• Title/Summary/Keyword: Self-Determination

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LC-MS/MS-based Quantification of Ten Neurotransmitters in Rat Limbic System and Serum: Application to Chronic Unpredictable Mild Stress-Induced Depression Rats

  • Mingyan Ma;Qiangxiang Chen;Wen Cao;Yubo Zhou;Aijuan Yan;Yanru Zhu
    • Mass Spectrometry Letters
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    • v.14 no.3
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    • pp.91-103
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    • 2023
  • As one of the most common mood disorders, numerous studies have shown depression is the main risk factor for non-suicidal self-harm. The pathogenesis of depression is complex, and a comprehensive and rapid measurement of monoamine neurotransmitters and their metabolites will be very helpful in understanding the pathogenesis of depression. Therefore, a rapid and sensitive underivatized liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous monitoring of the levels of ten neurotransmitters and their metabolites in rat serum and limbic system and successfully applied to quantify the changes of neurotransmitter levels in chronic unpredictable mild stress-induced rats. The analytes studied were mainly involved in tyrosine metabolism, tryptophan metabolism, and glutamate cycling pathways, which are important in the pathogenesis of depression. It had been verified the method was sensitive and effective, with satisfactory linearity, and met the requirements of biological sample determination. Levels of neurotransmitters in rat serum, hippocampus, amygdala, prefrontal cortex, striatum, and hypothalamus were determined via the method. The results showed serotonin, dopamine, norepinephrine, and their metabolites were decreased, glutamine was increased, and glutamate was disturbed in chronic unpredictable mild stress-induced depression rats. This method provides a new approach to studying the pathogenesis of depression and other neurological disorders.

Effect of a Career Value Clarification Program on Career Consciousness Maturity and Career Decision-Making of Female College Students

  • Jung-chul Heo
    • Journal of the Korea Society of Computer and Information
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    • v.28 no.11
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    • pp.191-199
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    • 2023
  • In this paper, we would like to propose how the career value clarification program effects the maturity of career consciousness and career decision-making of female college students. The subjects were 70 attending to K Women's College and pre-and post tests of the program were conducted to them. The results were presented: The career value clarification program had a significant effect on career determination, career involvement, career independence, and career dispositionality and in particular, was significant in reasonable type as one of career decision making variables. The results mentioned above indicate that the career value clarification program had a statistically significant effect on career maturity and career decision-making. To positively enhance career maturity and career decision-making in the subjects, the career value clarification program should encourage college women students to visit diverse institutes and organizations in their community to identify licenses and activities needed for career and be prepared for actual career. Colleges should actively invite related experts and give students opportunities to understand the definition of and values pursued in their career.

US, China and the Russo-Ukraine War: The Conditions for Generating a Mutually Perceived Hurting Stalemate and Consequent Ceasefire In Moscow and Kyiv

  • Benedict E. DeDominicis
    • International Journal of Advanced Culture Technology
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    • v.11 no.4
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    • pp.177-192
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    • 2023
  • A prerequisite for a lasting ceasefire is the emergence of a prevailing view in Moscow and Kyiv that the fighting has reached a hurting stalemate. In sum, they both lose more through continuing warfare than by a ceasefire. This study applies social identity dynamics of nationalism to this escalatory conflict. It generates findings that imply that China as a third-party great power intervening mediator can potentially play a pivotal role. Shifting the respective prevailing views in Moscow and Kyiv of their interaction from a zero-sum foundation requires proffering powerful economic and political third-party incentives. Effective inducement would facilitate national defense, development and prestige for Moscow as well as Kyiv. China arguably has the underutilized potential power capabilities necessary to alter the respective prevailing views of strategic relationships among the great powers within Moscow, Brussels and Washington. A prerequisite for success in striving effectively towards this strategic goal is cooperation with the Beijing despite skepticism from Washington. This study utilizes a process tracing methodological approach. It highlights that the foundations of the Russo-Ukraine war lie in the institutionalization within Euro-Atlantic integration of the Cold War assumption that the USSR was an imperialist revisionist actor. Russia is the USSR's successor state. Moscow's prevailing view is that Russian national self-determination was unjustly circumscribed in the multinational Soviet totalitarian Communist system. The Euro-Atlantic community is perceived as a neocolonial imperial threat by allying with post-1991 Ukrainian nationalism at Russia's expense. The study finds that acknowledging Eurasian regional multipolarity is necessary, if not sufficient, to coopt Beijing into a global political stabilization strategy. It functionally aims to promote international balancing to lessen potentials for horizontal as well as vertical escalation of the Russo-Ukrainian conflict.

Privacy model for DTC genetic testing using fully homomorphic encryption (동형암호를 활용한 DTC유전자검사 프라이버시모델)

  • Hye-hyeon Jin;Chae-ry Kang;Seung-hyeon Lee;Gee-hee Yun;Kyoung-jin Kim
    • Convergence Security Journal
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    • v.24 no.2
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    • pp.133-140
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    • 2024
  • The spread of Direct-to-Consumer (DTC) genetic testing, where users request tests directly, has been increasing. With growing demand, certification systems have been implemented to grant testing qualifications to non-medical institutions, and the scope of tests has been expanded. However, unlike cases in less regulated foreign countries, disease-related tests are still excluded from the domestic regulations. The existing de-identification method does not adequately ensure the uniqueness and familial sharing of genomic information, limiting its practical utility. Therefore, this study proposes the application of fully homomorphic encryption in the analysis process to guarantee the usefulness of genomic information while minimizing the risk of leakage. Additionally, to safeguard the individual's right to self-determination, a privacy preservation model based on Opt-out is suggested. This aims to balance genomic information protection with maintainability of usability, ensuring the availability of information in line with the user's preferences.

The Effect of Amateur Golfers' Passionate Behavior on Training Satisfaction and Training Performance (아마추어 골프선수의 열정적 행동이 훈련만족 및 훈련성과에 미치는 영향)

  • Joo-Won Kim
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.4
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    • pp.897-905
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    • 2023
  • This study attempted to reveal the influence of amateur golfers' passionate behavior on training satisfaction and training performance. Accordingly, according to the sample plan from April 1 to June 23, 2023, the key words were set for the first expert interview, "golf player," "golf training," and "golf match" to extract factors that meet the study, and are as follows through SPSS & AMOS 21.0. First, it was discovered that amateur golfers' harmony and obsessive passion had an impact (+) on training satisfaction, and second, passionate behavior had an impact on training performance. Third, it was found that training satisfaction affects training performance. Therefore, rather than distinguishing between success and failure in the process of converting to professional golf, the growth process and positive emotions should be equipped, and the expression of internalization in which self-determination is significant? Efficiency in training? The results are expected to vary depending on how it is handled.

A study on community care using AI technology (AI 기술을 활용한 커뮤니티케어에 관한 연구)

  • Seungae Kang
    • Convergence Security Journal
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    • v.23 no.5
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    • pp.151-156
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    • 2023
  • Currently, ICT is widely used in caring for the elderly living alone and preventing the disappearance of the elderly with dementia. Therefore, in this study, based on the government policy direction for the 4th industrial revolution, the use of AI technology-based care services, which are gradually increasing in community care, was sought to explore the current status and prospects for utilization and activation.AI speakers and caring robots, services that can be used for community care, help solve various problems experienced by the elderly, and are also used to relieve lack of conversation or loneliness by adding emotional functions. In order to activate community care using AI technology in the future: First, there is a need for continuous education to familiarize the elderly with AI devices and 'user experience (UX) design' for the elderly. Second, it is necessary to use human-centered technology that has a complementary relationship and enables emotional mutual relationships rather than using function-oriented technology. Third, it is necessary to solve ethical problems such as guaranteeing the user's right to self-determination and protecting privacy.

The Appropriateness of Probabilistic Rainfall of Disaster Impact Assessment System in Jeju Island (재해영향평가 적용 확률강우량의 적정성에 관한 연구 (제주도를 중심으로))

  • Hong-Jun Jo;Seung-Hyun Kim;Kwon-Moon Ko;Dong-Wook Lee
    • Ecology and Resilient Infrastructure
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    • v.11 no.2
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    • pp.55-64
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    • 2024
  • The disaster impact assessment system was introduced in 2005 as a disaster prevention procedure for comprehensive and systematic developmental projects. However, according to the 'Practical Guidelines for Disaster Impact Assessment', Jeju Island's unique hydrogeological features necessitate the calculation of isohyetal-based probabilistic rainfall, which can reflect altitude, when estimating probabilistic rainfall for flood volume determination, rather than using conventional methods. Despite Jeju Island being centered around Hallasan, there are three Automatic Weather Stations (AWS) located at the summit of Hallasan, making weather stations denser than in other cities and provinces. Therefore, it is judged that there would be no difficulty in applying conventional methods, such as utilizing the probabilistic rainfall data from the weather stations or employing the Thiessen method, to estimate flood volumes for small-scale project areas. Accordingly, this study conducts a comparative analysis of the impact of applying general probabilistic rainfall from weather stations and isohyetal-based probabilistic rainfall in site in the context of Jeju Island's disaster impact assessment system.

A Study on the Perception Changes of Physicians toward Duty to Inform - Focusing on the Influence of the Revised Medical Law - (설명의무에 대한 의사의 인식 변화 조사 연구 -의료법 개정의 영향을 중심으로-)

  • Kim, Rosa
    • The Korean Society of Law and Medicine
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    • v.19 no.2
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    • pp.235-261
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    • 2018
  • The Medical law stipulates regulations about the physician's duty to inform to contribute to patient's self-determination. This law was most recently revised on December 20, 2016, and came into effect on June 21, 2017. There has been much controversy about this, and it has been questioned whether or not it will be effective for physicians to comply with the duty to inform. Therefore, this study investigated perceptions of physicians of whether they observed the duty to inform and their legal judgment about that duty, and analyzed how the revision of the medical law may have affected the legal cognition of physician's duty to inform. This study was conducted through an online questionnaire survey involving 109 physicians over 2 weeks from March 29 to April 12, 2018, and 108 of the collected data were used for analysis. The questionnaire was developed by revising and supplementing the previous research (Lee, 2004). It consisted of 41 items, including 26 items related to the experience of and legal judgment about the duty to inform, 6 items related to awareness of revised medical law, and 9 items on general characteristics. The data were analyzed using SAS 9.4 program and descriptive statistics, Chi-square test, Fisher's exact test and Binary logistic regression were performed. The results are as follows. • Out of eight situations, the median number of situations that did not fulfill the duty to inform was 5 (IQR, 4-6). In addition, 12 respondents (11%) answered that they did not fulfill the duty to inform in all eight cases, while only one (1%) responded that he/she performed explanation obligations in all cases. • The median number of the legal judgment score on the duty to inform was 8 out of 13 (IQR, 7-9), and the scores ranged from a minimum of 4 (4 respondents) to a maximum of 11 (3 respondents). • More than half of the respondents (n=26, 52%) were unaware of the revision of the medical law, 27 (25%) were aware of the fact that the medical law had been revised, 20(18%) had a rough knowledge of the contents of the law, and only 5(5%) said they knew the contents of the law in detail. The level of awareness of the revised medical law was statistically significant difference according to respondents' sex (p<.49), age (p<.0001), career (p<.0001), working type (p<.024), and department (p<.049). • There was no statistically significant relationship between the level of awareness of the revised medical law and the level of legal judgment on the duty to inform. These results suggest that efforts to improve the implementation and cognition of physician's duty to inform are needed, and it is difficult to expect a direct positive effect from the legal regulations per se. Considering the distinct characteristics of medical institutions and hierarchical organizational culture of physicians, it is necessary to develop a credible guideline on the duty to inform within the medical system, and to strengthen the education of physicians about their duty to inform and its purpose.

Searching for a Curriculum to Reconceptualize Sexuality for Youth Sex Education : Nth Room Era, New Talk of 'Body' and 'Sex' from a Feminist Theological Point of View (청소년 성교육을 위한 성성(性性)의 재개념화 커리큘럼 모색 : N번방 시대, 여성신학적 관점에서 '몸'과 '성'을 새롭게 이야기하다)

  • Lee, Jooah
    • Journal of Christian Education in Korea
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    • v.67
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    • pp.301-337
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    • 2021
  • The researcher looked at the differences in views and various controversies surrounding Korean youth sexuality education in the wake of the Nth Room incident, which had a great impact on modern Korean society. Sex education for adolescents in Korea can be divided into public sex education through school sex education and the Youth Sexuality Center, and conservative/traditional Protestant sex education. Public sex education is partly influenced by feminist sexual ethics and comprehensive sex education abroad. Based on gender sensitivity and the right to sexual self-determination, four major projects are prevention of sexual harassment, prostitution, sexual violence, and domestic violence. However, the school sex education standard was criticized for stereotypes of gender roles and gender-discriminatory content, reinforced distorted myths about sexual violence, and exclusion of sexual diversity and various family types. Conservative/traditional Protestantism is based on the normal family ideology such as bisexual marriage, premarital chastity, and sexual ethics recognized only within marital relationships. It is a form of confrontation with public sex education while strongly opposing it. The researcher first analyzed the characteristics of public sex education, conservative/traditional Protestant sexual ethics and sex education, feminist sex ethics and sex education, and overseas youth sex education, respectively, while composing the curriculum for Korean youth sexuality education. And as a more fundamental solution to youth sexuality education, I pointed out that there are limits to asceticism, premarital chastity, gender sensitivity and sexual self-determination education, and found an alternative to the concept of body and sex in feminist theology. The researcher pointed out that it is necessary to reconceptualize the body and sex under the recognition that the most fundamental cause of distorted sexual culture is dualistic sex and understanding the body, centering on the research of various feminist theologians. And this was conceptualized into three concepts: holistic sexuality, mutual solidarity understood in relationships with others, and sexuality as a spirituality that extends to the global community. And with each curriculum, 1) Holistic Sexuality: Breathing, Narrative, Making the Shape of One's Body and Mind 2) mutual solidarity : Feeling the Breath of Others, Media Literacy through Conscientization, Sending a Good Wind 3) Sexuality as a spirituality that extends to global concern: It was proposed to pay attention to nature and to co-cultivate it, to listen to the earth's moans and create a new way of life, and to write a prayer with the earth and fellow living beings.

Informed Consent and Refusal of Treatment in Emergency Medical Situation (응급의료에서의 설명·동의 원칙과 응급의료거부죄)

  • Lee, Jung-eun
    • The Korean Society of Law and Medicine
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    • v.23 no.1
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    • pp.37-80
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    • 2022
  • By analyzing informed consent and the refusal of emergency medical treatment (called patient dumping) under the current Emergency Medical Service Act, this study suggests that an emergency medical professional is only liable for patient dumping if their duty to protect the patient's life takes precedence over the patient's right to self-determination. In emergency medical situations, as in general medical situations, medical treatment should be performed after the emergency medical professional informs the patient about the medical treatment, including its necessity and methods, and obtains consent from the patient. Refusing or evading the performance of emergency medical services on the excuse of the informed consent not considering a waiver or alteration of informed consent requirements without reasonable reasons violates the Emergency Medical Service Act and thus makes an emergency medical professional liable to administrative disposition or criminal penalty. In other words, depending on the existence of a waiver of alteration of the informed consent, patient dumping may be established. If the patient is a minor or has no decision-making ability, and their legal representative makes a decision against the patient's medical interests, the opinion of the legal representative is not unconditionally respected. A minor also has the right to decide over their body, and the decisions of their legal representatives should be in the patient's best interests. If the patient refuses treatment, in principle, the obligation of life protection of emergency medical professionals is the top priority. However, making these decisions in the aforementioned situations in the emergency medical field is difficult because of the absence of explicit regulations regarding these exceptional problems. This study aims to organize the following precedents of the Supreme Court of Korea. The court states that, when balancing the conflicting interests between the duty to provide emergency medical service and the duty to inform is unavoidable for emergency medical professionals, they should put the duty to protect the patient's life ahead of the duty to inform if the patient's life matters. Exceptionally, when a patient has seriously considered whether they should receive treatment before the emergency medical situation, their right to self-determination can be considered equal to the obligation of emergency medical professionals to provide emergency medical treatment. This research also suggests that an amendment of the Emergency Medical Service Act should include the following. First, the criteria for determining the decision-making ability of emergency patients should consist of medical content. Second, additional consent from a medical professional is unnecessary for first-aid treatment. Finally, new provisions for emergency medical obligations for minors, new provisions for the decision standard when there are conflicting opinions about the treatment of a patient, and new penalty provisions for professionals who suspend emergency medical examinations and treatments need to be established.