• Title/Summary/Keyword: Sensitivity Prediction

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Protein-Protein Interaction Prediction using Interaction Significance Matrix (상호작용 중요도 행렬을 이용한 단백질-단백질 상호작용 예측)

  • Jang, Woo-Hyuk;Jung, Suk-Hoon;Jung, Hwie-Sung;Hyun, Bo-Ra;Han, Dong-Soo
    • Journal of KIISE:Software and Applications
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    • v.36 no.10
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    • pp.851-860
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    • 2009
  • Recently, among the computational methods of protein-protein interaction prediction, vast amounts of domain based methods originated from domain-domain relation consideration have been developed. However, it is true that multi domains collaboration is avowedly ignored because of computational complexity. In this paper, we implemented a protein interaction prediction system based the Interaction Significance matrix, which quantified an influence of domain combination pair on a protein interaction. Unlike conventional domain combination methods, IS matrix contains weighted domain combinations and domain combination pair power, which mean possibilities of domain collaboration and being the main body on a protein interaction. About 63% of sensitivity and 94% of specificity were measured when we use interaction data from DIP, IntAct and Pfam-A as a domain database. In addition, prediction accuracy gradually increased by growth of learning set size, The prediction software and learning data are currently available on the web site.

Evaluation of Predictability of Global/Regional Integrated Model System (GRIMs) for the Winter Precipitation Systems over Korea (한반도 겨울철 강수 유형에 따른 전지구 수치모델(GRIMs) 예측성능 검증)

  • Yeon, Sang-Hoon;Suh, Myoung-Suk;Lee, Juwon;Lee, Eun-Hee
    • Atmosphere
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    • v.32 no.4
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    • pp.353-365
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    • 2022
  • This paper evaluates precipitation forecast skill of Global/Regional Integrated Model system (GRIMs) over South Korea in a boreal winter from December 2013 to February 2014. Three types of precipitation are classified based on development mechanism: 1) convection type (C type), 2) low pressure type (L type), and 3) orographic type (O type), in which their frequencies are 44.4%, 25.0%, and 30.6%, respectively. It appears that the model significantly overestimates precipitation occurrence (0.1 mm d-1) for all types of winter precipitation. Objective measured skill scores of GRIMs are comparably high for L type and O type. Except for precipitation occurrence, the model shows high predictability for L type precipitation with the most unbiased prediction. It is noted that Equitable Threat Score (ETS) is inappropriate for measuring rare events due to its high dependency on the sample size, as in the case of Critical Success Index as well. The Symmetric Extreme Dependency Score (SEDS) demonstrates less sensitivity on the number of samples. Thus, SEDS is used for the evaluation of prediction skill to supplement the limit of ETS. The evaluation via SEDS shows that the prediction skill score for L type is the highest in the range of 5.0, 10.0 mm d-1 and the score for O type is the highest in the range of 1.0, 20.0 mm d-1. C type has the lowest scores in overall range. The difference in precipitation forecast skill by precipitation type can be explained by the spatial distribution and intensity of precipitation in each representative case.

Study on the Prediction Technique of Vehicle Performance using Parameter Analysis (파라미터 해석을 통한 차량 성능 예측 기법 연구)

  • Kim, Ki-Chang;Kim, Chan-Mook;Kim, Jin-Taek
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2009.10a
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    • pp.647-653
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    • 2009
  • Taguchi parameter design is an approach to reducing performance variation of quality characteristic value in products and processes. Taguchi has used SN (Signal to Noise) ratio to achieve the appropriate set of operating conditions where variability around target is low in the Taguchi parameter design. This paper describes the prediction technique of vehicle performance using parameter analysis to reduce man hour and test development period as well as to achieve stable NVH performance. Design engineer could efficiently decide the design variable using parameter analysis database in early design stage. These improvements can reduce the time needed to develop better vehicles.

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Development of Structural Analysis and Construction Management System for Composite Cable Stayed Bridges (합성형 사장교의 시공단계해석 및 시공관리 시스템 개발)

  • 서주원;박정일;김남식;심옥진
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 1994.10a
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    • pp.95-102
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    • 1994
  • This paper presents a Cable Stayed Bridge Construction Management System, which consists of Structural System Identification Method (SSIM), Error Sensitivity Analysis and Optimum Error Adjustment & Prediction System. The 1st System Identification Method builds an error influence matrix using the linear superposition of each error modes. The 2nd SSIM also considers the second error mode term, which shows good error factor estimation. The optimal cable adjustment can be accomplished within the allowable range of both cable tension and camber. The Post processor, constituted with Motif and GL library on SGI platform, is useful for monitoring construction stage management by displaying construction data, adjustment and prediction results at each construction step.

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A Study on the Prediction and Control of Welding Deformation of the BRACKET TILT in Automotive Parts (I) - Application of FEA- (자동차 부품 BRACKET TILT의 용접변형 예측 미 제어에 관한 연구 (II) -유한요소법의 적용-)

  • 장경복;강성수
    • Journal of Welding and Joining
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    • v.16 no.6
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    • pp.104-112
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    • 1998
  • In the previous study, the countermeasure for welding deformation of bracket tilt is through up through experimental inspection for total process including welding process. For completeness of systematic examination of parts having sensitivity on welding deformation, the comparison and feedback between the result through simulation of welding process and experimental data is needed. In other words, it is necessary to control welding deformation that construct the prediction system for welding deformation through comparison and tuning with experimental data. In the present study, the application of FEA on welding process of bracket tilt with susceptibility to deformation is made and deformation behavior through change of welding sequence is focused on. It is used to improve the exactness of deformation analysis that three dimensional analysis for moving heat source, activated and deactivated bead element, and volume heat flux etc.

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Prediction of the Reflood Phenomena with modifications in RELAP5/MOD3.1

  • Jeong, Hae-Yong;No, Hee-Cheon
    • Proceedings of the Korean Nuclear Society Conference
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    • 1997.05a
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    • pp.409-414
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    • 1997
  • Reflood model in RELAP5/MOD3.1 are modified to improve the unrealistic prediction results of the model. In the new method, the modified Zuber pool boiling critical heat flux (CHF) correlation is adopted. The reflood drop size is characterized by the use of We=1.5 and the minimum drop size of 0.0007 m for $p^{*}\;{\leq}\;0.025$. To describe the wall to vapor heat transfer at low pressure and low flow condition, the Webb-Chen correlation is utilized . The suggested method has been verified through the simulations of the Lehigh University rod bundle reflood tests. Through sensitivity study it is shown that the effect of drag coefficients is dominant in the reflood model. It is proved that the present modifications result in much more improved quench behavior and accurate wan and vapor temperature predictions.

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Prediction of Hypertension Complications Risk Using Classification Techniques

  • Lee, Wonji;Lee, Junghye;Lee, Hyeseon;Jun, Chi-Hyuck;Park, Il-Su;Kang, Sung-Hong
    • Industrial Engineering and Management Systems
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    • v.13 no.4
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    • pp.449-453
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    • 2014
  • Chronic diseases including hypertension and its complications are major sources causing the national medical expenditures to increase. We aim to predict the risk of hypertension complications for hypertension patients, using the sample national healthcare database established by Korean National Health Insurance Corporation. We apply classification techniques, such as logistic regression, linear discriminant analysis, and classification and regression tree to predict the hypertension complication onset event for each patient. The performance of these three methods is compared in terms of accuracy, sensitivity and specificity. The result shows that these methods seem to perform similarly although the logistic regression performs marginally better than the others.

Stress intensity factors for 3-D axisymmetric bodies containing cracks by p-version of F.E.M.

  • Woo, Kwang S.;Jung, Woo S.
    • Structural Engineering and Mechanics
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    • v.2 no.3
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    • pp.245-256
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    • 1994
  • A new axisymmetric crack model is proposed on the basis of p-version of the finite element method limited to theory of small scale yielding. To this end, axisymmetric stress element is formulated by integrals of Legendre polynomial which has hierarchical nature and orthogonality relationship. The virtual crack extension method has been adopted to calculate the stress intensity factors for 3-D axisymmetric cracked bodies where the potential energy change as a function of position along the crack front is calculated. The sensitivity with respect to the aspect ratio and Poisson locking has been tested to ascertain the robustness of p-version axisymmetric element. Also, the limit value that is an exact solution obtained by FEM when degree of freedom is infinite can be estimated using the extrapolation equation based on error prediction in energy norm. Numerical examples of thick-walled cylinder, axisymmetric crack in a round bar and internal part-thorough cracked pipes are tested with high precision.

Buckling behaviour of plates partially restrained against rotation under stress gradient

  • Bedair, Osama K.
    • Structural Engineering and Mechanics
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    • v.4 no.4
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    • pp.383-396
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    • 1996
  • In this paper, the behavior of plates partially restrained against rotation under stress gradient is investigated. As a first stage, an energy formulation is presented to model this boundary condition and a general expression is derived for the prediction of the elastic buckling of the plate under this general loading condition. The accuracy of the derived expression is compared numerically using the Galerkin method with other available data for the two limiting conditions of rotationally free and clamped boundaries. Results show that the prediction is within a 5% difference. The influence of rotational restraint and stress gradient upon the buckling load and the associated buckling mode is investigated. Numerical results show sensitivity of the buckling mode to the degree of rotational restraint and the variation of the buckling load with the stress gradient.

ADAPTIVE CHANDRASEKHAR FILLTER FOR LINEAR DISCRETE-TIME STATIONALY STOCHASTIC SYSTEMS

  • Sugisaka, Masanori
    • 제어로봇시스템학회:학술대회논문집
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    • 1988.10b
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    • pp.1041-1044
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    • 1988
  • This paper considers the design problem of adaptive filters based an the state-space models for linear discrete-time stationary stochastic signal processes. The adaptive state estimator consists of both the predictor and the sequential prediction error estimator. The discrete Chandrasakhar filter developed by author is employed as the predictor and the nonlinear least-squares estimator is used as the sequential prediction error estimator. Two models are presented for calculating the parameter sensitivity functions in the adaptive filter. One is the exact model called the linear innovations model and the other is the simplified model obtained by neglecting the sensitivities of the Chandrasekhar X and Y functions with respect to the unknown parameters in the exact model.

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