• Archives of Craniofacial Surgery
• /
• v.22 no.5
• /
• pp.268-275
• /
• 2021

Background: The study aimed to evaluate nasal reconstruction techniques customized for Asians. The currently available nasal reconstruction guidelines are based on Caucasian patients, and their applicability is limited in Asian patients due to differences in anatomical and structural features. Methods: A retrospective analysis was performed of the medical records of 76 patients who underwent nasal reconstruction at a single center between January 2010 and June 2020. A comprehensive evaluation was conducted of patients' baseline demographics and clinical characteristics, including age, sex, medical history, defect size and location, reconstructive procedure, pathological diagnosis, postoperative complications, and recurrence. Results: In 59 cases (77%), nasal defects resulted from tumor ablation, and the remaining 17 cases involved post-traumatic (20%) and infection-induced (3%) tissue damage. The most common defect location was the alae, followed by the sidewalls, tip, and dorsum. Forehead flaps were the most commonly used reconstructive technique, followed by nasolabial advancement flaps, rotation flaps, and skin grafts. Each procedure was applied considering aspects of structural anatomy and healing physiology specific to Asians. Complications included nasal deformity, hypertrophic scarring, secondary infection, and partial flap necrosis, but no cases required additional surgical procedures. Tumors recurred in two cases, but tumor recurrence did not significantly affect flap integrity. Conclusion: Nasal reconstruction techniques applied considering Asians' facial features resulted in fewer postoperative complications and higher patient satisfaction than the approaches that are currently in widespread use. Therefore, this study is expected to serve as an essential reference for establishing treatment guidelines for nasal reconstruction in Asians.

• Journal of the Korean Institute of Gas
• /
• v.23 no.1
• /
• pp.54-61
• /
• 2019

As the market for portable electronic devices expands, the demand for Lithium Ion Battery (LIB) is also increasing. LIB has higher efficiency than other secondary batteries, but there is a risk of explosion / fire due to thermal runaway reaction. Especially, Electric Vehicles (EV) equipped with a large capacity LIB cell also has a danger due to a large amount of toxic gas generated by a fire. Therefore, it is necessary to analyze the risk of toxic gas generated by EV fire to minimize accident damage. In this study, the flow of toxic gas generated by EV fire was numerically analyzed using Computational Fluid Dynamic. Scenarios were established based on literature data and EV data to confirm the effect distance according to time and exposure standard. The purpose of this study is to analyze the risk of toxic gas caused by EV fire and to help minimize the loss of life and property caused by accidents.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.24 no.5
• /
• pp.35-53
• /
• 2021

A field survey was carried out targeting 59 pine wilt disease control areas distributed in Andong, and the ecological characteristics of the areas affected by pine wilt disease were analyzed using vegetation information, ecological information, and land use information. Vegetation characteristics of Pine wilt disease affected forest area showed a 3-layer vegetation structure, high percentage of accidental occurrence species (37%) and secondary vegetation species (59.6%), appearing 12 taxa naturalized plants and 3 taxa ecosystem disturbance organisms designated by the Ministry of Environment. Ecological information of Pine wilt affected area showed frequent occurrence of water stress in south and west slopes, low lying grounds in mountains, and in well-drained soils. Also, surrounding the area has been used as roads, tombs, and cultivation where intensive human activities were the cause of disturbance and stress to the pine forest. It was analyzed that the pine forest in Andong city suffered extensive damage due to the onset of pine wilt disease while the pine trees were weakened due to continuous human activities. Conclusively, the spread and onset of pine wilt disease are worsened by artificial factors than natural environmental conditions.

• Journal of Ginseng Research
• /
• v.45 no.1
• /
• pp.41-47
• /
• 2021

A wide range of studies have steadily pointed out the relation of oxidative stress to the primary and secondary causes of human disease and aging. As such, there have been multiple misconceptions about oxidative stress. Most of reactive oxygen species (ROS) generated from chronic diseases cause oxidative damage to cell membrane lipids and proteins. ROS production is increased by abnormal stimulation inside and outside in the body, and even though ROS are generated in cells in response to abnormal metabolic processes such as disease, it does not mean that they directly contribute to the pathogenesis of a disease. Therefore, the focus of treatment should not be on ROS production itself but on the prevention and treatment of diseases linked to ROS production, including types 1 and 2 diabetes, cancer, heart disease, schizophrenia, Parkinson's disease, and Alzheimer's disease. In this regard, Korean Red Ginseng (KRG) has been traditionally utilized to help prevent and treat diseases such as diabetes, cancer, inflammation, nervous system diseases, cardiovascular disease, and hyperlipidemia. Therefore, this review was intended to summarize in vivo animal and human clinical studies on the antioxidant activities of KRG and its components, ginsenosides.

• Explosives and Blasting
• /
• v.40 no.1
• /
• pp.29-38
• /
• 2022

Electronic detonators are now widely used in various construction sites and quarry mines. Including the sites where safety-thing is located nearby, Cases of using electronic detonators are increasing to maximize operational efficiency by improving blast fragmentation or reducing the cost of secondary blasting. This case study is about applying for electronic detonators on zone 00 construction site, which is the part of urban area metropolitan express rail A line project. Although the project was initially planned to utilize non-electric detonators, Electronic detonators are considered as the solution not only for safe and fast excavation, but also to minimize civil complaint and the damage of safety-thing. By applying electronic detonators, we were able to satisfy environmental regulations standards and prevent nearby safety-thing from getting damaged.

• Genomics & Informatics
• /
• v.20 no.3
• /
• pp.26.1-26.19
• /
• 2022

Diabetes and its related complications are associated with long term damage and failure of various organ systems. The microvascular complications of diabetes considered in this study are diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. The aim is to identify the weighted co-expressed and differentially expressed genes (DEGs), major pathways, and their miRNA, transcription factors (TFs) and drugs interacting in all the three conditions. The primary goal is to identify vital DEGs in all the three conditions. The overlapped five genes (AKT1, NFKB1, MAPK3, PDPK1, and TNF) from the DEGs and the co-expressed genes were defined as key genes, which differentially expressed in all the three cases. Then the protein-protein interaction network and gene set linkage analysis (GSLA) of key genes was performed. GSLA, gene ontology, and pathway enrichment analysis of the key genes elucidates nine major pathways in diabetes. Subsequently, we constructed the miRNA-gene and transcription factor-gene regulatory network of the five gene of interest in the nine major pathways were studied. hsa-mir-34a-5p, a major miRNA that interacted with all the five genes. RELA, FOXO3, PDX1, and SREBF1 were the TFs interacting with the major five gene of interest. Finally, drug-gene interaction network elucidates five potential drugs to treat the genes of interest. This research reveals biomarker genes, miRNA, TFs, and therapeutic drugs in the key signaling pathways, which may help us, understand the processes of all three secondary microvascular problems and aid in disease detection and management.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.26 no.1
• /
• pp.38-46
• /
• 2022

One of the main goal of gas turbine rim seal research is to prevent thermal damage at rotor-stator disk by preventing hot gas of main flow in turbine passage. To increase sealing performance, several studies related to the improvement of rim seal configuration have been conducted. In addition, research based on actual operating condition is needed in order to apply effective turbine rim seal configuration. In this study, numerical simulation was conducted with variation of rotor rim seal thickness. Radial and axial expansion cases were tested numerically in this study. As a result, the cases showed different pressure distribution, sealing performance and flow characteristics according to the amount of secondary flow.

• Journal of the Society of Disaster Information
• /
• v.18 no.3
• /
• pp.660-671
• /
• 2022

Purpose: This study is intended to confirm the business disruptive risk in the Serious Accidents, and propose a plan to comply with the Serious Accidents Punishment Act through the Disaster Mitigation Activity Management System. Method: Through literature review and case studies, the requirements and characteristics of each of the Serious Accidents Punishment Act, the Disaster Mitigation Activity Management System, and ISO 45001 were compared and analyzed, and implications were derived. Result: The business disruption and financial adverse effects caused by industrial accidents were identified. Based on this and by using the Disaster Mitigation Activity Management System, measures to link the documentation requirements of the the Serious Accidents Punishment Act to the Disaster Mitigation Activity Management System, and to manage the implementation records of the Serious Accidents Punishment Act's duty were derived. Conclusion: When establishing and operating the Disaster Mitigation Activity Management System, it can not only comply with the Serious Accidents Punishment Act but also contribute to maintaining business continuity and ESG management through the prevention of various disasters and the minimization of secondary damage, etc.

• Journal of the Korea Society of Computer and Information
• /
• v.27 no.6
• /
• pp.117-122
• /
• 2022

In this paper, we developed a vehicle control terminal using IoT and low-power long-distance communication (NB-IoT) technology. This system collects information on the location and status of a parked vehicle, and transmits the vehicle status to the vehicle owner's terminal in real time with low power to prevent vehicle theft, and in the case of a vehicle in motion, When primary information about the vehicle, such as an impact, is collected and transmitted to the server, the server analyzes the relevant data to generate secondary information on traffic congestion, road damage, and safety accidents. By sending it, you can know the exact arrival time of the vehicle at its destination. This terminal device is an IoT gateway for a vehicle and can be connected to various wired and wireless sensors inside the vehicle. In addition, the data collected from vehicle maintenance, efficient operation, and vehicles can be usefully used in the private or public sector.

• Proceedings of the Ginseng society Conference
• /
• 1998.06a
• /
• pp.300-311
• /
• 1998

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), one of the most notorious toxic environmental pollutants, induces various toxic effects in many organs including testes and is regarded as an endocrine disruptor. Korean ginseng, on the other hand, has been well known for its preventive effects on lox- ins, diabetes melltus and hyperlipidemia. We investigated, histopathologically, the effect of Korean Red ginseng water extract (KR-WE) on guinea pig testes damaged by TCDD. Ninety guinea pigs were divided into 6 groups: normal control (NC) group received vehicle and saline; TCDD,1191kg b.w., was administered intraperitoneally to the single dose TCDD-treated (77) group; 100 mghg b.w.16 and 200mg1kg b.w./d KR-WE were injected intraperitoneally to the preventive groups (PIOO and P2OO, respectively) for 28 days from 1 week before TCDD injection, and to the therapeutic groups (CIOO and C2OO, respectively) for 14 days since 1 week after TCDD administration. Increment of body weight was retarded to a larger extent by TCDD. Moreover, body weight of the 77 group decreased significantly 7 days after TCDD exposure, while that of preventive groups kept increasing. Decrease in body weight was not observed in KR-WE-treated groups. Weight decrease in testes caused by TCDD was remarkably protected by KR-WE. Testicles in 77 group displayed decreased tubular size and maturation arrest at the primary or secondary spermatocyte stage. On the other hand, maturation arrest in germ cells by TCDD was improved in KR-WE treated groups. Almost complete protection of the testes was observed in PIOO and P2OO groups. In addition, the therapeutic effect was noticed in C 100 and C2OO groups. These results provided strong evidence that Korean Red ginseng might be a useful agent for the prevention and treatment of testicular damage induced by environmental pollutants.