• YAKHAK HOEJI
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• v.46 no.1
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• pp.24-29
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• 2002

Enoyl-Acyl Carrier Protein Reductase (Fabl) of bacteria is hem as an important target for new antibacterial drugs and plays a determinant role in completing cycles of elongation in type-H fatty acid synthase system. In this study, a fabI gene from Staphylococcus aureus 6538p cloned in pET-l4b vector and FabI protein was over-produced in Escherichaia coli BL2l (DE3). $NH_2$-terminal His-tagged FabI protein was purified by nickel-nitrilotriacetic acid (Ni-NTA) metalaffinity chromatography Purified 6xHis-tagged FabI showed a catalytic activity on tram - 2 - octenoyl - N -acethlcysteamine by utilizing NADPH as a cofactor. For the discovery of new FabI inhibitors from chemical libraries, a target-oriented screening system using a 96-well plate was developed. About 10,000 chemical libraries from Korea Chemical Bank wore tested in this screening system, and 26 chemicals (0.25%) among them showed an inhibitory activity against FabI enzyme. This result showed that a new screening system can be used for the discovery of new FabI inhibitors.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4313-4318
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• 2013

This study aimed to explore attitudes towards cervical cancer screening among Japanese university students who had never had a Pap smear. Four focus-group discussions, each with 15 female university students, took place in November and December 2009. Discussions were recorded and transcripts were analyzed to extract attitudes of young women towards cervical cancer screening. The four themes that emerged were: i) a low sense of reality about cervical cancer; ii) a lack of knowledge about both cervical cancer and Pap smears; iii) a lack of motivation to get screened, and iv) a reluctance to visit the gynecologist. Participants who were interested in undergoing screening for cervical cancer cited the influence of conversations with friends and family, a diagnosis of cancer within their family, and relevant information from the media. The results indicate the importance of getting young women more interested in cervical cancer screening and overcoming their tendency to avoid visiting a gynecologist.

• Animal cells and systems
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• v.13 no.2
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• pp.97-103
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• 2009

Recently, great advance is achieved in the field of genome-wide functional screening using cell-based assay. Here, we briefly introduce well-established and typical cell-based assays of GPCR and some parameters which should be considered for genome-wide functional screening. Because of characters and importance of GPCR as drug targets, several ways of assay systems were devised. Among them, high-content screening (HCS) that is based on the analysis of image by confocal microscope is becoming favorite choice. The advances in this technology have been driven exclusively by industry for their convenience. Now, it is turn for academy to define more detail signaling networks via HCS using cDNA or siRNA libraries at genome-wide level. By isolating novel signaling mediators using cDNA or siRNA library, and postulating them as new candidates for therapeutic target, more understanding about life science and more increased chances to develop therapeutics against human disease will be achieved.

• IEMEK Journal of Embedded Systems and Applications
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• v.10 no.2
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• pp.109-117
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• 2015

In this paper, we have developed smart-phone App(application) for screening Dementia using bionic sensors, urine test and questionnaire. Since small amounts of urinary protein strongly predict faster cognitive decline in the elderly, smart-phone based urinalysis is adopted to screen dementia more accurately as well as bionic sensors such as $SpO_2$ and HRV(Heart Rate Variability). Firstly, DI(Dementia Index) is calculated from urinalysis, two bionic sensors and electric questionnaire, and then compared to the threshold from clinical test. Finally the results of Dementia screening is shown in your smart-phone and useful information to prevent or relieve Dementia is also given. We performed simple testing on persons aged over 60 and found out the proposed application can be useful devices for screening Dementia easily and quickly.

• Journal of Korean Institute of Industrial Engineers
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• v.22 no.1
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• pp.17-36
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• 1996

An economic two-stage screening procedure is presented when both lower and upper specification limits are given on the performance variable. A screening variable which is highly correlated with the performance variable is used first to decide whether an item should be accepted, rejected, or undecided. The performance variable is then used to classify the undecided items. The two variables are assumed to be jointly normally distributed. A cost model is constructed on the basis of six cost components; inspection costs of screening and performance variables and costs caused by type I and type II misclassification errors related with lower and upper specification limits. Optimal cutoff values on the screening variable are determined so that the average outgoing quality exceeds a prespecified level. Solution methods are provided for both known-parameter and unknown-parameter cases.

• Korean Journal of Computational Design and Engineering
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• v.20 no.4
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• pp.321-327
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• 2015

In the protein database search, 3D structural shape comparison for protein screening plays a important role. Protein databases have big size and have been grown rapidly. Exhaustive search methods cannot provide a satisfactory performance. As protein is composed of a set of spheres, the similarity calculation of two set of spheres is very expensive. Thus, a reasonable filtering method could be an answer for the speedup of protein screening. In this paper, we suggest a speedup method for protein screening with atom number and bounding sphere. We also show some experimental results for the validity of our method.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.11b
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• pp.621-624
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• 2001

A metal sheath provides a cable with electrostatic screening and a degree of magnetic screening. The presence of a screen on a cable also reduces the induction arising from the high-frequency components of transients caused by power-line switching and also induced transients from lightning strokes; such transient induced voltages are of increasing importance with the increasing use of miniaturized telecommunication equipment with very small thermal capacity. This paper describes electrostatic induction and electromagnetic induction caused by power interference. Also screening factors are proposed.

• Proceedings of the Korean Society for Quality Management Conference
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• 2009.10a
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• pp.3-10
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• 2009

When the measurement method for a performance variable is destructive or expensive, it is profitable to replace the performance variable with a highly correlated surrogate variable. In this paper we propose screening procedures using a surrogate variable with specified producer's and consumer's risks. Blending the basic concepts of acceptance sampling plans and screening procedures, the proposed model can be used effectively by quality professionals. Two models are considered: the normal model with dichotomous performance and continuous surrogate variables, and the bivariate normal model with continuous performance and surrogate variables. It is assumed the surrogate variable given the performance variable is normally distributed in the normal model, and performance and surrogate variables are jointly normally distributed in the bivariate normal model. For the two models, Producer's and consumer's risks are derived, and methods of finding the optimal screening procedures are presented. Numerical examples are also given.

• Journal of Korean Society for Quality Management
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• v.26 no.2
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• pp.39-50
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• 1998

A screening procedure, where one or more correlated variables are used for screeing, is reviewed from the point of statistical hypothesis testing. Without assuming a specific probability model for the joint distribution of the performance and screening variables, some principles are provided to establish the best screeing region. A, pp.ication examples are provided for two cases; ⅰ) the case where the performance variable is dichotomous and ⅱ) the case where the performance variable is continuous. In case ⅰ), a normal model is assumed for the conditional distribution of the screening variable given the performance variable. In case ⅱ), the performance and screening variables are assumed to be jointly normally distributed.

• The Journal of the Korea Contents Association
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• v.6 no.5
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• pp.56-65
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• 2006

Almost all of the nations run a game screening system which is characteristic depending on their communication policy. This article attempted comparative analysis about major nation's game screening systems by comparing three main aspects of their communication policy which are freedom of expression, complete opening of the contents to the public, and the balance between protection of adolescent and promotion of industry. It is shown that the screening system of USA, Europe and Japan stick well by the basic principles of communication policy, on the other hand Korea, South Africa Republic and Australia have some points that need improvement.