• Journal of Digestive Cancer Research
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• 제11권2호
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• pp.61-65
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• 2023

Globally, esophageal cancer is the seventh most common cancer, and the male-to-female ratio in esophageal adenocarcinoma (EAC) is significantly imbalanced at 4:1 to 8:1. Obesity, reflux, and smoking are known risk factors for this sex difference; however, fully explaining this remains challenging. Studies have investigated the link between exogenous sex hormones and esophageal cancer occurrence. A meta-analysis revealed a lower risk of EAC in female who had undergone hormone replacement therapy. Androgen-deprivation therapy in patients with prostate cancer was associated with a decreased risk of EAC. Tissue-based studies have reported varied results regarding the relationship between estrogen receptor expression and survival in female patients with esophageal squamous cell carcinoma (ESCC). Circulating hormone studies have suggested that higher testosterone and luteinizing hormone levels decreased EAC risk in men, and free testosterone was inversely correlated in female with ESCC. However, a high androgen-estrogen ratio in male patients with EAC was linked to increased odds of EAC. Sex hormones influence carcinogenesis, affecting cell proliferation, differentiation, metabolism, inflammation, and cell death. The studies were limited by the small sample size and varying hormone measurement methods; thus, future studies with definitive conclusions on the association between esophageal cancer and sex hormones are warranted.

• 한국수산과학회지
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• 제47권6호
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• pp.882-887
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• 2014

We studied oocyte steroidogenesis in blacktip grouper Epinephelus fasciatus ovarian follicles during vitellogenesis. Vitellogenic oocytes with average diameters of 0.45, 0.48 and 0.50 mm were incubated in vitro in the presence of $[^3H]17{\alpha}$-hydroxyprogesterone as a precursor. The steroid metabolites were analyzed using thin layer chromatography (TLC), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC/MS). The major metabolites in the vitellogenic oocytes were androstenedione ($A_4$), testosterone (T), estradiol-$17{\beta}$ ($E_2$), and estrone ($E_1$). The metabolites of androgen ($A_4$ and T) were higher in the 0.50-mm oocytes than in the 0.45- and 0.48-mm oocytes, while the estrogen metabolites (E2 and E1) were lower in the 0.50-mm oocytes. These results suggest that 0.50-mm oocytes are fully vitellogenic following initiation of the maturation process.

• Fisheries and Aquatic Sciences
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• 제25권1호
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• pp.12-19
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• 2022

In the present study, we investigated the effects of recombinant eel gonadotropins (rec-GTHs) on maturation induction in immature ovarian culture in vitro and sex steroid hormones in vivo in the Japanese eel Anguilla japonica. To study the in vitro effects of rec-GTHs on estradiol-17β (E2) production in immature ovarian tissues, ovarian tissues were incubated with different doses of rec-follicle-stimulating hormone (rec-FSH) or rec-luteinizing hormone (rec-LH). The results revealed that the E2 levels in the rec-FSH (0.1, 0.5, or 1 ㎍/mL)- and rec-LH (0.1 or 0.5 ㎍/mL)-treated groups were significantly higher than those in the female eels from the control group. Furthermore, to investigate the in vivo effects of rec-GTHs on the gonadosomatic index (GSI) and plasma sex steroid hormone levels, the eels were injected intraperitoneally with eel's ringer (control), salmon pituitary extract (SPE; for female eels), human chorionic gonadotropin (hCG; for male eels), rec-FSH, rec-LH, and rec-FSH + rec-LH once a week. The results revealed that except for the SPE and the hCG groups, none of the groups exhibited a significant difference in GSI values. However, in vivo plasma E2 levels increased at the end of 4 weeks after rec-FSH treatment in female eels. Based on these results, it is suggested that rec-GTHs may have a positive effect on sexual maturation in female eels; however, further studies on complementary rec-protein production systems and additional glycosylation of rec-hormones are needed to elucidate hormone bioactivity in vivo and in vitro.

• 약학회지
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• 제17권2호
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• pp.92-102
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• 1973

Hormone이 암발생과 밀접한 관계가 있음은 이미 1935년대에 밝혀진 바 있다. 즉 lacassagne은 estrogen이 토끼 자궁벽의 fibromyomatous transformation에 영향을 준다고 하였다. Nelson는 guinea-pig를 시험동물로 해서 estrogen을 장기투여한 결과 uterine fibroids가 수발됨을 확인한 이래, 유발됨을 확인한 이래, 이러한 hormone이 암발생의 장기요인이 됨으리 밝히게 되었다. 이러한 업적은 Lipschutz에 의해 더욱 수식되었다. 이러한 업적의 결과가 여러편의 종설로 발표되었다. 즉 Lacassagne, Zuckerman, Burrows등, Gardner는 각기 종설을 발표하여 이를 확증하기에 이르렀다. 한편 각개 hormone, 그중에서도 sex-hormone의 opposite action은 Steinach등 및 Sand에 의해 밝혀졌고 거세백서에 estrogen을 투여했을때 유기되는 vaginal mucosa의 epidermization이 testosterone의 투여에 의해 급속히 소진됨을 Currier 일파가 증명하였고 estrogen에 의해 유발된 웅백서 부속성선의 조직변성이 androgen의 동시투여의 소실됨이 homone에 의해 유발된 neoplastic에 대해 유효하리하는 것은 백명한 일이고 이러한 사실은 현재 실시로 허다히 이용되고 있는 것이다.

• Clinical and Experimental Reproductive Medicine
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• 제38권4호
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• pp.179-185
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• 2011

The ultimate function of the endometrium is to allow the implantation of a blastocyst and to support pregnancy. Cycles of tissue remodeling ensure that the endometrium is in a receptive state during the putative 'implantation window', the few days of each menstrual cycle when an appropriately developed blastocyst may be available to implant in the uterus. A successful pregnancy requires strict temporal regulation of maternal immune function to accommodate a semi-allogeneic embryo. To preparing immunological tolerance at the onset of implantation, tight temporal regulations are required between the immune and endocrine networks. This review will discuss about the action of steroid hormones on the human endometrium and particularly their role in regulating the inflammatory processes associated with endometrial receptivity.

• 한국양식학회지
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• 제17권3호
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• pp.161-166
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• 2004

The influence of TBTO (Tributyltin-Oxide) at a series of concentrations (0.52, 1.41 and 3.05 $\mu$g/L) for a period of 3 weeks on estradiol-17$\beta$, testosterone and cortisol levels in male Korean rockfish, Sebastes schlegeli was investigated. Compared to the stable concentration of estradiol-17$\beta$, plasma testosterone level was decreased significantly at the 3rd week after TBTO exposure in plasma of fish (＞1.41 $\mu$g/L). The most profound physiological variation in TBTO exposed fish was a dramatic increase in plasma cortisol level at 3rd week. Conclusively, TBTO exposure caused increase level of cortisol as well as alteration of testosterone in the Korean rockfish. These results suggest that TBTO at environmentally relevant (nanomolar) concentrations disrupt endocrine secretions.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1981년도 제15차 학술대회연제순서 및 초록
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• pp.14.3-15
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• 1981

상기도에 오는 Midline Granuloma는 비강, 부비동 및 인후두부에 발생하여 국소성 괴저성 염증 및 육아종이 진행성으로 주위조직을 침범하여 결국은 사망을 초래케되는 불치의 병으로 알려져 왔다. 이 질환은 1897년 McBride에 의하여 처음으로 기술되었고, 1933년 Stewart이래 많은 임상적 및 조직학적 연구가 있었다. 그러나 현재까지 그 원인 및 확실한 치료방법이 알려져 있지 않고 있다. 본원에서는 1964년 1월부터 1980년 12월까지 17년간 Midline Granuloma로 진단받고 치료받은 15례에 대한 임상적 관찰과 방사선치료 및 Steroid병용요법으로 치료받은 7례를 분석하여 다음과 같은 결과를 얻었다. 1) 성별 및 연령 : 30세부터 39세사이가 6례 (40%)로 가장 많았으며, 남자 13례 (87%) 여자 2례 (13%)였다. 2) 초발 병변 부위는 비강 및 비중격 부위가 8례 (53%), 인두편도 3례 (20%) 및 인두부 2례 (13%)의 순이었다. 3) 증상으로는 비폐색과 인두통이 각각 6례 (40%)로 가장 많았고, 두통5례(33%), 비루 및 안면 부종이 각각 3례(20%)의 순이었다. 4) 4례에서 균을 검출하였으며 포도상구균 2례, 녹농군 1례, 연쇄상구균이 1례였다. 5) 방사선 치료와 Steroid병용요법을 실시한 7례에서는 전례에서 현재까지 추적 관찰한 결과 재발이나 악화가 없었다. 6) Steroid와 항생제 치료를 받았던 5례중 2례는 사망하였고 3례는 일시적인 증상의 호전을 보였으나 그 후 악화를 보였다.

• 한국가축번식학회지
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• 제13권1호
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• pp.40-48
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• 1989

Guppy fry were treated for the first 40 days of life with 0, 20, 40, 60 & 100$\mu\textrm{g}$ of estradiol per gram of food in order to change the sex of normal males to functional females(genetic male). The present investigation deals with the effects of steroid hormones, such as $\beta$-estradiol and testosterone, on the sex differentiation in guppy and tilapia. The results obtained were summarized as follows. 1. In B (20$\mu\textrm{g}$/g diet) group 17$\beta$-estradiol-treated, 67.8% of male offsprings were produced. 2. In D (60$\mu\textrm{g}$/g diet) group 17$\beta$-treated, 67% of female offsprings were produced. 3. B, D groups of genetic male brooders had significantly different effects (P<0.01) upon sex ratios of their progeny. 4. This strongly indicates that sex direction has been achieved and that the male is the heterogametic sex. 5. The group that produced the highest percentage of male offspring(male percentage of observed number to expected number was 91%) contained only full-sibling male brooders to the sex-reversed female brooders. 6. After 7 months following treatment, the sex-reversed males had ovarian portion in the anterior region and a testicular portion in the posterior region of the same intersexual gonad, respectively. 7. At 7 months after treatment, the ovareis revealed a complete arrest of the ovarian formation, and appearances of spermatogenetic cell cysts among surviving auxocytes. 8. In most of sex-reversed fish, anterior portion of test is was devoid of sperm ducts including the seminal vesicle and vas deferens. 9. The male transferrin showed two strong bands, while the female transferrin showed a single weak band. 10. One of the two bands of male transferrin showed the same mobility with band of female transferrin.

• 한국환경생물학회:학술대회논문집
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• 한국환경생물학회 2002년도 학술대회
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• pp.141-144
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• 2002

Environmental estrogens are natural or synthetic substances present in the aquatic environment, especially in effluent from sewage treatment. However, the adverse effects of these estrogenic substances on fish reproduction are unknown. Di-2-ethylhexyl phthalate (DEHP) is the most common phthalate, which Ps used as a plasticizer in polyvinylchloride (PVC), and it is widespread in the environment and has been found in aquatic organisms and sediments. Therefore, juvenile common carps (Cyprinus carpio) were exposed to nominal concentrations of 17$\beta$-estradiol (E2) (0.5, 5, 50 $\mu\textrm{g}$/L) and DEHP (10, 100, 500 $\mu\textrm{g}$/L) for 21 days, to determine the adverse reproductive effects of these compounds on plasma vitellogenin (VTG) induction, sex steroid level, and gonad weight. Electrophoresis (SDS-PAGE) revealed that much of VTG was induced in fish exposed to 5 and 50 E$_2$ $\mu\textrm{g}$/L, but none of DEHP exposure showed induction. Enzyme-linked immunosorbent assay (ELISA) revealed that VTG was significantly induced in fish exposed to 5 and 50 E$_2$ $\mu\textrm{g}$/L, and combination of 50 E$_2$ $\mu\textrm{g}$/L with 10 and 500 DEHP $\mu\textrm{g}$/L, but none of DEHP exposure showed induction. Analysis of sex steroid levels in some fish revealed that testosterone (T) was detected in both male and female fish of the control and DEHP exposures, but none of fish exposed to 22 concentrations had detectable testosterone level. On the other hand, E$_2$ exposure induced 17$\beta$-estradiol in plasma of male fish, but there was no induction of 17$\beta$-estradiol in plasma of male fish exposed to DEHP. Comparison of gonadosomatic index (GSI) revealed that maximal E$_2$ exposure inhibited ovarian growth, but maximal DEHP exposure stimulated testicular growth. The results indicated that those comparisons can be a useful bio-indicator for determining adverse reproductive effect of endocrine disrupting chemicals (EDCs).

• 한국수산과학회지
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• 제31권4호
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• pp.574-580
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• 1998

가두리에서 사육된 조피볼락의 성숙 및 출산기 동안 혈장내 갑상선 및 성 스테로이드 호르몬의 농도 변화를 조사하였다. 혈장 L-thyroxine 농도는 난황형성기에 $35.2{\pm}5.7\;ng/m{\ell}$이었고. 이후 출산기에 $20.5{\pm}4.2\;ng/m{\ell}$ 까지 유의하게 감소하였다. 그리고. 휴지기에 $44.9{\pm}7.2\;ng/m{\ell}$의 높은 농도로 상승하였다. 혈장 3,5,3'-triiodo-L-thyronine 농도는 난황형성 기에 $12.9{\pm}1.6\;ng/m{\ell}$이었지만, 배란기에 $3.7{\pm}0.7\;ng/m{\ell}$으로 유의하게 감소했고, 이후 $52.9{\pm}7.0\;ng/m{\ell}$까지 증가했다. 혈장 estradiol-17 $\beta$의 농도는 난황형성기에 최고치를 나타내었지만. 출산기에 $0.3{\pm}0.1\;ng/m{\ell}$까지 크게 감소하였다. 혈장 testosterone의 농도는 난황형성기와 배란기에 각각 $1.8{\pm}0.3\;ng/m{\ell}$ 및 $2.1{\pm}0.7\;ng/m{\ell}$이었고, 이후 출산기에 $0.1{\pm}0.1\;ng/m{\ell}$까지 감소했다. 이상의 연구 결과를 종합하여 볼 때. 갑상선호르몬은 조피볼락의 성숙 및 출산에 관련될 가능성이 높다.