• Journal of Ginseng Research
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• v.48 no.4
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• pp.395-404
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• 2024

Background: Ginsenoside Rg₁ (Rg₁) is one of the main active components in Chinese medicines, Panax ginseng and Panax notoginseng. Research has shown that Rg₁ has a protective effect on the cardiovascular system, including anti-myocardial ischemia-reperfusion injury, anti-apoptosis, and promotion of myocardial angiogenesis, suggesting it a potential cardiovascular agent. However, the protective mechanism involved is still not fully understood. Methods: Based on network pharmacology, ligand-based protein docking, proteomics, Western blot, protein recombination and spectroscopic analysis (UV-Vis and fluorescence spectra) techniques, potential targets and pathways for Rg₁ against myocardial ischemia (MI) were screened and explored. Results: An important target set containing 19 proteins was constructed. Two target proteins with more favorable binding activity for Rg₁ against MI were further identified by molecular docking, including mitogen-activated protein kinase 1 (MAPK1) and adenosine kinase (ADK). Meanwhile, Rg₁ intervention on H9c2 cells injured by H₂O₂ showed an inhibitory oxidative phosphorylation (OXPHOS) pathway. The inhibition of Rg₁ on MAPK1 and OXPHOS pathway was confirmed by Western blot assay. By protein recombination and spectroscopic analysis, the binding reaction between ADK and Rg₁ was also evaluated. Conclusion: Rg₁ can effectively alleviate cardiomyocytes oxidative stress injury via targeting MAPK1 and ADK, and inhibiting oxidative phosphorylation (OXPHOS) pathway. The present study provides scientific basis for the clinical application of the natural active ingredient, Rg₁, and also gives rise to a methodological reference to the searching of action targets and pathways of other natural active ingredients.

• Journal of Nutrition and Health
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• v.57 no.3
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• pp.307-319
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• 2024

Purpose: This study compared the differences in health and dietary characteristics between middle-aged men and women according to their health-related quality of life. Methods: This study used the data from the 2019 and 2021 Korea National Health and Nutrition Examination Survey (KNHANES). The participants were men (n = 1,571) and women (n = 2,179) aged 40-59. A health-related Quality of Life Instrument with eight items (HINT-8) was used to measure the health-related quality of life. The participants were divided into four groups based on their HINT-8 total scores (high, mid-high, mid-low, and low). The general and health characteristics, mental health, and dietary behaviors were compared according to the quality of life. Results: Men with a lower quality of life had lower incomes, were more likely to be single, smoked and drank more, and perceived themselves as slim or obese. Women with a lower quality of life had a higher proportion of older age, obesity, lower education and income, hypercholesterolemia, and hypertriglyceridemia. Both men and women with a lower quality of life had higher proportions of subjectively perceiving poor health, weight gain over the past year, and considering themselves as obese. Both men and women with a lower quality of life had lower consumption frequencies of vegetables/mushrooms/seaweed and fruits. Conclusion: Both men and women with lower health-related quality of life had lower incomes, higher rates of perceiving their health as poor, and consumed vegetables/ mushrooms/seaweed and fruits less frequently, but they showed different characteristics in other aspects. Therefore, policy development tailored to men and women is necessary.

• Geophysics and Geophysical Exploration
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• v.27 no.2
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• pp.108-118
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• 2024

In this study, expressions for the magnetic field and magnetic gradient tensor due to an elliptical disk were derived. Igneous intrusions and kimberlite structures often have elliptical cylinders with axial symmetry and elliptical cross sections. An elliptical cylinder with varying cross-sectional areas was approximated using stacks of elliptical disks. The magnetic fields of elliptical disks were derived using the Poisson relation, which includes the direction of magnetization in the gravity gradient tensor, as described in a previous study (Rim, 2024). The magnetic gradient tensor due to an elliptical disk is derived by differentiating the magnetic fields, which is equivalent to obtaining ten triple-derivative functions acquired by differentiating the gravitational potential of the elliptical disk three times in each axis direction. Because it is possible to exchange the order of differentiation, the magnetic gradient tensor is derived by differentiating the gravitational potential of the elliptical disk three times, which is then converted into a complex line integral along the closed boundary curve of the elliptical disk in the complex plane. The expressions for the magnetic field and magnetic gradient tensor derived from a complex line integral in complex plane are perfectly consistent with those of the circular disk derived from the Lipschitz-Hankel integral.

• Journal of the Health Care and Life Science
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• v.10 no.2
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• pp.253-258
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• 2022

It is a widely known fact that MAC addresses can be collected using Wi-Fi from mobile phones that people carry. However, since collecting and using MAC addresses without individual consent entails many legal problems, it was difficult to actively utilize them. In order to prevent invasion of privacy information due to unintentional exposure of these MAC addresses in recent years, the method of protecting privacy information by exposing a randomly generated virtual MAC address rather than the MAC address of the actual device is applied to all mobile devices. is becoming By exposing a randomly generated virtual MAC address on a device, it becomes impossible to identify and track an individual using the MAC address. However, the fact that various facts can be estimated through MAC Address collection is still valid. By expanding the application of Random MAC Address, the possibility of invasion of privacy information has been completely removed from the MAC address that has been raised in the past, so that it can be used more actively than in the past. In this paper, we propose a method for automatically collecting and analyzing statistical information of hospital visitors using MAC addresses. The collection of hospital visitors using MAC Address is a low cost and relatively accurate method, and the analysis of hospital visitors through steady collection can provide very objective and scientific evidence for hospital operation.

• Journal of the Health Care and Life Science
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• v.10 no.2
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• pp.305-314
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• 2022

The purpose of this study is to investigate the effect of health behavioral factors such as general characteristics, lifestyle and disease characteristics on depression in patients with chronic diseases. To this end, among 7,359 people who participated in the 8th National Health and Nutrition Survey conducted from 2019 to 2020, chi-square test analysis between health behavior factors and depression for 1980 people aged 19 years or older with chronic diseases and no missing values in the basic survey items was performed. After that, binary logistic regression analysis was performed with the factors that were significant as independent variables. As a result of the analysis, depression was 1.49 times higher in women than men (CI: 1.086~2.044), and was 1.828 higher in smokers than in non-smokers (CI: 1.285~2.561). And the higher the income level, the lower the depression. In particular, the odds ratio was 28.034 (CI: 13.132~59.849) in 'not stressful' versus 'very stressed', which had the greatest effect when the intensity of stress was very high. And the influence of subjective health cognition and sleeping hours was also relatively high. This study is meaningful in that it identified the priority of health behavior factors that should be practiced to improve depression in patients with chronic diseases. And since the number of comorbidity was not significant in the occurrence of depression, it would be necessary to identify the extent to which each type of chronic disease affects depression and to suggest policy alternatives tailored to each patient group.

• Journal of the Health Care and Life Science
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• v.10 no.2
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• pp.351-359
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• 2022

The subjects of this study were 167 students in the 3rd and 4th grade of Nursing who had experienced clinical practice at G University located in E-gun, Chungcheongbuk-do. The data collection period was from December 1 to December 18, 2020. The collected data were analyzed using the SPSS 26.0 program, and the general characteristics of subjects, clinical practice stress and clinical practice satisfaction were analyzed by frequency, percentage, mean, and standard deviation. Differences in nursing professionalism were analyzed by t-test and one-way ANOVA. The correlation between clinical practice stress, clinical practice satisfaction, and nursing professionalism was analyzed using Pearson Correlation Coefficients, and stepwise multiple regression was used to analyze factors affecting the nursing profession. As a result of the study, major satisfaction (β=.256, p=.001) was the strongest influencing variable, and clinical practice satisfaction (β=.237, p=.004) and clinical practice stress (β=.-.143, p= .068) were identified as factors affecting nursing professionalism. The explanatory power of these total variables was 21.8% (F=.14..44, p=.000). The above research results suggest that it is necessary to develop and apply educational strategies and specific programs to improve nursing professionalism.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.27 no.5
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• pp.274-285
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• 2024

Purpose: To evaluate prolonged esomeprazole use in Japanese pediatric patients for reflux esophagitis (RE) maintenance therapy and prevention of gastric (GU) and/or duodenal ulcers (DU) while using non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA). Methods: This multicenter, open-label, parallel-group, phase III study (NCT03553563) included patients who were administered esomeprazole according to body weight (10 mg/day [Groups 1 and 3] and up to 20 mg/day [Groups 2 and 4] for patients weighing 10-20 kg and ≥20 kg, respectively). Efficacy outcomes for Groups 1 and 2 (maintenance therapy for healed RE) and Groups 3 and 4 (prevention of long-term NSAID/LDA use-associated GU/DU) were the presence/absence of RE relapse and GU/DU recurrence, respectively. Results: Esomeprazole as maintenance therapy was associated with a low RE recurrence rate, independent of body weight or dosage. Recurrence rates of RE were 0.0% and 5.3% for Groups 1 and 2, respectively. In patients previously diagnosed with GU and/or DU due to long-term NSAID/LDA use, the recurrence rates of GU/DU during weeks 0-32 were 11.1% and 0.0% in Groups 3 and 4, respectively. Conclusion: Long-term use of 10- or 20-mg, once-daily esomeprazole demonstrated a favorable benefit-risk balance in preventing RE and suppressing recurrence of GU and/or DU secondary to NSAID or LDA therapy in Japanese pediatric patients. No new safety concerns were identified. Esomeprazole may be a viable option for managing RE and preventing GU and DU in Japanese pediatric patients.

• Science of Emotion and Sensibility
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• v.27 no.1
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• pp.47-58
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• 2024

This study aimed to investigate the role of student immediacy in learning-related positive affective experiences in the technology-mediated education context. In particular, perceived social presence was expected to mediate the relationship between student immediacy and positive affect. Moreover, we hypothesized the moderating role of technology readiness in the relationship between student immediacy and perceived social presence. To test this hypothesis, a survey of approximately 500 undergraduate students who have attended non-face-to-face online courses was conducted. The results revealed that social presence fully mediated the relationship between immediacy and positive affect. That is, students who scored high on the immediacy scale tended to experience a greater level of social presence during online classes; consequently, they tended to demonstrate more positive affect. As expected, technology readiness moderated the relationship between immediacy and social presence. Unlike previous studies that mainly focused on instructor immediacy, the present study contributed to immediacy literature by empirically testing the positive effect of student immediacy on learning. Furthermore, this study revealed the potential importance of communication competence and its progress in predicting student participation and satisfaction, which could have been changed since the COVID-19 pandemic.

• Journal of the Korea Computer Graphics Society
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• v.30 no.3
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• pp.61-69
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• 2024

Mixed reality(MR) technology combines the advantages of virtual reality(VR) and augmented reality(AR) technology, allowing MR users to interact with virtual objects against the background of the real world. In addition, since virtual objects interact with the real world, users can experience a higher immersion. This study proposes electric circuit practical training content using Meta Quest Pro to produce immersive MR content based on reality. To this end, first, the development process for producing MR content by linking Meta Quest Pro equipment with the Unity 3D engine is organized. Then, based on the traditional electric circuit practical training method used in elementary school science classes, virtual electric circuit practical training content with the same training method and operation process is produced based on MR. Finally, survey experiments are conducted to analyze the presence and experience of the MR-based educational environment provided using the produced content. Through this, the usability of the proposed practical training content is evaluated and future research directions are suggested.

• Therapeutic Science for Rehabilitation
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• v.13 no.3
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• pp.85-100
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• 2024

Objective : This case study aimed to explore dysphagia symptoms in post-cardiac transplantation patients and evaluate the effectiveness of dysphagia rehabilitation therapy in an occupational therapy clinic. Methods : A patient with post-cardiac transplant dysphagia underwent videofluoroscopic swallowing studies to assess the Functional Dysphagia Scale (FDS), Penetration-Aspiration Scale (PAS), and Dysphagia Outcome and Severity Scale (DOSS). Assessments were performed three times at two-week intervals. The treatment, administered from July 19 to August 21, 2023, included eight sessions of 30 minutes each. Treatments included corrective techniques (tongue-hold maneuver, chin tuck against resistance, mendelsohn maneuver, effortful swallowing, and respiratory muscle exercise) and compensatory strategies (chin-tuck position, multiple swallowing, modification of volume, and viscosity), alongside caregiver education. Results : The FDS scores decreased from 50 to 30, PAS scores improved from 5 to 3, and DOSS scores improved from Stage 2 to Stage 4. Conclusion : Dysphagia rehabilitation therapy improved swallowing function in a post-cardiac transplantation patient. However, further studies are required to confirm these findings.