• 대한한의학원전학회지
• /
• 제19권4호
• /
• pp.219-225
• /
• 2006

The result is the followings after investigating composition, dosage and usage of Sagunjatang(四君子湯), Samultang(四物湯), Palmultang(八物湯), Sipjeondaebotang(十全大補湯) in literature by country and Era 1. Sagunjatang has become equal to Panax ginseng(人蔘), Atractylodes japonica(白朮), Poria cocos(복령) each for 2 Jeon(錢), Glycyrrhiza uralensis(甘草) 1 jeon since the Ming Dynasty in China and it is standardized by Panax ginseng, Atractylodes japonica, Poria cocos and Glycyrrhiza uralensis each for 1 Jeon 2 Pun(分) 5 Ri(里) since Dongeuibogam in Korea. 2. Samultang has become equal to Angelica gigas(當歸) and Rehmannia glutinosa(地黃) each three Jeon, Cnidium officinale(川芎) is 1 Jeon 2 Pun or 1 jeon and Paeonia lactiflora(芎藥) 2 Jeon since the Ming Dynasty in China and it is standardized by Angelica gigas, Cnidium officinale, Paeonia lactiflora and Rehmannia glutinosa each for 1 Jeon 2 Pun 5 Ri since Dongeuibogam in Korea. 3. In the case of Palmultang, compositional usage of medicine was different in the Ming Dynastry and the Ching(靑) Dynastry in China. Total dosage was increased and ratio of Angelica gigas and Rehmannia glutinosa was increased comparatively in the Ching Dynasty. All prescription of medicine was consisted of 1 Jeon 2 Pun and specific dosage was presented except Euirimchwalyo(醫林撮要) that dosage was not recorded in Korea. 4. Sipjeondaebotang tended to increase total dosage in the latter part in China. Dosage was mostly used 1 Jeon thus Dongeuibogam but Bangyakhap(方藥合編) used 1 Jeon 5 Pun differentially.

• 대한예방한의학회지
• /
• 제18권1호
• /
• pp.53-65
• /
• 2014

The concentration of 5 metals such as As, Cd, Co, Cr and Pb in 5 frequent using herbal medicinal prescriptions in Korea were analyzed according to the consuming area. The ready prepared 5 prescription samples were obtained from Korean regional hospitals nationwide. All the sample were well powdered and pre-treated to being a solution, and then analyzed by ICP/MS. As was detected the highest concentration of 0.55 mg/kg in Ojeoksan of Gyunggi-do, the lowest was 0.01 mg/kg of Sipjeondaebotang of Seoul C. The highest concentration of Co was found to be in Bojoongikgitang of Seoul B and the lowest was also detected in Bojoongikgitang of Seoul A. Cd concentration, Ojeoksan of Chungcheong-do, Bojoongikgitang of Seoul B and yookmijihwangtang of Chungcheong-do showed the low level of 0.1 mg/kg. In turn, the highest level of Cr was 5.59 mg/kg in Ojeoksan of Gyunggi-do B. The lowest concentration of Cr was 0.04 mg/kg in Sipjeondaebotang of Seoul C and the highest was 0.94 mg/kg in Samooltang of Gangwon-do. Finally, the lowest concentration of Pb was 0.00 mg/kg in Sipjeondaebotang of Chungcheong-do and the highest was 0.134 mg/kg in Ojeoksan of Jeju-do. As a result it seems that the same prescription can not guaranteed the safety from toxic metals since those metal concentrations are dramatically varied according to the area where the each prescribed medicine available.

• 대한한의학회지
• /
• 제29권1호
• /
• pp.156-166
• /
• 2008

Objective : Pamooltang (PM) and Sipjeondaebotang (SC) are used in Korea to treat many diseases such as sterility, menstrual disorder, and general prostration. We made a comparative study of PM and SC which are different in component ratio between Astragalus membranaceus BUNGE (AC) and Cinnamomum cassia PRESL. (CC). Methods : Anti-oxidation was studied by 1.1.-diphenyl-2-picrylhydrazyl (DPPH) assay and anti-inflammation was investigated by prostaglandin $E_2\;(PGE_2)$ and nitric oxide (NO) inhibition assay. For immune response activities, this study used NO synthesis on RAW 264.7 cells and splenocyte proliferation. Results : The results showed that PM and SC components had no significant effect of anti-oxidation or anti-inflammation. However, we observed their effects upon inducible NO synthesis in Raw 264.7 cells. The SC2 stimulated NO synthesis $11.42\pm1.36{\mu}M$ (control; $0.89\pm0.00{\mu}M$). PM and SC components had the effect of immune response which in a dose-dependent manner significantly induced the splenocyte proliferation. The splenocyte proliferation induced by SC2 was higher than others at the concentration of 1, 10, 100, 1000 and 2000 ${\mu}g/ml$. The SC8 was shown to up-regulate IgG, 100 ${\mu}g/ml$ 3.3 times, 1000 ${\mu}g/ml$ 2.6 times as a control. Conclusions : These results may have important implications for our understanding of the ratios of AC and CC in SC.

• 생약학회지
• /
• 제29권4호
• /
• pp.283-292
• /
• 1998

The hemopoietic effects of deer blood (whole blood, blood cell, plasma, respectively) were examined using in vivo rat model. Experimental animals (Sprague-Dawley rat, male, 200 g) were divided into negative control group (injection of saline), positive control group (injection of Sipjeondaebotang) experimental groups (injection of whole blood, blood cell, plasma) and healthy control group. Cyclophosphamide(150mg/kg) was injected into experimental groups, negative and positive control group to induce bone marrow supression. After 8 days, freez dried deer blood (whole blood, blood cell, plasma respectively) and Sipjeondaebotang of 200 mg/kg in dose was administered orally into experimental groups and positive control group, once a day for 3 days (A group) and once a day for 12 days (B group) respectively. And then body weight and organ weight, biochemical profile (ALB, GOT, GPT, PRO, CRE), hematological values (WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT) and CBC differentiation (Neutro, Lymph, Mono, Reticulo) were carried out. Finally, platelets were specially increased in the plasma treated A group and reticulocytes were specially increased in the plasma treated B group.

• 대한예방한의학회지
• /
• 제9권1호
• /
• pp.119-133
• /
• 2005

Traditional herbal medicine is widely used among the Korean people, and other eastern Asian countries employ similar therapies as well. In recent years, due to increasing interest in herbal medicines, many researches have been made on the toxicity and side effects of herbal medications. Through private and public media, there have been many opinions suggesting taking herbal medicines is very harmful, especially on the liver and kidney functions. This assertion has been mainly presented by the doctors that practice western medicine, But this assertion is never based on adequate knowledge of herbal medicine. This study aims to provide the evidences that taking herbal medicines is safe on the renal functions. Four frequently used herbal medications(Sipjeondaebotang, Bojungigitang, Ojeoksan, and Yukmijihwangtang) were used to test the toxicity of herbal medicine oh the lab animal model(SD-Rat). There is no significant difference in body weight and kidney weight after herbal medication for 1 month. In all experimental groups, no abnormal findings were observed in histological study, and lab renal function index(BUN, creatinine, uric acid). These results say that four herbal multi-used-medicines, when medicated, is safe from the renal toxicity in lab animal model.

• 대한예방한의학회지
• /
• 제19권3호
• /
• pp.103-113
• /
• 2015

Objective : Five most generally adopting basic oriental prescriptions (yookmijihwangtang, ojeoksan, sipjeondaebotang, samultang, bojoongikgitang) samples were collected from 10 oriental hospitals nationwide and the transferring ratio to aqueous phase (TRAP) were calculated. Method : The samples are grounded evenly and the decocted at $120^{\circ}C$ for 12 min on hot plate and then filtered. The concentrations of As, Cd, Co, Cr and Pb in before and after decoction were measure by ICP/MS and the TRAPs were calculated. Results : The concentrations of As, Cr and Pb in the ground samples before decoction were all below criteria level, and TRAP values were also very low (<10%). For Cd, although some ground samples before decoction showed relatively high concentration level compare to the criteria level, because of their low TRAP (~3%), the actual concentrations in the decoction were quite low compare the criteria level. The Co's concentrations in the ground samples before decoction were all relatively low level. However, the TRAP of Co was astonishingly high value of around 40% average. Conclusion : The toxic heavy metal concentrations in the decoction were very low compare to the criteria level. The TRAPs are less than <10% except Co. The toxic heavy metals in the prescriptions are mainly remained in the residue and the only very small fraction may transferred to the decoctions. Therefore the toxicity of the oriental herbal medicine about the toxic heavy metal may be overstressed. The Co's TRAP turned out to be quite high value (40% average). Since the criteria level wes not established yet, the safety of decoctions according to Co was not fully confirmed.

• 대한한의학방제학회지
• /
• 제13권1호
• /
• pp.161-178
• /
• 2005

This report describes 47 studies related to the use of Fructus Schisandra main blended prescriptions from Donguibogam. The following conclusions were reached through investigations on the prescriptions that use Fructus Schisandra as a key ingredient. 1.34% of a cough, 10.6% of a consumptive disease, recorded the largest number of clinical frequency of the prescriptions in therapeutic use when Fructus Schisandra was taken as a monarch drug in prescriptions 2. Prescriptions that utilize Fructus Schisandra as the main ingredient are used in the treatmeant of a cough, a consumptive disease, an exogenous febrile disease, a carbuncle, and cellulitis, and they are also used for treating 11 different types of diseases. 3. The prescriptions are compounded with Fructus Schisandra as a monarch drug can apply to a deficiency syndrome of the lung a deficiency syndrome of both the lung and the stomach, a deficiency syndrome both the spleen and the lung a deficiency syn-drome of the kidney, a hypofunction of the bladder with cold syndrome, a cold of insufficiency type, a deficiency syndrome of the heart, a heat syndrome of the stomach, an affective by cold, an invasion by wind, a consumptive disease. 4. The dosage of Fructus Schisandra is 5pun(about 1.88g) to 5jeon(about 18.75g), however 1jeon(about 3.75g) has been taken the most for clinical application. 5. When Fructus Schisandra is combined with base prescriptions such as Ijintang Chungliongsan, Saengmaksan, it applies symtoms of cough. In addition, when Fructus Schisandra is combined with base prescriptions such as Liukmizihwangtang, Ssangbohwan, Sipjeondaebotang, it utilizes a consumtive disease.

• 혜화의학회지
• /
• 제13권1호
• /
• pp.129-146
• /
• 2004

From the study of Prescription on mammary diseases, the following conclusions are obtained. 1. The Lurosan (漏蘆散), Jechetang (猪蹄湯), Tongyutang (湧泉散) are often used for galactostasis in Prescription. The classification of prescription by efficacy is Chungyelyak(淸熱解毒藥), Lisuyak (利尿通淋藥), Hwalyelyak(活血祛瘀藥), etc. and the frequency of used medicines is Luro(漏蘆),Tongcho(通草),Jejo(제조), Chensangab(穿山甲),etc.. 2. The Makyajeon(麥芽煎), Sipjeondaebotang(十全大補湯) are often used for galactorrhea in Prescription. The classification of prescription by efficacy is Bogiyak(補氣藥), Bohelyak(補血藥), Sosikyak (消食藥), etc., and the frequency of used medicines is Insam (人蔘), Dangggwi(當歸), Makya(麥芽),etc.. 3. The Jogaksan(조角散), Gwarusan(瓜蔞散) are often used for mammary abscess in Prescription. The classification of prescription by efficacy is Hwalyelyak(活血祛瘀藥), Chunghwaye1damyak(淸化熱痰藥), Ligiyak(理氣藥), etc., and the frequency of used medicines is Jogakja(조角刺), Sahyang(麝香), Chongpee(靑皮),etc.. 4. The Yengyotang(連翹湯), Makyatang(麥芽湯), Lyengpayujagenbang(令敗乳自退方)are often used for distending pain of the breast due to galactostasis in Prescription. The classification of prescription by efficacy is Chungyelhaedokyak(淸熱解毒藥), Chunghwayeldamyak(淸化熱痰藥)etc., and the frequency of used medicines is Yengyo(連翹), Gwaru (瓜樓),etc.. 5. The Gwarusan (瓜蔞散), Danchungpitang(單靑皮湯), Yengyotang(連翹湯), Gamisoyosan(加味逍 遙散)are often used for mammay abscess in Prescription. The classification of prescription by efficacy is Chunghwayeldamyak(淸化熱痰藥), Hwalyelgeoyak(活血祛瘀藥), Chungyelyak(淸熱解毒藥),etc., and the frequency of used medicines is Jogakja(조角刺), Yengyo(連翹), Chongpee(靑皮),etc.. 6. The Sipyukmi1yugium(十六味流氣飮), Chungpitang(靑皮湯)are often used for breast carcinoma in Prescription. The classification of prescription by efficacy is Hwalyelyak(活血祛瘀藥), Ligiyak(理氣藥)etc., and the frequency of used medicines is Doyin(桃仁), Jogakja, Chongpee(靑皮), Jagak(枳殼),etc.

• 대한한방내과학회지
• /
• 제19권1호
• /
• pp.491-504
• /
• 1998

Mainly side effects of antitumor chemotheraphy are fatigue, G-Ⅰ trouble(such as vomitting, nausea, diarrhea) and reduction of medullary function etc. Differentiated from syndromes in oriental medicine, above symptoms are recognized to 'Deficiency of both ki(vital energy) and blood'. And SDT(Sipjeondaebotang) has been widely used in 'Deficiency of both ki(vital energy) and blood'. Dr. Mun's SDTG(Sipjeondaebotanggamibang) consists of SDT plus several herb medicines-these have antitumor effect and reduce chemotherapheutic side effect. This experiment was undertaken to study the effects of SDTG on chemotherapheutic side effect and cytotoxicity. The results obtained in this study were as follows: Antitumor activities of the ethanol extract from SDTG(Sipjeondaebotanggamibang) and MMC(Mytomycin) on ascitis form of calcinoma in mice is a little improved. Especialy mean survival times of the group of SDTG(200mg/kg) and MMC(0.1mg/kg) is improved over 50%. When SDTG and MMC is administrated together, the weight of tumor is more decreased than MMC alone. The effect of the ethanol extract from SDTG and MMC on the lysosomal enzymes in Ehrich ascites carcinoma cell are more significantly improved than MMC alone. SDTG extract increases both NKcell conjugation and cyto-lysis against target cell. According to the above results it is recognized that SDTG increases the chemotherapheutic cytotoxicity of MMC and the activity of NKcell.

• 대한한의학방제학회지
• /
• 제24권3호
• /
• pp.131-152
• /
• 2016

Objectives ： This study was to evaluate Sibjeondaebo-tang’s(Shiquan dabutang) effect to rat hypothyroidism which induced by 6-n-propyl-2-thiouracil(PTU)Methods ： Aqueous extracts of Sibjeondaebo-tang(Shiquan dabutang)(21.29%) were administered by oral dose of 300 and 150 mg/kg(rat’s body weight) for 42 days from 2 weeks before start of PTU treatment. During this moment the body weight, thyroid gland weights, liver weight, serum thyroid hormone, lipid content and liver antioxidant defense system were measured with histopathological changes of thyroid glands, Liver and these result were compared with LevoT₄ 0.5mg/kg treated ratsResults ： As a result of PTU treatment, marked decreases of body weight, liver weight, serum thyroid hormone levels of T₃, T₄, triglyceride content and liver CAT activation were observed with marked increases of thyroid gland weight, thyroid gland hormone TSH, activate liver H₂O₂ and SOD, serum Total cholesterol, HDL and AST amount were admitted. In addition, marked hyperplasia of follicular cells with reduce of follicular colloid contents and sizes were showed at histopathological inspections. These PTU-induces histopathological changes related to hypothyroidism were significantly reduced by treatment of both different dosages of Sibjeondaebo-tang(Shiquan dabutang).Conclusions： This study suggest that Sibjeondaebo-tang(Shiquan dabutang) extracts have favorable effect on the thyroid hormone productions with beneficial effect on hypothyroidism medicated by modulatory effects on antioxidant defense system.