• Journal of Life Science
• /
• v.31 no.12
• /
• pp.1120-1127
• /
• 2021

Depression has a negative impact on social functioning due to its high prevalence and increased suicide rate, and is a disease with a high economic burden. Depression is related to diverse brain-related phenomena, such as neuroinflammation, synaptic dysfunction, and cognitive deficit. As antidepressant drugs used in clinical trials have shown poor therapeutic effects, antidepressant drugs that show rapid efficacy urgently need to be developed. Although studies on various genes, proteins, and signaling pathways related to depression have been conducted, the pathogenesis of depression has not been clearly elucidated. Sirtuin 1 is a nicotinamide-adenine dinucleotide- (NAD+-) dependent histone deacetylase and is involved in cell differentiation, apoptosis, autophagy, and cancer metabolism. Recent genetic studies found that sirtuin 1 is a potential target gene for depression. In addition, preclinical studies reported that sirtuin 1 signaling affects depression-like behavior. In this review, we attempt to present up-to-date knowledge of depression and sirtuin 1. We describe the various roles of sirtuin 1 in the regulation of glial activation, circadian rhythm, neurogenesis, and cognitive function and the effects of its expression on depression. Further, we discuss the effect of sirtuin 1 on the impairment of neural plasticity, one of the key mechanisms of depression, and the associated mechanisms of sirtuin 1.

• Therapeutic Science for Rehabilitation
• /
• v.11 no.3
• /
• pp.65-80
• /
• 2022

Objective : This study examined the psychometric properties of the 12-item Coping Orientation to Problems Experienced Scale (COPE) using Rasch analysis. COPE is one of the instruments used to measure stress-coping skills. Methods : The study participants were 480 community-dwelling older adults. We tested the instrument's unidimensionality assumption using principal component analysis (PCA). Item fit was examined using infit-and-outfit mean-square (MnSq) and standardized fit statistics (ZSTD). The precision and item difficulty hierarchies of the instrument were examined. The item-difficulty hierarchy was investigated to identify the easy and difficult items. We tested differential item functioning (DIF) for sex and age groups. Results : PCA revealed that the instrument met the unidimensionality assumption (eigenvalue = 1.78). Among the 12 items, item 2 was removed because of misfit (Infit MnSq = 1.33, Infit ZSTD = 5.05, Outfit MnSq = 1.56, Outfit ZSTD = 7.15). The remaining 11 items demonstrated a conceptual item-difficulty hierarchy. The person strata value was 3.10, which is equivalent to a reliability index value of 0.81. There was no DIF for the sex and age groups (DIF contrast <0.27). Conclusion : The findings indicated that the revised COPE-11 has adequate item-level psychometric properties and can accurately measure stress coping skills.

• International Journal of Computer Science & Network Security
• /
• v.22 no.11
• /
• pp.141-148
• /
• 2022

The development of the education system and the labor market today requires new conditions for unification and functioning, the introduction of an innovative culture in the field of Education. The construction of modern management of innovative development of a higher education institution requires consideration of the existing theoretical, methodological and practical planes on which its formation is based. The purpose of the article is to substantiate the modern paradigm of organizing the mechanism of managing the innovative development of higher education institutions. Innovation in education is represented not only by the final product of applying novelty in educational and managerial processes in order to qualitatively improve the subject and objects of management and obtain economic, social, scientific, technical, environmental and other effects, but also by the procedure for their constant updating. The classification of innovations in education is presented. Despite the positive developments in the development of Education, numerous problems remain in this area, which is discussed in the article. The concept of innovative development of higher education institutions is described, which defines the prerequisites, goals, principles, tasks and mechanisms of university development for a long-term period and should be based on the following principles: scientific, flexible, efficient and comprehensive. The role of the motivational component of the mechanism of innovative development of higher education institutions is clarified, which allows at the strategic level to create an innovative culture and motivation of innovative activity of each individual, to make a choice of rational directions for solving problems, at the tactical level - to form motives for innovative activity in the most effective directions, at the operational level - to monitor the formation of a system of motives and incentives, to adjust the directions of motivation. The necessity of the functional component of the mechanism, which consists in determining a set of steps and management decisions aimed at achieving certain goals of innovative development of higher education institutions, is proved. The monitoring component of the mechanism is aimed at developing a special system for collecting, processing, storing and distributing information about the stages of development of higher education institutions, prediction based on the objective data on the dynamics and main trends of its development, and elaboration of recommendations.

• 한국노년학
• /
• v.39 no.1
• /
• pp.37-60
• /
• 2019

This study was attempt to derive the aging trajectories of Korean elderly people and identify its characteristics. In particular, this study used the successful aging model of Rowe and Kahn as an analytical framework. Using the Korean Longitudinal Study of Ageing(KLoSA), this study applied group-based multi-trajectory analysis to identify multiple aging trajectories in sample of Korean elder aged 65~74(n=2,682). This study also used several demographic characteristics as baseline predictors to identify the characteristics of each aging trajectory. Five dimensions were analyzed in the multi-trajectory model: chronic disease, physical functional limitation, cognitive functioning, depressive symptom and social engagement. As a result of the analysis, five aging trajectories were identified: successful aging(17.8%), usual aging (33.9%), health declining aging(18.2%), pathological aging(7.9%), and aging with mild cognitive impairment(22.1%). In general, the odds of experiencing successful aging were high in men, low-aged, highly educated, high-income, and spousal elderly. On the other hand, for the elderly, who are under-educated, low-income, and high-aged, there was a high probability of experiencing a relatively difficult aging process. In particular, the odds of experiencing a mild cognitive impairment aging was high in older, lower-income women without a spouse.

• Korean Journal of Psychosomatic Medicine
• /
• v.31 no.2
• /
• pp.72-78
• /
• 2023

Objectives : This study aims to identify various psychiatric symptoms and psychosomatic symptoms caused by COVID-19 infection and investigate their long-term impact. Methods : A systematic literature review was conducted, selecting papers from domestic and international databases using keywords such as "COVID-19" and "psychosomatic." A total of 16 papers, including those using structured measurement tools for psychosomatic symptoms, were included in the final analysis. Results : Psychiatric symptoms such as anxiety, depression, and somatic symptoms have been reported in acute COVID-19 infection, while long-term post-COVID symptoms include chest pain and fatigue. The frequency of long-term psychosomatic symptoms has been estimated to be 10%-20%. Factors contributing to these symptoms include psychological and social stress related to infectious diseases, gender, elderly age, a history of psychiatric disorders, and comorbid mental illnesses. It is suggested that systemic inflammation, autoimmune responses, and dysregulation of the autonomic nervous system may be involved. Conclusions : Psychosomatic symptoms arising after COVID-19 infection have a negative impact on quality of life and psychosocial functioning. Understanding and addressing psychiatric aspects are crucial for symptom prevention and treatment.

• Journal of the Daesoon Academy of Sciences
• /
• v.49
• /
• pp.229-263
• /
• 2024

The purpose of this article is to elucidate the origins of the symbolic significance of traditional Korean talismanic ornaments such as dried pollack, bokjori (luck-bringing strainer), silk threads, and sokotture (a nose-block). Previous studies have primarily interpreted the magical meanings of these ornaments based on their shapes or functions, but such approaches are limited due to this likely being an ex-post-facto interpretation. This study argues that the symbolic meanings of these ornaments originated from the socio-economic characteristics of the time. These items were food resources or products closely related to the economic activities of the people of the time, and therefore, could be considered symbols of abundance and fortune. In particular, dried pollack served as an important food resource and commodity during the Late Joseon Dynasty, even functioning as a quasi-currency, and considering that fish are seen as symbols of abundance and fertility in various cultures around the world, its symbolic significance becomes clearer. Bokjori and sokotture acquired the meaning of abundance by being associated with major goods or properties of the time such as rice and cattle, and silk thread was linked to sericulture, a significant source of income for farmers of the time. These economic characteristics form the basis of the symbolism of these ornaments, and the function of these talismans can be seen as a secondary symbolism added in the process of social justification of these customs. This study reveals that economic motives underlie magical-religious customs and suggests that a broad consideration of the cultural and ecological environment of the time is necessary to understand the origins and transformations of cultural phenomena.

• Journal of Preventive Medicine and Public Health
• /
• v.31 no.3 s.62
• /
• pp.503-515
• /
• 1998

In order to investigate the factors influencing QOL and life satisfaction of the physically disabled, the author interviewed, by using structuralized questionnaire, 440 individuals among the physically disabled who were participated in Health Examination from April to July, 1997. The questionnaire consisted of the general characteristics(sex, age, marital status, family number, etc), the Reintegration to Normal Living Index(RNLI) to assess QOL, and the single item of five-likert scale to evaluate life satifaction. The means of RNLI were $16.2{\pm}4.8$ in total score, $12.2{\pm}3.4$ in daily functioning and $4.0{\pm}2.1$ in perception of self. The respondents were less reintegrated toward social activities and relationships than impairments or disabilities. While the satisfied group was 47.3%, the dissatisfied group was 52.7%. As the results of multiple regression and logistic regression analysis, the significant predictors of QOL were age, education, job, grade of disability and subjective health status. The life satisfaction were related to economic status, job and subjective health status. To improve QOL and life satisfaction of the physically disabled, it is important that we improve their basic socioeconomic status by getting a job through rehabilitation education and induce them to have positive self-assessment by extending the opportunity of social participation.

• Journal of the Korean Society for Library and Information Science
• /
• v.10
• /
• pp.39-70
• /
• 1983

The concept of the public library defined by the Korean Library Association does not describe the current state of the Korean public library but describes the public libraries in the western society. Korean public library was formed after the western public library but it was modified and reconciled with the tradition of Korea. The difference between the concepts occured in the acculturation process of the Korean public library. According to the International Encyclopeadia of the Social Sciences, acculturation comprehends those phenomena which result when groups of individuals having different cultures come into continuous firsthand contact, with subsequent changes in the original cultural patterns of either of both groups. Korea opened its door to western world in 1876, and it began to contact with the western world. As the consequence, the concept of the public library of the West diffused to Lee Dynasty which were characterized by the confucianism and the extended family system. These two characteristics were against the public library concept and it could not function as it was and it had to be modified to fit to Korean society. The American public library was formed by the diffusion of English public library. The concept fitted in the colonial American society which was characterized by the Christianity and nuclear family system. Religion and family life were closely knitted together and they contributed much to the formation of the American public library. Also the society needed various information to form their new nation. The need of the public library grew and the public library repidly developed as the American society was urbanized and industrialized. The changes of Korean public library has passed the following process of acculturation. 1. The Korean culture contacted with Western world. 2. The public library concept diffused to Korea, but the people were illiterate and the need of the public library was for the preservation of the old books. The collection was not for people. 3. The function of the public library in Korea was altered slightly as several intellectuals who formed the first modern public library tried to literate Koreans as a means of liberation :from Japan through the library service. 4. The traditional libraries such as sodandg and hyangyo disorganized and finally disappeared as the traditional elements of the culture disappeared and the new cultural elements prevailed in Korea. 5. When the traditional elements of culture were disorganized, a reinterpretation of the diffused culture appeared. With the appearance of the vouth group which was not existed in the traditional society, cultural facilities for them were needed. They began to use public library as their reading rooms. This pattern has been institutionalized ever since in Korean public library. 6. When the new element of the culture spread, the traditional cultural elements react against this element. As the new public libraries sprung out, there were movements to restore the old Korean tradition of the family libraries and Hyangyo to counteract to the new libraries. This movements were not successful and they all disappeared as they could not keep up the rapid social change occurred in the Korean society. 7. In the process of the cultral change, cultural lag occurred between the public library and the users who could not adopt to the new library. This has been continued to the present time. 8. This diffused concept of the public library was modified and became native to Korean society. However, the acculturation of the public library concept has not changed the traditional ideas of Korean people and their behavior. The Korean society recently has been changing rapidly and the function of the Korean public library is improving accordingly; 1. The extended Korean family system is disorganizing. As the consequence, the public library could substitute the family system offering information and recreation service, etc. 2. The growth of educated population is requiring a variety of library materials. An individual library can not meet the needs of them and cooperative library service will be needed to share resources. The public library will become the center of the cooperative service. 3. The Koreans are watching TV more hours than they read printed materials. For them, the public library needs to collect audiovisual materials. Especially the teaching materials should be all audiovisualized for the effective teaching. 4. Technology is developing rapidly in Korea, especially computer technology is applied in many parts of the society. This will also influence library service. The public library will be developing as the centralized library computer system. When the Korean public library functions as the extended family system and the center of the cooperative library system, the Korean public library will be functioning as the public library defined by the Korean Library Association.

• Journal of Preventive Medicine and Public Health
• /
• v.30 no.3 s.58
• /
• pp.630-642
• /
• 1997

The purpose of this study was to examine the mortality risk associated with cognitive impairment among the rural elderly. The subjective of study was 558 of 'A Study on the Depression and Cognitive Impairment in the Rural Elderly' of Jung Ae Rhee and Hyang Gyun Jung's study(1993). Cognitive impairment and other social and health factors were assessed in 558 elderly rural community residents. For this study, a Korean version of the Mini-Mental State Examination(MMSEK) was used as a global indicator of cognitive functioning. And mortality risk factors for each cognitive impairment subgroup were identified by univariate and multivariate Cox regression analysis. At baseline 22.6% of the sample were mildly impaired and 14.2% were severely impaired. As the age increased, the cognitive function was more impaired. Sexual difference was existed in the cognitive function level. Also the variables such as smoking habits, physical disorders had the significant relationship with cognitive function impairment. Across a 3-year observation period the mortality rate was 8.5% for the cognitively unimpaired, 11.1% for the mildly impaired, and 16.5% for the severly impaired respendents. And the survival probability was .92 for the cognitively unimpaired, .90 for the mildly impaired, and .86 for the severly impaired respondents. Compared to survival curve for the cognitively unimpaired group, each survival curve for the mildly and the severely impaired group was not significantly different. When adjustments models were not made for the effects of other health and social covariates, each hazard ratio of death of mildly and severely impaired persons was not significantly different as compared with the cognitively unimpaired. But, as MMSEK score increased, significantly hazard ratio of death decreased. Employing Cox univariate proportional hazards model, statistically other significant variables were age, monthly income, smoking habits, physical disorders. Also when adjustments were made for the effects of other health and social covariates, there was no difference in hazard ratio of death between those with severe or mild impairment and unimpaired persons. And as MMSEK score increased, significantly hazard ratio of death did not decrease. Employing Cox multivariate proportional hazards model, statistically other significant variables were age, monthly income, physical disorders. Employing Cox multivariate proportional hazards model by sex, at men and women statistically significant variable was only age. For both men and women, also cognitive impairment was not a significant risk factor. Other investigators have found that cognitive impairment is a significant predictor of mortality. But we didn't find that it is a significant predictor of mortality. Even though the conclusions of our study were not related to cognitive impairment and mortality, early detection of impaired cognition and attention to associated health problems could improve the quality of life of these older adults and perhaps extend their survival.

• Clinical and Experimental Pediatrics
• /
• v.52 no.11
• /
• pp.1207-1215
• /
• 2009

Purpose:To review and determine the complications in 76 child abuse cases recorded by a multidisciplinary hospital-based child protection team between 1987 and 2007. Methods:We retrospectively reviewed the reports and medical records of child abuse cases maintained by a university hospital-based child protection team. We devised a questionnaire for standardized interviews with the victims' guardians to determine the current physical and mental status of the children; questionnaires were answered by social workers of the child protection team who interviewed the present fosterers of 24 (35.8%) children. Results:Of the 76 children, 6 were infants, 10 were 1-3 years old, were 3-10 years old, and 19 were over 10 years old. Seven children (9.2%) were neglected and 27 (35.5%) and 44 (57.9%) were sexually and physically abused, respectively. In more than half of the cases, the perpetrators were the father or mother of the children. Most children (41 cases, 53.9%) were abused at their homes. The mean follow-up duration from the time of abuse infliction was $54.3{\pm}49.2$ months, and the current mean age of the children was $8.3{\pm}6.4$ years. Moderate and severe developmental delay and physical disability were observed in 6 (25.0%) and 3 (12.5%) cases, respectively. In 13 children (54.2%), the Global Assessment of Functioning Scale (GAF) score was less than 60, which indicates mild mental disability. Conclusion:A hospital-based child protection team may witness the different proportion of abuse types and patterns by conducting a nation-wide survey of child abuse cases.