Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Mitochondria-Targeted Vitamin E Protects Skin from UVB-Irradiation

  • Kim, Won-Serk (Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Ikyon (College of Pharmacy, Yonsei University) ;
  • Kim, Wang-Kyun (College of Pharmacy, Yonsei University) ;
  • Choi, Ju-Yeon (Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Doo Yeong (College of Pharmacy, Yonsei University) ;
  • Moon, Sung-Guk (College of Pharmacy, Yonsei University) ;
  • Min, Hyung-Keun (Cleanup Dermatologic Clinic) ;
  • Song, Min-Kyu (Cleanup Dermatologic Clinic) ;
  • Sung, Jong-Hyuk (College of Pharmacy, Yonsei University)
  • Received : 2015.08.18
  • Accepted : 2015.10.13
  • Published : 2016.05.01
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Abstract

Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing effect of MVE in animal models. We found that MVE increased the proliferation and survival of fibroblasts at low concentration (i.e., nM ranges). In addition, MVE increased collagen production and downregulated matrix metalloproteinase1. MVE also increased the proliferation and survival of HaCaT cells. UVB increased reactive oxygen species (ROS) production in fibroblasts and HaCaT cells, while MVE decreased ROS production at low concentration. In an animal experiment, MVE accelerated wound healing from laser-induced skin damage. These results collectively suggest that low dose MVE protects skin from UVB irradiation. Therefore, MVE can be developed as a cosmetic raw material.

Keywords

References

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