• The Korean Journal of Physiology and Pharmacology
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• v.12 no.6
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• pp.299-306
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• 2008

Sometimes, spinal cord injury (SCI) results in various chronic neuropathic pain syndromes that occur diffusely below the level of the injury. It has been reported that behavioral signs of neuropathic pain are expressed in the animal models of contusive SCI. However, the observation period is relatively short considering the natural course of pain in human SCI patients. Therefore, this study was undertaken to examine the time course of mechanical and cold allodynia in the hindpaw after a spinal cord contusion in rats for a long period of time (30 weeks). The hindpaw withdrawal threshold to mechanical stimulation was applied to the plantar surface of the hindpaw, and the withdrawal frequency to the application of acetone was measured before and after a spinal contusion. The spinal cord contusion was produced by dropping a 10 g weight from a 6.25 and 12.5 mm height using a NYU impactor. After the injury, rats showed a decreased withdrawal threshold to von Frey stimulation, indicating the development of mechanical allodynia which persisted for 30 weeks. The withdrawal threshold between the two experimental groups was similar. The response frequencies to acetone increased after the SCI, but they were developed slowly. Cold allodynia persisted for 30 weeks in 12.5 mm group. The sham animals did not show any significant behavioral changes. These results provide behavioral evidence to indicate that the below-level pain was well developed and maintained in the contusion model for a long time, suggesting a model suitable for pain research, especially in the late stage of SCI or for long term effects of analgesic intervention.

• Archives of Reconstructive Microsurgery
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• v.18 no.1
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• pp.9-15
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• 2009

Whether a seven days course of anti-${\alpha}{\beta}$-T cell receptor-antibody (${\alpha}{\beta}$-TCRmAb) combined with FK506 therapy promotes survival of limb allografts in fully MHC-mismatched combination (Brown Norway $\rightarrow$ Lewis) was examined. Eight animals received 250 ${\mu}g$/kg/day of ${\alpha}{\beta}$-TCRmAb for 7 days and 2 mg/kg/day of FK506 postoperatively (Combination therapy group). Eight animals had FK506 only (Mono-therapy group) and five animals did not have treatment (Control group). Clinical signs of early rejection with edema or erythema in the skin occurred at an average of 8.6${\pm}$1.5 days postoperatively in Control group and 59.0${\pm}$8.3 days in Mono-therapy group, both of which proceeded to irreversible rejection with necrosis of the epidermis and finally mummification. In Combination therapy group, all animals showed evidence of early rejection at an average of 56.8${\pm}$12.6 days postoperatively, however, in 4 of 8 limbs, early rejection resolved without any treatment and limbs survived >1 year. At 9 months postoperatively, donor skin grafts were accepted and third-party skin grafts were rejected by all four survivors, demonstrating donor-specific tolerance. Little or no detectable chimerism was observed in any of the 4 surviving animals at one-year postoperatively. Combination therapy of ${\alpha}{\beta}$-TCRmAb and FK506 resulted in long-term survival in fully MHC-mismatched limb transplants.

• Journal of the Korean Institute of Navigation
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• v.14 no.4
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• pp.53-70
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• 1990

Much efforts have been made to improve the training education system for last decades. however, it still leaves much room form improving the system. The reason for this is that the have been many changes in given educational conditions, national and international, and that there existed the lack of training facilities on shore and the limits of capacity on the training ship. The existing program adopts a straight-through system of which the course has to be completed at same time, and also forces students to study the course, disregarding their aptitude for sea life. Consequently, the program resulted in frustrating the learning desire of some students and, as a consequence, in deteriorating the quality of the entire training education. This paper aims to develop an efficient training program including curriculla by the literature survey and the teaching and sea experiences on the training ship "HANBADA" and merchant ships, where the authors have been for many years. Compared with the existing one, the new training model suggested in this paper has some advantages as follows : First, the new model adopts multi-state system which consists of various short-term training courses according to each purpose. This system will be helpful for student to find their aptitude for sea life earlier and to understand classes of major subjection shore. Second, the model includes new curriculla which consist of core subjects (for example, navigation, marine operation, marine transportation, watch keeping and nautical English for deck cadets and internal and external combustion engine, auxiliary machinery, electric and electronics and engine maintenance for engine cadets), by incorporating existing 20 subjects in 5 subjects. These curriculla may contribute to embodying the characteristics of training education where the above mentioned subjects must be linked with each other. In order to implement this new training model efficiently and effectively, the following prerequisties must be prepared : $\circled1$ The contents of each subject included in the new model should be systematically developed. $\circled2$ The educational schedule should be adjusted according to the new model.new model.

• Korean Journal of Clinical Pharmacy
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• v.31 no.3
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• pp.171-179
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• 2021

Background: Need for regulatory science is emerging with the development of pharmaceutical industry. It is essential to train regulatory science experts to meet the needs of technology and regulations to evaluate advanced products. Major regulatory science countries are conducting the regulatory science activities and fostering the experts. Methods: Published literature and the relevant website of European Union (EU) were reviewed and criteria were developed. In particular, we focused on in depth descriptions of the Innovative Medicines Initiative program, which was conducted twice. Results: EU is striving to provide funding and training experts for the development of the regulatory science by horizon 2020 and regulatory science to 2025. Innovative medicines initiative (IMI) is a public-private partnership aimed at the development of the pharmaceutical industry, including the regulatory science. IMI education and training projects have provided various education and training course including short-term curriculum and master and doctoral course. The difference between South Korea's regulatory science expert training project in 2021 and the EU's IMI education and training projects is participation of pharmaceutical companies. While the pharmaceutical companies participate in the IMI project to select project topics and form a community, South Korea's project is focused on the Ministry of Food and Drug Safety and universities. Conclusion: Through successful active networks with regulatory party, pharmaceutical companies, and universities, a great innovative advance of regulatory science in South Korea is expected.

• Journal of Science Education
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• v.46 no.3
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• pp.237-254
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• 2022

The purpose of this study is to examine the changes in the science teaching professionalism self-perception of pre-service elementary teacher as shown in science education lesson course. The subjects of this study were 25 pre-service elementary teachers enrolled in the second year at G National university of education. And the scale of this study were derived and applied by modifying and supplementing the scale of previous studies. The results of this study are as follows: it was found that science teaching professionalism and self-perception of pre-service elementary teachers are improving. In short, it was found that there are significant changes in all sub-domains such as professionalism development efforts, educational contents, instructional method, educational environment and atmosphere, assessment and science teaching preference. As a result of examining the related contents in detail along with the combustion-related science lesson plan, Padlet, and post-test descriptive question responses, there were some good categories and some categories that needed to be supplemented. Based on these results, a plan for enhancing the science teaching professionalism of pre-service elementary teacher needs to be considered.

• Journal of Practical Engineering Education
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• v.15 no.2
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• pp.341-349
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• 2023

At the K University level in the first semester of the 2022, regarding the courses opened as intensive completion-type major knowledge linking, under the name of 'Collage', 47 students were formed along with students majoring in electronic engineering (21 students) and included 26 students from 14 other majors. It was convergencly conducted as a 5-week completion-type independent course, and the results of responses to 10 items on the 5-point Likert scale questionnaire were summarized. The organized results were tested for four items (reliability, normality, correlation, average difference between 2 groups), and it was confirmed that there was a difference in learning satisfaction depending on the difficulty of the learning topic and the grade of the student. In addition, it was confirmed that more than 65% of the students responded with a positive evaluation of 'moderate' or higher in the five questionnaire items with high correlation.

• Korean Journal of Biological Psychiatry
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• v.24 no.2
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• pp.75-81
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• 2017

Objectives Obsessive-compulsive disorder (OCD) is a chronic and disabling psychiatric disorder. The duration of untreated illness (DUI) has been suggested as one of the predictors of clinical course and outcome in various psychiatric disorders. There is increasing evidence that cognitive dysfunction is associated with the prognosis of OCD. The aim of this study was to investigate the influence of DUI on the neurocognitive functions in patients with OCD. Methods Sixty-two patients with a DSM-IV diagnosis of OCD from the outpatient clinic were included in this study. We defined the short DUI if the DUI was 2-year or less and the long DUI if it was longer than 2-year. Neurocognitive functions were assessed by visuospatial memory function test and 4 subsets of K-WAIS such as vocabulary, arithmetic, block design and picture arrangement. Differences in neurocognitive functions as well as clinical variables between OCD patients with short DUI and those with long DUI were investigated. Correlation analyses were also performed to determine the correlation between DUI and neurocognitive functions. Results Compared with the short DUI group, the long DUI group performed worse in the block design test, which measures executive function. The long DUI group also had a higher level of compulsive symptom severity than the short DUI group. However, the DUI was not correlated with neurocognitive functions. Conclusions Findings in this preliminary study suggest that the long DUI in patients with OCD is associated with more severe executive dysfunction. Studies with larger samples and longitudinal design are needed to further confirm the prognostic role of the DUI in OCD.

• Journal of Korean Society of Water and Wastewater
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• v.22 no.5
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• pp.531-540
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• 2008

The main advantage of dissolved air flotation (DAF) in water treatment process is the small dimension compared with conventional gravity sedimentation and it can be basically reduced by the separation zone performed with the short solid-liquid separation time. Fine bubbles make such a short time possible to carry out solid from liquid separation as a collector on the course of water treatment. Therefore, the dimension of separation zone in DAF process is practically determined by the rise velocity of the bubble-floc agglomerates, which is a floc attached with several bubbles. To improve flotation velocity and particle removal efficiency in DAF process, many researchers have tried to attach bubbles as much as possible to flocs. Therefore, the maximum number of attached bubble on a floc and the rise velocity of bubble-floc agglomerates considered as the most important factor to design the separation zone of flotation tank in DAF process was simulated based on the population balance theory. According to the simulation results of this study, the size and volume concentration of bubble influenced on the possible number of attached bubble on a floc. The agglomerates attached with smaller bubble was more sensitive to hydraulic loading rate in the separation zone of DAF process. For the design of a high rate DAF process applied over surface loading 40 m/hr. it is required a precise further study on the variation of bubble property and behavior including in terms of bubble size distribution.

• Journal of Welding and Joining
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• v.32 no.4
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• pp.39-45
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• 2014

Today, the development of digitized information media and info-communications are bringing many changes. Due to the development of IT thechnology, we can learn wherever, whenever, regardless of time and place. Machine drawing subject is a very important in mechanical engineering course, but it's studyed only basic theory in a short period, average 1~2weeks. So that, students think that the mechanical drawing is of minor importance. Such ideas make them difficult to impove sense of space in isometric drawing and drawing skill. Therefore, in this paper, augmented reality-based contents through the system, Mechanical Drawing of education to meet the effectiveness and satisfaction, student learning can be spontaneously it was construct self-system. And, Theoretical part of the Mechanical Drawing is proposed ensure more efficient and easier training. In this paper, we were test operation for user effectualness of proposed service at Korea Polytechnics Colleges a industrial facilities management in Daegu. Target user are 66 students, and The students were divided into experimental group and comparison group. Experimental results, experimental group was able to do systematically experience many Projection Drawing and Pictorial Drawing in short schooltime. And, The test operation results showed that have the possibility to meet education effectiveness and user satisfaction in this augmented reality-based contents system.

• The Journal of the Korea Contents Association
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• v.9 no.7
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• pp.241-247
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• 2009

The purpose of this study was to investigate consciousness about the disabled on dental hygiene students and search for course of dental hygiene education as oral health care with the disabled. The subjects in this study were 538 dental hygiene students from three college in Jeonnam province. For statistical analyses of collected data, the descriptive analyses and chi-square were adopted. The obtained results were as follows. Seniors showed positive attitude about the disabled and dental service of the disabled(p<0.05). The common types of contact the disabled were physical Cerebral palsy and inner disabled were rarely. The problems are difficulty in communication, short of clinical experience in dental service of the disabled, noncooperation of the disabled, short of knowledge in dental service of the disabled. To dental service of the disabled, demand as necessity of education was 87.5%, theory and practice at the same time was 68.0% in pattern of education. Finally, 49.5% of respondents observed special dental clinic to utilization pattern of dental service of the disabled.