• 한국실내디자인학회논문집
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• 제19권3호
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• pp.77-85
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• 2010

The Therme Vals is a hotel and spa which combines a complete sensory experience designed by Peter Zumthor. This study aims to find emotional design approaches of the Therme Vals through references, observation from site visit, interview and discussion related to this topic. This space was designed for visitors to luxuriate and rediscover the ancient benefits of bathing. The combinations of light and shade, open and enclosed spaces and linear elements make for a highly sensuous and restorative experience. The study observed the emotional design characteristics of the Therme Vals through space approach, aesthetic and experiential sides. For space approach side, emotional experience in gradual process to approach the space was mentioned, for aesthetic side, mystical combination of light, stone and water was observed, for experiential side, 5 senses experience and space programing for adjusting the density of the space were observed. This study found that the spa has the quality of spiritual, soul-touching delight like religious experience. The fascination for the mystic qualities of a world of stone within the mountain, for darkness and light, for light reflections on the water or in the steam saturated air, pleasure in the unique acoustics of the bubbling water in a world of stone, the ritual of bathing-all these notions were explained in Peter Zumthor's construction details. In the result of the interview and discussion, people love the space and praised it highly for the emotional design regardless of space experience, age, sex or ethnicity. Emotional design approaches based on human nature, materiality, and memory of the places is more powerful than other emotional design ideas with technical devices, special themes, digital effects, vivid colors and shapes.

• Journal of Microbiology and Biotechnology
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• 제28권10호
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• pp.1604-1613
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• 2018

Lactobacillus rhamnosus GG (LGG) is a probiotic commonly used in fermented dairy products. In this study, RNA-sequencing was performed to unravel the effects of acid stress on LGG. The transcriptomic data revealed that the exposure of LGG to acid at pH 4.5 (resembling the final pH of fermented dairy products) for 1 h or 24 h provoked a stringent-type transcriptomic response wherein stress response- and glycolysis-related genes were upregulated, whereas genes involved in gluconeogenesis, amino acid metabolism, and nucleotide metabolism were suppressed. Notably, the pilus-specific adhesion genes, spaC, and spaF were significantly upregulated upon exposure to acid-stress. The transcriptomic results were further confirmed via quantitative polymerase chain reaction analysis. Moreover, acid-stressed LGG demonstrated an enhanced mucin-binding ability in vitro, with 1 log more LGG cells (p < 0.05) bound to a mucin layer in a 96-well culture plate as compared to the control. The enhanced intestinal binding ability of acid-stressed LGG was confirmed in an animal study, wherein significantly more viable LGG cells (${\geq}2log\;CFU/g$) were observed in the ileum, caecum, and colon of acid-stressed LGG-treated mice as compared with a non-acid-stressed LGG-treated control group. To our knowledge, this is the first report showing that acid stress enhanced the intestine-binding ability of LGG through the induction of pili-related genes.

• BMB Reports
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• 제51권4호
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• pp.163-164
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• 2018

CONSTANS (CO) induces the expression of FLOWERING LOCUS T (FT) in the photoperiodic pathway, and thereby regulates the seasonal timing of flowering. CO expression is induced and CO protein is stabilized by FLAVIN-BINDING KELCH REPEAT F-BOX PROTEIN 1 (FKF1) in the late afternoon, while CO is degraded by CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) during the night. These regulatory cascades were thought to act independently. In our study, we investigated the relationship between FKF1 and COP1 in the regulation of CO stability in response to ambient light conditions. A genetic analysis revealed that FKF1 acts as a direct upstream negative regulator of COP1, in which cop1 mutation is epistatic to fkf1 mutation in the photoperiodic regulation of flowering. COP1 activity requires the formation of a hetero-tetramer with SUPPRESSOR OF PHYA-105 (SPA1), [$(COP1)_2(SPA1)_2$]. Light-activated FKF1 has an increased binding capacity for COP1, forming a FKF1-COP1 hetero-dimer, and inhibiting COP1 homo-dimerization at its coiled-coil (CC) domain. Mutations in the CC domain result in poor COP1 dimerization and misregulation of photoperiodic floral induction. We propose that FKF1 represses COP1 activity by inhibiting COP1 dimerization in the late afternoon under long-day conditions, resulting in early flowering.

• 한국조명전기설비학회:학술대회논문집
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• 한국조명전기설비학회 2004년도 춘계학술대회 논문집
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• pp.469-472
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• 2004

본 논문에서는 직선형 피스톤 액추에이터의 응용모델을 제안하고 이를 구현하였다. 구성된 액추에이터의 해석을 위해서 패러데이 법칙으로부터 기본 방정식을 유도하였고, 이를 바탕으로 소형, 경량, 고속 응답을 요구하는 시스템에 적용 가능한 실험적 자료를 얻었다. 또한 본 논문에서는 자계로부터 일반적으로 구할 수 있는 전자기력을 에너지 변환 이론적 관점에서 기계 방정식과 결합하고 전원 공급부의 인가 전압의 변화로부터 액추에이터에 나타나는 현상을 Matlab 프로그램을 활용하여 간접적 방법으로 고찰하였다. 그 결과는 실제적인 설계에 적용할 경우 설계 프로그램의 자료나 부분적 변경시 참조 할 수 있으리라 사료된다. 이 결과를 바탕으로 Linear Actuator MfdBl 시스템과 구현된 직선형 피스톤 액추에이터의 동작이 실제 시스템에 활용될 수 있는 방법으로 가능함을 검증할 수 있었다.

• 한국산학기술학회논문지
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• 제16권11호
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• pp.7599-7606
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• 2015

연구에서는 자기 통제력이 있다고 판단되는 대학생들의 스마트폰 중독(SPA)에 따른 학습장애(LD), 주의력결핍장애(ADHD), 우울증(Depression)의 연관성을 알아보고자 하였다. 스마트폰 중독 정도와 학습장애 상관분석 결과 46의 상관을 보였다(p<0.001). 스마트폰 중독 정도와 주의력결핍장애 상관분석 결과 48의 상관을 보였다(p<0.001). 한편, 학습장애와 주의력결핍장애 전체 점수간의 상관분석 결과 64의 상관을 보였다(p<0.001). 학습장애(LD) 다중비교 결과 스마트폰 중독 정도가 낮은 그룹의 학습장애(LD)이 스마트폰 중독 정도가 높은 그룹보다 평균차이는 통계적으로 유의하였다. 스마트폰 중독 정도가 낮은 그룹의 주의력 결핍(ADHD)이 스마트폰 중독 정도가 매우 높은 그룹보다 평균차이는 통계적으로 유의하였다. 스마트폰 중독 정도가 낮은 그룹의 우울증(Depression)이 스마트폰 중독 정도가 높은 그룹보다 평균차이는 통계적으로 유의하였다.

• 융합정보논문지
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• 제8권3호
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• pp.107-114
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• 2018

최근 항공 산업이 활성화됨에 따라 복합재 관련 해석 소프트웨어의 개발이 요구되고 있다. 복합재 해석은 전문적인 구조 해석 및 시험 평가가 필요하다. 따라서 복합재 구조 해석을 위해서는 기존의 상용 소프트웨어를 사용할 수밖에 없으나 기존의 상용 소프트웨어들은 제한적인 기능만을 제공하고 있다. 특히 항공기 복합재 스파 구조물의 코너 부 구조 해석에 특화된 소프트웨어는 전무하기 때문에 구조 해석에 많은 인적 자원과 시간이 소비되고 있다. 이를 해소하기 위해서 기존의 코너 부 구조 해석 절차를 반영하고 복수의 파손 기준을 제공하는 사용자 친화적인 GUI 기반의 자동화 소프트웨어를 개발하였다. 개발한 소프트웨어의 구조 해석 결과에 대한 신뢰성을 검증하기 위해 기존의 구조 해석 결과와 비교한 결과, 구조 해석 성능에 문제가 없음을 확인하였다.

• 정보보호학회논문지
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• 제32권6호
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• pp.1059-1068
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• 2022

양자 컴퓨터의 계산 능력을 고려하여 설계된 양자 내성 암호 NTRU는 수학적으로 안전한 암호 조건을 만족하지만 하드웨어 구현 과정에서는 전력 분석 공격과 같은 부채널 공격 특성을 고려해야 한다. 본 논문에서는 NTRU의 복호화 과정 중 발생하는 전력 신호를 분석할 경우 개인 키가 노출될 가능성이 있음을 검증한다. 개인 키를 복구하는 데에는 단순 전력 분석 공격(Simple Power Analysis, SPA), 상관 전력 분석 공격(Correlation Power Analysis, CPA)과 차분 딥러닝 분석 공격(Differential Deep Learning Analysis, DDLA)을 모두 적용할 수 있었다. 이러한 전력 부채널 공격에 대응하기 위한 기본적인 대응책으로 셔플링 기법이 있으나 보다 효과적인 방법을 제안한다. 제안 방식은 인덱스별로 곱셈(multiplication)후 누산(accumulation)을 하는 것이 아니라 계수별로 누산 후 덧셈만 하도록 함으로써 곱셈 연산에 대한 전력 정보가 누출되지 않도록 하여 CPA 및 DDLA 공격을 방어할 수 있다.

• 한국동물위생학회지
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• 제46권2호
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• pp.167-173
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• 2023

An 8-year-old female neutered Maltese dog exhibited signs of serious thunderstorm phobia including panting, wandering, shivering, hiding, crying or whining, or trying to escape from the house. In this study, we administered clomipramine and alprazolam and observed behavioral improvement for 3 years. Clinical symptoms measured according to the storm phobia assessment (SPA) were significantly high with an initial total score of 19 points. However, it improved to a total score of 8 on day 176 after drugs administration and returned to the normal level with the total score of 5 points on the 983 days. When the symptoms for the first 4 treatments and the last 4 treatments were compared in 2 groups, the total score of all clinical symptoms decreased to -62.83% in the last 4 treatments. This study found that treatment with alprazolam and clomipramine was associated with a decrease in clinical signs of storm anxiety, suggesting that two drugs would be effective in reducing symptoms caused by anxiety, thunderstorm phobia, and noise phobia. In this follow up study, we hope that more studies would be conducted on behavior modification for treatment of storm phobia in veterinary medicine.

• Plant Breeding and Biotechnology
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• 제1권1호
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• pp.1-8
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• 2013

Low-temperature stress is an important factor controlling the growth and development of rice (Oryza sativa L.) in temperate region. In this study, a molecular linkage map consisting of 136 SSR markers was employed to identify QTL associated with cold tolerance at the seedling stage. 80 recombinant inbred lines (RILs) from an intersubspecific cross between Milyang23 (O. sativa ssp. Indica) and Hapcheonaengmi3, a japonica weedy rice and the parents were evaluated for leaf discoloration and SAPD value of seedlings. Rice plants were grown for 15 days in the low-temperature condition (13/20℃ day/night) and the control condition (25/20℃ day/night) in the growth chamber. The degree of leaf discoloration showed a highly significant correlation with the SPAD value in the low-temperature plot (r = -0.708, P < 0.0001). A total of four QTLs for SPAD were identified and the phenotypic variance explained by each QTL ranged from 5.4 to 16.0%. Two QTLs detected in the control condition were located on chromosomes 2 and 5, respectively. Two QTL on chromosomes 1 and 4 were detected at the low-temperature condition and Hapcheonaengmi3 alleles increased the SPAD values at these loci. Substitution mapping was conducted to delimit the position of qSPA-4 using introgression lines derived from the same cross. Results indicated that qSPA-4 was located in a 810-Kb region flanked by RM16333 and RM16368. The results indicated that Hapcheonaengmi3 contains QTL alleles that are likely to improve cold tolerance of Indica rice.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제16권4호
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• pp.25-32
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• 2010

Despite the growing interest in recreation as one of the ways to maintain physical and mental health in modern society, access to leisure facility is an issue for individuals with disabilities. This paper identifies inaccessible features to propose the ways to promote participation and usage of the leisure facilities for individuals with disabilities. A survey of individuals with disabilities is conducted to determine preferred leisure facilities depending on types of disabilities. The result of this survey is used to evaluate current condition of regulated National leisure facility and forest, which include barrier-free facilities (e.g. interconnecting zones, interior spaces, lavatories and other facilities), signage, approachable information kiosks, emergency egress, and detectable warnings. The common issues (e.g. guiding mechanism, accessible route, safety factors, and barrier-free facilities/services) in various types of recreational facilities (e.g. forest recreational center, spa and hot springs, Amusement Park, ski resort) were identified and analyzed.