Journal of Pharmaceutical Investigation
- Volume 21 Issue 2
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- Pages.85-90
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- 1991
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Biopharmaceutical Studies of 1,2-Ethanediolester and 1,4- Butanediolester of Flurbiprofen
플루비푸로펜의 1,2-에탄디올에스테르와 1,4-부탄디올에스테르의 생물 약제학적 연구
- Rho, Jae-Il (Kyung Dong Pharm. Co.,Ltd.) ;
- Lee, Wan-Ha (College of Pharmacy, Sung Kyun Kwan University)
- Published : 1991.06.20
Abstract
Prodrugs of flurbiprofen, 1,2-ethanediolester(FE) and 1,4-butanediolester(FB) were prepared and their biopharmaceutical studies were performed. The prodrugs showed high stability in simulated gastric fluid, simulated intestinal fluid and pancreatin-saturated solution. Pharmacokinetic parameters of the prodrugs were similar to those of their parent drug. However they showed less acute toxicity and gastric irritation and higher anti-inflammatory and analgesic effects.
Keywords
- prodrug;
- flurbiprofen;
- biopharmaceutical studies;
- pharmacokinetic parameters;
- acute toxicity;
- gastric irritation;
- anti-inflammatory and analgesic effects