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EFFECTS OF FLUORIDE MOUTHRINSE ON CELL ACTIVITY OF GINGIVAL FIBROBLASTS OF CHILDREN (불소양치용액이 소아 치은 섬유아세포의 세포활성에 미치는 영향에 관한 연구)

  • Lee, Dong-Hyun;Lee, Kwang-Hee
    • Journal of the korean academy of Pediatric Dentistry
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    • v.24 no.1
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    • pp.204-219
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    • 1997
  • The use of fluoride is one of the most effective methods for caries prevention. Fluoridation of public water supply has been recognized, for many years, as an effective way to reduce dental caries. The fluoride supplement has been recommended when the natural fluoride was unavailable or below the optimal range. However the mechanism of caries prevention by fluoride has not yet been clarified and it is well known that an overdose of fluoride results inacute and chronic toxicity, especially dental fluorosis. Fluoride mouthrinsing solution is widely used in dentistry due to its effectiveness in carrying anticariogenic action. Understanding the effects of fluoride mouthrinsing solution on human gingival fibroblasts will provide the safety rationale for its use during the caries preventive therapy. The purpose of this study was to evaluate the cytotoxic effect of fluoride mouthrinsing solution on the human gingival fibroblast in vitro. The human gingival fibroblasts were cultured from healthy gingiva on the extracted deciduous teeth of children. Cells were inoculated into a 24-well plate with $1{\times}10^4cells/well$ of medium at $37^{\circ}C$, 100% humidity, 5% $CO_2$ incubator for 24 hours. And the cells were counted by using the hemocytometer at each designed study. Human gingival fibroblasts were cultured in growth medium after one minute application range of 0.02%-0.2% NaF solution and 0.1% $SnF_2$ solution. The cells used in this study were between fifth to eighth passage number. The cell morphology was examined by inverted microscope and cell proliferation was measured by incorporating $[^3H]$-thymidine into DNA. DNA synthesis by human gingival fibroblasts was assessed by $[^3H]$-thymidine uptake assays while the cell activity was measured by MTT assay. Each concentrated fluoride mouthrinsing solution was estimated for its biocompatability with fibroblasts by the tissue culture technique. The results of this study were as follows : 1. It was observed that at 0.05%, 0.2% NaF mouthrinsing solution the cytoplasmic processes became globular. When 0.1% $SnF_2$ mouthrinsing solution was applied, the cytoplasmic process and cell morphology were disappeared. 2. DNA synthetic activity was reduced regardless of the concentration of the fluoride mouthrinsing solution. However, the result is statistically insignificant except 0.1% $SnF_2$ mouthrinsing solution(p<0.05). 3. Our results indicate that 0.02%, 0.05% concentrations of NaF mouthrinsing solution caused minimal cytotoxicity. But 0.2% NaF and 0.1% $SnF_2$ concentration were a significant difference between the cell activity in the experimental group and control group (p<0.05). 4. After appling 0.05% & 0.02% NaF fluoride mouthrinsing solution, cell activity was restored to the control groups level according to incubating time. The results suggest that direct exposure to fluoride solution inhibits gingival fibroblast activity. Therefore, for the most effective use of fluoride use, lowering the concentration of fluoride mouthrinsing is advisable because it maintains biocompatability and free ion in the oral fluid.

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A Parallelization Technique with Integrated Multi-Threading for Video Decoding on Multi-core Systems

  • Hong, Jung-Hyun;Kim, Won-Jin;Chung, Ki-Seok
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.7 no.10
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    • pp.2479-2496
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    • 2013
  • Increasing demand for Full High-Definition (FHD) video and Ultra High-Definition (UHD) video services has led to active research on high speed video processing. Widespread deployment of multi-core systems has accelerated studies on high resolution video processing based on parallelization of multimedia software. Even if parallelization of a specific decoding step may improve decoding performance partially, such partial parallelization may not result in sufficient performance improvement. Particularly, entropy decoding has often been considered separately from other decoding steps since the entropy decoding step could not be parallelized easily. In this paper, we propose a parallelization technique called Integrated Multi-Threaded Parallelization (IMTP) which takes parallelization of the entropy decoding step, with other decoding steps, into consideration in an integrated fashion. We used the Simultaneous Multi-Threading (SMT) technique with appropriate thread scheduling techniques to achieve the best performance for the entire decoding step. The speedup of the proposed IMTP method is up to 3.35 times faster with respect to the entire decoding time over a conventional decoding technique for H.264/AVC videos.

The Selection of Roof Waterproofing Methods using the Analytic Hierarchy Process (AHP) Technique (AHP 기법을 활용한 지붕방수공법 선정에 관한 연구)

  • Choi, Oh-Young;Cho, Hong-Gyu;Kim, Gwang-Hee
    • Journal of the Korea Institute of Building Construction
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    • v.10 no.4
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    • pp.95-103
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    • 2010
  • The purpose of this study is to propose a decision-making technique for selecting waterproofing methods using the Analytic Hierarchy Process (AHP) technique. In this study, a questionnaire survey was given to a group of specialists, which included design specialists, construction specialists, and maintenance specialists, regarding their experience with roof waterproofing methods. The 1st level hierarchy of the questionnaire survey addressed the function, economics, and maintenance of each of the roof waterproofing methods. The rank of 13 items of questionnaire, which is the 2nd level hierarchy of the questionnaire survey, is calculated using Expert Choice Solution. The analysis of questionnaire survey shows that each specialist selects different roof waterproofing methods, and all specialists make much of waterproof performance.

Node Activation Technique for Finite Element Model : Ⅰ. Theory (유한요소 모델의 절점 활성화 기법 : Ⅰ. 이론)

  • Jo, Jin Yeon;Kim, Do Nyeon;Kim, Seung Jo
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.31 no.4
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    • pp.26-34
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    • 2003
  • In this paper, a novel technique is proposed to arbitrarily activate the nodal points in finite element model through the meshless approximation methods such as MLS(moving least squares method), and theoretical investigations are carried out including the consistency and boundeness of numerical solution to prove the validity of the proposed method. By using the proposed node activation technique, one can activate and handle only the concerned nodes as unknown variables among the large number of nodal points in the finite element model. Therefore, the proposed technique has a great potential in design and reanalysis procedure.

Korean Word Learning System Using Automatic Question Generation Technique (자동 문제 생성 기술을 이용한 한국어 어휘학습시스템)

  • Choe, Su-Il;Im, Ji-Hui;Choe, Ho-Seop;Ock, Cheol-Young
    • Korean Journal of Cognitive Science
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    • v.17 no.4
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    • pp.271-286
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    • 2006
  • In this paper, we introduce automatic question generation technique using the language resources like User-Word Intelligent Network(U-WIN) and Korean dictionary including quite a for of information. And we present Korean word learning system with this technique. The item pool method which almost learning-system are using makes some problems. As a solution of the problems, we classified into 8 question type and implemented the Korean word learning system which is making the Korean question automatically by using the morphological and semantic information according to the automatic question generation pattern of each type.

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Ram Accelerator Optimization Using the Response Surface Method (반응면 기법을 이용한 램 가속기 최적설계에 관한 연구)

  • Jeon Yong-Hee;Jeon Kwon-Su;Lee Jae-Woo;Byun Yung-Hwan
    • 한국전산유체공학회:학술대회논문집
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    • 2000.05a
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    • pp.159-165
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    • 2000
  • In this paper, numerical study has been done for the improvement of the superdetonative ram accelerator performance and for the design optimization of the system. The objective function to optimize the premixture composition is the ram tube length required to accelerate projectile from initial velocity $V_o$ to target velocity $V_e$. The premixture is composed of $H_2,\;O_2,\;N_2$ and the mole numbers of these species are selected at design variables. RSM(Response Surface Methodology) which is widely used for the complex optimization problems is selected as the optimization technique. In particular, to improve the non-linearity of the response and to consider the accuracy and efficiency of the solution, design space stretching technique has been applied. Separate sub-optimization routine is introduced to determine the stretching position and clustering parameters which construct the optimum regression model. Two step optimization technique has been applied to obtain the optimal system. With the application of stretching technique, we can perform system optimization with a small number of experimental points, and construct precise regression model for highly non-linear domain. The error to compared with analysis result is only $0.01\%$ and it is demonstrated that present method can be applied more practical design optimization problems with many design variables.

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A Four Leg Shunt Active Power Filter Predictive Fuzzy Logic Controller for Low-Voltage Unbalanced-Load Distribution Networks

  • Fahmy, A.M.;Abdelslam, Ahmed K.;Lotfy, Ahmed A.;Hamad, Mostafa;Kotb, Abdelsamee
    • Journal of Power Electronics
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    • v.18 no.2
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    • pp.573-587
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    • 2018
  • Recently evolved power electronics' based domestic/residential appliances have begun to behave as single phase non-linear loads. Performing as voltage/current harmonic sources, those loads when connected to a three phase distribution network contaminate the line current with harmonics in addition to creating a neutral wire current increase. In this paper, an enhanced performance three phase four leg shunt active power filter (SAPF) controller is presented as a solution for this problem. The presented control strategy incorporates a hybrid predictive fuzzy-logic based technique. The predictive part is responsible for the SAPF compensating current generation while the DC-link voltage control is performed by a fuzzy logic technique. Simulations at various loading conditions are carried out to validate the effectiveness of the proposed technique. In addition, an experimental test rig is implemented for practical validation of the of the enhanced performance of the proposed technique.

Predicting BVI Loadings and Wake Structure of the HARTII Rotor Using Adaptive Unstructured Meshes

  • Yu, Dong-Ok;Jung, Mun-Seung;Kwon, Oh-Joon;Yu, Yung-H.
    • International Journal of Aeronautical and Space Sciences
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    • v.10 no.2
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    • pp.95-105
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    • 2009
  • The flow fields around the HARTII rotor were numerically investigated using a viscous flow solver on adaptive unstructured meshes. An overset mesh and a deforming mesh technique were used to handle the blade motion including blade deflection, which was obtain from the HARTII experimental data. A solution-adaptive mesh refinement technique was also used to capture the rotor wake effectively. Comparison of the sectional normal force and pitching moment at 87% radial station between the two cases, with and without the blade deflection, showed that the blade loading is significantly affected by blade torsion. It was found that as the mesh was refined, the strength of tip vortex is better preserved, and the magnitude of high frequency blade loading, caused by blade-vortex interaction (BVI), is further magnified. It was also found that a proper time step size, which corresponds to the cell size, should be used to predict unsteady solutions accurately. In general, the numerical results in terms of the unsteady blade loading and the rotor wake show good agreement with the experimental data.

A Fault Diagnosis Using System Matrix In Expert System (System matrix를 사용한 고장진단 전문가 시스템)

  • Sim, K.J.;Kim, K.J.;Ha, W.K.;Chu, J.B.;Oh, S.H.
    • Proceedings of the KIEE Conference
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    • 1989.07a
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    • pp.233-236
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    • 1989
  • This paper deals with the expert system using network configuration and input information composed of protective relays and tripped circuit breakers. This system has knowlegebase independent on network dimension because network representation consists of the type of the matrix. Therefore, the knowlege of network representation is simplified, the space of knowlege is reduced, the addition of facts to the knowlege is easy and the expansion of facts is possible. In this paper, the network representation is defined to system matrix. This expert system based on the system matrix diagnoses normal, abnormal operations of protective devices as well as possible fault sections. The brach and bound search technique is used: breadth first technique mixed with depth first technique of primitive PROLOG search technique. This system will be used for real time operations. This expert system obtaines the solution using the pattern matching in working memory without no listing approach for rule control. This paper is written in PROLOG, the A.I. language.

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Ram Accelerator Optimization Using the Response Surface Method (반응면 기법을 이용한 램 가속기 최적설계에 관한 연구)

  • Jeon Kwon-Su;Jeon Yong-Hee;Lee Jae-Woo;Byun Yung-Hwan
    • Journal of computational fluids engineering
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    • v.5 no.2
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    • pp.55-63
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    • 2000
  • In this paper, the numerical study has been done for the improvement of the superdetonative ram accelerator performance and for the design optimization of the system. The objective function to optimize the premixture composition is the ram tube length, required to accelerate projectile from initial velocity V/sub 0/ to target velocity V/sub e/. The premixture is composed of H₂, O₂, N₂ and the mole numbers of these species are selected as design variables. RSM(Response Surface Methodology) which is widely used for the complex optimization problems is selected as the optimization technique. In particular, to improve the non-linearity of the response and to consider the accuracy and the efficiency of the solution, design space stretching technique has been applied. Separate sub-optimization routine is introduced to determine the stretching position and clustering parameters which construct the optimum regression model. Two step optimization technique has been applied to obtain the optimal system. With the application of stretching technique, we can perform system optimization with a small number of experimental points, and construct precise regression model for highly non-linear domain. The error compared with analysis result is only 0.01% and it is demonstrated that present method can be applied to more practical design optimization problems with many design variables.

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