• Journal of the Korean institute of surface engineering
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• v.52 no.2
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• pp.84-89
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• 2019

We fabricated durable anti-reflective(AR) layer with silica globular coating on polymer by two steps. Firstly, nano-protrusions of polymer were formed by plasma etching known as R.I.E(reactive ion etching) process. Secondly, silica globular coating was deposited on polymer nano-protrusions for mechanically protective and optically enhancing AR layers by RF magnetron sputter. And then durable antireflective polymers were synthesized adjusting plasma power and time, working pressures of RIE and RF sputtering processes. Consequently, we acquired the average transmission (94.10%) in the visible spectral range 400-800 nm and the durability of AR layer was verified to sustain its transmission until 5,000 numbers by rubber test at a load of 500 gf.

• Ceramist
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• v.21 no.3
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• pp.283-292
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• 2018

Here, we introduce various type of inorganic nanostructure synthesized with functional nanoparticles and silica. From two decades ago, functional inorganic nanoparticles have been synthesized and highlighted, now we moved to next level of wet-chemical synthesis. By integrating functional nanoparticles with silica, we were able to synthesize multi-functional nanostructure, which expand the applications of nanoparticles to catalyst, drug carrier, sensors. In this context, silica has been spotlighted due to its versatility. Silica has highly biocompatible, relatively transparent and stable under harsh conditions. Thus it can be used as good supporter to synthesize complex multi-functional nanostructure when mixed with other functional nanoparticles. A various shape of complex nanostructures have been synthesized including core-shell type, yolk-shell type and janus type etc. In this paper, we have described the purposes of synthesizing silica noncomplex and various case studies for biomedical applications and self-assembly.

• IMMUNE NETWORK
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• v.12 no.3
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• pp.104-112
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• 2012

Silica is one of the most abundant compounds found in nature. Immoderate exposure to crystalline silica has been linked to pulmonary disease and crystalline silica has been classified as a Group I carcinogen. Ultrafine (diameter <100 nm) silica particles may have different toxicological properties compared to larger particles. We evaluated the effect of ultrafine silica nanoparticles on mouse bone marrow-derived dendritic cells (BMDC) and murine dendritic cell line, DC2.4. The exposure of dendritic cells (DCs) to ultrafine silica nanoparticles showed a decrease in cell viability and an induction of cell death in size- and concentration-dependent manners. In addition, in order to examine the phenotypic changes of DCs following co-culture with silica nanoparticles, we added each sized-silica nanoparticle along with GM-CSF and IL-4 during and after DC differentiation. Expression of CD11c, a typical DC marker, and multiple surface molecules such as CD54, CD80, CD86, MHC class II, was changed by silica nanoparticles in a size-dependent manner. We also found that silica nanoparticles affect inflammatory response in DCs in vitro and in vivo. Finally, we found that p38 and NF-${\kappa}B$ activation may be critical for the inflammatory response by silica nanoparticles. Our data demonstrate that ultrafine silica nanoparticles have cytotoxic effects on dendritic cells and immune modulation effects in vitro and in vivo.

• Journal of the Korea Organic Resources Recycling Association
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• v.31 no.3
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• pp.5-13
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• 2023

In this study, a comparative study is conducted on the synthesis methods for silica nanoparticle employing the silicon sludge waste generated from the semiconductor manufacturing processes. Specifically, acid-washed silicon sludge wastes with no impurities are employed as the precursors of sol-gel and hydrothermal methods for silica nanoparticles preparation. The morphologies and properties of silica nanoparticles synthesized via two synthetic methods are examined by various analysis methods. As a result, silica nanoparticles from the sol-gel method are fabricated with high purity and uniform shape, while the hydrothermal method exhibits advantages in yield and ease of synthetic process. This comparative study offers detailed experimental results on the two synthetic methods for silica nanoparticle synthesis, which may contribute to the establishment of manufacturing high-value materials using the by-products generated in the semiconductor process.

• Proceedings of the Materials Research Society of Korea Conference
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• 2007.11a
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• pp.148.2-148.2
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• 2007

• Applied Chemistry for Engineering
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• v.21 no.5
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• pp.514-521
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• 2010

A new one-shot process was employed to fabricate proton exchange membranes (PEMs) over conventional solvent-casting process. Here, PEMs containing nano-dispersed silica nanoparticles were fabricated using one-shot process similar to the bulk-molding compounds (BMC). Different components such as reactive dispersant, urethane acrylate nonionmer (UAN), styrene, styrene sulfuric acid and silica nano particles were dissolved in a single solvent dimethyl sulfoxide (DMSO) followed by copolymerization within a mold in the presence of radical initiator. We have successfully studied the water-swelling and proton conductivity of obtained nanocomposite membranes which are strongly depended on the surface property of dispersed silica nano particles. In case of dispersion of hydrophilic silica nanoparticles, the nanocomposite membranes exhibited an increase in water-swelling and a decrease in methanol permeability with almost unchanged proton conductivity compared to neat polymeric membrane. The reverse observations were achieved for hydrophobic silica nanoparticles. Hence, hydrophilic and hydrophobic silica nanoparticles were effectively dispersed in hydrophilic and hydrophobic medium respectively. Hydrophobic silica nanoparticles dispersed in hydrophobic domains of PEMs largely suppressed swelling of hydrophilic domains by absorbing water without interrupting proton conduction occurred in hydrophilic membrane. Consequently, proton conductivity and water-swelling could be freely controlled by simply dispersing silica nanopartilces within the membrane.

• Journal of Radiation Industry
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• v.6 no.3
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• pp.273-279
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• 2012

Silica hybrid silver nanoparticles showing the strong antimicrobial activity, in which nano-silver is bound to silica molecules, has been synthesized using ${\gamma}-irradiation$ at room temperature. The present study relates to an antimicrobial composition for coating fiber products comprising silica hybrid silver nanoparticles. In this study, we describe antimicrobial fiber products coated with the silica hybrid silver nanoparticles and a method of antimicrobially treating fiber products by coating the fiber products with the silica hybrid silver nanoparticles. The antimicrobial fiber products exhibited excellent antimicrobial effects. In detailed practice, when the present composition comprising nanosized silica-silver was applied to a cloth (fabric) in a concentration of $6.4mg\;yard^{-1}$, the viable cell number decreased to less than 10 cells before and after laundering, resulting in a reduction of 99.9% or greater in the viable cell number. The present composition displays long-lasting potent disinfecting effects on bacteria. Also, we investigated the toxicity of silica hybrid silver nanoparticles in rats. The skin of rats was treated with a 30 ppm nanoparticles solution ($2ml\;Kg^{-1}$) for 8 days. No toxicity was detected in the treatment. These results suggest that the fiber products coated with the silica hybrid silver nanoparticles can be used to inhibit the growth of various microorganisms.

• 한국연소학회:학술대회논문집
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• 2006.10a
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• pp.196-201
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• 2006

Silica(SiO2) nanoparticles are used as additives in plastics and rubbers to improve mechanical, electrical, magnetic properties and optical material. Silica nanoparticles were synthesized by the gas phase thermal oxidation of several kinds of precursors in many types of reactor. Diffusion flame reactor has some advantages compared with other types of reactors. In this study, we investigated the generation of silica nanoparticles on the effect of residence time by tetraethylothosilicate(TEOS) in a turbulent diffusion flame reactor controlled by providing reactant flowrate and reactor geometry affect particle morphology, particle size and particle size distribution. To determine the flame residence time, flame length should be determined which was examined by ICCD image. Particle size, distribution and morphology were performed with TEM.

• KEPCO Journal on Electric Power and Energy
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• v.7 no.1
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• pp.167-169
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• 2021

In this study, monodispersive silica nanoparticles with double mesoporous shells were synthesized, and the pore size of synthetic mesoporous silica nanoparticles was controlled. Cetyltrimethylammonium chloride (CTAC), N, N-dimethylbenzene, and decane were used as soft template and induced to form outer mesoporous shell. The resultant double mesoporous silica nanoparticles were consisted of two layers of shells having different pore sizes, and it has been confirmed that outer shells with larger pores (Mean pore size > 2.5 nm) are formed directly on the surface of the smaller pore sized shell (Mean pore size < 2.5 nm). It was confirmed that the regulation of the molar ratio of pore expansion agents plays a key role in determining the pore size of double mesoporous shells.

• Korean Chemical Engineering Research
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• v.61 no.4
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• pp.570-575
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• 2023

Targeted anticancer drug delivery systems are needed to enhance therapeutic efficacy by selectively delivering drugs to tumor cells while minimizing off-target effects, improving treatment outcomes and reducing toxicity. In this study, a silica-based nanocarrier capable of targeting drug delivery to cancer cells was developed. First, silica nanoparticles were synthesized by the Stöber method using the surfactant cetyltrimethylammonium bromide (CTAB). Increasing the ratio of EtOH in the solvent produced uniformly spherical silica nanoparticles. Washing the nanoparticles removed unreacted residues, resulting in a non-toxic carrier for drug delivery in cells. Upon surface modification, the pH-responsive polymer, polyethyleneimine (PEI) exhibited slow doxorubicin release at pH 7.4 and accelerated release at pH 5.5. By exploiting this feature, we developed a system capable of targeted drug release in the acidic tumor microenvironment.