• Research in Plant Disease
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• v.27 no.2
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• pp.84-90
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• 2021

In June 2019, Angelica acutiloba plants showing virus-like symptoms such as chlorotic local lesion and mosaic on the leaves were found in a greenhouse in Nonsan, South Korea. To identify the causal virus, we collected 6 symptomatic A. acutiloba leaf samples and performed reverse transcription polymerase chain reaction (RT-PCR) analysis using specific detection primers for three reported viruses including tomato spotted wilt virus (TSWV). RT-PCR results showed that five symptomatic samples were positive for TSWV. Mechanical sap inoculation of one of the collected TSWV isolate (TSWV-NS-AG28) induced yellowing, chlorosis and mosaic symptoms in A. acutiloba and necrotic local lesions and mosaic in Solanaceae species. Phylogenetic analysis based on the complete genome sequences showed that TSWV-NS-AG28 had a maximum nucleotide identity with TSWVNS-BB20 isolated from butterbur in Nonsan, South Korea. To our knowledge, this is the first report of TSWV infection in A. acutiloba.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.1
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• pp.75-83
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• 2021

Over-urbanization has contributed to the increase in traffic problems. This makes the need for effective road planning and design more important than ever. I have been able to learn how to build a new road, and how to use it. However, in spite of the importance of good road planning, there are no systematic standards or methods for calculating traffic volume on railroad routes. Therefore, in this study, to strengthen the competitiveness of railroads, the concept of line capacity is introduced to railroads, and a clear standard and method for calculating railroad line capacity are presented. Based on the results, the line capacity of main railway lines for domestic railways was calculated. By applying the method of calculating the line capacity presented in this study, the capacity of existing railway lines and newly expanded routes can be calculated. It is expected that our findings will be able to provide systematic standards that can be applied to yield a more effective investment and design planning stage; the findings will also help improve the efficiency of railroad operation.

• Journal of Life Science
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• v.31 no.6
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• pp.537-542
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• 2021

Schisandra nigra Max., a dioecious plant native to Jeju Island in Korea, is cultivated on a small scale for fruit production. As fruit-producing female individuals are generally considered to be more valuable than male, early identification of plant sex at the seedling stage is important. In this study, a sequence-characterized amplified region (SCAR) marker associated with a female-specific region in the genome of S. nigra was investigated. Of 120 randomly amplified polymorphic DNA (RAPD) primers, one primer (OPB-03) consistently amplified a 749 bp band in female plants. The female-specific PCR product was isolated and cloned, and the nucleotide sequences were then determined. Southern hybridization performed using the female-specific fragment as a probe produced positive signals only in genomic DNA from the female plants. This result revealed that the 749 bp segment of DNA was present in the genome of female plants but absent in the genome of male plants. A SCAR primer pair was designed based on the RAPD marker to amplify a 436 bp fragment in the genomic DNA of female plants. This primer pair amplified the expected size of DNA fragment in female plants and four monoecious individuals collected from a natural population. The SCAR marker identified in this study can be used to distinguish female-flowering individuals at the seedling stage.

• Journal of Biomedical Engineering Research
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• v.43 no.5
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• pp.341-352
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• 2022

Medical image segmentation is the most important task in radiation therapy. Especially, when segmenting medical images, the liver is one of the most difficult organs to segment because it has various shapes and is close to other organs. Therefore, automatic segmentation of the liver in computed tomography (CT) images is a difficult task. Since tumors also have low contrast in surrounding tissues, and the shape, location, size, and number of tumors vary from patient to patient, accurate tumor segmentation takes a long time. In this study, we propose a method algorithm for automatically segmenting the liver and tumor for this purpose. As an advantage of setting the boundaries of the tumor, the liver and tumor were automatically segmented from the CT image using the 2D CoordConv DeepLab V3+ model using the CoordConv layer. For tumors, only cropped liver images were used to improve accuracy. Additionally, to increase the segmentation accuracy, augmentation, preprocess, loss function, and hyperparameter were used to find optimal values. We compared the CoordConv DeepLab v3+ model using the CoordConv layer and the DeepLab V3+ model without the CoordConv layer to determine whether they affected the segmentation accuracy. The data sets used included 131 hepatic tumor segmentation (LiTS) challenge data sets (100 train sets, 16 validation sets, and 15 test sets). Additional learned data were tested using 15 clinical data from Seoul St. Mary's Hospital. The evaluation was compared with the study results learned with a two-dimensional deep learning-based model. Dice values without the CoordConv layer achieved 0.965 ± 0.01 for liver segmentation and 0.925 ± 0.04 for tumor segmentation using the LiTS data set. Results from the clinical data set achieved 0.927 ± 0.02 for liver division and 0.903 ± 0.05 for tumor division. The dice values using the CoordConv layer achieved 0.989 ± 0.02 for liver segmentation and 0.937 ± 0.07 for tumor segmentation using the LiTS data set. Results from the clinical data set achieved 0.944 ± 0.02 for liver division and 0.916 ± 0.18 for tumor division. The use of CoordConv layers improves the segmentation accuracy. The highest of the most recently published values were 0.960 and 0.749 for liver and tumor division, respectively. However, better performance was achieved with 0.989 and 0.937 results for liver and tumor, which would have been used with the algorithm proposed in this study. The algorithm proposed in this study can play a useful role in treatment planning by improving contouring accuracy and reducing time when segmentation evaluation of liver and tumor is performed. And accurate identification of liver anatomy in medical imaging applications, such as surgical planning, as well as radiotherapy, which can leverage the findings of this study, can help clinical evaluation of the risks and benefits of liver intervention.

• Journal of Internet of Things and Convergence
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• v.8 no.4
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• pp.25-40
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• 2022

This study aimed to understand the increasing number of elder abuses in South Korea, where entry into the super-aged society is imminent, by implementing text mining analysis. Korean Academic journals were obtained from 2004, the establishment year of the senior care agency, to 2021. We performed natural language processing of the titles, keywords, and abstracts and divided them into three segments of periods to identify latent meanings in the data. The results illustrated that the first section included 81 papers, the second 64, and the third 104 respectively, averaging 13.8 annually, which increased its numbers from 2014 until the decrease below the annual average in 2020. Word frequency demonstrated that the common keywords of the entire segments were 'elder abuse,' 'elders,' 'influences,' 'factors,' 'recognition,' 'family,' 'society,' 'prevention plans,' 'experiences,' 'abused elders,' 'abuse prevention,' 'depression,' etc., in consecutive order. TF-IDF indicated that 'influences,' 'recognition,' 'society,' 'prevention plans,' 'abuse prevention,' 'experiences,' 'depression,' etc., were the common keywords of all divisions. Network text analysis displayed that the commonly represented keywords were 'elder abuse,' 'elders,' 'influences,' 'factors,' 'characteristics,' 'recognition,' 'family,' 'prevention plans,' 'society,' 'abuse prevention,' and 'experiences' in the entire sections. concor analysis presented that the first segment consisted of 5 groups, the second 7, and the third 6. We suggest future directions for elder abuse research based on the results.

• Journal of the Korea Society of Computer and Information
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• v.27 no.9
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• pp.1-12
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• 2022

Traditional methods of measuring corneal ulcers were difficult to present objective basis for diagnosis because of the subjective judgment of the medical staff through photographs taken with special equipment. In this paper, we propose a method to detect the ulcer area on a pixel basis in corneal ulcer images using a semantic segmentation model. In order to solve this problem, we performed the experiment to detect the ulcer area based on the DeepLab model which has the highest performance in semantic segmentation model. For the experiment, the training and test data were selected and the backbone network of DeepLab model which set as Xception and ResNet, respectively were evaluated and compared the performances. We used Dice similarity coefficient and IoU value as an indicator to evaluate the performances. Experimental results show that when 'crop & resized' images are added to the dataset, it segment the ulcer area with an average accuracy about 93% of Dice similarity coefficient on the DeepLab model with ResNet101 as the backbone network. This study shows that the semantic segmentation model used for object detection also has an ability to make significant results when classifying objects with irregular shapes such as corneal ulcers. Ultimately, we will perform the extension of datasets and experiment with adaptive learning methods through future studies so that they can be implemented in real medical diagnosis environment.

• The Journal of Engineering Geology
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• v.32 no.4
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• pp.467-482
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• 2022

The Yeonghae basin is located at the northeastern part of the Yangsan fault (YSF; a potentially active fault). The study of the architecture of the Yeonghae basin is important to understand the activity of the Yangsan fault system (YSFS) as well as the basin formation mechanism and the activity of the YSFS. For this study, Digital Elevation Model (DEM) was used to highlight the marginal faults, and structural fieldwork was performed to understand the geometry of the intra-basinal structures and the nature of the bounding faults. DEM analysis reveals that the eastern margin is bounded by the northern extension of the YSF whereas the western margin is bounded by two curvilinear sub-parallel faults; Baekseokri fault (BSF) and Gakri fault (GF). The field data indicate that the YSF is striking in the N-S direction, steeply dipping to the east, and experienced both sinistral and dextral strike-slip movements. Both the BSF and GF are characterized dominantly by an oblique right-lateral strike-slip movement. The stress indicators show that the maximum horizontal compressional stress was in NNE to NE and NNW-SSE, which is consistent with right-lateral and left-lateral movements of the YSFS, respectively. The plotted structural data show that the NE-SW is the predominant direction of the structural elements. This indicates that the basin and marginal faults are mainly controlled by the right-lateral strike-slip movements of the YSFS. Based on the structural architecture of the Yeonghae basin, the study area represents a contractional zone rather than an extensional zone in the present time. We proposed two models to explain the opening and developing mechanism of the Yeonghae basin. The first model is that the basin developed as an extensional pull-apart basin during the left-lateral movement of the YSF, which has been reactivated by tectonic inversion. In the second model, the basin was developed as an extensional zone at a dilational quadrant of an old tip zone of the northern segment of the YSF during the right-lateral movement stage. Later on, the basin has undergone a shortening stage due to the closing of the East Sea. The second model is supported by the major trend of the collected structural data, indicating predominant right-lateral movement. This study enables us to classify the Yeonghae basin as an inverted strike-slip basin. Moreover, two opposite strike-slip movement senses along the eastern marginal fault indicate multiple deformation stages along the Yangsan fault system developed along the eastern margin of the Korean peninsula.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.5D
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• pp.453-459
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• 2010

In the study of traffic safety, it is utmost important to obtain more reliable estimates of the expected crashes for a site (or a segment). The observed crashes have been mainly used as the estimate of the expected crashes in Korea, while the empirical Bayes (EB) estimates based on the Poisson-gamma mixture model have been used in the USA and several European countries. Although numerous studies have used the EB method for estimating the expected crashes and/or the effectiveness of the safety countermeasures, no past studies examine the difference in the estimation errors between the two estimates. Thus, this study compares the estimation errors of the two estimates using a Monte Carlo simulation study. By analyzing the crash dataset at 3,000,000 simulated sites, this study reveals that the estimation errors of the EB estimates are always less than those of the observed crashes. Hence, it is imperative to incorporate the EB method into the traffic safety research guideline in Korea. However, the results show that the differences in the estimation errors between the two estimates decrease as the uncertainty of the prior distribution increases. Consequently, it is recommended that the EB method be used with reliable hyper-parameter estimates after conducting a comprehensive examination on the estimated negative binomial model.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.37-37
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• 2021

Calystegia soldanella L. is a perennial herbaceous halophyte belonging to the convolvulaceae family, which mainly grows in coastal sand dunes in Korea. Shoots and rhizomes are edible, and roots called 'Hyoseon Chogeun' are known to have medicinal effects such as antipyretic, sterilization, and diuretic. In addition, physiological activities of antioxidant, anti-inflammatory, antiviral, antifungal and PTP-1B (protein tyrosine phosphate-1B) inhibition have been reported. In this study, in vitro induction cell lines of C. soldanella L. collected from the coastal sand dunes in Jeju island was redifferentiated into adventitious roots that can be used as medicinal resources. Also the biomass of mass-proliferated adventitious roots using a bioreactor were evaluated. Plants of C. soldanella L. were collected from the crevice of the seashore in the coastal area of Taeheung 2-ri, Namwon-eup, Seogwipo-si. Then, it was separated into leaves, stems, rhizomes, and roots, and surface sterilized with 70% ethyl alcohol and 2% NaOCl (sodium hypochlorite). After washing with sterilized water, each organ section was cultured in Hormone-free MS medium (Murashige & Skoog Medium). As a result, the induction response rates were evaluated at 85% and 55%, respectively, in terms of callus formation and shoot generation in the rhizome segment. In the case of the adventitious roots morphological characteristics induced by single-use treatment of auxin-based plant growth regulators IBA and NAA from redifferentiated shoots were compared. Most efficient adventitious root culture method as a rooting rate, number, length, and biomass proliferation in the bioreactor system was confirmed when treated by culturing in MS salts, Sucrose 30 g·L^-1, and IBA 1mg·L^-1 for 4 weeks. In this study, the medium composition and culture period were confirmed using a bioreactor system to mass-proliferate adventitious roots derived from C. soldanella L. in Jeju island. Also this adventitious root line developed a new medicinal material could increase value of the bio-industry ingredient through quantitative and qualitative screening of phyto-bioactive compounds.

• Korean Circulation Journal
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• v.52 no.4
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• pp.304-319
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• 2022

Background and Objectives: De-escalation of dual-antiplatelet therapy through dose reduction of prasugrel improved net adverse clinical events (NACEs) after acute coronary syndrome (ACS), mainly through the reduction of bleeding without an increase in ischemic outcomes. Whether the benefits of de-escalation are sustained in highly thrombotic conditions such as ST-elevation myocardial infarction (STEMI) is unknown. We aimed to assess the efficacy and safety of de-escalation therapy in patients with STEMI or non-ST-segment elevation ACS (NSTE-ACS). Methods: This is a pre-specified subgroup analysis of the HOST-REDUCE-POLYTECH-ACS trial. ACS patients were randomized to prasugrel de-escalation (5 mg daily) or conventional dose (10 mg daily) at 1-month post-percutaneous coronary intervention. The primary endpoint was a NACE, defined as a composite of all-cause death, non-fatal myocardial infarction, stent thrombosis, clinically driven revascularization, stroke, and bleeding events of grade ≥2 Bleeding Academic Research Consortium (BARC) criteria at 1 year. Results: Among 2,338 patients included in the randomization, 326 patients were diagnosed with STEMI. In patients with NSTE-ACS, the risk of the primary endpoint was significantly reduced with de-escalation (hazard ratio [HR], 0.65; 95% confidence interval [CI], 0.48-0.89; p=0.006 for de-escalation vs. conventional), mainly driven by a reduced bleeding. However, in those with STEMI, there was no difference in the occurrence of the primary outcome (HR, 1.04; 95% CI, 0.48-2.26; p=0.915; p for interaction=0.271). Conclusions: Prasugrel dose de-escalation reduced the rate of NACE and bleeding, without increasing the rate of ischemic events in NSTE-ACS patients but not in STEMI patients.