• 대한한방부인과학회지
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• 제19권3호
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• pp.191-201
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• 2006

Purpose : Skin Resistance Variability(SRV) is a kind of biofunctional signal, and it can show the function of autonomic nervous system, especially in the sympathetic nerve. The objective of this study is to find out the differences of SRV of reproductive women with aging. Method : We measured SRV(by CP-6000A) of 151 women who visited Gynecologic Clinic. And the results were classified according to age, by five groups. After detection of SRV, we performed correlation analysis and ANOVA by SPSS 12.0. Results : 1. The SRV was measured twice. It resulted in seven areas. In 1, 2, 3 areas, the second results were higher than first results in every groups. In 4, 5, 6, 7 areas, the first results were higher than second results in every groups. 2. The SRV of lower part (4, 5, 6, 7 area) on the body was higher than that of higher part (1, 2, 3 area). 3. The SRV in the youngest group was higher than the oldest group in 1, 2, 3 area of second trial. Conclusion : With relations to the standardization and objectification of oriental medicine, we expect that these results contribute to gynecologic clinic in the department of diagnosis of functional abnormality of hypothalamus-hypophysis-ovarian axis (H-P-O axis).

• 대한한방부인과학회지
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• 제20권2호
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• pp.176-187
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• 2007

Purpose: Recent studies show that Skin Resistance Variability(SRV) could be related to the functions of Hypothalamus-Pituitary-Ovary(H-P-O) axis. 7-Zone-Diagnostic System is oriental medicine measuring system using SRV. To know the differences of SRV of normal and abnormal menstrual cycle groups, we research the SRV of the two groups. Methods: We measured SRV of two groups that were consist of 126 women who took CP-6000A test in Sangji Oriental Medical Hospital from Mar. 2004 to Feb. 2006. After detection of SRV, we performed correlation analysis by SPSS 12.0. Results: The SRV was measured twice in 7 areas. By the results of 1st trial on Factor AA of the SRV, the patient group's results were lower than normal group's results in all 7 areas. And there were remarkable differences in 1, 2, 3, 4, 5, 7 areas between two groups. By the results of 2nd trial on Factor AA of the SRV, the patient group's results were lower than normal group's results in all 7 areas similar to 1st trial results. And there were remarkable differences in 2, 3 areas between two groups. Conclusion: Comparing normal group with patient group, these results may reflect the relations of abnormal menstrual cycle and H-P-O axis functions. Because patient's results were lower than normal's in all 7 areas. And remarkable different results in 2, 3 areas were repeated by twice trial all. Further study will be needed.

• Korean Chemical Engineering Research
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• 제46권2호
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• pp.211-216
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• 2008

아토피의 치료를 위해 사용되는 부펙사막은 연고제 형태로 사용되는 약물이다. 부펙사막은 피부 장벽효과에 의해 실제 전달되는 양은 매우 적다. 이러한 문제를 갖는 부펙사막의 피부전달 효율을 증가시키기 위하여 마이크로니들을 이용해 피부처리를 실시하였다. 약물의 피부투과량과 피부에서 약물의 전달형태를 알아보기 위하여 부펙사막에 FITC를 결합시켰으며 이를 포함하는 하이드로겔을 제조하여 피부에 도포하였다. 약물의 피부투과량을 확인하기 위해서 형광분광계를 사용하여 분석하였으며 약물의 전달형태를 확인하기 위하여 형광필터가 장착된 마이크로현미경을 사용하였다. 실험결과 마이크로니들로 처리된 피부에서 부펙사막의 피부투과량이 대조군에 비해 5~20배 이상 증가되었으며 마이크로니들 처리횟수가 증가함에 따라서 더 크게 증가될 수 있음을 확인하였다.

• 방송공학회논문지
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• 제22권2호
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• pp.182-192
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• 2017

본 논문에서는 컬러와 운동 정보를 혼합한 손 추적 시스템을 제안하고자 한다. 손의 검출 및 추적은 많은 경우 피부색을 모델링하여 검출을 하는 방식을 사용한다. 하지만 이와 같은 방법으로는 빛이나 주변 사물에 의해 영향을 많이 받기 때문에 정확한 값을 일정하게 도출해 낼 수 없었다. 또한, 피부색에 의존하므로, 손뿐만 아니라 얼굴 및 비부 색과 비슷한 색을 갖는 배경 등에 의해 추적이 방해받을 수 있다. 이에 본 논문은 운동 히스토리 기법(MHI)을 이용하여 움직임을 파악한 후 이를 CamShift와 결합함으로서, 효과적으로 추적할 수 있도록 설계하였다. 제안된 시스템은 C/C++을 기반으로 구현하였으며, 실험에서 제안 방법이 안정적이고 우수한 성능을 보여줌을 증명하였다.

• 한국산학기술학회논문지
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• 제14권11호
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• pp.5834-5840
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• 2013

최근 들어, 초고속의 유무선 인터넷과 스마트 기기가 널리 보급됨에 따라 사진이나 동영상 형태의 유해 영상들이 급속히 보급되고 있다. 본 논문에서는 입력되는 영상에서 음란성을 대표하는 여성의 유두 영역을 자동으로 추출하여 유해 영상을 보다 효과적으로 탐지하는 새로운 방법을 제안한다. 제안된 알고리즘은 먼저 입력된 영상의 RGB 색상공간을 $YC_bC_r$ 공간으로 변환하여 사람의 피부색상 영역을 검출한다. 그리고 본 논문에서 새롭게 정의한 유두 맵을 적용하여 검출된 피부 영역으로부터 유두의 후보 영역들을 추출한다. 그런 다음, 기하학적인 특징을 사용하여 유두의 후보영역 중에서 실제 유두 영역만을 강건하게 필터링하고, 여성의 유두 영역을 포함하고 있는 영상을 유해한 영상이라고 판단한다. 성능을 비교 평가하는 실험결과에서는 제안된 색상과 기하학적인 특징 기반의 알고리즘이 유해 영상을 기존의 방법에 비해 보다 정확하게(4.1% 향상) 탐지한다는 것을 실험을 통해 보여준다.

• 대한의생명과학회지
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• 제9권2호
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• pp.75-84
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• 2003

To evaluate the influence of hepatic oxygen free radical systems on liver injury by topical p-phenylenediamine (PPD) application on rat skin, PPD (25 mg/16.5 $\textrm{cm}^2$) was topically applied to the abdominal region 5 times every other day and sacrificed. By PPD treatment, increasing rate of liver weight/body weight (%), serum activities of alanine aminotransferase and aspartate aminotransferase and decreasing rate of microsomal glucose-6-phosphatase activity were higher in the rats fed tungstate supplemented diet than those fed a standard diet. These findings indicate that group fed tungstate supplemented diet have more severe liver injury compared with group fed standard diet on topical PPD application. However, the activities of oxygen free radical generating enzymes such as xanthine oxidase (XO) and cytochrome P450 dependent aniline hydroxylase and those of oxygen free radical scavenging enzymes were not found to be different between these two animal groups. In the present study, a novel monitoring method to detect the generating of oxygen free radicals in liver extract was devised. Throughout this method, the oxidized PPD produced by oxygen free radicals was determined colorimetrically. The increasing rate of PPD oxidation by liver homogenate was higher in tungstate fed animals than in standard diet fed ones. Among the fractionations of liver extract, the mitochondrial and postmitochondrial fractions in the liver extract of tungstate fed animals led to a higher availability of PPD oxidation by PPD treatment compared with standard diet fed ones. In conclusion, these results suggest that an enhanced liver injury in tungstate fed animals treated with PPD may be due to oxygen free radicals produced in other systems except oxygen free radicals generating from cytosolic XO system. Especially, oxidative availability by PPD can be used for oxygen free radical detection in some tissue.

• 대한한방부인과학회지
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• 제25권1호
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• pp.79-92
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• 2012

Purpose: Obesity affects dysfunction of Hypothalamus-Pituitary-Ovary(H-P-O) axis. Dysfunction of H-P-O axis could be related to Skin Resistance Variability (SRV). This study investigated the impacts of obesity which related to female age on SRV. Methods: We randomly selected 400 women who had taken CP-6000A test and InBody test on the same day at Oriental Hospital of Sangji University from Jan. 2008 to Jun. 2011. In this study, the Body Mass Index(BMI) range of normal group is 18.5~24.9, obesity group is over 25, the age range of childbearing age group is 24~34 years, post-menopause group is 50~65 years. 139 women that met the criteria of this study were assorted by their BMI and age. After detection of SRV, SPSS 19.0 has conjugated for data analysis and the independent samples t-test and paired samples t-test were used to verify the results. Results: At 1st and 2nd trial, the height of 3 area of childbearing age obesity group was significantly higher than that of childbearing age normal group. At 1st and 2nd trial, the height of 1, 2 area of childbearing age obesity group was higher than that of childbearing age normal group, but there were no significant difference. At 1st and 2nd trial, the height of 1, 2, 3 area of post-menopause obesity group was mostly higher than that of post-menopause normal group, but there were no significant difference. Conclusions: This study showed the SRV of obesity group was higher than that of normal group in most of 1, 2, 3 area. Further study will be needed.

• 대한의용생체공학회:의공학회지
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• 제45권2호
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• pp.95-100
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• 2024

Vitiligo is a condition characterized by the destruction or dysfunction of melanin-producing cells in the skin, resulting in a loss of skin pigmentation. Facial vitiligo, specifically affecting the face, significantly impacts patients' appearance, thereby diminishing their quality of life. Evaluating the efficacy of facial vitiligo treatment typically relies on subjective assessments, such as the Facial Vitiligo Area Scoring Index (F-VASI), which can be time-consuming and subjective due to its reliance on clinical observations like lesion shape and distribution. Various machine learning and deep learning methods have been proposed for segmenting vitiligo areas in facial images, showing promising results. However, these methods often struggle to accurately segment vitiligo lesions irregularly distributed across the face. Therefore, our study introduces a framework aimed at improving the segmentation of vitiligo lesions on the face and providing an evaluation of vitiligo lesions. Our framework for facial vitiligo segmentation and lesion evaluation consists of three main steps. Firstly, we perform face detection to minimize background areas and identify the face area of interest using high-quality ultraviolet photographs. Secondly, we extract facial area masks and vitiligo lesion masks using a semantic segmentation network-based approach with the generated dataset. Thirdly, we automatically calculate the vitiligo area relative to the facial area. We evaluated the performance of facial and vitiligo lesion segmentation using an independent test dataset that was not included in the training and validation, showing excellent results. The framework proposed in this study can serve as a useful tool for evaluating the diagnosis and treatment efficacy of vitiligo.

• Biomolecules & Therapeutics
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• 제32권4호
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• pp.499-507
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• 2024

Specific sensitivity of the skin to ultraviolet B (UVB) rays is one of the mechanisms responsible for widespread skin damage. This study tested whether 1,3,5-trihydroxybenzene (THB), a compound abundant in marine products, might inhibit UVB radiationinduced NADPH oxidase 4 (NOX4) in both human HaCaT keratinocytes and mouse dorsal skin and explore its cytoprotective mechanism. The mechanism of action was determined using western blotting, immunocytochemistry, NADP⁺/NADPH assay, reactive oxygen species (ROS) detection, and cell viability assay. THB attenuated UVB-induced NOX4 expression both in vitro and in vivo, and suppressed UVB-induced ROS generation via NADP⁺ production, resulting in increased cell viability with decreased apoptosis. THB also reduced the expression of UVB-induced phosphorylated AMP-activated protein kinase (AMPK) and phosphorylated c-Jun N-terminal kinase (JNK). THB suppressed UVB-induced NOX4 expression and ROS generation by inhibiting AMPK and JNK signaling pathways, thereby inhibiting cellular damage. These results showed that THB could be developed as a UV protectant.

• 한국정보통신학회논문지
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• 제19권12호
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• pp.2785-2791
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• 2015

이 논문에서는 한방 치료에서 피부에 직침된 침의 제거를 위한 침 검출 방법을 제안한다. 명암도 영상에서 형태학적 열기 연산을 이용하여 침 후보 영역이 검출되고 크기 정보 등을 이용하여 거짓 침 후보 영역이 제거된다. 각 후보영역에서 canny 에지 검출기를 사용하여 에지 점들을 찾고 이들 점들을 선분으로 근사화한다. 선분들의 방향과 선분간의 거리를 기반으로 하는 형태학적 분석을 통해 두 개의 주요 선분을 찾고 침 머리 부분을 검출한다. 119개의 침이 직침된 16개의 영상에 대한 실험 결과 97.5 %의 검출율을 얻었다.