• 생물정신의학
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• 제12권2호
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• pp.136-142
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• 2005

Object:The intracellular action of the antidepressant, venlafaxine, was studied in C6-gliomas using heat shock protein 70(HSP70) immunocytochemistry and HSP70 Western blots because HSP70 is associated with stress and depression. Methods:To examine how the glucocorticoid affects the expression of HSP70 in nerve cells, the rat C6 glioma cell was treated with dexamethasone for 6 hours. In addition, venlafaxine was administered to the experimental groups of C6 glioma cells for 1, 6, 24, and 72 hours each, after which the expression of HSP70 was investigated. Finally, venlafaxine and dexamethasone were simultaneously administered to the experimental groups for 1, 6, 24, and 72 hours, followed by an investigation of the expression of HSP70. Results:The short term(1 hour) venlafaxine treatment significantly increased the level of HSP70 expression. The short term treatment of venlafaxine with dexamethasone also increased the level of HSP70 expression but this reduction was not statistically significant. The long term(72 hours) venlafaxine with dexamethasone treatment significantly reduced the level of HSP70 expression. The long term treatment of venlafaxine also reduced the level of HSP70 expression but this reduction was not statistically significant. Dexamethasone(10uM, 6hours) did not affect the level of HSP70 expression compared with controls. Conclusion:Venlafaxine increases the expression of HSP70 at short term treatment, but prolonged treatment with dexamethasone suppresses the expression of HSP70.

• 가정과삶의질연구
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• 제14권4호
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• pp.219-232
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• 1996

This study was investigated the perceived level of stress and the coping method which the adolescent were confronting. The subject of this investigation was high school students who resided in the City of Pusan. Life Event Scale and Coping Methods Scale were used as the methods for examination. The data were analyzed using M, SD, t-test one-way ANOVA scheffe-test and Pearson's correlation related with this study problem were tested. The results of this study are as follows: 1. The perceived level of teenager's stress was little low with M=1.65 When dividing sphere of perceived level the stress by school problem was the highest and the circumstance problem personal one family one and a companion one are followed in regular sequence. 2. It was found that degree of stress made a difference according to the sex course grade school year religion parents's presence or absence SES the satisfactory degree of school life the satisfactory degree of school life the satisfactory degree of home life and the rearing attitude of parents. 3. As the coping score of teenager's stress was M=2.54. The short-term coping method was higher compared with the long-term one regarding coping methods. 4. It was found that the coping method of stress differed from each other according to variables of sex school year the satisfactory degree of school life and the satisfactory degree of home life. 5. It was found that the perceived level of stress had negative correlation with the coping method and especially long-term coping method had higher negative correlation.

• 콘크리트학회지
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• 제3권4호
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• pp.107-115
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• 1991

플라이애쉬를 혼입한 고강도 콘크리트의 초기 및 장기 강도 특성과 작업성 특성에 관한 연구를 수행하였다. 이를 위하여 강도 수준이 다른 6종류의 기본 배합을 선정하고 각 기본 배합을 선정하고 각 기본 배합에 대하여 플라이애쉬 첨가량을 0, 10, 20, 30%로 변화시켜 가면서 그 특성을 실험하였다. 또한, 고강도 플라이애쉬 콘크리트의 슬럼프 감소현상을 분석하기 위하여 4종류의 배합을 추가하여 실험하였다. 연구 결과, 제2종 포틀랜드 시멘트를 사용한 경우, 플라이애쉬를 10%혼입한 콘크리트는 대부분 28일 이전에 일반 콘크리트보다 높은 강도를 발현하였다. 또한, 플라이애쉬 첨가량이 증가함에 따라 보통강도 콘크리트의 슬럼프값은 감소하였으며, 고강도 콘크리트의 슬럼프값을 일정하게 유지시키기 위해서는 더 많은 양의 고유동화제가 사용되었다.

• 한국주거학회논문집
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• 제26권6호
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• pp.169-180
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• 2015

This study was carried out to offer direction to the Housing Management Support Center in terms of its key features and specific operational tasks. The research involved the property management office (n=35) and Resident Representatives of the apartment blocks (n=52). Advisory Services conducted a consumer survey, as well as a survey of expert interviews (n=15). Survey results were as follows: (1) the Managing Director and secretary residents were satisfied with the Diagnosis and Advisory services; (2) the administrative support services need to address housing issues, including a long-term repair plan and advice on using long-term repair reserves and "conflict resolution associated with public housing management"; and (3) there was a greater need for a "basic, common-sense Housing Management Information Base to provide services to the Resident Representatives of the apartment blocks". Based on the survey results, the main roles of the Housing Management Support Center are to act as a House of Commons Administrator to handle complaints with counseling, diagnosis and advice; to support the Resident Committees; to provide professional training, research, and investigation; to support community revitalization; to manage the business of guidance and inspection; to coordinate conflicts and disputes; to build a comprehensive source of information; and to build networks.

• The Journal of Asian Finance, Economics and Business
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• 제8권10호
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• pp.11-17
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• 2021

This study aims to know the contribution of external debt to Indonesia's economic growth. The data used a source from the Central Bank of Indonesia from 2011 to 2020. This empirical study uses a quantitative approach with Error Correction Model as the regression method. Government expenditure, government revenue, export, import, inflation, and exchange rate are control variables. The result of the descriptive statistic shows economic growth in Indonesia increased gradually from 2011 to 2020. The increase in economic growth occurred regardless of the contribution of external debt. It does, however, inform the public that Indonesia's economic system has seen successful investments. The result of the study is classified into long-term and short-term. External debt contributes to growth in the long term and has a significant impact. The study's findings will give Indonesia optimism that it can manage external debt as a source of domestic investment. This research may also persuade Indonesia to maintain its economic potency in the future. In the future, this research can be perfected, by adding a threshold level on the amount of Indonesia's external debt.

• 환경영향평가
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• 제21권1호
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• pp.185-199
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• 2012

Ecotourism has been attracting much attention as an example industry that can vitalize local economy markets and preserve natural resources. Implementation of 'Ecotourism Designation System' is under consideration to provide ecotourism products that can both emphasize the original meanings of ecotourism and ensure stronger trust from customers than ever before. This research introduced the direction, principles, subjects, and assessment indicators by subjects in terms of implementing the system and proposed fundamentals for both designation assignment and score calculation. In the face of implementing such a system in Korea, the investigation sought subjects whose target areas and programs are in need of examination. For assessment criteria by subjects, six assessment indicators were selected in the end for ecotourism sites, including: (1) the value of natural/ecological preservation (2) facility's ecological design (3) understanding both the environment and local culture (4) systems connecting local communities for cooperation (5) long/short term preservation and maintenance strategies/plans (6) willingness to further develop ecotourism and cooperative platform. In addition, seven assessment indicators were selected for program assignments, including: (1) the value of natural/ecological preservation (2) minimization of environmental effects (3) expansion of environmental understanding (4) sharing the local culture (5) vitalizing local connections and economical activities among communities (6) securing and maintaining professionality among human resources (7) odds of continuation, creativity, and aptness to improve programs. After considering the pros and cons of both categorizing system and yes/no system, implementation of categorizing system for the short term and yes/no for the long term were suggested, followed by additional suggestions of a score calculation system for each system. The official implementation of the 'Ecotourism Designation System' is scheduled for launch in 2013 after the trial operation in 2012. The assessment indicators and fundamentals suggested in this research, considering judgment, must be improved via systematic and practical methods through the trial operation.

• 농촌지도와개발
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• 제30권2호
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• pp.119-129
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• 2023

This study aims to identify the types of safety accidents that occur during maintenance and repair operations and analyze the root causes. We used the logic tree diagramming to extract the root causes of 65 safety incidents specifically related to maintenance and repair work out of a total of 1,024 agricultural safety incidents that occurred between 2007 and 2020 collected by investigation with interviews. The extracted root causes were analyzed by categorizing them into six different safety system classifications. The results of the analysis and suggestions are as follows. Incidents related to maintenance and repair work, which can lead to irreversible safety hazards, have occurred frequently. These incidents were found to be occurring due to the overlapping of various safety system errors such as personal protective system and safety operation procedure. In the short term, it is necessary to emphasize compliance with the use of personal protective equipment, and enhancement of maintenance training. In the long term, it is necessary to establish a legal distinction for maintenance and repair work and clarify the responsible parties. Introducing a maintenance system is also crucial to prevent occupational injuries during maintenance and repair in agriculture.

• 한국치위생학회지
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• 제9권2호
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• pp.57-71
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• 2009

This study aims to investigate the stress factors of students in Dental Hygiene Department who will soon take the national examination, corresponding countermeasures and relationship of internal and external personality. On the basis of the results from investigation, this study will identify the methods to effectively cope with stress and to take the national examination with more positive thinking for the students and faculty members in Dental Hygiene Department, who have to pass the difficult test, the national examination. The structured questionnaires were given to junior students in Dental Hygiene Department in three colleges, to identify the stress factors, methods to deal with stress and A/B personality types. For the stress factor by field, the M college showed significantly higher stress about curriculum and assignment than the C college. In the stress factor analysis by item, the lack of information on national examination in the test area, all items in learning environment, a quantity of assignment that doesn't help the preparation of national examination in the assignment area, and lack of information on employment in job area demonstrated the significant difference(p<0.05). For the methods of subjects to deal with stress, several subcategories of long-term and short-term adaptation had significance. In case of the methods to deal with stress by personality type, B type in the short-term adaptation method in M college and A type in the long-term adaptation method in C college were significantly higher(p<0.05). As for the correlation between the population sociological features and stress factors by personality type, health status had the high correlation with test in the test area. In other areas, the travel hours to school showed the significant correlation. The higher the records were, the longer the travel hours were and the better the health status was, the higher the long-term adaptation method scores were. Moreover, the personality of A type showed the higher scores in the long-term adaptation method than that of B type. The health status and personality type showed the significant correlation(p<0.05). In conclusion, it is required to prevent any situations b identify the personality type and stress reasons of the students in Dental Hygiene Department who will take the national examination soon. The additional requirement is the continuing interest and counseling of faculty members to help students to cope with stress with positive attitude.

• Journal of Gastric Cancer
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• 제2권3호
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• pp.157-162
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• 2002

Purpose: The prognosis of stage IV gastric cancer is very grave. However, some of these patients survive long periods after surgery. This study was undertaken to investigate various clinico-pathological profiles related to the prognosis for these long-term survivors. Materials and Methods: One hundred fifty-five patients with stage IV gastric cancer who underwent a gastric resection from 1992 to 1997 at Hanyang University Hospital were evaluated. Thirty-three patients who survived more than 5 years after surgery were designated as long-term survivors (LTS); on the other hand, one hundred twenty-two patients who died within 5 years after surgery were named as short-term survivors (STS). Results: The rate of the patients with T4, preoperative serum level of CA19-9 greater than 37 U/g protein, and peritoneal dissemination was lower for the LTS than in for the STS (P=0.002, P=0.045, and P=0.0000, respectively). Tumors were smaller (7.3 cm vs. 8.9 cm, P=0.030) and metastatic lymph node were fewer (19.7 vs. 28.8, P=0.019) for the LTS than for the STS. Curative surgery ($\76\%\;vs.\;\46\%$, P=0.002) and a subtotal gastrectomy ($\76\%\;vs.\;46\%$, P=0.026) were performed more frequently for the LTS than for the STS. From a univariate survival analysis, depth of invasion, distant metastasis, extent of gastric resection, postoperative chemotherapy, and curability were statistically significant factors. From a multivariate survival analysis, curability, depth of invasion, and extent of gastric resection were independent prognostic factors. Conclusions: If feasible, we have to exert our efforts to achieve curative surgery although the tumor is considered to be a stage IV gastric cancer. Thereafter, multi-modality treatments including chemotherapy can be considered to improve the prognosis.

• 한국동물학회:학술대회논문집
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• 한국동물학회 1995년도 한국생물과학협회 학술발표대회
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• pp.82-82
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• 1995

Regulation of enzyme synthesis by transcriptional and translational control systems provides rather stable adaptation to change of amino acid level in the growth medium, while manipulation of enzyme activity through endproduct feedback inhibition represents rather short-term and reversible ways of adjusting metabolic fluctuation of amino acid level. Various control mechanisms interplay to regulate genes encoding enzymes for amino acid biosynthesis in the yeast, Sacchromyces cerevisiae. When amino acids are in short supply, genes under a cross-pathway regulatory mechanism Or general amino acid control (general control) increase their action, in which Gcn4p is the major positive regulator of gene expression. When cells are cultured in minimal medium, basal level expression is also regulated by supplementary control elements, where inorganic phosphate level is additionally involved. Most of amino acid biosynthetic genes are also regulated by the level of endproduct of the pathway. This pathway-specific regulatory mechanism is called specific amino acid control (specific controD, under which gene expression is reduced when endproduct is present in the medium. Derepression of a gene through general control can be usually overridden by repression through specific control, where the endproduct level of that particular pathway is high and not limiting. In this presentation, regulatory factors for basal level expression and general control of yeast amino acid biosynthesis will be discussed, m addition to pathway-specific repression patterns and interaction between CrOSS- and specific-control mechanisms. Preliminary results are also presented from the investigation of the cloned genes in the threonine biosynthetic pathway of the yeast. yeast.