• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.1
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• pp.67-71
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• 2010

Impingement of a high power laser pulse (above 1 GW/$cm^2$) on a metal foil causes its ablation, which is characterized by a rapid expulsion of matter and the initiation of a strong shock wave inside the solid metal. The shock propagates through the foil and reverberates on the rear side, causing its deformation and microparticle ejection, which were deposited on the foil prior to ablation. Based on this principle, we are developing a new drug delivery system - Biolistic gun. Current study is focused on the controllability, stability, efficiency of the system, and characterization of the penetration shapes in various conditions. We have tested the system by applying direct and confined ablation. Several different media combinations were used for confinement-BK7 glass, water, BK7 glass with water, and succulent jelly(ultrasono jelly, RHAPAPHRM). Biological tissue was replicated by a 3% gelatin solution. Present data shows that the confinement results in enhancement of penetration shape reached by 5 um cobalt microparticles. Based on the analysis of the experimental results we observe that the penetration shape of microparticles can be controlled by adjusting the thickness of confinement media.

• Journal of the Korean GEO-environmental Society
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• v.15 no.11
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• pp.53-59
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• 2014

It has been generally recognized that the conventional rockfall protection nets have several problems to actual field application in the aspect of shock absorption, lack of pullout bearing capacities, and net damages. Because of the recognition, authors have tried to develop a new rockfall protection system consisted of shock absorption parts and hexagonal net configuration. In the previous research by the authors, the performance of the newly developed rockfall protection system has been investigated through the laboratory tests and the full-scale testing. In this study, subsequently, numerical analysis program is organized to make a confirmation of the structural stability and performance. For the correct design procedure of the hexagonal net system, it is essential to understand the various mechanical behavior of the entire system. It is also important to be reproduced the systematic characteristics of the system acquired by laboratory and full-scale testing by numerical analysis in order to carry out the numerical experiment to understand various mechanical behavior of the system. As a conclusion, the hexagonal net has better performance in mechanical and physical behavior compared with that of the rectangular net. Furthermore, due to the hexagonal net shows a good performance in aspect of the load distribution, it gives a good alternative in long-term management of the rockfall protection net.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.2 s.51
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• pp.141-146
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• 2005

Unstable cosmetic active ingredients could rapidly break down in chemical and photochemical process. Therefore, it has become a very important issue to encapsulate active ingredient for the stabilization. 7-Dehydrocholesterol (7-DHC), a precursor of vitamin $D_3$, has been shown to increase levels of protein and mRNA for heat shock protein in normal human epidermal keratinocytes. However, topical dermal application of 7-DHC is restricted due to its poor solubility and chemical unstability. In this study, 7-DHC was incorporated into nano-emulsion (NE), solid lipid nano-particle (SLN), and chitosan coated solid lipid nano-particle (CASLN), respectively. In order to prepare NE and SLN dispersion, high-pressure homogenization at temperature above the melting point of lipid was used Hydrogenated lecithin and polysorbate 60 were used as stabilizer for NE and SLN. CASLN was prepared by high speed homogenizing after adding chitosan solution to the SLN dispersion and showed positively charged particle properties. Decomposition rate of 7-DHC in NE, SLN and CASLN was studied as a function of time at different temperature. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) studies were performed to characterize state of lipid modification. It appeared that CASLN is the most effective to stabilize 7-DHC and may be used for a useful topical dermal delivery system.

• Korean Journal of Applied Biomechanics
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• v.20 no.4
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• pp.395-406
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• 2010

The purpose of this study was to analyze the changes in kinematic and kinetic parameters of lower extremity joint according to rehabilitation period. Fourteen collegiate male athletes(age: $22.1{\pm}1.35$ years, height: $182.46{\pm}9.45cm$, weight: $88.63{\pm}9.25kg$) and fourteen collegiate athletes on functional ankle instability(age: $21.5{\pm}1.35$ years, height: $184.45{\pm}9.42cm$, weight: $92.85{\pm}10.85kg$) with the right leg as dominant were chosen. The subjects performed drop landing. The date were collected by using VICON with 8 camera to analyze kinematic variables and force platform to analyze kinetic variables. There are two approaches of this study, one is to compare between groups, the other is to find changes of lower extremity joint after rehabilitation. In comparison to the control group, FAI group showed more increased PF & Inversion at IC and decreased full ROM when drop landing. Regarding the peak force and loading rate, it resulted in higher PVGRF and loading. FAI group used more increased knee and hip ROM because of decreased ankle ROM to absorb the shock. And it used sagittal movement to stabilize. In terms of rehabilitation period, FAI group showed that landing patterns were changed and it increased total ankle excursion and used all lower extremity joint close to normal ankle. Regarding the peak force and loading rate, FAI group decreased PVGRF and loading rate. and also showed shock absorption using increased ankle movement. And COP variable showed that proprioception training increased stability during 8 weeks. The results of this study suggest that 8 weeks rehabilitation period is worthwhile to be considered as a way to improve neuromuscular control and to prevent sports injuries.

• Journal of Drive and Control
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• v.13 no.2
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• pp.10-18
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• 2016

A front-end loader (FEL) mounted on an agricultural tractor is one of the most commonly used implements to mechanize routine agricultural tasks. When the FEL is used with a loaded bucket, careful operation is required to maintain safety and avoid spillage when the tractor passes a bump because a change in the gravity center of the tractor due to varied loadings can affect the stability of the tractor. Use of a boom suspension system consisting of accumulators and orifice dampers can be instrumental in reducing pitching vibrations while increasing the handling performance of the FEL-mounted tractor. The objective of this research was to reduce bump shocks by adding an orifice and a flow control valve to the original hydraulic circuit composed solely of accumulators. A simulation study was performed using the SimulationX program to investigate the effects of an accumulator and an orifice-throttle damper on bump shocks. Results showed that the peak pressure on a boom cylinder and the vertical acceleration of a bucket were significantly affected by use of both an accumulator and an orifice damper. In a field test conducted with a 75-kW tractor, the peak pressure of the boom cylinder, and the root mean square (RMS) vertical acceleration of the bucket and seat were reduced by on average, 23.0, 42.2, and 44.9% respectively, as compared to those measured with the original accumulator system, showing that an improved design for the accumulator hydraulic circuit can reduce bump shocks. Further studies are needed to design a tractor suspension system that includes the effects of cabin suspension and tires as well as dynamic analysis.

• Journal of Pharmacopuncture
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• v.22 no.1
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• pp.28-34
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• 2019

Background: Breast cancer is a complex, heterogeneous disease and one of the most common malignancies in women worldwide. The efficacy of chemotherapy as an important breast cancer treatment option has been severely limited because of the inherent or acquired resistance of cancer cells. The molecular chaperone heat shock protein 90 (HSP90) upregulated in response to cellular stress is required for functions such as conformational maturation, activation and stability in more than 200 client proteins, mostly of the signaling type. In this study, the expression of HSP90 isoforms including $HSP90{\alpha}$ and $HSP90{\beta}$ in breast cancer cell lines before and after treatment with doxorubicin (DOX) was assessed. Material and Methods: The cell cytotoxicity of DOX in MDA-MB-231 and MCF-7 cell lines was determined using the MTT assay. immunofluorescence and western blotting techniques were used to determine the expression of $HSP90{\beta}$ in the cell lines before and after DOX treatment. Immunofluorescence was also conducted to ascertain the expression of $HSP90{\alpha}$. Results: The MTT assay results showed that the MDA-MB-231 cells ($IC_{50}=14.521{\mu}M$) were more sensitive than the MCF-7 cells ($IC_{50}=16.3315{\mu}M$) to DOX. The immunofluorescence results indicated that the expression of $HSP90{\alpha}$ in both cell lines decreased after exposure to DOX. The western blot and immunofluorescence analyses showed that $HSP90{\beta}$ expression decreased in the MCF-7 cells but increased in the MDA-MB-231 cells after DOX treatment. Conclusion: The obtained results suggested that $HSP90{\alpha}$ and $HSP90{\beta}$ expression levels were reduced in the MCF-7 cells after exposure to DOX. In the MDA-MB-231 cells, $HSP90{\alpha}$ expression was reduced while $HSP90{\beta}$ was found to be overexpressed following DOX treatment.

• Fashion & Textile Research Journal
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• v.16 no.6
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• pp.1001-1007
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• 2014

We surveyed the wearing characteristics of hip protectors. The problems of existing hip protectors were identified and the directions for improvement were presented. The evaluation of wearing characteristics was conducted on the 100 elderly women (60 to 85 years) with 5 types of hip protector. The questionnaire was composed of history and characteristics on falling, hip protector acceptance, preference, use characteristics and improvement requirements. The result of wearing characteristic evaluation indicated that 52% of the subject experienced falling in winter. Incidents resulting from falling occurred: outdoors (74.5%), bathroom (10.9%), and kitchen (5.5%). Body parts to be protected were in several areas: 35.6% for lumbar, 26.9% for hip joint, and 15% for hip bone. Participants prefer a belt B type design at a rate of 56.9% because it provided a sense of stability by clinging to the body and upholding the waist. Belt B type was the most appropriate in terms of fit, allowance, mobility, and design except pad thickness. To reduce the risk of hip fracture, hip protector needs to be designed in consideration of user's type of fall and body shape. The pattern and size of a hip protector has to be improved in regards to the amount of discomfort. An objective evaluation is needed for the ergonomic design of a hip protector based on and analysis of 3D body image of the elderly and the shock-absorbing quality of pad.

• Transactions of the Korean hydrogen and new energy society
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• v.25 no.3
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• pp.271-279
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• 2014

A 25kW-class polymer electrolyte membrane (PEM) fuel cell system has been developed for the propulsion of a leisure boat. The fuel cell system was designed to satisfy various performance requirements, such as resistance to shock, stability under rolling and pitching oscillations, and durability under salinity condition, for its marine applications. Then, the major components including a 30kW-class PEM fuel cell stack, a DC-DC converter, a seawater cooling system, secondary battery packs, and balance of plants were developed for the fuel cell system. The PEM fuel cell stack employs a unique design structure called an anodic cascade-type stack design in which the anodic cells are divided into several blocks to maximize the fuel utilization without hydrogen recirculation devices. The performance evaluation results showed that the stack generated a maximum power of 31.0kW while maintaining a higher fuel utilization of 99.5% and an electrical efficiency of 56.1%. Combining the 30-kW stack with other components, the 25kW-class fuel cell system boat was fabricated for a leisure. As a result of testing, the fuel cell system reached an electrical efficiency of 48.0% at the maximum power of 25.6kW with stable operability. In the near future, two PEM fuel cell systems will be installed in a 20-m long leisure boat to supply electrical power up to 50kW for propelling the boat and for powering the auxiliary equipments.

• Journal of Korean Society of Steel Construction
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• v.24 no.1
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• pp.73-80
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• 2012

The adoption of a composite beam system is regarded as a simple but effective solution because it improves the overall stiffness, strength and stability of the structure by welding shear studs. However, welding shear studs poses problems including electric shock and weld defects. Mechanical methods have emerged as an alternative to metallurgical methods for connecting the H-beam and shear connector. Four specimens were tested in order to compare the structural behavior of the proposed composite beams with that of the classical composite beam given the condition of horizontal loading. With the original composite beam (FCB-SB specimen) using stud bolts, hysteresis loops are stable, but its strength decreased with the crashing of the concrete slab around the column. The suggested composite beams using shear connectors also yielded stable hysteresis loops. Consequently, use of the suggested composite beams instead of the original composite beam are recommended.

• Journal of Korea Water Resources Association
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• v.34 no.1
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• pp.45-55
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• 2001

Transcritical flow is a term intended to denote the existence of both supercritical and subcritical flows within a computational domain. The major problems that need to be addressed while modeling transcritical flows include handling the differing features of signal propagation in subcritical and supercritical flow regions and maintaining conservation. The present study proposes the implicit ENO method as a high-resolution scheme for transcritical flow. This implicit ENO scheme is based on the ENO method, a new class of uniformly high-order-accurate essentially non-oscillatory implicit scheme, which has the advantage of unconditional stability. The implicit ENO scheme has not been used for the transcritical flow in open channel until now. As a result of application to the hypothetical dam-break flow, the implicit ENO scheme was ploved to produce accurate results with good robustness even though in the case of verb strong shock wave.