• 제목/요약/키워드: Sequence Management

검색결과 839건 처리시간 0.033초

Survey of the Applications of NGS to Whole-Genome Sequencing and Expression Profiling

  • Lim, Jong-Sung;Choi, Beom-Soon;Lee, Jeong-Soo;Shin, Chan-Seok;Yang, Tae-Jin;Rhee, Jae-Sung;Lee, Jae-Seong;Choi, Ik-Young
    • Genomics & Informatics
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    • 제10권1호
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    • pp.1-8
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    • 2012
  • Recently, the technologies of DNA sequence variation and gene expression profiling have been used widely as approaches in the expertise of genome biology and genetics. The application to genome study has been particularly developed with the introduction of the nextgeneration DNA sequencer (NGS) Roche/454 and Illumina/ Solexa systems, along with bioinformation analysis technologies of whole-genome $de$ $novo$ assembly, expression profiling, DNA variation discovery, and genotyping. Both massive whole-genome shotgun paired-end sequencing and mate paired-end sequencing data are important steps for constructing $de$ $novo$ assembly of novel genome sequencing data. It is necessary to have DNA sequence information from a multiplatform NGS with at least $2{\times}$ and $30{\times}$ depth sequence of genome coverage using Roche/454 and Illumina/Solexa, respectively, for effective an way of de novo assembly. Massive shortlength reading data from the Illumina/Solexa system is enough to discover DNA variation, resulting in reducing the cost of DNA sequencing. Whole-genome expression profile data are useful to approach genome system biology with quantification of expressed RNAs from a wholegenome transcriptome, depending on the tissue samples. The hybrid mRNA sequences from Rohce/454 and Illumina/Solexa are more powerful to find novel genes through $de$ $novo$ assembly in any whole-genome sequenced species. The $20{\times}$ and $50{\times}$ coverage of the estimated transcriptome sequences using Roche/454 and Illumina/Solexa, respectively, is effective to create novel expressed reference sequences. However, only an average $30{\times}$ coverage of a transcriptome with short read sequences of Illumina/Solexa is enough to check expression quantification, compared to the reference expressed sequence tag sequence.

LNGC용 Power Management System 시뮬레이터 모델링 및 특성분석 (Power Management System Simulator Modeling and Characteristics Analysis for Electric Propulsion Ship)

  • 김영민;전경원;정상용
    • 전기학회논문지
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    • 제64권6호
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    • pp.878-884
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    • 2015
  • In this paper, Power Management System(PMS) simulator for Liquid Nature Gas Carrier(LNGC) is developed. Major components of power system for LNGC, such as generator, diesel engine and governor, transformer, circuit breaker, and 3 phase loads models are built based on MATLAB/SIMULINK. With these designed major parts, PMS simulator modeling is carried out. Based on MATLAB/Graphical User Interface, PMS simulator control for LNGC, and Human Machine Interface for monitoring is designed. PMS simulator for LNGC carries out simulation according to sequence of characteristics analysis. By comparing results of predicted simulation for each sequence to that of characteristics analysis, the reliability of PMS simulator for LNGC will be verified.

순서 독립적인 셋업타임을 가진 동일작업의 병렬기계 배치스케줄링 (Parallel Machine Scheduling with Identical Jobs and Sequence-Independent Setup Times)

  • 최병천;박명주
    • 한국경영과학회지
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    • 제39권3호
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    • pp.83-91
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    • 2014
  • We consider the problem of scheduling identical jobs with sequence-independent setup times on parallel machines. The objective is to minimize total completion times. We present the pseudopolynomial-time algorithm for the case with a fixed number of machines and an efficient approximation algorithm for our problem with identical setup times, which is known to be NP-hard even for the two-machine case.

Scheduling Algorithms for the Maximal Total Revenue on a Single Processor with Starting Time Penalty

  • Joo, Un-Gi
    • Management Science and Financial Engineering
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    • 제18권1호
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    • pp.13-20
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    • 2012
  • This paper considers a revenue maximization problem on a single processor. Each job is identified as its processing time, initial reward, reward decreasing rate, and preferred start time. If the processor starts a job at time zero, revenue of the job is its initial reward. However, the revenue decreases linearly with the reward decreasing rate according to its processing start time till its preferred start time and finally its revenue is zero if it is started the processing after the preferred time. Our objective is to find the optimal sequence which maximizes the total revenue. For the problem, we characterize the optimal solution properties and prove the NP-hardness. Based upon the characterization, we develop a branch-and-bound algorithm for the optimal sequence and suggest five heuristic algorithms for efficient solutions. The numerical tests show that the characterized properties are useful for effective and efficient algorithms.

고객 요구 집단에 의한 일정계획 수립에 관한 연구 (A Study on Scheduling by Customer Needs Group)

  • 양광모;박재현;강경식
    • 대한안전경영과학회:학술대회논문집
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    • 대한안전경영과학회 2002년도 추계학술대회
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    • pp.233-238
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    • 2002
  • The product process is sequence of all the required activities that a company must perform to develop, and manufacture a product. These activities include marketing, research, engineering design, quality assurance, manufacturing, and a whole chain of suppliers and vendors. The process also comprises all strategic planning, capital investments, management decisions, and tasks necessary to create a new product. manufacturing processes must be created so that the product can be produced in the product facility Purchasing new equipment and training workers may be required if new technology is to be used. Tools, fixtures, and the sequence of steps in the manufacturing processes must all be developed to allow rapid, high-quality, cost effective production. Also, it may be needed to be rearrange the production facility to adapt to the new manufacturing processes. Therefore, this study tries to proposed that Scheduling by customer needs group for minimizing the problem and reducing inventory, product development time, cycle time, and order lead time.

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RNN과 강화 학습을 이용한 자동 문서 제목 생성 (Automatic Document Title Generation with RNN and Reinforcement Learning)

  • 조성민;김우생
    • Journal of Information Technology Applications and Management
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    • 제27권1호
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    • pp.49-58
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    • 2020
  • Lately, a large amount of textual data have been poured out of the Internet and the technology to refine them is needed. Most of these data are long text and often have no title. Therefore, in this paper, we propose a technique to combine the sequence-to-sequence model of RNN and the REINFORCE algorithm to generate the title of the long text automatically. In addition, the TextRank algorithm was applied to extract a summarized text to minimize information loss in order to protect the shortcomings of the sequence-to-sequence model in which an information is lost when long texts are used. Through the experiment, the techniques proposed in this study are shown to be superior to the existing ones.

철도분야 응용을 위한 전문가 시스템을 이용한 복합적층판의 적층순서 최적설계 (Stacking Sequence Optimization of Composite Laminates for Railways Using Expert System)

  • 김정석
    • 한국철도학회논문집
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    • 제8권5호
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    • pp.411-418
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    • 2005
  • This paper expounds the development of a user-friendly expert system for the optimal stacking sequence design of composite laminates subjected to the various rules constraints. The expert system was realized in the graphic-based design environment. Therefore, users can access and use the system easily. The optimal stacking sequence is obtained by means of integration of a genetic algorithm, finite element analysis. These systems were integrated with the rules of design heuristics under an expert system shell. The optimal stacking sequence combination for the application of interest is drawn from the discrete ply angles and design rules stored in the knowledge base of the expert system. For the integration and management of softwares, a graphic-based design environment that provides multi-tasking and graphic user interface capability is built.

웹 서비스를 이용한 워크플로우 관리 시스템의 설계 방안 (Design of Workflow Management System using Web Services)

  • 오명은;이용표;한상용
    • 한국전자거래학회:학술대회논문집
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    • 한국전자거래학회 2003년도 종합학술대회 논문집
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    • pp.230-235
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    • 2003
  • A Workflow Management System is one which provides procedural automation of a business process by management of the sequence of work activities. The existing workflow management systems have limitation of interaction among application systems. In this paper, we propose a new workflow management system that can be adapted in dynamically changed paradigm of distributed computing by using Web Service. System Architecture and prototyping execution model of the system is described in BPEL4WS.

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Design Structure Matrix: A Model Proposal and Implementation on Harbor and Building Design Project

  • Akram, Salman;Kim, Jeonghwan;Pi, Seungwoo;Seo, Jongwon
    • 한국건설관리학회논문집
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    • 제14권1호
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    • pp.144-152
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    • 2013
  • Design is an iterative, generative, and multidisciplinary process by its nature. Iteration occurs often in most of the engineering design and development projects including construction. Design iterations cause rework, and extra efforts are required to get the optimal sequence and to manage the projects. Contrary to simple design, isolation of the generative iterations in complex design systems is very difficult, but reduction in overall iterations is possible. Design depends upon the information flow within domain and also among various design disciplines and organizations. Therefore, it is suggested that managers should be aware about the crucial iterations causing rework and optimal sequence as well. In this way, managers can handle design parameters related to such iterations pro-actively. There are a number of techniques to reduce iterations for various kinds of engineering designs. In this paper, parameter based Design Structure Matrix (DSM) is chosen. To create this DSM, a survey was performed and then partitioned using a model. This paper provides an easy approach to those companies involved in or intend to be involved in "design and build projects".