• Korean Journal of Pharmacognosy
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• v.51 no.3
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• pp.151-157
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• 2020

When blood vessels are damaged, a rapid hemostatic reaction occurs to minimize blood loss and maintain normal circulation. Platelet activation and aggregation is essential in this process. However, excessive platelet aggregation or abnormal platelet aggregation may be the cause of cardiovascular disease, such as thrombosis, stroke and atherosclerosis. Therefore, it is important to prevent and treat cardiovascular disease by finding substances that can regulate platelet activation and suppress aggregation reactions. Isoscopoletin, which is mainly found in the roots of plants Artemisia or Scopolia, has been reported to have potential pharmacological effects on anticancer and Alzheimer's disease, but its role and mechanisms for platelet aggregation and thrombus formation are unknown. This study confirmed the effect of isoscopoletin on major regulation of collageninduced human platelet aggregation, TXA₂ production and intracellular granular secretion (ATP and serotonin release). In addition, the effects of isoscopoletin on phosphorylation of phosphorylated proteins PI3K/Akt and MAPK involved in signal transduction in platelet aggregation was studied. As a result, isoscopoletin significantly inhibited the phosphorylation of PI3K/Akt and MAPK, significantly inhibiting platelet aggregation through TXA₂ production and intracellular granular secretion (ATP and serotonin release). Therefore, we suggest that isoscopoletin is an anti-platelet substance that regulates phosphorylation of phosphorus proteins such as PI3K/Akt and MAPK and is valuable as a preventive and therapeutic agent for platelet-derived cardiovascular disease.

• Korean Journal of Environment and Ecology
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• v.19 no.1
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• pp.31-45
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• 2005

This study was carried out to investigate the vascular plants of the construct-reserved sites of ecological forests in Deokdong-ri, Baekwoon-myeon, Jecheon-si, and Chungcheongbuk-do, Korea and the period was from March to October, 2004. The results of surveying the vascular plants were recorded as 371 taxa; 83 families, 238 genera, 324 species, 44 varieties and 3 forma. There were 4 species of rare and endangered plants as designated by Korea Forest Service; Eranthis stellata, Paeonia japonica, Viola albida and Scopolia japonica. There were 9 species of Koreanendemic plants Pseudostellaria coreana, Melandryum seoulense, Clematis trichotoma, Deutzia coreana, Spiraea prunifolia for. simpliciflora, Ajuga spectabilis, Weigela subsessilis, Cirsium setidens and Saussurea nutans. Ten species of naturalized plants were observed Panicum dichotomiflorum, Rumex crispus, Amaranthus retroflexus, Lepidium apetalum, Trifolium repens, Oenothera Jamayckiana, Erigeron annuus, Erigeron canadensis, Bidens frondosa and Taraxacum officinale. In the results of analysis by floristic region, the specific plants were summarized as 52 taxa; 30 families, 47 genera, 49 species and 3 varieties.

• Korean Journal of Environment and Ecology
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• v.19 no.2
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• pp.112-118
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• 2005

Based on the specific plant species for environmental assesment by the Ministry of Environment(MoE), a total of 68 taxa were identified; 29 taxa for the floristic degree(FD) I, 12 taxa for the FD II, 11 taxa for the FD III, 9 taxa for the FD IV and 6 taxa for the FD V. The endangered plant species, in Woraksan National Park, such as Lilium cernum and Berchemia berchemiaefolia are categorized as the Conservation Degree (CD) II which is designated by the MoE. The rare and endangered species such as Crypsinus hastatus, Lilium cernum, Berchemia berchemiaefolia, Lilium callossum, Gastrodia elata, Aristolochia contorta, Koelreuteria paniculata, Rhododendron tschonoskii, Scopolia japonica, Cypripedium macranthum, Paeonia japonica and Thymus quinquecostatus including 12 plant taxa are categorized as Rare and Endangered Plant Species by the Korea Forest Service.

• Korean Journal of Environment and Ecology
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• v.17 no.3
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• pp.210-223
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• 2003

This study was carried out to investigate the flora of Mt. Baekwoon. The flora of Mt. Baekwoon was surveyed from October, 2000 to August, 2001. In the results of survey, the vascular plant species in Mt. Baekwoon were summarized as 468 taxa; 90 families, 272 genera, 411 species, 1 subspecies 49 varieties and 7 forms. The rare plants designated by Korea Forestry Service were nine species; Lilium distichum, Gastrodia elata, Viola diamantica, Hylomecon hylomeconoides, Aristolochia contorta, Asarum maculatum, Rodgersia podophyllu, Viola albida, Scopolia japonica and Scrophularia koraiensis. And the endemic plants were nineteen species; Asarum maculatum, Melandryum seoulense, Clematis trichotoma, Aconitum pseudo-laeve var. erectum, Hylomecon hylomeconoides, Chrysosplenium barbatum, Spiraea prunifolia for. simpliciflora, Robus hongnoensis, Vicia venosa var. cuspidata, Tilia taquetii, Viola seoulensis, Viola diamantica, Ajuga spectubilis, Scrophularia koraiensis, Weigela subsessilis, Adenophora remotiflora, Cirsium setidens, Saussurea macrolepis and Saussurea seoulensis.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.15 no.1
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• pp.89-105
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• 2012

This study is carried out to survey and analyse the vascular plants distributed around the Jusan Reservoir, Juwangsan national park. The results are as follows. The numbers of vascular plants were 377 taxa; 85 families, 253 genera, 332 species, 3 subspecies, 37 varieties and 5 forma. The endangered plants designated by Ministry of Environment were 2 taxa; Berchemia berchemiaefolia (Makino) Koidz. and Iris odaesanensis Y.N.Lee. The rare plants designated by Korea Forest Service were 6 taxa; Eranthis stellata Maxim., Aristolochia contorta Bunge, Aristolochia manshuriensis Kom., Berchemia berchemiaefolia (Makino) Koidz., Scopolia japonica Maxim. and Iris odaesanensis Y.N.Lee. The endemic plants were 4 taxa; Carpinus laxiflora (Siebold & Zucc.) Blume, Pseudostellaria coreana (Nakai) Ohwi, Philadelphus schrenkii Rupr. and Weigela subsessilis (Nakai) L.H.Bailey. The specific plants by floristic region were 38 taxa; Juglans mandshurica Maxim., Salix chaenomeloides Kimura, Hylomecon vernalis Maxim., Lonicera praeflorens Batalin, Erythronium japonicum (Baker) Decne., Potentilla dickinsii Franch. & Sav., Celtis aurantiaca Nakai, Anemone reflexa Steph. & Willd., Cimicifuga heracleifolia Kom. and so forth. The naturalized plants were 20 taxa; Fallopia dumetorum (L.) Holub, Chenopoidum album L., Lepidium apetalum Willd., Veronica persica Poir., Conyza canadensis (L.) Cronquist, Taraxacum officinale Weber and so forth.

• YAKHAK HOEJI
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• v.52 no.3
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• pp.232-239
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• 2008

The aim of this study was to evaluate if a composition of herb extracts, PLX-PLS was effective to treat atopic dermatitis (AD) in mice. SPZZC is a composition of herb extracts containing the roots of Scopolia parviflora and Paeonia lactiflora, the herb of Zizania caudiflora, the fruit of Ziziphus jujuba and the leaf of Chinese arborvitae. AD in BALB/c mouse was induced by patching ovoalbumin on the backside, while it in NC/Nga mouse was induced by repeated application of 1-chloro 2,4-dinitrobenzene (DNCB). Mice were topically treated with SPZZC or Domohorn ointment on the backside for 2 weeks (BALB/c) or 1 week (NC/Nga). Scratching behavior, clinical skin severity and the levels of WBC, neutrophil, eosinophil and total serum IgE were measured. After AD induction, scores of scratching behavior and clinical skin severity and the levels of WBC, neutrophil, eosinophil and total serum IgE were increased. Treatment with SPZZC significantly decreased scores of scratching behavior and clinical skin severity in a dose dependent manner in NC/Nga and BALB/c mice. Treatment with SPZZC 2% significantly decreased also the levels of WBC, neutrophil, eosinophil and total serum IgE. Especially, treatment of SPZZC 2% reduced more rapidly score of clinical skin severity than clobetasol cream. These results suggest that the SPZZC may be an alternative substance for the management of AD.

• Journal of Life Science
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• v.18 no.7
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• pp.974-979
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• 2008

The powdery mildew, a fungal plant disease found in varieties of plant cultures, is occurred by attack with Fusarium sp., Sphaerotheca sp., Leveilluna sp., and Eryshipe sp.. In this study we investigated the control of Fusarium graminearum, a barley powdery mildew fungus, by natural plant extracts. Among the 900 plant extracts tested, Zanthoxylum schinifolium, Ligusticum acutilobum, Bidens frondosa L., Dictamnus dasycarpus, Evodia officinalis, Disporum sessile, Scopolia japonica Max., Styrax japonica S. et Z., Dictamnus dasycarpus Turcz., Sinomenium acutum Rehder et Wils., Eugenia aromaticum, Rubus parvifolius L., Reynoutria elliptica, Coptis chinensis, Paeonia lactiflora Pall., Rheum undalatum, Paeonia suffruticosa, Oenothera odorata Jacq., Euphorbia pekinensis Rupr., and Nepeta cataria were selected based on spore germination inhibition assay. Further mycelial growth inhibition assay with economical and safety considerations led us to finally select Z. schinifolium (sancho) for control of F. graminearum. To produce antifungal sancho extract, methanol was suitable for extraction and subsequent fractionations of the extract showed that the water residue mainly had antifungal activity. The sancho extract and its fractions showed minor antibacterial activity against different pathogenic or food spoilage bacteria, but they did not show any harmful effects against young tomato plant by treatment of $1,000\;{\mu}g/ml$ in green chamber test. These results suggested that the extract of sancho has high potentials on control of a powdery mildew fungus, F. graminearum.

• Journal of The Korean Society of Clinical Toxicology
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• v.4 no.1
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• pp.48-51
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• 2006

With well-being boom recently, the common people, but not experts, are increasingly taking in them directly by picking wild herbs. However, only experts can distinguish between edible vegetables and poisonous herbs from the wild herbs. Especially, it is not even easy for experts to distinguish them only by looking into buds in spring without flowers or fruit. So, sometimes many patients are being carried into the emergency room by the toxic symptom after taking by misunderstanding the poisonous herbs as edible vegetables. For herb intoxication as well as drug intoxication, what kinds of vegetables patients took in, and when and how much they took in them are important information for curing. Of course, in the case of intoxicating in the wild herbs, the patients can have a lot of symptoms and sings-hemodynamic alteration and abnormal neurologic sign as well as gastrointestinal symptoms-according to the kinds of herbs which they took in. Therefore, it is difficult to find the kinds of herbs which they took in through the specific symptoms. Recently we experienced a case with showing typical anticholinergic symptoms after ingestion of Scopolia japonica. As a result, the publicity activities about the wild plants needs because if the person without their previous knowledge take in the poisonous herbs, serious side effects can be produced..

• Korean Journal of Plant Resources
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• v.17 no.2
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• pp.169-182
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• 2004

The purpose of this study is carried out accurately to grasp the vascular plants in Mt. Bakdal (825 m of sea level), Goesan-gun, Chungcheongbuk-do. In the results of survey from October, 2000 to August, 2001, the vascular plant species in Mt. Bakdal were summarized as 458 taxa; 91 families, 275 genera, 391 species, 62 varieties and 5 forms. The rare plants designated by Korea Forestry Service were six species; Lilium distichum, Iris uniflora var. carisina, Hylomecon hylomeconoides, Viola albida, Scopolia japonicus and Scrophularia koraiensis. And the endemic plants were seventeen species; Melandryum seoulense, Aconitum pseudo-laeve var. erectum, Hylomecon hylomeconoides, Spiraea prunifolia for. simpliciflora, Rubus hongnoensis, Gleditsia japonica var. koraiensis, Lespedeza ${\times}$ tomentella, Vicia venosa var. cuspidata, Vicia venosissima, Tilia taquetii, Ajuga spectabilis, Paulownia coreana, Scrophularia koraiensis, Weigela subsessilis, Lonicera subsessilis, Cirsium setidens and Saussurea seoulensis. The sixteen species were recorded in the surveyed sites as the naturalized plants; Rumex acetocella, Rumex crispus, Fallopia dumetora, Chenopodium glaucum, Amaranthus retroflexus, Robinia pseudo-acacia, Amorpha fruticosa, Trifolium repens, Abutilon avicennae, Hibiscus trionum, Oenothera odorata, Oenothera lamarckiana, Erigeron annuus, Erigeron canadensis, Bidens frondosa and Carduus crispus.

• Korean Journal of Environment and Ecology
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• v.32 no.2
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• pp.176-184
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• 2018

This study was intended to provide basic data for more ecological and systematic preservation and management planning of forest vegetations in the Baekdudaegan sector between Danmoknyeong and Guryongnyeong where biodiversity is considered to be very important. A vegetation survey using the Zurich-Montpellier (Z.-M.) method of phytosociology was carried out in a total 142 sites to examine the environmental characteristics. The survey showed the forest vegetation types of one community group, two communities, four groups, and four subgroups. Quercus mongolica and Acer pseudosieboldianum, which fall under Constancy Class V, were dominant species and deemed to be the key species of the forest ecosystem management plan for the investigated areas. Regarding species diversity, it was found that the dominant species of the VT3 type were evenly distributed in the area while the species of the VT4 type showed not only a diverse composition but also the most abundant number of species. Moreover, there were 24 of rare plants found in the Danmoknyeong-Guryongnyeong section: the critically endangered species include Dracocephalum rupestre; the endangered species include Saxifraga octopetala; the vulnerable species include Paeonia japonica, Euphorbia fauriei, Hanabusaya asiatica, and Parasenecio pseudotaimingasa; the least concern species include Aristolochia manshuriensis, Rodgersia podophylla, Salvia chanryoenica, Scopolia japonica, and Parasenecio firmus.