Journal of Pharmaceutical Investigation

  • 제38권2호
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  • Pages.87-92
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  • 2008
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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목초액을 첨가한 하이드로 겔 제제로부터 우르솔릭산의 피부 침적 및 보습에 미치는 영향

The effect on skin deposition and moisturizing of ursolic acid in hydrogel system containing wood vinegar

  • 이계원 (건양대학교 제약공학과 제제 개발실) ;
  • 이주연 (건양대학교 의료 뷰티학과)
  • Lee, Gye-Won (Laboratory of Galenic Technology, Department of Pharmaceutical Engineering, Konyang University) ;
  • Lee, Ju-Yeon (Department of Medicinal Beauty, Konyang University)
  • 발행 : 2008.04.21
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초록

Wood vinegar is well known as a softening agent affecting on the stratum corneum that is easy to penetrate into the skin. In this study, we prepared mixed ursolic acid hydrogel with wood vinegar(1, 2, 5%) as a penetration enhancer. The accumulation of ursolic acid in the skin from hydrogels was evaluated in vitro hairless mouse skin and skin moisturizing effect of them was evaluated using the corneometer and the tewermeter. And the role of stratum corneum as a protective barrier was evaluated as well. The hydrogels were retained about 40% of water retention capacity 2hrs and had better effect on the stripped skin than full-thickness skin. The accumulation of ursolic acid through stripped skin from hydrogels with wood vinegar was not change compared to normal skin, which indicated the action site of wood vinegar and the accumulation site of ursolic acid would be stratum corneum. From these result, we could find wood vinegar seems to be a good enhancer for active materials with anti-wrinkle and anti aging effect such as ursolic acid, and can be a developed topical delivery system maintaining excellent water retention capacity.

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