• Animal cells and systems
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• v.2 no.4
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• pp.471-476
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• 1998

The G protein-activated inwardly rectifying $K^＋$ channel (GIRK1) was coex-pressed in Xenopus oocytes along with the $5-HT_{1A}$ receptor, a 7-helix receptor known to be coupled to $K^＋$ channels in many neural tissues. Thus, the activation of the $5-HT_{1A}$ receptor by its agonist leads to the opening of GIRK1. The GIRK1 current was measured using the two electrode voltage clamp technique with bath application of 5-HT in the presence of various external potassium concentrations $[K^＋]_0$. GIRK1 showed a strong inward rectification since only hyperpolarizing voltages evoked inward currents. $K^{+}$ was the major ion carrier as evidenced by about 44㎷ voltage shift corresponding to a 10-fold external 〔$K^＋$〕 change. 5-HT induced a concentration-dependent inward $K^＋$ current ($EC_{50}{\equation omitted}10.7nM$) which was blocked by $Ba^{2＋}$. Pertussis toxin (PTX) pre-treatment reduced the $K^＋$ current by as much as about 70%, suggesting that PTX-sensitive G protein ($G_i or G_o$ type) are involved in the $5-HT_{1A}$ receptor-GIRK1 coupling in Xenopus oocytes.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.7
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• pp.945-950
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• 2002

Shape optimization of a flow system is done to obtain the required effects, in the engineering fields. Most of these designs are accomplished by empirical or numerical analysis. In empirical analysis, it is difficult to obtain an optimal shape in the feasible design region. And, in numerical method, it usually needs much calculation expenses for shape optimization, because of design sensitivity analysis. In this study, we used the growth-strain method having only one distributed parameter such as a design variable. It optimizes a shape by making a distributed parameter such as dissipation energy uniform in a flow system, and then applied to two-flow systems. In order to overcome the stability occurred in numerical analysis performed by Azegami, the equation of volumic strain has been modified. Also, the shapes were compared with the known optimal shapes for the flow systems. Consequently, we confirm that the modified growth-strain method is very efficient and practical in shape optimization of the flow systems.

• Journal of Korean Ophthalmic Optics Society
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• v.1 no.2
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• pp.7-11
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• 1996

The size of pupil with pupillary light reflex is determined by the amount of a luminance. and it is dependent with the distribution function of the retinal illuminance which is the amount of transmittance for the external light due to the size of pupil, and the detector of cone and rod due to the amount of the luminance. The change of the pupil size with the luminance can be expressed with the mathematical model $$y(x)={\alpha}+{\beta}\frac{1}{1+{e}{x}{p}(x-x_0)/{\theta}}$$ where ${\alpha}$ is the size of the pupil diameter in a maximum value of the luminance, ${\beta}$ is the deviation of the pupil's diameter between maximum and minimum, ${\theta}$ is the parameter showed the degree of a sensitivity. Comparing with the experimental value of P.Moon et al, We known that the equation of the model is very compatible.

• The Journal of the Acoustical Society of Korea
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• v.11 no.3
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• pp.25-39
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• 1992

Undesired vibratory motion of a simply supported plate is controlled with piezoelectric sensors and actuators. Appropriate dynamic equations of the sensor and actuator are derived and coupled with the dynamic equation of the plate for the construction of an active feedback vibration control system. Analytic solutions are obtained for amplitude response of the plate, reflecting the combined effect of external driving forces and piezoelectric control moments. Numerical examples are presented to illustrate the effectiveness of this approach for two types of external forces, i.e. a concentrated point load and a piezoelectric plate driver. Calculation results show that the sensors and actuators can be efficient tools to mitigate the sensitivity of the structure to external sources of vibration. The method investigated in this work is applicable to arbitrary external loading conditions and control algorithms.

• Journal of the Society of Naval Architects of Korea
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• v.48 no.3
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• pp.189-199
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• 2011

Austenite stainless steel(ASS), aluminum alloy and nickel steel alloy are the most widely used in many cryogenic applications due to superior mechanical properties at low temperature. The Face-Centered Cubic(FCC) and Hexagonal Close-Packed(HCP) materials are used for the primary and secondary insulation barrier of Liquefied Natural Gas(LNG) carrier tank and various kinds of LNG applications currently. In this study, tensile tests of ASS, aluminum alloy and nickel steel alloy were carried out for the acquisition of quantitative mechanical properties under the cryogenic environment. The range of thermal condition was room temperature to $-163^{\circ}C$ and strain rate range was 0.00016/s to 0.01/s considering the dependencies of temperatures and strain rates. The comprehensive test data were analyzed in terms of the characteristics of mechanical behavior for the development of constitutive equation and its application.

• Journal of Korean Society for Quality Management
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• v.43 no.4
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• pp.471-488
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• 2015

Purpose: Double sampling $T^2$ chart is a useful tool for detecting a relatively small shift in process mean when the process is controlled by multiple variables. This paper finds the optimal design of the double sampling $T^2$ chart in both economical and statistical sense under Weibull failure model. Methods: The expected cost function is mathematically derived using recursive equation approach. The optimal designs are found using a genetic algorithm for numerical examples and compared to those of single sampling $T^2$ chart. Sensitivity analysis is performed to see the parameter effects. Results: The proposed design outperforms the optimal design of the single sampling $T^2$ chart in terms of the expected cost per unit time and Type-I error rate for all the numerical examples considered. Conclusion: Double sampling $T^2$ chart can be designed to satisfy both economic and statistical requirements under Weibull failure model and the resulting design is better than the single sampling counterpart.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.9 no.3
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• pp.125-131
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• 1997

In order to analyze the feasibility of the drain layer construction method, which is one of the beach protection methods, a hybrid model is constructed by combining the wave model and the seepage flow model. The used wave model is the analytic solution given by Shuto (1972). and the seepage flow model is used by Richards equation which governs the saturated-unsaturated flow in the porous media. It is concluded by the sensitivity analysis of the hybrid model that the most sensitive parameter in the flow field within the beach is the saturated hydraulic conductivity. The developed hybrid model will be efficiently used in the analysis of the parameter when the drain layers are constructed in the beach, if the field datas are obtained more.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.1
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• pp.61-66
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• 2006

The simple Langmuir isotherm is frequently employed to describe the equilibrium behavior of protein adsorption on a wide variety of adsorbents. The two adjustable parameters of the Langmuir isotherm - the saturation capacity, or $q_m$, and the dissociation constant, $K_d$ - are usually estimated by fitting the isotherm equation to the equilibrium data acquired from batch equilibration experiments. In this study, we have evaluated the possibility of estimating $q_m$ and $K_d$ for the adsorption of bovine serum albumin to a cation exchanger using batch kinetic data. A rate model predicated on the kinetic form of the Langmuir isotherm, with three adjustable parameters ($q_m,\;K_d$, and a rate constant), was fitted to a single kinetic profile. The value of $q_m$ determined as the result of this approach was quantitatively consistent with the $q_m$ value derived from the traditional batch equilibrium data. However, the $K_d$ value could not be retrieved from the kinetic profile, as the model fit proved insensitive to this parameter. Sensitivity analysis provided significant insight into the identifiability of the three model parameters.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.04a
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• pp.309-312
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• 2007

The cryogenic fluid is the propellant for the liquid rocket engine. The design of space launcher vehicle is guided by minimum size and weight criteria, so the turbo pump solicits high impeller speed. Such high speed results in a zone of pressure drop below vapor pressure causing caivtation around inducer blades. The cryogenic fluid has different characters from isothermal fluid like water. The cryogenic fluid has very sensible thermodynamic properties and the phase change undergoes evaporative cooling. So, the developed code has to be modified cavitation modeling and it is added the energy equation for temperature sensitivity.

• Journal of the Korean Society of Propulsion Engineers
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• v.22 no.3
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• pp.14-20
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• 2018

An estimation law of air mass flow rate for high speed engine control is presented. The variables of mass estimation equations are modified to measurable variables which can be obtained during flight, and the effectiveness of each variable to the estimation accuracy is evaluated. The equation is modified to a simplified form, and the uncertainty is evaluated. In addition, reference data for the selection of estimation methods is suggested by considering the sensitivity analysis of sensor error.