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The Protective Effects of Statins towards Vessel Wall Injury Caused by a Stent Retrieving Mechanical Thrombectomy Device : A Histological Analysis of the Rabbit Carotid Artery Model

  • Lee, Seung Hwan;Shin, Hee Sup;Oh, Inho
    • Journal of Korean Neurosurgical Society
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    • v.64 no.5
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    • pp.693-704
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    • 2021
  • Objective : Endovascular mechanical thrombectomy (MT) has been regarded as one of the standard treatments for acute ischemic stroke caused by large vessel occlusion. Despite the wide use of stent retrievers for MT, arterial intimal damage caused when deployed stent is pulled has been a certain disadvantage. We hypothesized that statin could protect and stabilize vessel damage after endovascular MT using a stent retriever. In this animal study, we observed the protective effects of the statins towards MT-induced vessel wall injury. Methods : Twenty-eight carotid arteries of fourteen rabbits were used in the experiments with MT using stent retriever. We divided the rabbits into four groups as follows : group 1, negative control; group 2, positive control; group 3, statin before MT; and group 4, statin after MT. After MT procedures, we harvested the carotid arteries and performed histomorphological and immunohistochemical analyses. Results : In histomorphological analysis with hematoxylin and eosin and Masson's trichrome stain, significant intimal thickening (p<0.05) was observed in the positive control (group 2), compared to in the negative control (group 1). Intimal thickening was improved in the statin-administered groups (groups 3 and 4 vs. group 2, p<0.05). We also observed that statin administration after MT (group 4) resulted in a more effective decrease in intimal thickness than statin administration before MT (group 3) (p<0.05). We performed immunohistochemical analysis with the antibodies for tumor necrosis factor-alpha (TNF-α), cluster of differentiation (CD)11b, and CD163. In contrast to the negative control (group 1), the stained percentage areas of all immunological markers were markedly increased in the positive control (group 2) (p<0.05). Based on statin administration, the percentage area of TNF-α staining was significantly reduced (p<0.05) in group 3, compared to the positive control group (group 2). However, significant differences were not observed for CD11b and CD163 staining. In group 4, no significant differences were observed for TNF-α, CD11b, and CD163 staining (p≥0.05). The differences in the percentage areas of the different markers between the statin-administered groups (groups 3 and 4) were also not revealed. Conclusion : We presented that statin administration before and after MT exerted protective effects towards vessel wall injury. The efficacy of statins was greater post-administration than pre-administration. Thus, statin administration in routine prescriptions in the peri-procedural period is strongly advised.

A Study on the Space Innovation of Public Libraries Belonging to Chungcheongnam-do Office of Education (충남교육청 소속 공공도서관의 공간혁신에 관한 연구)

  • Lim, Jeong-Hoon;Oh, Hyoung-Seok;Lee, Byeong-Ki
    • Journal of Korean Library and Information Science Society
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    • v.52 no.4
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    • pp.103-126
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    • 2021
  • This study aims to propose a plan to restructure libraries as a complex space for education and culture for 19 public libraries belonging to the Chungcheongnam-do Office of Education. For the purpose of this, case surveys and user surveys of complex facilities of domestic and foreign public institutions were conducted. Based on the findings, a space restructuring strategy was suggested by dividing the library space into the following ways: a space to learn (a comprehensive data room, a theme data inquiry room, a future classroom, a blended learning center, a STEAM training room, and an online lecture learning room), a space to express (a foyer, a maker room, a digital media creation room and an online lecture production room), a space to share (a club room, a group study room, a well-being complex culture space, a convenient living space, rest area, and a browsing area), and a space to enjoy (a performance-thought playground, infant and child archives, a digital virtual experience room, a specialized alcove room, and an outdoor reading room). In addition, a restructuring model of public libraries belonging to the Office of Education was proposed, such as a leading model, a basic model, a joint model, and a minimum model, in consideration of the size of the building, the size of the library, and the level of service and space.

25-Hydroxyvitamin D level is associated with mortality in patients with critical COVID-19: a prospective observational study in Mexico City

  • Parra-Ortega, Israel;Alcara-Ramirez, Diana Guadalupe;Ronzon-Ronzon, Alma Angelica;Elias-Garcia, Fermin;Mata-Chapol, Jose Agustin;Cervantes-Cote, Alejandro Daniel;Lopez-Martinez, Briceida;Villasis-Keever, Miguel Angel;Zurita-Cruz, Jessie Nallely
    • Nutrition Research and Practice
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    • v.15 no.sup1
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    • pp.32-40
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    • 2021
  • BACKGROUND/OBJECTIVES: Considering the high number of deaths from coronavirus disease 2019 (COVID-19) in Latin American countries, together with multiple factors that increase the prevalence of vitamin D deficiency, we aimed to determine 25-hydroxyvitamin D (25[OH]D) levels and its association with mortality in patients with critical COVID-19. SUBJECTS/METHODS: This was a prospective observational study including adult patients with critical COVID-19. Data, including clinical characteristics and 25(OH)D levels measured at the time of intensive care unit admission, were collected. All patients were followed until hospital discharge or in-hospital death. The patients were divided into those surviving and deceased patient groups, and univariate and multivariate logistic regression analyses were performed to determine independent predictors of in hospital mortality. RESULTS: The entire cohort comprised 94 patients with critical COVID-19 (males, 59.6%; median age, 61.5 years). The median 25(OH)D level was 12.7 ng/mL, and 15 (16%) and 79 (84%) patients had vitamin D insufficiency and vitamin D deficiency, respectively. The median serum 25(OH)D level was significantly lower in deceased patients compared with surviving (12.1 vs. 18.7 ng/mL, P < 0.001). Vitamin D deficiency was present in 100% of the deceased patients. Multivariate logistic regression analysis revealed that age, body mass index, other risk factors, and 25(OH)D level were independent predictors of mortality. CONCLUSIONS: Vitamin D deficiency was present in 84% of critical COVID-19 patients. Serum 25(OH)D was independently associated with mortality in critical patients with COVID-19.

The Flora of Vascular Plants in Mt. Ilimsan and Its Adjacent Areas (in Boseong-gun, Jeonnam-do, Korea) (전남 보성군 일림산 일원 관속식물상)

  • Shin, Soon-Ho;Oh, Chan-Jin;You, Han-Choon
    • Korean Journal of Environment and Ecology
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    • v.36 no.3
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    • pp.277-302
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    • 2022
  • This study aims to establish the floristic data and identify the useful plant resources of Mt. Ilimsan and its adjacent areas. The survey was conducted 27 times from March 31, 2020 to August 22, 2021. It identified 500 taxa consisting of 101 families, 304 genera, 444 species, 11 subspecies, 42 varieties, and 3 formas. A total of 853 plant specimens were collected. There were 16 taxa designated as endemic plants and 7 taxa designated as the rare plants by the Korea Forest Service, and 5 taxa designated as the red list plants by the Ministry of Environment. Moreover, the floristic target species by the Ministry of the Environment found in this mountain were 69 taxa, including 49 taxa for floristic degree I, 7 for floristic degree II, 11 for floristic degree III, and 2 for floristic degree IV. Biological resources subject to export approval by the Ministry of Environment were 159 taxa. The alien plants were 49 taxa, of which 5.6 percent were naturalized, and the urbanization index was 7.9 percent. Ecosystem-disturbing invasive alien plants designated by the Ministry of Environment were 6 taxa.

Analysis of Patent Trends in Agricultural Machinery (최신 농업기계 특허 동향 조사)

  • Hong, S.J.;Kim, D.E.;Kang, D.H.;Kim, J.J.;Kang, J.G.;Lee, K.H.;Mo, C.Y.;Ryu, D.K.
    • Journal of Practical Agriculture & Fisheries Research
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    • v.23 no.2
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    • pp.99-111
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    • 2021
  • The connected farm that agricultural land, agricultural machinery and farmer are connected with an IoT gateway is in the commercialization stage. That has increased productivity, efficiency and profitability by intimate information exchange among those. In order to develop the educational program of intelligent agricultural machinery and the agricultural machinery safety education performance indicator, this study analyzed patent trends of agricultural machine with unmanned technology used in agriculture and efficiency technology applied advanced technologies such as ICT, robots and artificial intelligence. We investigated and analyzed patent trends in agricultural machinery of Korea, the USA and Japan as well as the countries in Europe. The United States is an advanced country in the field of unmanned technology and efficiency technology used in agriculture. Agricultural automation technology in Korea is insufficient compared to developed countries, which means rapid technological development is needed. In the sub-fields of field automation technology, path generation and following technology and working machine control technology through environmental awareness have activated.

Floristic Study of Gayasan National Park in Korea (가야산국립공원의 관속식물상)

  • Han, Seahee;Leem, Hyosun;Jang, Hyun-Do;Kim, Yoon-Young;So, Soonku
    • Korean Journal of Plant Resources
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    • v.35 no.2
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    • pp.248-288
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    • 2022
  • The study on vascular plants of Gayasan National Park was conducted in 2016 over a period of 34 days from March to October 2016. As the study, a total of 768 taxa were recorded, including 118 families, 396 genera, 691 species, 15 subspecies, 51 varieties, and 11 forms. In the vascular plants, four endangered wild plants were recorded, Ponerorchis cucullata (L.) X.H.Jin, Trientalis europaea var. arctica (Fisch.) Ledeb., Cypripedium macranthos Sw., and Pedicularis hallaisanensis Hurus. Taxa of Least Concern (LC) or higher level on National Red List published by the Ministry of Environment of Korea were 21 taxa for example Tricyrtis macropoda Miq., and Lilium cernuum Kom. A total of 37 Korean endemic plants were investigated for example Abies koreana E.H.Wilson and Impatiens atrosanguinea (Nakai) B.U.Oh & Y.P.Hong. A total of 162 taxa of floristic regional indicators (3rd to 5th degree) were investigated including 9 taxa of V, 15 taxa of IV, 38 taxa of III, 45 taxa of II, and 53 taxa of I. Naturalized plants were recorded a total of 46 taxa with a Naturalization Index of 6.0%, the Urbanization Index was calculated to be 14.3% and 5 taxa of ecosystem disturbance plants were investigated such as Sicyos angulatus L., Rumex acetosella L., and Humulus scandens (Lour.) Merr. As the result of comparison with previous studies, in this study a total of 206 taxa were newly identified including 62 families, 144 genera, 184 species, 2 subspecies, 15 varieties, and 5 forms.

A study on machine learning-based defense system proposal through web shell collection and analysis (웹쉘 수집 및 분석을 통한 머신러닝기반 방어시스템 제안 연구)

  • Kim, Ki-hwan;Shin, Yong-tae
    • Journal of Internet Computing and Services
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    • v.23 no.4
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    • pp.87-94
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    • 2022
  • Recently, with the development of information and communication infrastructure, the number of Internet access devices is rapidly increasing. Smartphones, laptops, computers, and even IoT devices are receiving information and communication services through Internet access. Since most of the device operating environment consists of web (WEB), it is vulnerable to web cyber attacks using web shells. When the web shell is uploaded to the web server, it is confirmed that the attack frequency is high because the control of the web server can be easily performed. As the damage caused by the web shell occurs a lot, each company is responding to attacks with various security devices such as intrusion prevention systems, firewalls, and web firewalls. In this case, it is difficult to detect, and in order to prevent and cope with web shell attacks due to these characteristics, it is difficult to respond only with the existing system and security software. Therefore, it is an automated defense system through the collection and analysis of web shells based on artificial intelligence machine learning that can cope with new cyber attacks such as detecting unknown web shells in advance by using artificial intelligence machine learning and deep learning techniques in existing security software. We would like to propose about. The machine learning-based web shell defense system model proposed in this paper quickly collects, analyzes, and detects malicious web shells, one of the cyberattacks on the web environment. I think it will be very helpful in designing and building a security system.

Development of Korean Warrior Platform Architecture (한국형 워리어플랫폼 아키텍처 개발 연구)

  • Kim, Wukki;Shin, Kyuyong;Cho, Seongsik;Baek, Seungho;Kim, Yongchul
    • Journal of Convergence for Information Technology
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    • v.11 no.5
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    • pp.111-117
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    • 2021
  • With the rapid development of advanced science and technology including the 4th industrial revolution, the future battlefield environment is evolving at a rapid pace. In order to actively respond to issues such as reduction of military resources and shortening of service period, and to emphasize the realization of human-centered values, the Ministry of National Defense is re-establishing the role of the Army in accordance with the defense reform and is promoting the Warrior Platform, a next-generation individual combat system. In this paper, we intend to present the optimal warrior platform architecture suitable for the Korean Army by realizing the concept of future ground operations and analyzing overseas cases. We analyze the essential abilities required of individual combatants and the abilities required for each unit type, and specifically presents a plan for integration and linkage of warrior platform equipment. We also propose an efficient business promotion direction by presenting the data flow and power connection diagram between the devices that need integration and interworking.

Prioritizing Themes Using a Delphi Survey on Patient Safety Theme Reports (환자안전 주제별 보고서의 주제 우선순위 설정: 델파이 조사를 통한 분석)

  • Park, Jeong Yun;Shin, Eun-Jung;Kim, Rhieun;Kim, Sukyeong;Park, Choon-Seon;Park, Taezoon;Choi, Yun-Kyoung;Heo, Young-Hee
    • Quality Improvement in Health Care
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    • v.28 no.1
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    • pp.45-54
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    • 2022
  • Purpose: The study aims to identify the theme list and priority criteria of patient safety theme reports in South Korea. Methods: The survey was conducted twice, and the importance of each criterion and theme was measured on a nine-point scale using the Delphi technique by a panel of 19 patient safety experts. The criteria included severity, universality, preventability, and organizational-social impact. Descriptive statistics such as frequency, percentage, mean, standard deviation, median, and interval quartile range were used to analyze the data. Results: The parameters were assigned a weighted average of 35% for severity, 20% for universality, 30% for preventability, and 15% for organizational-social impact, respectively. The final top three rankings were surgery safety, blood transfusion safety, and medication safety. In addition to expert opinion, for the theme that is selected based on the priority ranking, one to five sub-topics can be derived from the theme based on the priority ranking, societal demands, or the yearly priority list of patient safety incidents. Conclusion: It is recommended that the official patient safety center distribute the report in the form of a summary that can be utilized nationwide at medical institutions, government institutions, and other places. Updates, as well as accumulated theme reports, will serve as the baseline data for the proposal of the system and for the policy designed to implement and improve institutions' safety practices as a standard of domestic patient safety practice guidelines.

DNN Model for Calculation of UV Index at The Location of User Using Solar Object Information and Sunlight Characteristics (태양객체 정보 및 태양광 특성을 이용하여 사용자 위치의 자외선 지수를 산출하는 DNN 모델)

  • Ga, Deog-hyun;Oh, Seung-Taek;Lim, Jae-Hyun
    • Journal of Internet Computing and Services
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    • v.23 no.2
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    • pp.29-35
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    • 2022
  • UV rays have beneficial or harmful effects on the human body depending on the degree of exposure. An accurate UV information is required for proper exposure to UV rays per individual. The UV rays' information is provided by the Korea Meteorological Administration as one component of daily weather information in Korea. However, it does not provide an accurate UVI at the user's location based on the region's Ultraviolet index. Some operate measuring instrument to obtain an accurate UVI, but it would be costly and inconvenient. Studies which assumed the UVI through environmental factors such as solar radiation and amount of cloud have been introduced, but those studies also could not provide service to individual. Therefore, this paper proposes a deep learning model to calculate UVI using solar object information and sunlight characteristics to provide an accurate UVI at individual location. After selecting the factors, which were considered as highly correlated with UVI such as location and size and illuminance of sun and which were obtained through the analysis of sky images and solar characteristics data, a data set for DNN model was constructed. A DNN model that calculates the UVI was finally realized by entering the solar object information and sunlight characteristics extracted through Mask R-CNN. In consideration of the domestic UVI recommendation standards, it was possible to accurately calculate UVI within the range of MAE 0.26 compared to the standard equipment in the performance evaluation for days with UVI above and below 8.