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http://dx.doi.org/10.4162/nrp.2021.15.S1.S32

25-Hydroxyvitamin D level is associated with mortality in patients with critical COVID-19: a prospective observational study in Mexico City  

Parra-Ortega, Israel (Auxiliary Diagnostic Services, Hospital Infantil de Mexico Federico Gomez, Ministry of Health (SSA))
Alcara-Ramirez, Diana Guadalupe (Auxiliary Diagnostic Services, Hospital Infantil de Mexico Federico Gomez, Ministry of Health (SSA))
Ronzon-Ronzon, Alma Angelica (Radiology and Imaging Service, General Zone Hospital 48, Instituto Mexicano del Seguro Social)
Elias-Garcia, Fermin (Auxiliary Diagnostic Services, Hospital Infantil de Mexico Federico Gomez, Ministry of Health (SSA))
Mata-Chapol, Jose Agustin (Auxiliary Diagnostic Services, General Zone Hospital 48, Instituto Mexicano del Seguro Social)
Cervantes-Cote, Alejandro Daniel (Auxiliary Diagnostic Services, General Zone Hospital 48, Instituto Mexicano del Seguro Social)
Lopez-Martinez, Briceida (Auxiliary Diagnostic Services, Hospital Infantil de Mexico Federico Gomez, Ministry of Health (SSA))
Villasis-Keever, Miguel Angel (Analysis and Synthesis of the Evidence Research Unit, National Medical Center XXI Century, Instituto Mexicano del Seguro Social)
Zurita-Cruz, Jessie Nallely (Facultad de Medicina Universidad Nacional Autonoma de Mexico, Hospital Infantil de Mexico Federico Gomez)
Publication Information
Nutrition Research and Practice / v.15, no.sup1, 2021 , pp. 32-40 More about this Journal
Abstract
BACKGROUND/OBJECTIVES: Considering the high number of deaths from coronavirus disease 2019 (COVID-19) in Latin American countries, together with multiple factors that increase the prevalence of vitamin D deficiency, we aimed to determine 25-hydroxyvitamin D (25[OH]D) levels and its association with mortality in patients with critical COVID-19. SUBJECTS/METHODS: This was a prospective observational study including adult patients with critical COVID-19. Data, including clinical characteristics and 25(OH)D levels measured at the time of intensive care unit admission, were collected. All patients were followed until hospital discharge or in-hospital death. The patients were divided into those surviving and deceased patient groups, and univariate and multivariate logistic regression analyses were performed to determine independent predictors of in hospital mortality. RESULTS: The entire cohort comprised 94 patients with critical COVID-19 (males, 59.6%; median age, 61.5 years). The median 25(OH)D level was 12.7 ng/mL, and 15 (16%) and 79 (84%) patients had vitamin D insufficiency and vitamin D deficiency, respectively. The median serum 25(OH)D level was significantly lower in deceased patients compared with surviving (12.1 vs. 18.7 ng/mL, P < 0.001). Vitamin D deficiency was present in 100% of the deceased patients. Multivariate logistic regression analysis revealed that age, body mass index, other risk factors, and 25(OH)D level were independent predictors of mortality. CONCLUSIONS: Vitamin D deficiency was present in 84% of critical COVID-19 patients. Serum 25(OH)D was independently associated with mortality in critical patients with COVID-19.
Keywords
Vitamin D; COVID-19; SARS-CoV-2 virus; mortality; critical illness;
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