the intermediate group, and the beginning group. The verbal protocol of their writing processes revealed that they approached writing tasks differently. While the advanced writers focused on generating texts and ideas and examined their writing at both global and local levels, the other two groups of students tended to focus on evaluating text at the local level and generated fewer ideas and less text. The findings from this study are then compared to those of some major studies of the composing process as conclusions are subsequently drawn about the specific needs of Korean college writers.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2005.04a
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• pp.371-374
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• 2005

We accomplished optimization for pump and treat (P&T) designs in consideration of degradation processes such as retardation and biodegradation, which are significant for contaminant fate in hydrogeology. For more desirable remediation, optimal pumping duration and minimum pumping rate constraint problems are studied. After a specific P&T duration, it replaces the P&T with the enhanced natural attenuation (ENA), which induces aerobic biodegradation by maintaining oxygen concentration. The design in this strategy carries out the optimization for the number and locations of oxygen injection wells.