• 대한약침학회지
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• 제14권2호
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• pp.75-80
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• 2011

Objectives & Methods: This research may accounts for Self Targeting Therapy (STT) which is a peculiar operation of Mountain Ginseng Pharmacopuncture. The objectives include analysis of its mechanism and reporting of clinical cases. Results: 1. STT of Mountain Ginseng Pharmacopuncture refers to the function of curing and making a diagnosis of the disease by oneself. 2. The mechanism of STT is to pursue the latent illness and make the remedial action by oneself. In this process, the symptom of latent disease is outwardly expressed. 3. The most popular symptom expressed is manifestation of pecular sensation along the specific meridians. Then followed headache, dizziness, powerless and etc. Diverse symptoms can be expressed by a patient. 4. If the revealed symptoms are carefully observed, the cause of the disease or the patient state can be diagnosed easily. Conclusion: The mechanism of STT of Mountain Ginseng Pharmacopuncture can be a great asset in clinical trials. Other studies on STT of Mountain Ginseng Pharmacopuncture should be followed in the future.

• Journal of Pharmaceutical Investigation
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• 제40권4호
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• pp.201-212
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• 2010

Self-organized nanogels from polysaccharide derivatives offer a promising approach in treatment of cancer due to their flexibility in chemistry and their ability to improve the therapeutic index of a drug by modifying biodistribution by their preferential localization at target sites and lower distribution in normal healthy tissues. These properties have promoted studies of active cancer targeting by self-organized nanogels for even better accumulation in solid tumors. However although many researchers have reported their potential by using cell culture systems and small animal tumor models in cancer therapy, these nanogels need more decoration such as conjugation with targeting moiety and endowment of stimuli-sensitivity for precise targeting of the cancer site. In this review, we summarize the recent efforts in developing novel targeting approaches via active endocytosis and stimuli-sensitive systems responding to hyperthermic or acidic tumor pH conditions.

• 한국보육지원학회지
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• 제5권2호
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• pp.43-71
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• 2009

본 연구는 가정이나 학교생활에서의 부적응 행동 아동을 대상으로 미술치료를 실시하여 우울 및 불안 감소와 자아존중감 향상에 어떠한 효과가 있는지 알아보기 위한 것이었다. 연구대상은 J시 초등학교 1학년 여자 아동(만 7세)으로 주 2회, 50분씩 총 24회기 미술치료 프로그램을 적용하였으며, 치료 종결부분에 어머니-아동과 함께 6회기 미술치료를 실시하였다. 아동의 우울 및 불안 감소를 알아보기 위해 Kovacs와 Beak(1977)이 개발한 Children's Depression Inventory(CDI)를 조수철 이영식(1990)이 번안한 한국형 아동용 우울 척도와 자아존중감 향상을 알아보기 위해 Reynolds와 Richmond(1978)가 제작한 Revised Child Manifest Anxiety Scale(RCMAS)을 조수철 최진숙(1990)이 번안한 척도를 사용하였다 그리고 아동의 정서적인 평가를 위해 KHTP, KFD 그림검사를 사전-사후로 실시하여 분석하였으며, 프로그램 진행과정에서의 아동의 변화를 회기별로 분석하였다. 본 연구의 결과는 다음과 같다. 첫째, 미술치료가 아동의 우울 및 불안을 감소시키는데 효과가 있었다. 둘째, 미술치료가 아동의 자아존중감을 향상시키는데 효과가 있었다. 셋째, 아동의 KHTP, KFD 그림검사에서는 긍정적으로 정서적 안정이 변화되었으며, 가족의 소속감 응집력이 강화되어 친밀한 가족으로 변화하였다. 넷째, 회기별 미술치료 프로그램 진행과정에서 아동의 우울 및 불안이 감소되고 자아존중감이 향상되었다. 이상의 연구결과를 통해 미술치료가 부적응 행동 아동의 우울 및 불안을 감소시키고 자아존중감을 향상시키는데 긍정적인 효과가 있음을 알 수 있었다.

• BMB Reports
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• 제50권3호
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• pp.117-125
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• 2017

Most of the cancers are still incurable human diseases. According to recent findings, especially targeting cancer stem cells (CSCs) is the most promising therapeutic strategy. CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. Most of all, the presence of CSCs is closely associated with tumorigenesis and therapeutic resistance. Despite the numerous efforts to target CSCs, current anti-cancer therapies are still impeded by CSC-derived cancer malignancies; increased metastases, tumor recurrence, and even acquired resistance against the anti-CSC therapies developed in experimental models. One of the most forceful underlying reasons is a "cancer heterogeneity" due to "CSC plasticity". A comprehensive understanding of CSC-derived heterogeneity will provide novel insights into the establishment of efficient targeting strategies to eliminate CSCs. Here, we introduce findings on mechanisms of CSC reprogramming and CSC plasticity, which give rise to phenotypically varied CSCs. Also, we suggest concepts to improve CSC-targeted therapy in order to overcome therapeutic resistance caused by CSC plasticity and heterogeneity.

• 국제물리치료학회지
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• 제10권2호
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• pp.1810-1817
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• 2019

Background: Effect of cervical and lumbar tractions on the reduction in the angle of curvature and the effect of a correction exercise or a general traction method on balance, muscle strength, pain, and body alignment, however insufficient research has been undertaken on self traction exercises targeting patients with scoliosis. Purpose: To determine the effect of cervical and lumbar tractions on the reduction in the angle of curvature and the effect of a correction exercise or a general traction method on balance, muscle strength, pain, and body alignment. Design: Randomized controlled clinical trial (single blinded) Methods: Twelve adults(20s) with scoliosis were included in this study and performed a traction program that was composed of a 5-min warm-up exercise, a 15-min main exercise, and a 5-min cool-down exercise (25 minutes in total), three times a week for four weeks. The Chiro traction machine was used for the self-traction exercise. Vertebral alignment, muscle strength, and flexibility were compared before and after the intervention using the paired T-test. Results: The scoliosis angle, pelvic torsion, and lumbar extensor were significantly changed by intervention; however, there was no significant difference in flexibility. Conclusion: The results revealed that self-traction exercise activated blood flow through the extension and contraction of muscles, effectively increasing the function of the muscles around the vertebrae.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.5947-5954
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• 2012

The cancer stem cell (CSC) model states that cancers are organized in cellular hierarchies, which explains the functional heterogeneity often seen in tumors. Like normal tissue stem cells, CSCs are capable of self-renewal, either by symmetric or asymmetric cell division, and have the exclusive ability to reproduce malignant tumors indefinitely. Current systemic cancer therapies frequently fail to eliminate advanced tumors, which may be due to their inability to effectively target CSC populations. It has been shown that embryonic pathways such as Wnt, Hedgehog, and Notch control self-renewal and cell fate decisions of stem cells and progenitor cells. These are evolutionary conserved pathways, involved in CSC maintenance. Targeting these pathways may be effective in eradicating CSCs and preventing chemotherapy or radiotherapy resistance.

• 한국학교ㆍ지역보건교육학회지
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• 제16권2호
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• pp.101-114
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• 2015

Objectives: Find out how it affects anxiety situations and self-esteem targeting the critical period of development of self-esteem in the lower grades in elementary school based on laughter therapy in having a positive influence on physical health promotion and positive emotional cultivation. And to verify the effects of laughter activity was to provide preliminary data on mental health education and guidance of school life. Methods: By targeting Ulsan Y elementary school, second grade 7 class, 191 students conducted test self-esteem and anxiety. Homogeneous group of experimental and control groups were selected in each one class. Classified as experimental group carried out laughter activity programs and control group did not carried out. Also the separation of the application program before and after, then it were performed preliminary-post-further as same checklist. Program coverage period is 12 weeks and 30 minutes per session was conducted twice a week. Differences between the experimental group and the comparison group has conducted the independent samples t-test, and if the difference between the experimental group and the comparison group were verified by performing a variance analysis(Oneway ANOVA) and post multiple comparisons. Results: Analysis of the experimental group decreased anxiety in the post-test than the pre-test as a whole, in particular, sub-areas of concern, shame and shyness was shown to be effective, and decision of the difficulty was not significant by insignificant reduction. In addition, self-esteem was increased in overall score. The score of collective self-esteem and School life self-esteem were more increased, and domestic self-esteem was not significant by slight increases. In contrast, the comparison group showed no significant difference in all areas of anxiety and self-esteem of pre-test and post-test. Conclusions: In experiments on self-esteem and anxiety of lower grade in elementary school through laughter activity program, comparison group it did not show an effect by accident, and experimental group showed meaningful effects that self-esteem was increased and anxiety was reduced. Thus, laughter activity can be seen that improving self-esteem, anxiety reduction and etc, is very beneficial to mental health.

• Journal of Ginseng Research
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• 제48권3호
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• pp.266-275
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• 2024

Cancer stem cells (CSCs) are a rare subpopulation of cancer cells that exhibit stem cell-like characteristics, including self-renewal and differentiation in a multi-stage lineage state via symmetric or asymmetric division, causing tumor initiation, heterogeneity, progression, and recurrence and posing a major challenge to current anticancer therapy. Despite the importance of CSCs in carcinogenesis and cancer progression, currently available anticancer therapeutics have limitations for eradicating CSCs. Moreover, the efficacy and therapeutic windows of currently available anti-CSC agents are limited, suggesting the necessity to optimize and develop a novel anticancer agent targeting CSCs. Ginseng has been traditionally used for enhancing immunity and relieving fatigue. As ginseng's long history of use has demonstrated its safety, it has gained attention for its potential pharmacological properties, including anticancer effects. Several studies have identified the bioactive principles of ginseng, such as ginseng saponin (ginsenosides) and non-saponin compounds (e.g., polysaccharides, polyacetylenes, and phenolic compounds), and their pharmacological activities, including antioxidant, anticancer, antidiabetic, antifatigue, and neuroprotective effects. Notably, recent reports have shown the potential of ginseng-derived compounds as anti-CSC agents. This review investigates the biology of CSCs and efforts to utilize ginseng-derived components for cancer treatment targeting CSCs, highlighting their role in overcoming current therapeutic limitations.

• 기본간호학회지
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• 제15권1호
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• pp.60-70
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• 2008

Purpose: This study was done to identify types of smoking decision making-temptation in adolescents and characteristics related to type among student smokers. Method: Data collection was done from March to July. 2006. A survey was administered to 275 students in 13 high schools and 15 middle schools in Seoul, South Korea. To identify types and characteristics smoking decision making-temptation in adolescents, cluster analysis using the K-mean method was employed. Characteristics of the influential variables according to the identified types of adolescent smokers were evaluated using ANOVA. Results: Four types of smoking pattern in adolescents were identified: habitual craving (17.7%), nicotine dependence (35.8%), feeblemindedness (28.4%), and self control (18.1%). The score for nicotine dependency was higher in the habitual craving type than any other type (F=11.79, p=.001), while the score for self efficacy for smoking abstinence was higher in the self control type (F=23.06, p=.000). Conclusions: Findings from this study suggest that effective interventions for smoking cessation in adolescents require not only active implementation of nicotine replacement therapy but also development of individualized approaches for each person targeting change in the social environment that may lead to positive smoking decisional balance.

• 인간행동과 음악연구
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• 제10권1호
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• pp.25-45
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• 2013

본 연구는 비음악 전공자들의 음악치료 진로선택과정 경험을 살펴보고자 하였다. 이를 위해 서울지역에 소재한 대학의 음악치료전공 대학원생 중 학부에서 음악을 전공하지 않은 학생 5명을 대상으로 심층면담 하여 근거이론 도출을 위한 예비연구를 수행하였다. 연구 결과, 비음악 전공자들의 음악치료 진로선택과정은 삶의 구체적 목표 설정에 대한 지속적인 동기와 취업이나 진학과 같은 현실적인 자극을 받아 사회인으로서의 역할 결정에 대한 갈등을 경험하는 것으로 유발되었다. 이는 자신을 둘러싼 현실적인 상황과 음악치료에 대한 구체적인 탐색을 야기하였고, 개인적 특성과 외부적 요인 그리고 음악적 배경이 상호작용 하였다. 그 경험은 자신의 본능과 잠재성에 깊이 관여하고 있는 '음악아(Music Child)'와의 관계 재설정을 통한 '자기(self)' 통합과 성장의 추구로 이어졌다. 또한 관계 속에서 의미 있는 존재가 되고자 하는 욕구가 진로선택 과정에서 자신의 포부를 구체화 할 수 있도록 지속적인 영향을 미쳤다. 이 연구는 비음악 전공자들이 음악치료학으로 진로를 선택하게 되는 과정을 분석함으로써 음악치료에 입문한 비음악 전공자들에 대한 실제적 정보를 제공했다는 점에서 그 의의가 있다.