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Single Oral Dose Toxicity Test of Coix lacryma-jobi var. ma-yuen Stapf Sprout in Sprague-Dawley Rats (의이엽 (薏苡葉)의 Sprague-Dawley 랫드를 이용한 단회경구투여 독성시험)

  • Kim, Min Ju;Lee, Jeong Hoon;Shin, Mi-Rae;Roh, Seong-Soo
    • The Korea Journal of Herbology
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    • v.36 no.5
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    • pp.109-115
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    • 2021
  • Objectives : 'Johyun' yulmoo which is a new variety of Coix lacryma-jobi var. ma-yuen Stapf sprout was developed and registered by Rural development administration in 2004. This variety was derived from the cross between single cross of Suwon-6 and Okayama and UCN300-25 as F1. It is characterized by early maturity, short plant height, a strong resistance, and a superior yield and is suitable for the central and northern regions. Accordingly, we were performed and evaluated single oral dose toxicity test of 'Johyun' yulmoo sprout (JYS) in Sprague-Dawley (SD) rats. Methods : Single oral dose toxicity test was performed using with male and female rats. Rats were divided into two groups: Group 1, vehicle-treated rats (Control); Group 2, JYS 5000 mg/kg-treated rats. JYS was orally administered to male and female rats at dose levels of 5000 mg/kg. Animals were monitored on the mortality, clinical signs, body weight changes, and necropsy findings for 14 days. groups : Group 1, vehicle-treated rats (Control); Group 2, JYS 5000 mg/kg-treated rats. JYS was orally administered to male and female rats at dose levels of 5000 mg/kg. Animals were monitored on the mortality, clinical signs, body weight changes, and necropsy findings for 14 days. Results : After oral treatment of JYS, we could not find any mortality at 5000 mg/kg. Compared with the control group, there were also no significant differences in clinical sign, weight changes, weight gain, and gross abnormalities in JYS 5000 mg/kg-treated group. Conclusions : Taken together, these results suggest that approximate lethal dose of JYS was considered as over 5000 mg/kg. Results from this study provide scientific evidence for the safety of JYS. Moreover, this study could be used as a basis for dose-setting data of the repeated dose 13-week oral toxicity test of JYS.

Variance Component Quantitative Trait Locus Analysis for Body Weight Traits in Purebred Korean Native Chicken

  • Cahyadi, Muhammad;Park, Hee-Bok;Seo, Dong-Won;Jin, Shil;Choi, Nuri;Heo, Kang-Nyeong;Kang, Bo-Seok;Jo, Cheorun;Lee, Jun-Heon
    • Asian-Australasian Journal of Animal Sciences
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    • v.29 no.1
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    • pp.43-50
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    • 2016
  • Quantitative trait locus (QTL) is a particular region of the genome containing one or more genes associated with economically important quantitative traits. This study was conducted to identify QTL regions for body weight and growth traits in purebred Korean native chicken (KNC). F1 samples (n = 595) were genotyped using 127 microsatellite markers and 8 single nucleotide polymorphisms that covered 2,616.1 centi Morgan (cM) of map length for 26 autosomal linkage groups. Body weight traits were measured every 2 weeks from hatch to 20 weeks of age. Weight of half carcass was also collected together with growth rate. A multipoint variance component linkage approach was used to identify QTLs for the body weight traits. Two significant QTLs for growth were identified on chicken chromosome 3 (GGA3) for growth 16 to18 weeks (logarithm of the odds [LOD] = 3.24, Nominal p value = 0.0001) and GGA4 for growth 6 to 8 weeks (LOD = 2.88, Nominal p value = 0.0003). Additionally, one significant QTL and three suggestive QTLs were detected for body weight traits in KNC; significant QTL for body weight at 4 weeks (LOD = 2.52, nominal p value = 0.0007) and suggestive QTL for 8 weeks (LOD = 1.96, Nominal p value = 0.0027) were detected on GGA4; QTLs were also detected for two different body weight traits: body weight at 16 weeks on GGA3 and body weight at 18 weeks on GGA19. Additionally, two suggestive QTLs for carcass weight were detected at 0 and 70 cM on GGA19. In conclusion, the current study identified several significant and suggestive QTLs that affect growth related traits in a unique resource pedigree in purebred KNC. This information will contribute to improving the body weight traits in native chicken breeds, especially for the Asian native chicken breeds.

Effect of Bromobenzene Pretreatment on the Hepatic Glutathione Content and Glutathione S-transferase Activity in Bromobenzene Treated Rats (흰쥐에 있어서 Bromobenzene전처치가 간조직 중 Glutathione 및 Glutathione S-transferase활성에 미치는 영향)

  • 신중규
    • Journal of Environmental Health Sciences
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    • v.23 no.2
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    • pp.83-88
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    • 1997
  • To evaluate the effect of bromobenzene pretreatment on the bromobenzene metabolism, the animal group was induced the stage of slight liver damage with 7 times bromobenzene injection every two days (400 mg/kg body wt. i.p.). In the present experimental animal model, the single dose of bromobenzene(400 mg/kg body wt. i.p.) was injected to the bromobenzene-pretreated rats and the hepatic aniline hydroxylase(AH) activity, glutathione(GSH) content and glutathione S-transferase (GST) activity were determined at the intervals of 2, 4, 8, 24 hours throughout 24 hr. The activities of hepatic AH and GST were generally higher in bromobenzene-pretreated rats than those in normal group throughout the whole course of experiment. Furthermore, the decreasing rate of hepatic GSH content was also higher in bromobenzene pretreated rats than in normal rats. Moreover, the value of V$_{max}$ in hepatic GST was higher in bromobenzene pretreated rats than that in the normal rats. In conclusion, these results indicate that the pretreatment of bromobenzene may rather enhance the bromobenzene metabolism.

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Effect of Lead and Cadmium on Liver and Blood Phase in Rat (납 및 카드뮴이 흰쥐의 간과 혈액상에 미치는 영향)

  • 주병찬;홍사욱
    • Environmental Analysis Health and Toxicology
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    • v.2 no.1_2
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    • pp.43-53
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    • 1987
  • Among the environmental toxic metals, cadmium and lead compounds are very hazard for human health because these may affect the biological function of human body and furthermore enhance the cause of various disease. In recent years, as the view of environmental toxicology, the combination of toxic metals suffering human health is especially significant cadmium chloride (10 mg/kg P. 0., 1 mg/kg I.P.) and lead acetate (20 mg/kg P.O., 2 mg/kg I.P.) were administered to rats for 4 weeks on alternate days and then examined the effect of these on body weight, tissue weight and also biochemical function in blood and tissue were investigated and comparision of the two experimental groups such as single and combined administration. According to the results of this experiment, accumulation of heavy metals increased and biological metabolic function grew worse but, in tissue, toxic effect decreased by combined administration and intraperitoneal administration was more toxic than per OS.

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Spacecraft Attitude Control with a Two-axis Variable Speed Control Momentum Gyro

  • Bang, Hyo-Choong;Park, Young-Woong;Lee, Jung-Shin
    • 제어로봇시스템학회:학술대회논문집
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    • 2004.08a
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    • pp.1747-1753
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    • 2004
  • CMG(Control Momentum Gyro) is a control device being used for spacecraft attitude control constructing relatively large amount of torque compared to conventional body-fixed reaction wheels. The CMG produces gyroscopic control torque by continuously varying the angular momentum vector direction with respect to the spacecraft body. The VSCMG(Variable Speed Control Momentum Gyro) has favorable advantages with variable speed to lead to better control authority as well as singularity avoidance capability. Attitude dynamics with a VSCMG mounted on a two-axis gimbal system are derived in this study. The dynamic equation may be considered as an extension of the single-axis counterpart. Also, a feedback control law design is addressed in conjunction with the dynamic equations of motion.

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A study of interior stress of plastic clutch master cylinder body (플라스틱 클러치 마스터 실린더 바디의 응력해석에 관한 연구)

  • Lee, Jong-Hyung;So, Yoon-Sub;Kwon, Yung-Shin;Lee, Chun-Gon;Kim, Jae-Young
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.6 no.2
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    • pp.47-51
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    • 2007
  • Special quality of automobile clutch master cylinder(CMC) and analyzed aluminum, plastic material comparison. Efficiency of plastic master cylinder can modularize higher, light weight anger of parts, several piece parts by single parts, prove NVH(Noise, Vibration, Harshness) than aluminum master cylinder as analysis result. Also, structure is easy simplicity, exchange, maintenance costs can be reduced and decrease environmental pollution because recycling is superior. According as content of glass fiber increases, mechanical properties of matter of material increase equally and glass fiber changed variously by condition on manufacturing process. Through comparison analysis with Plastic Body development connection site, did verification.

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Effect of shear on poly(styrene-b-isoprene) copolymer micelles

  • Bang, Joon-A;Lodge, Timothy P.
    • Korea-Australia Rheology Journal
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    • v.19 no.4
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    • pp.227-232
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    • 2007
  • The use of various shearing apparatuses to study the phase behavior of poly(styrene-b-isoprene) diblock copolymer micelles is described. A DMTA rheometer was modified so that one can apply oscillatory shear and obtain the scattering pattern along the shear gradient direction. A cone and plate shear cell was designed to access scattering along the shear vorticity direction, and both oscillatory and steady shear can be applied. The most popular way to employ steady shear on relatively low viscosity fluids is to use a Couette cell, because a high shear rate can be readily achieved without disturbing the sample by overflow. In this work, oscillatory shear was used to obtain a single crystal-like scattering pattern, and thereby to examine the mechanism of the thermotropic transition between face-centered cubic (fcc) and body-centered cubic (bcc) lattices. By applying the steady shear, the response of the fcc lattices to various shear rates is discussed.

First Record of the Jawfish Stalix toyoshio (Perciformes: Opistognathidae) from the South Sea, Korea

  • Oh, Jin-A;Kim, Sung;Kim, Byung-Jik
    • Ocean and Polar Research
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    • v.30 no.3
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    • pp.347-349
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    • 2008
  • A single juvenile of the jawfish Stalix toyoshio (24.0 mm standard length) was collected from the South Sea of Korea at a depth of 135 m during box-corer sampling. The specimen was characterized by the absence of stripes on both the body and vertical fins, well-developed cephalic pore systems, yellowish body and fins, six transversely-forked dorsal fin spines, and five mandibular pores. Here, we describe the specimen, which represents the first record of S. toyoshio from Korea and the second record from the northwestern Pacific.

Posture Symmetry based Motion Capture System for Analysis of Lower -limbs Rehabilitation Training

  • Lee, Seok-Jun;Jung, Soon-Ki
    • Journal of Korea Multimedia Society
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    • v.14 no.12
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    • pp.1517-1527
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    • 2011
  • This paper presents a motion capture based rehabilitation training system for a lower-limb paretic patient. The system evaluates the rehabilitation status of the patient by using the bend posture of the knees and the weight balance of the body. The posture of both legs is captured with a single camera using the planar mirror. The weight distribution is obtained by the Wii Balance Board. Self-occlusion problem in the tracking of the legs is resolved by using k-nearest neighbor based clustering with body symmetry and local-linearity of the posture data. To do this, we present data normalization and its symmetric property in the normalized vector space.

A comparative study between stress concentration factor of the infinite plate with elliptic hole and presuure coefficient of the potential flow around elliptic cylinder (추원공을 가진 무한평판의 응력집중계수와 추원주를 가진 Potential Flow 의 응력계수와 비교연구)

  • ;;Yoon, Kab Young
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.5 no.4
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    • pp.354-361
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    • 1981
  • This study aims to compare stress concentratior factors in a loaded elastic body of the infinite plate with pressure coefficients of a fluid in the potential flow. First in view of hydrodynamics, when a single elliptic cylinder in the form of a bluff body stands in the potential flow, the pressure distribution(doefficient, C$\_$p/around the elliptic cylicder which is changed according to the position(angular displacements)is theoretically analyzed and calulated; secondly, in view of theory of elasticity, when an eliptic hole which is made on a flat plate gets tension, the stress distribution(factor) around the elliptic hole which is changed according to the position(angular displacements )is theoretically(K$\_$t/) and experimentally (K$\_$e/) measured; and finally. The results are compard and examined.