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http://dx.doi.org/10.3795/KSME-B.2010.34.1.67

New Drug Delivery System Based on a Laser-Induced Shockwave  

Han, Tae-Hee (School of Mechanical and Aerospace Engineering, Seoul National University)
Lee, Hyun-Hee (School of Mechanical and Aerospace Engineering, Seoul National University)
Gojani, Ardian B. (School of Mechanical and Aerospace Engineering, Seoul National University)
Yoh, Jai-Ick (School of Mechanical and Aerospace Engineering, Seoul National University)
Publication Information
Transactions of the Korean Society of Mechanical Engineers B / v.34, no.1, 2010 , pp. 67-71 More about this Journal
Abstract
Impingement of a high power laser pulse (above 1 GW/$cm^2$) on a metal foil causes its ablation, which is characterized by a rapid expulsion of matter and the initiation of a strong shock wave inside the solid metal. The shock propagates through the foil and reverberates on the rear side, causing its deformation and microparticle ejection, which were deposited on the foil prior to ablation. Based on this principle, we are developing a new drug delivery system - Biolistic gun. Current study is focused on the controllability, stability, efficiency of the system, and characterization of the penetration shapes in various conditions. We have tested the system by applying direct and confined ablation. Several different media combinations were used for confinement-BK7 glass, water, BK7 glass with water, and succulent jelly(ultrasono jelly, RHAPAPHRM). Biological tissue was replicated by a 3% gelatin solution. Present data shows that the confinement results in enhancement of penetration shape reached by 5 um cobalt microparticles. Based on the analysis of the experimental results we observe that the penetration shape of microparticles can be controlled by adjusting the thickness of confinement media.
Keywords
Drug Delivery System; Laser Ablation; Plasma; Shockwave;
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