• 한국의류산업학회지
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• 제25권2호
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• pp.248-254
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• 2023

This study aims to measure the skin rigidity of different facial areas among Koreans and propose guidelines for each area's skin rigidity that can be applied with a facial robot for testing respiratory protective devices. The facial skin rigidity of 40 participants, which included 20 men and 20 women, aged 20 to 50, was analyzed. The rigidity measurement was conducted in 13 facial areas, including six areas in contact with the mask and seven non-contact areas, by referring to the facial measurement guidelines of Size Korea. The facial rigidity was measured using the Durometer RX-1600-OO while in a supine position. The measurement procedure involved contacting the durometer vertically with the reference point, repeating the measurement of the same area five times, and using the average of three values whose variability was between 0.4 and 4.2 Shore OO. The rigidity data analysis used precision analysis, descriptive statistics analysis, and mixed-effect ANOVA. The analysis confirmed the rigidity of the 13 measurement areas, with the highest rigidity of the face being at the nose and forehead points, with values of 51.2 and 50.8, respectively, and the lowest rigidity being at the chin and center of the cheek points, with values of 19.2 and 20.7, respectively. Significant differences between gender groups were observed in four areas: the tip of the nose, the point below the chin, the area below the lower jaw, and the inner concha.

• 한국농촌생활과학회지
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• 제6권1호
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• pp.25-30
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• 1995

This study was designed to obtain the basic data developing the UV ray protective garments for the plastichouse workers. Two subjects were volunteered for 1hr. wear test in plastic house, and the ensembles was composed of one of three kinds blouse (UV blocking blouse, polyester/cotton 47/53 blouse, and polyester blouse), shorts, sleeveless undershirts, pants and socks. The measurements were rectal temperature, skin temperature, microclimate inside clothing, subjective sensation, and the colour difference of UV sensor. The results were as follows: 1. Microclimate especially, temperature inside clothing of polyester blouse was the highest among the garments. And UV-proof polyester blouse showed the lower mean skin temperature and microclimate than others. Showing the highest sweat volume. 2. No significant difference on UV ray blocking function among 3 kinds of garment was shown. 3. We could conform that in spring for the plastic house wぉw s garment low thermal insulating value and wide covering area were more important factors than UV blocking function of fabric.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.13-34
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• 2003

Fructose-1, 6-diphosphate (FOP), a glycolytic metabolite is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FOP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart. In this study, we examined whether FDP has protective effects on UV-induced oxidative damage in skin cell culture system and human skin in vivo. FDP had a protective role in UVB-induced LDH release and ROS accumulation in HaCaT although it did not show direct radical scavenging effect in the experiment using 1, 1-diphenyl-2-picrylhydrazyl (DPPH). FDP also preserved cellular GSH content after UV irradiation in HaCaT and normal human fibroblast culture system. Cellular oxidative stress induces multiple downstream signaling pathways that regulate expression of multiple gene including MMP-1 and collagen, we examined the effects of FDP on UV-induced alteration of these protein expression in fibroblast culture and human skin in vivo. The increased MMP-1 expression in fibroblast and human skin by UV irradiation was significantly decreased by FDP. FDP also prevented the UV-induced decrease of collagen expression in fibroblast and human skin. Moreover, the decreasing the intracellular levels of reducing equivalents in human fibroblast by glutathione (GSH) depletion lowered the UVA dose threshold for reduction of procollagen expression, indicating that the differences of glutathione contents define the susceptibility of fibroblasts towards UV-induced reduction of procollagen expression. FDP also preserved cellular GSH content after UV irradiation, indicating that FDP has protective effects on UV-induced reduction of procollagen expression, which are possibly through maintaining intracellular reducing equivalent. Based on these premises, we examined the effect of daily use of a moisturizer containing FDP on facial wrinkle in comparison with vehicle moisturizer lacking FDP. In the clinical study, FDP significantly decreased facial wrinkle compared with vehicle alone after 6 months of use. Our results suggest that FDP has anti-aging effects in skin by increasing cellular antioxidant system and preventing oxidative signal and inflammatory reaction. Therefore FDP may be useful anti-aging agent for cosmetic purpose.

• The International Journal of Costume Culture
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• 제3권1호
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• pp.30-40
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• 2000

The purpose of this research was to device thermal comfort model for radiation power plant workers in protective clothing. Three fabrics commonly used in protective workwear were made into coveralls of identical design and were evaluated by adult healthy males in four simulated work environment. It was investigated between the physiological response and subjects comfort according to environmental variance and clothing types. The of simulated work enviro mensent was controlled under four different humidity and temperature of each type. (Temperature 20±1℃, RH 40∼70%±5%, Temperature 30±1℃, RH 40∼70%±5%) An index of physiological response was connected with the thermal comfort designed. Mean skin temperature, skim temperature, Axillasy temperature ear canal temperature, clothing climate, total sweat, blood pressure, and R-R interval were be evaluated. Skin temperature difference ocurring during exercise and rest were significant only with respect to time and regions of the body, This despite physical differences in the three coveralls, particulary mass statistically experiment. Also, an index of subject wearing sensation was designed for thermal comfort after investigation determined the kind of clothes and the type of environment. As a result of this research, two types of multiple regressions was deviced to estimate thermal comfort of the protective clothing.

• 한국의류산업학회지
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• 제10권5호
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• pp.683-689
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• 2008

The purpose of this study was to investigate physiological responses such as rectal temperature, skin temperature, micro climate, sweat rate and subjective sensations using cold protective clothing with five different clo value. The clo value was measured by thermal manikin in windless condition. Healthy five 20's males volunteered as subjects for wearing trial experiment. The climate chamber was controlled at $50^{\circ}C$, 65% RH. The experiment consisted of repeated exercise and recovery periods. We found that the higher clo value has, the higher mean skin temperature, micro climate and sweat rate show. They felt warm and wet with higher insulation clothing. Thermal comfort increased in the last recovery period after exercise. There was significant difference between five cold protective clothing. In correlation analysis of clo value, it showed that correlation coefficient(r) values were more than 0.8. Therefore, in terms of clothing insulation, we found that correlation between thermal manikin experiment and wearing trial experiment was high. Clothing insulation could be variable according to many factors such as body movement, covering area, clothing gap, layering and design. Considering the body movement, we thought that insulation measurement need to carry out both thermal manikin experiment and wearing trial experiment.

• 한국의류산업학회지
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• 제12권3호
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• pp.372-380
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• 2010

The purpose of this study were to investigate a preference and demand performance of UV protective hat for outdoor sports activities. Data collected from 259 adults from survey were analyzed by frequence analysis, crosstabs, t-test, and ANOVA using SPSS 17.0. The results are as follows. A demand performanc of UV protective hats were a demand performance for designs, colors, fabrics, lightness, UV protection, and easy care. It showed that the respondents worn the hats for skin health and didn't wear for sun block. The demand performance of UV protective hat showed difference according to gender and age. The favorite type of UV protective hat was cap, and there was no difference between young and old age. Male preferred the cap styles, while female preferred the wide brim styles for UV protection. The preferred fiber contents of the respondents were cotton and functional fiber.

• Nutrition Research and Practice
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• 제12권1호
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• pp.29-40
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• 2018

BACKGROUND/OBJECTIVES: Ultraviolet radiation (UV) is a major cause of skin photoaging. Previous studies reported that ethanol extract (PET) of Prunus persica (L.) Batsch flowers (PPF, peach flowers) and its subfractions, particularly the ethylacetate (PEA) and n-butanol extracts (PBT), have potent antioxidant activity and attenuate the UV-induced matrix metalloproteinase (MMP) expression in human skin cells. In this study, we investigated the protective activity of PPF extract against UV-induced photoaging in a mouse model. MATERIALS/METHODS: Hairless mice were treated with PET or a mixture of PEA and PBT either topically or orally along with UV irradiation. Histological changes and biochemical alterations of mouse skin were examined. Major phenolic compounds in PPF extract were analyzed using an ACQUITY UPLC system. RESULTS: The overall effects of topical and oral treatments with PPF extract on the UV-induced skin responses exhibited similar patterns. In both experiments, the mixture of PEA and PBT significantly inhibited the UV-induced skin and epidermal thickening, while PET inhibited only the UV-induced epidermal thickening. Treatment of PET or the mixture of PEA and PBT significantly inhibited the UV-induced MMP-13 expression, but not type I collagen expression. Topical treatment of the mixture of PEA and PBT with UV irradiation significantly elevated catalase, superoxide dismutase (SOD) and glutathione-peroxidase (GPx) activities in the skin compared to those in the UV irradiated control group, while oral treatment of the mixture of PEA and PBT or PET elevated only catalase and SOD activities, but not GPx. Thirteen phytochemical compounds including 4-O-caffeoylquinic acid, cimicifugic acid E and B, quercetin-3-O-rhamnoside and kaempferol glycoside derivatives were identified in the PPF extract. CONCLUSIONS: These results demonstrate that treatment with PET or the mixture of PEA and PBT, both topically or orally, attenuates UV-induced photoaging via the cooperative interactions of phenolic components having anti-oxidative and collagen-protective activities.

• 동의생리병리학회지
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• 제24권6호
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• pp.950-955
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• 2010

In this study, we prepared CheonJeongKiBo-Dan(7 oriental medicinal plants, 7OMP: Astragalus Membranaceus root, Panax Ginseng root, Glycyrrhiza Glabra (licorice) root, Schizandra Chinensis fruit, Polygonatum Odoratum, Rehmannia Glutinosa root, Paeonia Albiflora root) by extracting them in one reactor and studied its efficacies on skin. UV irradiation has been suggested as a major cause of photoaging in skin. In order to investigate protective effects against UV-B induced cellular damage, 7OMP was extracted with 70% ethanol and dissolved in DMSO. The protective effect was detected by MTT assay, reactive oxygen species (ROS) generation, phosphorylation of ATR and p53 in human dermal fibroblast cell system after UV-B irradiation. 7OMP reduced UV-B-induced cellular damage in HDFs cells, and inhibited ROS generation. UV-B-induced toxicity accompanying ROS production and the resultant DNA damage are responsible for activation of ATR, p53 and Bad. In this study, 7OMP hampered phosphorylations of ATR and p53 in human dermal fibroblasts. Therefore, 7OMP may be protective against UV-induced skin photoaging.

• Biomolecules & Therapeutics
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• 제24권3호
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• pp.305-311
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• 2016

Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing effect of MVE in animal models. We found that MVE increased the proliferation and survival of fibroblasts at low concentration (i.e., nM ranges). In addition, MVE increased collagen production and downregulated matrix metalloproteinase1. MVE also increased the proliferation and survival of HaCaT cells. UVB increased reactive oxygen species (ROS) production in fibroblasts and HaCaT cells, while MVE decreased ROS production at low concentration. In an animal experiment, MVE accelerated wound healing from laser-induced skin damage. These results collectively suggest that low dose MVE protects skin from UVB irradiation. Therefore, MVE can be developed as a cosmetic raw material.

• BMB Reports
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• 제44권4호
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• pp.256-261
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• 2011

PEP-1 peptide has been used for transduction of native protein into mammalian cells. This work describes the findings that the fusion of PEP-1 to target proteins led to protein truncation likely in a non-protein-specific manner. Approximately 75% of PEP-1-MsrA fusion protein was truncated in the N-terminal region of MsrA between Lys-27 and Val-28 during expression in Escherichia coli and purification. This large protein truncation was also observed in another PEP-1 fused protein, PEP-1-MsrB2, in the N-terminal region of MsrB2. The full-length PEP-1-MsrA protein was rapidly transduced into keratinocyte cells within 15 min. The transduced PEP-1-MsrA was functionally active and could protect skin cells against oxidative stress- and ultraviolet radiation-induced cell death. Collectively, our data demonstrated the protective roles of MsrA in skin cells and, moreover, may raise a concern of protein truncation caused by fusion of PEP-1 about the general use of this peptide for protein transduction.