• Molecules and Cells
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• 제43권7호
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• pp.591-599
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• 2020

Complex cell-to-cell communication underlies the basic processes essential for homeostasis in the given tissue architecture. Obtaining quantitative gene-expression of cells in their native context has significantly advanced through single-cell RNA sequencing technologies along with mechanical and enzymatic tissue manipulation. This approach, however, is largely reliant on the physical dissociation of individual cells from the tissue, thus, resulting in a library with unaccounted positional information. To overcome this, positional information can be obtained by integrating imaging and positional barcoding. Collectively, spatial transcriptomics strategies provide tissue architecture-dependent as well as position-dependent cellular functions. This review discusses the current technologies for spatial transcriptomics ranging from the methods combining mechanical dissociation and single-cell RNA sequencing to computational spatial re-mapping.

• Spatial Information Research
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• 제10권3호
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• pp.421-438
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• 2002

GIS을 활용하는 다양한 응용분야에서 공간데이터베이스의 상세한 정도(추상화 수준)는 그 목적에 따라 달라진다. 추상화 수준이 달라지면 공간자료의 기하학적인 단순화뿐 아니라, 객체(인스턴스), 공간 및 속성 자료, 위상관계, 의미관계 등이 변화되거나 유지되어야 한다. 이와 관련하여 본 연구에서는 원시 공간데이터베이스를 추상화하여 목표데이터베이스를 생성하는 방법을 제시하였다. 공간데이터베이스를 추상화하는 연산자를 재정의하고, 어떤 객체에 어떤 연산자들을 어떤 순서로 적용하여야 하는지에 대한 기준을 제시하고, 이 기준에 따라 워크플로우를 제시하였으며, 프로토타입시스템을 개발하여 타당성을 검토했다.

• 한국측량학회:학술대회논문집
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• 한국측량학회 2007년도 춘계학술발표회 논문집
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• pp.295-299
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• 2007

Today, ubiquitous technology (e.g. computers or networked devices pervade everywhere we are) has enlarged by great advancement of information and communication technologies. If ubiquitous technologies is applied to, innovation of spatial information technology is expected. traditional spatial information technologies such as survey, GIS, GPS, LBS, and RS and ubiquitous technology gradual1y have been converged. The aim of this study is to create shared visions in spatial information technologies by scenario based roadmapping. So, we surveyed the state of the art in main spatial information technologies, market status and patent map. Consequently, prospects of spatial information technologies is suggested. The aim of 1st and 2nd NGIS project focused on map supplier was to develop digital map(e.g. framework data, various thematic map). As a result, the best technology of digital mapping is achieved in the world. But, there is not enough to develop GIS and LBS solution. Current market in GIS S/W and Telematics is about 384billon won and 250billion won. a patent is applied in the order, like a USA(1571case, 47%), Japan(883case, 26%), EU(478case, 14%), Korea(446case, 13%). In the future, spatial information technology fused on ubiquitous technology will be focused on user's demand and developing convenience context. The developing target will be realtime monitoring of 3D spatial data based on high resolution coordinate system, sharing and supplying multi-sensor data considered users demand, location service by ubiquitous technologies.

• Spatial Information Research
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• 제19권3호
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• pp.83-93
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• 2011

도시의 기반 시설은 국가 또는 도시의 기술적인 발전 정도를 표현하는 지표적인 의미를 가지므로 이들을 효과적으로 관리하고 운영하는 것은 매우 중요하다. 본 논문에서는 u-City에서 지능적으로 도시의 지하 시설물을 관리하기 위한 상황인식 시스템을 제안하고, 이에 대한 알고리즘 및 프로토타입(prototype)을 개발한다. 제안된 상황인식 시스템의 알고리즘 작성은 USN(ubiquitous sensor network)환경에서 시설물을 관리하고 있는 각종 센서가 이상 신호를 감지하여 알람을 발생시킨 시점부터 상황인식 시스템이 발생한 알람의 원인을 찾아낸 후 그 결과를 도시공간정보 통합 플랫폼과 주변의 모듈에 전송해 주는 시점까지이다. 그리고 이 알고리즘을 기반으로 동작하는 상황인식 시스템의 프로토타입을 구현한 후 단위 테스트를 수행하여 구현된 프로토타입의 유효성을 검증하였다. 본 논문에서 구현된 지하시설물의 관리를 위한 알고리즘과 프로토타입은 검증 및 수정 작업을 거친 후 실제적인 시스템 개발로 연결될 것이며, 도시의 여러 가지 시설물을 관리하는 관련 시스템들의 참조모델로서 유용하게 사용될 것이라 기대한다.

• Animal cells and systems
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• 제2권1호
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• pp.65-69
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• 1998

The hippocampus and prefrontal cortex are regarded as the highest-order association cortices. The hippocampus has been proposed to store "cognitive maps" of external environments, and the prefrontal cortex is known to be involved in the planning of behavior, among other functions. Considering the prominent functional roles played by these structures, it is not surprising to find direct monosynaptic projections from the hippocampus to the prefrontal cortex. Rhythmic stimulation of this projection patterned after the hippocampal EEG theta rhythm induced stable long-term potentiation of field potentials in the prefrontal cortex. Comparison of behavioral correlates of hippocampal and prefrontal cortical neurons during an a-arm radial maze, working memory task shows a striking contrast. Hippocampal neurons exhibit clear place-specific firing patterns, whereas prefrontal cortical neurons do not show spatial selectivity, but are correlated to different stages of the behavioral task. These data lead to the hypothesis that the role of hippocampal projection to the prefrontal cortex is not to impose spatial representations upon prefrontal activity, but to provide a mechanism for learning the spatial context in which particular behaviors are appropriate.propriate.

• 한국CDE학회논문집
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• 제16권6호
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• pp.437-448
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• 2011

A robotic spatial augmented reality (RSAR) system combines a robotics technology with a spatial augmented reality system (SAR) where cameras are used to recognize real objects and projectors augment information and user interface directly on the surface of the recognized objects, rather than relying on handheld display devices. Moreover, a robotic module is actively used to discover and utilize the context of users and environments. The control of a RSAR system involves several issues from different technical fields such as classical inverse kinematics of motors where projector-camera pairs are mounted, inverse projection problems to find appropriate internal/external parameters of projectors and cameras, and image warping in graphics pipeline to compensate the kinematic constraints. In this paper, we investigate various control issues related to a RSAR system and propose basic approaches to handle them, specially focused on the prototype RSAR system developed in ETRI.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2003년도 ISIS 2003
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• pp.459-462
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• 2003

Selectivity estimation of queries not only provides useful information to the query processing optimization but also may give users with a preview of processing results. In this paper, we investigate the problem of selectivity estimation in the context of a spatial dataset. Although several techniques have been proposed in the literature to estimate spatial query result sizes, most of those techniques still have some drawback in the case that a large amount of memory is required to retain accurate selectivity. To eliminate the drawback of estimation techniques in previous works, we propose a new method called MW Histogram. Our method is based on two techniques: (a) MinSkew partitioning algorithm that processes skewed spatial datasets efficiently (b) Wavelet transformation which compression effect is proven. We evaluate our method via real datasets. With the experimental result, we prove that the MW Histogram has the ability of providing estimates with low relative error and retaining the similar estimates even if memory space is small.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.31-36
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• 2005

Intelligent Space (iSpace) is the space where many intelligent devices, such as computers and sensors, are distributed. According to the cooperation of many intelligent devices, the environment comes to have intelligence. In iSpace, the locations of multiple humans and other objects are obtained and tracked by using multiple camera and color-based method. In addition, we describe a context-aware information system which is based on Spatial-Knowledge-Tags (SKT). SKT system enables humans to access information and data by using spatial location of human and stored information in storage. The proposed tracking method is applied to the intelligent environment and its performance is verified by the experiments.

• 한국지능시스템학회논문지
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• 제22권4호
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• pp.515-520
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• 2012

In brain computer interface (BCI) system, the most important part is classification of human thoughts in order to translate into commands. The more accuracy result in classification the system gets, the more effective BCI system is. To increase the quality of BCI system, we proposed to reduce noise and artifact from the recording data to analyzing data. We used auditory stimuli instead of visual ones to eliminate the eye movement, unwanted visual activation, gaze control. We applied independent component analysis (ICA) algorithm to purify the sources which constructed the raw signals. One of the most famous spatial filter in BCI context is common spatial patterns (CSP), which maximize one class while minimize the other by using covariance matrix. ICA and CSP also do the filter job, as a raw filter and refinement, which increase the classification result of linear discriminant analysis (LDA).

• 대한공간정보학회지
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• 제5권2호
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• pp.55-63
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• 1997

문화재에 대한 정밀 수치자료의 획득과 공간분석 체계의 구축은 대상물의 보존 차원에서 매우 중요한 의미를 지니고 있다. 본 연구는 문화재즐 보다 효율적으로 관리하기 위한 기하학적 수치자료의 획득과 이의 정량적 공간분석에 관한 것이다. 공주 무령왕릉 군에 대한 동일좌표계 상에서의 3차원 정밀 실측과 영상해석을 실시하여 수치자료의 기반을 구축하고 다양한 기하학적 분석은 물론 3차원 모니터링을 수행하므로서 보존대책의 기초자료를 제공할 수 있었다.