The Korean Journal of Cytopathology (대한세포병리학회지)

The Korean Society for Cytopathology (대한세포병리학회)
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Estrogen Receptor Analysis in Fine Needle Aspirates and Frozen Sections from Human Breast Carcinomas

세침흡인 검사물을 이용한 유방암세포 에스트로젠수용체 분석 : 동결절편조직과의 비교

  • Gong, Gyung-Yub (Departments of Pathology, Asan Medical Center College of Medicine, University of Ulsan) ;
  • Ahn, Se-Hyun (Departments of General Surgery, Asan Medical Center College of Medicine, University of Ulsan) ;
  • Park, Kun-Choon (Departments of General Surgery, Asan Medical Center College of Medicine, University of Ulsan) ;
  • Choe, Ghee-Young (Departments of Pathology, Asan Medical Center College of Medicine, University of Ulsan) ;
  • Yu, Eun-Sil (Departments of Pathology, Asan Medical Center College of Medicine, University of Ulsan) ;
  • Lee, In-Chul (Departments of Pathology, Asan Medical Center College of Medicine, University of Ulsan)
  • 공경엽 (울산대학교 의과대학 서울중앙병원 병리학교실) ;
  • 안세현 (울산대학교 의과대학 서울중앙병원 일반외과학교실) ;
  • 박건춘 (울산대학교 의과대학 서울중앙병원 일반외과학교실) ;
  • 최기영 (울산대학교 의과대학 서울중앙병원 병리학교실) ;
  • 유은실 (울산대학교 의과대학 서울중앙병원 병리학교실) ;
  • 이인철 (울산대학교 의과대학 서울중앙병원 병리학교실)
  • Published : 1994.06.30
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Abstract

The expression of sex steroid hormone receptors by neoplastic cells is an important predictor of response to hormone therapy. Thus, the selection of treatment modality is often based on the identification of receptors in tumor tissue. Various monoclonal antibodies of high specificity are now available for analyzing the estrogen receptor (ER). With these antibodies, biochemical enzyme immunoassay and immunohistochemistry using histologic sections have been used for ER analysis. We used fine needle aspirates from 15 human primary breast carinomas for the analysis of ERs. The semiquantitative receptor values obtained in cytologic specimens were correlated well with those from histologic specimens. The results of ER in fine needle aspirates were concordant with ER in histologic specimens(r=0.94). Only three cases showed a little difference in staining intensity and proportion of positive cells. Our results showed a good correlation between the receptor values determined in cytologic smears and those determined in tissue sections. It is suggested that measurement of the ER in cytologic smears may be a reliable technique which can be performed on aspiration cytologic samples.

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