• The Korean Journal of Cytopathology
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• v.5 no.1
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• pp.10-14
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• 1994

The expression of sex steroid hormone receptors by neoplastic cells is an important predictor of response to hormone therapy. Thus, the selection of treatment modality is often based on the identification of receptors in tumor tissue. Various monoclonal antibodies of high specificity are now available for analyzing the estrogen receptor (ER). With these antibodies, biochemical enzyme immunoassay and immunohistochemistry using histologic sections have been used for ER analysis. We used fine needle aspirates from 15 human primary breast carinomas for the analysis of ERs. The semiquantitative receptor values obtained in cytologic specimens were correlated well with those from histologic specimens. The results of ER in fine needle aspirates were concordant with ER in histologic specimens(r=0.94). Only three cases showed a little difference in staining intensity and proportion of positive cells. Our results showed a good correlation between the receptor values determined in cytologic smears and those determined in tissue sections. It is suggested that measurement of the ER in cytologic smears may be a reliable technique which can be performed on aspiration cytologic samples.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.1
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• pp.145-156
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• 2016

Objective : We performed a literature review for developing the clinical phenotype evaluation system of atopic dermatitis.Methods : We searched the papers that describe symptoms for atopic dermatitis through Oriental Medicine Advanced Searching Integrated System(OASIS) and Korean Studies Incategoryation Service System(KISS). We looked through all the papers and finally chose 47 papers that are suitable for inclusion. Then, we extracted symptoms from these papers and arranged them in order of frequency and validity through experts' conference.Results : We found 360 papers and chose 47 papers. We decided to include general information of patients, systemic and dermatologic symptoms in evaluation category of atopic dermatitis. Through experts' conference, it was decided that general information has age, sex and body type; Systemic symptoms have 9 items; Dermatologic symptoms have 15 items.Conclusion : To evaluate atopic dermatitis objectively, the standardization of diagnostic tool is needed. Therefore we developed a clinical phenotype evaluation system of atopic dermatitis.

• Korean Journal of Environment and Ecology
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• v.23 no.5
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• pp.460-470
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• 2009

The purpose of this research is to suggest appropriate directions for the desirable ecotourist attraction management through the investigation of the tourist's satisfaction with ecotourism in case of Geumgang birdwatching destination. This research focus on the identification of the determinants of the ecotourist's satisfaction and the estimated regression model. The results of this study for the tourist's satisfaction with the ecotourism are summarized as follows. First, as a result of the factor analysis of the tourist's satisfaction variables, five factors like 'knowledge information', 'experience', 'ecological value', 'guide service', 'facilities environment' are deduced. Second, as a result of the test of significance, the difference of the satisfaction with ecotourism in aspect of the tourist's demographic characteristics like age and academic background is confirmed to be statistically significant except sex. Third, the tourist's satisfaction with ecotourism appears to be positively correlative with the tourist's overall satisfaction.

• Imaging Science in Dentistry
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• v.43 no.1
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• pp.1-6
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• 2013

Purpose: This study investigated the possible correlation between the mineralization of the second molars and the chronological age of a sample population of the state of Paraiba, Brazil. Materials and Methods: One thousand eight hundred fifty-four digitized panoramic images using a scanner of a private dental radiology service were obtained in six months. Of these, 457 were selected from patients aged 4.6 to 16 years who met certain criteria. The images were assessed twice by a radiologist with 5 years experience. A minimum interval of 30 days between the evaluations of the same patient was established. To analyze the relationship between chronological age, calcification level proposed by Demirjian et al in 1973, gender, and tooth, a multiple linear regression model was adjusted, taking age as the response variable (p<0.05). Results: The gender and calcification level were significantly correlated with the age of the patients (p<0.05). There was a significant difference between the average age of the patients' upper teeth compared to the lower ones in both genders (p<0.05). The dental development occurred earlier in female individuals than in male ones, and there was no significant difference between the right and left second permanent molars. Conclusion: It was observed that ethnic variables are related to certain parameters of age and sex identification in the Brazilian population, providing important information for forensic evaluations.

• Korean Journal of Korean Medical Institute of Dermatology and Aesthetics
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• v.1 no.1
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• pp.114-126
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• 2005

Objectives : The results of this study have given an insight into the clinical effects of Chungsang-bangpoong-tang, Gami-bunso-tang, Chogyung-san on treatments against Acne patients. Methods : We are investigated with deciphered-Acne 54 cases at the division of dermatology in Jaseng oriental medicine hospital from 9, August 2000 to until 26, February 2001. To demonstrated in accordance with patients, orally administrated with Chungsang-bangpoong-tang, Gami-bunso-tang, Chogyung-san, respectively. Results : These results found that sex distinction with a disease caused much more 85.2% female than 14.8% male in the proportion of males to females. specifically, which is mainly ranked with 21 to 25 years of female and 26 to 30 years of male. On the hand, the distribution interval of a case history is broadly followed by disease below 10 to 35 years in male, whereas 21 to 25 years in female. Also, interval of the period-treatment is indicated within more than five years both female and male. In point-lesion, facies is majority and according to the cheek, jaw, back, frontal and the whole body, respectively. Specifically, mainly appeared according to the facies, back, whereas facies, cheek in female. In Distribution of Symptomic Identification, most of them is 肺經風熱, and then 衝任不調型, 脾胃濕熱, Etc. The self-assessment of total is Excellent 4 cases, Good 4 cases, Fair 11 cases, Poor 2 cases. Conclusions : These results suggest that in the identify of symptoms as 肺經風熱, 脾胃濕熱, 衝任不調型 may be playa role in the significant usefulness and have need of application for the clinical trials against Acne' patients.

• Molecules and Cells
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• v.28 no.5
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• pp.455-461
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• 2009

Calcineurin is a $Ca^{2+}$/Calmodulin activated Ser/Thr phosphatase that is well conserved from yeast to human. It is composed of catalytic subunit A (CnA) and regulatory subunit B (CnB). C. elegans homolog of CnA and CnB has been annotated to tax-6 and cnb-1, respectively and in vivo function of both genes has been intensively studied. In C. elegans, calcineurin play roles in various signaling pathways such as fertility, movement, body size regulation and serotonin-mediated egg laying. In order to understand additional signaling pathway(s) in which calcineurin functions, we screened for binding proteins of TAX-6 and found a novel binding protein, HLH-11. The HLH-11, a member of basic helix-loop-helix (bHLH) proteins, is a putative counterpart of human AP4 transcription factor. Previously bHLH transcription factors have been implicated to regulate many developmental processes such as cell proliferation and differentiation, sex determination and myogenesis. However, the in vivo function of hlh-11 is largely unknown. Here, we show that hlh-11 is expressed in pharynx, intestine, nerve cords, anal depressor and vuvla muscles where calcineurin is also expressed. Mutant analyses reveal that hlh-11 may have role(s) in regulating body size and reproduction. More interestingly, genetic epistasis suggests that hlh-11 may function to regulate serotoninmediated egg laying at the downstream of tax-6.

• Proceedings of the Zoological Society Korea Conference
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• 1999.10b
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• pp.31-31
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• 1999

Characterization of mutant mice has been utilized as an animal model for the study of human inherited diseases. In addition to the pathogenesis stduy using the mutant mice, the mice have been used for the identification of the genes causing the phenotypes. Functional cloning and positional cloning are two approaches, depending on the phenotypes of the mutant mice. Though it takes a long time positional cloning has been well used to identify the gene of which function can not be presumed from the mouse phenotype. Recently by the advance of the molecular tools and the human genome project close to 10,000 genetic markers are developed to make the procedure faster. We obtained a new mutant mouse, sims, spontaneously arose and the affected mouse has a mild tremor and seizure was observed. Homozygote in either sex is sterile since uterus growth in female and seminal vesicle in male are not induced for the growth in puberty, implying the abnormal hormonal regulation during puberty. Supporting this, there is no detectable testosterone in the serum of the mutant male and the brain of the mutant is 30% heavier than littermate. To identify the location of the mutated gene, intraspecies cross to CAST/Ei was carried out and the 37 affected mice was analyzed for the linkage. The gene was mapped on chromosome 18, 20 cM from the centromere. More than 500 F2 progenies have been analyzed for the linkage and the locus becomes narrow within 3cM between Egrl and Fgf gene.f gene.

• Journal of the Korea Convergence Society
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• v.10 no.8
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• pp.237-243
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• 2019

This study used latent profile analysis to identify heterogeneous subgroups with respect to the perception of work environment among workers in residential facilities for people with disabilities. The final model yielded five latent profiles of the perception of work environment: 'low workload group' who scored low in time pressure and job responsibility, 'discrimination perception group' who scored low in supervisor support and high in sex and academic/regional discriminations, 'positive perception group' who scored high in work autonomy and peer and supervisor supports, 'high workload group' who scored high in workload, time pressure, and job responsibility, and 'average group' who scored average in most areas. In the case of job satisfaction, positive perception group was the highest, followed by average group, low and high workload groups, and discrimination perception group.

• Genomics & Informatics
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• v.16 no.4
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• pp.31.1-31.7
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• 2018

The prevalence of metabolic syndrome (MS) in the nonobese population is not low. However, the identification and risk mitigation of MS are not easy in this population. We aimed to develop an MS prediction model using genetic and clinical factors of nonobese Koreans through machine learning methods. A prediction model for MS was designed for a nonobese population using clinical and genetic polymorphism information with five machine learning algorithms, including naïve Bayes classification (NB). The analysis was performed in two stages (training and test sets). Model A was designed with only clinical information (age, sex, body mass index, smoking status, alcohol consumption status, and exercise status), and for model B, genetic information (for 10 polymorphisms) was added to model A. Of the 7,502 nonobese participants, 647 (8.6%) had MS. In the test set analysis, for the maximum sensitivity criterion, NB showed the highest sensitivity: 0.38 for model A and 0.42 for model B. The specificity of NB was 0.79 for model A and 0.80 for model B. In a comparison of the performances of models A and B by NB, model B (area under the receiver operating characteristic curve [AUC] = 0.69, clinical and genetic information input) showed better performance than model A (AUC = 0.65, clinical information only input). We designed a prediction model for MS in a nonobese population using clinical and genetic information. With this model, we might convince nonobese MS individuals to undergo health checks and adopt behaviors associated with a preventive lifestyle.

• Journal of the Korea Society of Computer and Information
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• v.14 no.10
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• pp.111-121
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• 2009

Public Information Documental of the administrative, legislative and judicial etc. is lastingness documental and need administration. Whenever the crime event happens, judicature's documental is lent frequently to reference data and is returned, event posting of documental, hysteresis inquiry, lending/return, conservation search, documental exhaust management must consist for administration of lastingness documental. RFID is utilized by the practical use plan of recent Ubiquitous information. Because attaching tag to lastingness documental that use RFID in this treatise, register and manage documental, and chase hysteresis, and design upkeep, present condition analysis of lastingness documental to search, S/W, H/W, network layout, Ubiquitous RFID lastingness recording administration system. Construct lastingness recording administration system after a performance experiment and a chase experiment that is applied in spot that attach 900MHz important duty's RFID tag. After construction practice, create link sex with connection system, security analysis and Forensic data and analyze improvement effect. Is going to contribute Ubiquitous information technology application and Forensic technology development in country documental administration through. research of this treatise.