• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.21 no.1
• /
• pp.165-172
• /
• 2017

Recently, many supports about the education linked with industrial field have been provided in technical specialized high schools. In order to keep pace with the global trend to emphasize software education and to move away from traditional grammar-based programming learning, various physical computing tools have been used in the education fields. For this study, we conducted a programming class using Raspberry Pi for technical high school students. In the class, students were instructed to produce actual results based on the knowledge they had learned. Project-based learning was used to help students create products and thus they performed tasks while discussing and collaborating on a team-by-team basis. In particular, self-regulation learning strategies were considered to provide effective project-based instruction. After the class, we interviewed the students' satisfaction with it. The results showed that the students' satisfaction was high, and the fellow teachers also had a lot of possibilities and expectations about the programming instruction and project-based learning using Raspberry Pi.

• The Research Journal of the Costume Culture
• /
• v.23 no.6
• /
• pp.1004-1020
• /
• 2015

The purpose of this study is to assess whether the emotional leadership of the CEO of a fashion company has a significant influence on corporate performance. In this study, a survey was conducten on employees of fashion companies from August 1 to 30, 2015, and 350 copies of questionnaires were collected and used for analysis. Factor analysis, reliability analysis, and regression analysis were employed to analyze the data using SPSS software (ver. 21.0). According to the study results, if a fashion company CEO has higher emotional leadership, it leads to an increase in the job satisfaction and performance of the staff members, and an improvement in new product performance thanks to more investment and development and an expanded R&D staff. Additionally, the higher emotional leadership of the CEO contributes to an increase in operating profits, sales, and market share. Therefore, the importance of organizational culture was confirmed by its regulation effect on the emotional leadership and management performance of a fashion company. According to the results of this study, the emotional leadership of a CEO plays an important role in improving the performance of a fashion company, and future studies are needed to identify how to enhance the corporate performance of a fashion company from various perspectives.

• Journal of Digital Contents Society
• /
• v.6 no.1
• /
• pp.55-62
• /
• 2005

In this paper, we propose the new technique to compute the optimal route by considering the direction of distribution vehicles and the location for delivery, developing the algorithm of the shortest route to approach the location as applying the gemetic algorithm. This approach makes it possible for us to find the best route even under itineraries which include many destinations. Lively studies are currently in progress on the development of vehicle navigation software, combining PDA GPS, and electronic maps. Many web-sites are providing a varier of services which use electronic maps. Popular among these services is one that computes the optimal route between two positions that a user inputs. This service of computing the optimal route plays an important role in distribution industries such as home-delivery. For the distribution system. the construction of a vehicle regulation system enables us to calculate and manipulate the optimal route for distribution vehicles, to enhance the efficiency in making use of vehicles and labor, and to reduce costs.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2017.06a
• /
• pp.130-130
• /
• 2017

Sorghum bicolor is considered as copper-tolerant species. The present study was conducted to understand the copper tolerance mechanism in Sorghum seedling roots. Morphological and effects of Cu on other interacting ions were observed prominently in the roots when the plants were subjected to different concentrations (0, 50, and $100{\mu}M$) of $CuSO_4$. However, the morphological characteristics were reduced by Cu stress, and the most significant growth inhibition was observed in plants treated with the highest concentration of $Cu^{2+}$ ions ($100{\mu}M$). In the proteome analysis, high-throughput two-dimensional polyacrylamide gel electrophoresis coupled with MALDI-TOF-TOF mass spectrometry was performed to explore the molecular responses of Cu-induced sorghum seedling roots. In two-dimensional silver-stained gels, a total of 422 differentially expressed proteins (${\geq}1.5-fold$) were identified using Progenesis SameSpot software. A total of 21 protein spots (${\geq}1.5-fold$) from Cu-induced sorghum roots were analyzed by mass spectrometry. Of the 21 differentially expressed protein spots from Cu-induced sorghum roots, a total of 10 proteins were up-regulated, and 11 proteins were down-regulated. The abundance of the most identified protein species from the roots that function in stress response and metabolism was significantly enhanced, while protein species involved in transcription and regulation were severely reduced. The results obtained from the present study may provide insights into the tolerance mechanism of seedling roots in Sorghum.

• Asian-Australasian Journal of Animal Sciences
• /
• v.28 no.6
• /
• pp.876-887
• /
• 2015

Dicer, an ribonuclease type III type endonuclease, is the key enzyme involved in biogenesis of microRNAs (miRNAs) and small interfering RNAs (siRNAs), and thus plays a critical role in RNA interference through post transcriptional regulation of gene expression. This enzyme has not been well studied in the Indian water buffalo, an important species known for disease resistance and high milk production. In this study, the primary coding sequence (5,778 bp) of bubaline dicer (GenBank: AB969677.1) was determined and the bubaline Dicer1 biocomputationally characterized to determine the phylogenetic signature among higher eukaryotes. The evolutionary tree revealed that all the transcript variants of Dicer1 belonging to a specific species were within the same node and the sequences belonging to primates, rodents and lagomorphs, avians and reptiles formed independent clusters. The bubaline dicer1 is closely related to that of cattle and other ruminants and significantly divergent from dicer of lower species such as tapeworm, sea urchin and fruit fly. Evolutionary divergence analysis conducted using MEGA6 software indicated that dicer has undergone purifying selection over the time. Seventeen divergent sequences, representing each of the families/taxa were selected to study the specific regions of positive vis-$\grave{a}$-vis negative selection using different models like single likelihood ancestor counting, fixed effects likelihood, and random effects likelihood of Datamonkey server. Comparative analysis of the domain structure revealed that Dicer1 is conserved across mammalian species while variation both in terms of length of Dicer enzyme and presence or absence of domain is evident in the lower organisms.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.24
• /
• pp.10847-10853
• /
• 2015

Background: Lapatinib, a dual tyrosine kinase inhibitor that interrupts the epidermal growth factor receptor (EGFR) and HER2/neu pathways, has been indicated to have significant efficacy in treating HER2-positive breast cancer. However, acquired drug resistance has become a very serious clinical problem that hampers the use of this agent. In this study, we aimed to screen small molecule drugs that might reverse lapatinib-resistance of breast cancer by exploring differentially expressed genes (DEGs) via a bioinformatics method. Materials and Methods: We downloaded the gene expression profile of BT474-J4 (acquired lapatinib-resistant) and BT474 (lapatinib-sensitive) cell lines from the Gene Expression Omnibus (GEO) database and selected differentially expressed genes (DEGs) using dChip software. Then, gene ontology and pathway enrichment analyses were performed with the DAVID database. Finally, a connectivity map was utilized for predicting potential chemicals that reverse lapatinib-resistance. Results: A total of 1, 657 DEGs were obtained. These DEGs were enriched in 10 pathways, including cell cycling, regulation of actin cytoskeleton and focal adhesion associate examples. In addition, several small molecules were screened as the potential therapeutic agents capable of overcoming lapatinib-resistance. Conclusions: The results of our analysis provided a novel strategy for investigating the mechanism of lapatinib-resistance and identifying potential small molecule drugs for breast cancer treatment.

• Journal of Biosystems Engineering
• /
• v.28 no.4
• /
• pp.305-314
• /
• 2003

The ROPS of an agricultural tractor is designed to protect its driver when the tractor overturns. Although the current OECD tests to determine whether the ROPS meets the requirements of the OECD regulation are desirable, they need long time to test. We experimental time and effort by using CAE. We conducted a finite element analysis for the ROPS design of a Dae-Dong tractor cabin in an attempt to reduce the design and manufacturing time. This study shows the interpretative skill using MARC(v.2000) for designing ROPS and difference between the results of testing and FEA. Design process is generally divided into two phases: a concept and a detail design. The concept design uses simple analysis to predict structural behavior, whereas the detail design involves a finite element analysis performed by the results of the concept design. This study focused on the detail design and used Patran(v.2000r2) and MARC(v.2000) of the MSC software corporation. The model consisted of 4812 elements and 4582 nodes. Four tests. specified in the OECD standards, were performed: (1) longitudinal loading test (2) rear crushing test (3) side loading test (4), and front crushing test. Independent analyses were also performed for each test, along with a sequential analysis. When compared, the results of the independent and sequential analyses were found to be similar to the test results.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.21 no.1
• /
• pp.43-50
• /
• 2013

The stringent emission regulation and future shortage of fossil fuel motivate the research of alternative powertrain. In this study, a system of proton exchange membrane fuel cell has been modeled to analyze the performance of the fuel cell system for automotive application. The model is composed of the fuel cell stack, air compressor, humidifier, and intercooler, and hydrogen supply which are implemented by using the Matlab/Simulink(R). Fuel cell stack model is empirical model but the water transport model is included so that the system performance can be predicted over various humidity conditions. On the other hand, the model of air compressor is composed of motor, static air compressor, and some manifolds so that the motor dynamics and manifold dynamics can be investigated. Since the model is concentrated on the strategic operation of compressor to reduce the power consumption, other balance of components (BOP) are modeled to be static components. Since the air compressor model is empirical model which is based on curve fitting of experiments, the stack model is validated with the commercial software and the experiments. The dynamics of air compressor is investigated over unit change of system load. The results shows that the power consumption of air compressor is about 12% to 25% of stack gross power and dynamic response should be reduced to optimize the system operation.

• Development and Reproduction
• /
• v.16 no.1
• /
• pp.59-67
• /
• 2012

Previously, we found that $Zap70$ (Zeta-chain-associated protein kinase) expressed in the mouse oocytes and played significant role in completion of meiosis specifically at MI-MII (metaphase I-II) transition. Microinjection of $Zap70$ dsRNA into the cytoplasm of germinal vesicle oocyte resulted in MI arrest, and exhibited abnormalities in their spindles and chromosome configurations. The purpose of this study was to determine the mechanisms of action of $Zap70$ in oocyte maturation by evaluating downstream signal networking after $Zap70$ RNAi (RNA interference). The probe hybridization and data analysis were used by Affymetrix Gene Chip Mouse Genome 430 2.0 array and GenPlex 3.0 (ISTECH, Korea) software, respectively. Total 1,152 genes were up (n=366) and down (n=786) regulated after $Zap70$ RNAi. Among those genes changed, we confirmed the expressional changes of the genes involved in the regulation of actin cytoskeleton and MAPK (mitogen-activated protein kinase) signaling pathway, since the phenotypes of $Zap70$ RNAi in oocytes were found in the changes in the chromosome separation and spindle structures. We confirmed the changes in gene expression in the actin skeletal system as well as in the MAPK signaling pathway, and concluded that these changes are main cause of the aberrant chromosome arrangement and abnormal spindles after $Zap70$ RNAi.

• Proceedings of the SAREK Conference
• /
• 2008.11a
• /
• pp.469-474
• /
• 2008

The objective of this study is to propose basic design guidelines for more effective air ventilation system in apartments. It is well known that ventilation depends on whether the room doors are open or closed as well as people's living patterns. This study considers 84 ㎡-sized apartment which has extended living room without balcony. Ventilation of bathroom and kitchen is not considered. The height of the building, external air pressure and air infiltration through the windows are also neglected. The regulation on indoor air quality made it mandatory that the air change per hour be more than 0.7. Four models are suggested to study the effect of open and closed doors. Models 1 and 3 are open door types and models 2 and 4 are closed door types. The open types have 50 mm hole near the top of the door to substitute exhaust outlet. The ventilation effectiveness was evaluated by 3-dimensional numerical simulation using finite volume method by a commercial software. This work compares air flow, temperature of air, age of air and the efficiency of ventilation of apartments with wooden doors of bedroom 1 and 2, which are open or closed.