• Journal of Pharmaceutical Investigation
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• 제38권2호
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• pp.87-92
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• 2008

Wood vinegar is well known as a softening agent affecting on the stratum corneum that is easy to penetrate into the skin. In this study, we prepared mixed ursolic acid hydrogel with wood vinegar(1, 2, 5%) as a penetration enhancer. The accumulation of ursolic acid in the skin from hydrogels was evaluated in vitro hairless mouse skin and skin moisturizing effect of them was evaluated using the corneometer and the tewermeter. And the role of stratum corneum as a protective barrier was evaluated as well. The hydrogels were retained about 40% of water retention capacity 2hrs and had better effect on the stripped skin than full-thickness skin. The accumulation of ursolic acid through stripped skin from hydrogels with wood vinegar was not change compared to normal skin, which indicated the action site of wood vinegar and the accumulation site of ursolic acid would be stratum corneum. From these result, we could find wood vinegar seems to be a good enhancer for active materials with anti-wrinkle and anti aging effect such as ursolic acid, and can be a developed topical delivery system maintaining excellent water retention capacity.

• Nuclear Engineering and Technology
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• 제55권1호
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• pp.215-221
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• 2023

Proton treatment may deliver a larger dose to a patient's skin than traditional photon therapy, especially when a range shifter (RS) is inserted in the beam path. This study investigated the effects of an RS on skin dose while considering RS with different thicknesses, airgaps and materials. First, the physical model of the scanning nozzle with RS was established in the TOol for PArticle Simulation (TOPAS) code, and the effects of the RS on the skin dose were studied. Second, the variations in the skin dose and isocenter beam size were examined by reducing the air gap. Finally, the effects of different RS materials, such as polymethylmethacrylate (PMMA), Lexan, polyethylene and polystyrene, on the skin dose were analysed. The results demonstrated that the current RS design had a negligible effect on the skin dose, whereas the RS significantly impacted the isocenter beam size. The skin dose was increased considerably when the RS was placed close to the phantom. Moreover, the magnitude of the increase was related to the thickness of the inserted RS. Meanwhile, the results also revealed that the secondary proton primarily contributed to the increased skin dose.

• 한국의류학회지
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• 제32권10호
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• pp.1651-1658
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• 2008

This study was to decided the proper garment pressure level on the human body parts. Six volunteers (female: 30-40years) put on the same types of bands, a brief, and a non-woven gown. Garment pressure was measured in regular order with the elastic band on the human body parts such as the upper arm, the waist, the thigh, and the calf. At the same time, physiological responses such as the skin blood flow rate on 2 fingers, 7 different skin temperatures, rectal temperature, heat rates, and subjective responses about the pressure sensation, thermal sensation, and humidity sensation were measured and inquired. The results were as follows; 1. The thicker subcutaneous fat thickness, the higher the mean garment pressure on pressurizing the upper arm(p<.001). Also the thicker subcutaneous fat thickness. the thicker the upper arm circumference. 2. Heart rates increased pressured the upper arm and decreased pressured the waist, the thigh, and the calf. The higher the garment pressure, the higher heart rates on all body parts were pressured. Especially lean subjects showed higher physiological load than others. 3. On pressurizing the upper arm, heart rates, rectal temperature, and mean skin temperature were higher than without pressured state and pressured other body parts.4. The proper garment pressure levels were decided 30gf/$cm^2$ for fat people, 20gf/$cm^2$ for others on the upper arms and 24gf/$cm^2$ on the calf.

• Archives of Plastic Surgery
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• 제39권2호
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• pp.126-129
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• 2012

Background : Facial capillary malformations (CMs) rarely recede; they often become darker and raised in proportion to their growth. These malformations may hypertrophy in adulthood, resulting in increased disfigurement and dysfunction. Laser treatment is considered a first-line therapy for focal CMs, but thick wide lesions, which are accompanied by hypertrophy and have a well-circumscribed nodularity, may be treated with surgical excision and reconstruction. Methods : We retrospectively reviewed the records of 25 consecutive patients who had undergone complete or partial excisions of facial capillary malformations in our unit. After the excisions, the defects that encompassed their facial aesthetic units were subsequently covered by various methods, including primary closures, local flaps, expanded flaps, split-thickness skin grafts, and full thickness skin grafts. Results : The data demonstrated satisfactory results and reliability. Our patients were treated without significant complications, and all of the patients were moderately or fully satisfied with the outcome of their surgeries. Conclusions : Among the many reconstructive options for adult patients with facial capillary malformations, thick split-thickness skin grafts can be a good choice for the coverage of widely excised wounds.

• Archives of Plastic Surgery
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• 제35권5호
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• pp.615-618
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• 2008

Purpose: Pyoderma gangrenosum is a rare cutaneous ulcerative disease. First described in 1930, the condition is characterized by progressive ulceration with deeply undermined purple-red edge. The lower extremities are most commonly affected but other parts of the skin and mucous membranes may also be involved. Although medical treatments with topical wound therapy are commonly used, surgical intervention is still controversial. In this paper, we report an atypical case of pyoderma gangrenosum which was characterized by extensive soft tissue breakdown. Methods: A 27-year-old male patient was referred to our institution with a $7{\times}8cm$ sized deeply undermined ulceration with pus-like discharge and fever. Incision and drainage was performed at another clinic 3 days prior to admission to our institution. After a thorough physical examination and the MRI review, a diagnosis of necrotizing faciitis was made. Accordingly, fasciotomy and debridement was performed. However, the wound enlarged progressively and the patient remained highly febrile for 9 days after the treatment. Septic screening did not reveal any occult infection. After a secondary review of the case, the initial diagnosis of necrotizing fasciitis was rejected and changed to pyoderma gangrenosum. With the use of dexamethasone intravenously, the wound improved dramatically and the fever was eliminated. Steroid mediation was tapered with duration of 1 month. The wound was stabilized and subsequently covered with split-thickness skin graft. Results: Split-thickness skin grafting with 1 : 1.5 mesh was successfully taken. Conclusion: Initial clinical features of pyoderma gangrenosum are very similar to that of necrotizing fasciitis. High fever and progressive ulceration with severe pain could invite earlier surgical approach. The advancing wound margins (the well defined violaceous, undermined border and necrotic ulcer base) and lack of isolation of pathogenic organism was used to make the correct diagnosis of pyoderma gangrenosum. We achieved a good result with proper medication and split-thickness skin graft.

• Journal of Yeungnam Medical Science
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• 제5권2호
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• pp.25-30
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• 1988

조직확장술에 의해 확장된 토끼의 피부를 관찰하여, 확장의 정도에 따른 피부의 조직학적인 변화를 단계적으로 추적해 본 결과를 요약하면 다음과 같다. 1. 표피층의 전반적인 두께 변화는 미약하였으나, 확장초기에는 거의 변화가 없다가 과도한 확장시 얇아지는 경향을 보였다. 2. 진피층의 두께는 확장이 진행됨에 따라 점차 얇아졌으며, 진피층내의 교원섬유조직은 확장의 초기단계에서부터 현저히 증가되어 있었다. 3. 진치층내의 혈관의 분포정도는 확장이 진행됨에 따라 점차 증가하였다. 4. 피부부속기들은 6배정도의 과도한 확장상태에서도 광학현미경상 구조의 변화를 보이지 않았다. 5. 피부근층(panniculus carnosus)은 6배 정도의 과도한 확장상태에서도 구조적 변화나 두께의 변화를 보이지 않았다.

• 대한예방한의학회지
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• 제14권1호
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• pp.97-110
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• 2010

The wound healing process can be categorized as follows : inflammation, fibroplasia, neovascularization, collagen deposition, epithelialization, and wound contraction. During the healing process, various growth factors are secreted to accelerate wound healing. Previous studies have demonstrated that endogenous growth factors, such as vascular endothelial growth factor(VEGF) are the important regulatory polypeptides for coordinating the healing process. They are released from macrophages, fibroblasts, and keratinocytes at the site of injury and participate in the regulation of reepithelization, granulation tissue formation, collagen synthesis and neovascularization. Onchung-Um has been used clinically to treat various skin diseases. In addition, Onchung-Um has been also used for congestive inflammations. In the present study, we evaluated the effects of Onchung-Um on wound healing process and wound size reduction in rats. Full-thickness skin wounds ($15mm\;{\times}\;15mm$) were created on the back of rats. Rats were then divided into 2 groups : The Onchung-Um treated group that was orally administered with a dose of 193.9mg/100g of Onchung-Um extract per day for 15 days and Control group without Onchung-Um administration. Moreover, the histological changes and VEGF immunoexpressions of two groups were estimated. In results, wound closures were significantly accelerated by oral administration of Onchung-Um extract. Furthermore, in Onchung-Um treated group, there were significant increases in fibroblast migration, epithelialization compared with the Control group. VEGF expressions were also increased in Onchung-Um treated group. This study has therefore demonstrated the Onchung-Um can significantly improve the quality of wound healing and scar formation and the oral administration of Onchung-Um extract may increase early tissue angiogenesis in the incisional wound of an experimental animal model.

• 한국의류학회지
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• 제23권4호
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• pp.551-562
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• 1999

This study was intended to investigate the effect on the human body such as subcutaneous fat thickness the circumference of extremities etc. of the clothing training of putting on thin clothes periodically from the cold period. The subjects were divided into the clothing training group and the non-training group, The training group was asked to wear cool clothes in daily life and to wear the training clothes of T-shirts with half-length sleeves and pants and perform the clothing training for two hours daily three times a week in a cold environment over the period from November to February. The non-training group was asked to lead a life wearing comfortable clothes. Then a comparative experiment was conducted at 15$\pm$1$^{\circ}C$, 50$\pm$5% R, H and 0.25m/sec before and after the clothing training. After the clothing training regardless of gender subcutaneous fat thickness was more increased and total clothing weight per the surface area of the body was decreased in the training group than the non-training group. The training group showed lower skin temperature in the limbs and lower average skin temperature than the non-training group irrespective of gender which proved the effect of the clothing training. The training group was shown to have attendancy toward a greater sense of warmth and a less sense of discomfort which proved the effect of the clothing training.

• Journal of Korean Biological Nursing Science
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• 제22권1호
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• pp.36-44
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• 2020

Purpose: The purpose of this study was to predict measuring site suited for abdominal skin fold thickness (ASFT) by measuring the distribution of abdominal subcutaneous fat thickness (AScFT) and ascertain the correlations among obesity indicators. Methods: The size of analysis materials was 124 secondary data measured by ultrasonic device, bioelectrical impedance analyzer and caliper. Data were analyzed using t-test, and Pearson's correlation. Results: The average of AScFT was 10.63± 6.79mm with its range 1.39-36.16 mm, and AScFT of female and of central parts were thicker than those of male and outer parts in the abdomen. The average of ASFT was 29.26±12.59 mm. Site 5 on Figure 1 was most similar to the average of AScFT in both sexes. Body mass index (BMI) and waist hip ratio (WHR) were 23.65±3.98 and 0.88±0.05 respectively. The body weight, BMI, WHR, visceral fat, ASFT vs AScFT revealed in significant correlation (r= .29, r= .55, r= .39, r= .33. r= .29). Conclusion: BMI and WHR seem more useful than other obesity indicators, when obesity control is necessary for Type 2 diabetes patients. Site 5 on Figure 1 is most suitable site to measure ASFT.

• 사상체질의학회지
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• 제27권2호
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• pp.240-253
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• 2015

Objectives The aim of this study was to investigate the effects of GalGunSeungGi-Tang (GST) on allergic contact dermatitis (ACD) induced by 2,4-dintrochlorobenzone (DNCB) Methods In this study, The changes of body weight, ear weight, ear thickness, spleen weight, dorsum skin thickness, symptom score by eyesight, histological finding, proliferation rates of splenocyte in vitro and in vivo are investigated to check effects of GST. The mice are divided into four group; Normal (naive mice), Control (DW administered), GST-L (GST 500mg/Kg/day administered), GST-H (GST 1,000mg/Kg/day administered). Results GST inhibited weight of ear significantly (P < 0.05) and also thickness (P < 0.01). In addition, There are significant decrease in thickness of dorsum skin and proliferation rates of splenocyte in vivo in GST administered group. Finally, GST reduced symptom score and hyperkeratosis, hyperpigmentation, increase of granulocyte and parakeratosis in histological finding. Conclusions These results suggest that GST can decrease symptoms of ACD.