• Journal of Pharmaceutical Investigation
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• v.21 no.2
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• pp.85-90
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• 1991

Prodrugs of flurbiprofen, 1,2-ethanediolester(FE) and 1,4-butanediolester(FB) were prepared and their biopharmaceutical studies were performed. The prodrugs showed high stability in simulated gastric fluid, simulated intestinal fluid and pancreatin-saturated solution. Pharmacokinetic parameters of the prodrugs were similar to those of their parent drug. However they showed less acute toxicity and gastric irritation and higher anti-inflammatory and analgesic effects.

• IE interfaces
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• v.20 no.2
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• pp.121-132
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• 2007

The facility layout problem (FLP) involves the positioning of facilities within a given workplace in order to minimize the material flow distance between facilities. In this paper, we focus on the FLP in which the each facility has a rectangular shape and an input and output points. We develop a heuristic algorithm in which the facilities are arranged according to the layout algorithm using center of gravity and then simulated annealing algorithm is applied to improve the solution. A comparison of the computational results with exiting algorithms shows that the proposed algorithm provides better solutions in reasonable range of computational time.

• Journal of the Korea Institute of Military Science and Technology
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• v.16 no.4
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• pp.481-485
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• 2013

Rotor wake causes unsteady aerodynamics of rotor blade. So, accurate prediction of wake is very important and vortex method is good solution for this problem. Aerodynamic force of the rotor blade is calculated by potential panel method and the rotor wake is simulated by vortex particle method. The vortex particle method is easier to treat wake-body interaction and has better performance to expect the effect of ground and fuselage interaction. Rotor in hovering and forward flight condition is simulated through these methods. Thrust and surface pressure of rotor are compared with experiment data.

• Structural Engineering and Mechanics
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• v.57 no.1
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• pp.21-43
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• 2016

A conditional probability based approach known as Particle Filter Method (PFM) is a powerful tool for system parameter identification. In this paper, PFM has been applied to identify the vehicle parameters based on response statistics of the bridge. The flexibility of vehicle model has been considered in the formulation of bridge-vehicle interaction dynamics. The random unevenness of bridge has been idealized as non homogeneous random process in space. The simulated response has been contaminated with artificial noise to reflect the field condition. The performance of the identification system has been examined for various measurement location, vehicle velocity, bridge surface roughness factor, noise level and assumption of prior probability density. Identified vehicle parameters are found reasonably accurate and reconstructed interactive force time history with identified parameters closely matches with the simulated results. The study also reveals that crude assumption of prior probability density function does not end up with an incorrect estimate of parameters except requiring longer time for the iterative process to converge.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2008.04a
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• pp.416-421
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• 2008

A Metropolis genetic algorithm (MGA) is a newly-developed hybrid algorithm combining simple genetic algorithm (SGA) and simulated annealing (SA). In the algorithm, favorable features of Metropolis criterion of SA are incorporated in the reproduction operations of SGA. This way, MGA alleviates the disadvantages of finding imprecise solution in SGA and time-consuming computation in SA. It has been successfully applied and the efficiency has been verified for the practical structural design optimization. However, applicability of MGA for the wider range of problems should be rigorously proved through the solution of mathematical optimization problems. Thus, performances of MGA for the typical mathematical problems are investigated and compared with those of conventional algorithms such as SGA, micro genetic algorithm (${\mu}GA$), and SA. And, for better application of MGA, the effects of acceptance level are also presented. From numerical Study, it is again verified that MGA is more efficient and robust than SA, SGA and ${\mu}GA$ in the solution of mathematical optimization problems having various features.

• Nuclear Engineering and Technology
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• v.48 no.3
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• pp.727-732
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• 2016

A simple and rapid spectrophotometric method has been developed to enable the determination of plutonium concentration in an irradiated fuel solution in the presence of all fission products. An excess of ceric ammonium nitrate solution was employed to oxidize all the valence states of plutonium to +6 oxidation state. Interference due to the presence of fission products such as ruthenium and zirconium, and corrosion products such as iron in the envisaged concentration range, as in the irradiated fuel solution, was studied in the determination of plutonium concentration by the direct spectrophotometric method. The stability of plutonium in +6 oxidation state was monitored under experimental conditions as a function of time. Results obtained are reproducible, and this method is applicable to radioactive samples resulting before the solvent extraction process during the reprocessing of fast reactor spent fuel. An analysis of the concentration of plutonium shows a relative standard deviation of <1.2% in standard as well as in simulated conditions. This reflects the fast reactor fuel composition with respect to uranium, plutonium, fission products such as ruthenium and zirconium, and corrosion products such as iron.

• Journal of the Korean Ceramic Society
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• v.56 no.4
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• pp.387-393
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• 2019

A N₂H₄-Cu(I)-HNO₃ solution was used to dissolve magnetite powders and a simulated oxide film on Inconel 600. The addition of Cu(I) ions to N₂H₄-HNO₃ increased the dissolution rate of magnetite, and the reaction rate was found to depend on the solution pH, temperature, and [N₂H₄]. The dissolution of magnetite in the N₂H₄-Cu(I)-HNO₃ solution followed the contracting core law. This suggests that the complexes of [Cu⁺(N₂H₄)] formed in the solution increased the dissolution rate. The dissolution reaction is explained by the complex formation, adsorption of the complexes onto the surface ferric ions of magnetite, and the effective electron transfer from the complexes to ferric ions. The oxide film formed on Inconel 600 is satisfactorily dissolved through the successive iteration of oxidation and reductive dissolution steps.

• Structural Engineering and Mechanics
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• v.60 no.5
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• pp.795-807
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• 2016

This study tries to examine the effect of different parameters on stress analysis of infinite plates with central quasi-triangular cutout using particle swarm optimization (PSO) algorithm and also an attempt has been made to introduce general optimum parameters in order to achieve the minimum amount of stress concentration around this type of cutout on isotropic and orthotropic plates. Basis of the presented method is expansion of analytical method conducted by Lekhnitskii for circular and elliptical cutouts. Design variables in this study include fiber angle, load angle, curvature radius of the corner of the cutout, rotation angle of the cutout and at last material of the plate. Also, diagrams of convergence and duration time of the desired problem are compared with Simulated Annealing algorithm. Conducted comparison is indicative of appropriateness of this method in optimization of the plates. Finite element numerical solution is employed to examine the results of present analytical solution. Overlap of the results of the two methods confirms the validity of the presented solution. Results show that by selecting the aforementioned parameters properly, less amounts of stress can be achieved around the cutout leading to an increase in load-bearing capacity of the structure.

• Journal of Advanced Marine Engineering and Technology
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• v.28 no.5
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• pp.818-826
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• 2004

The spray-induced mixing characteristics and thermal decomposition of aqueous urea solution into ammonia have been studied to design optimum sizes and geometries of the mixing chamber in SCR(Selective Catalytic Reduction) system. The cold flow tests about the urea-injection nozzle were performed to clarify the parameters of spray mixing characteristics such as mean diameter and velocity of drops and spray width determined from the interactions between incoming air and injected drops. Discrete particle model in Fluent code was adopted to simulate spray-induced mixing process and the experimental results on the spray characteristics were used as input data of numerical calculations. The simulation results on the spray-induced mixing were verified by comparing the spray width extracted from the digital images with the simulated Particle tracks of injected drops. The single kinetic model was adopted to predict thermal decomposition of urea solution into ammonia and solved simultaneously along with the verified spray model. The hot air generator was designed to match the flow rate and temperature of the exhaust gas of the real engines The measured ammonia productions in the hot air generator were compared with the numerical predictions and the comparison results showed good agreements. Finally, we concluded that the design capabilities for sizing optimum mixing chamber were established.

• Advances in materials Research
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• v.6 no.4
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• pp.317-328
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• 2017

In this paper, an improved theoretical solution for interfacial stress analysis is presented for simply supported concrete beam bonded with a sandwich FGM plate. Interfacial stress analysis is presented for simply supported concrete beam bonded with a sandwich plate. This improved solution is intended for application to beams made of all kinds of materials bonded with a thin plate, while all existing solutions have been developed focusing on the strengthening of reinforced concrete beams, which allowed the omission of certain terms. It is shown that both the normal and shear stresses at the interface are influenced by the material and geometry parameters of the composite beam. A numerical parametric study was performed for different simulated cases to assess the effect of several parameters. Numerical comparisons between the existing solutions and the present new solution enable a clear appreciation of the effects of various parameters. The results of this study indicated that the FGM sandwich panel strengthening systems are effective in enhancing flexural behavior of the strengthened RC beams.