• 대한약침학회지
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• 제25권4호
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• pp.326-343
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• 2022

Neurological disorders represent a substantial healthcare burden worldwide due to population aging. Acorus gramineus Solander (AG) and Acorus tatarinowii Schott (AT), whose major component is asarone, have been shown to be effective in neurological disorders. This review summarized current information from preclinical and clinical studies regarding the effects of extracts and active components of AG and AT (e.g., α-asarone and β-asarone) on neurological disorders and biomedical targets, as well as the mechanisms involved. Databases, including PubMed, Embase, and RISS, were searched using the following keywords: asarone, AG, AT, and neurological disorders, including Alzheimer's disease, Parkinson's disease, depression and anxiety, epilepsy, and stroke. Meta-analyses and reviews were excluded. A total of 873 studies were collected. A total of 89 studies were selected after eliminating studies that did not meet the inclusion criteria. Research on neurological disorders widely reported that extracts or active components of AG and AT showed therapeutic efficacy in treating neurological disorders. These components also possessed a wide array of neuroprotective effects, including reduction of pathogenic protein aggregates, antiapoptotic activity, modulation of autophagy, anti-inflammatory and antioxidant activities, regulation of neurotransmitters, activation of neurogenesis, and stimulation of neurotrophic factors. Most of the included studies were preclinical studies that used in vitro and in vivo models, and only a few clinical studies have been performed. Therefore, this review summarizes the current knowledge on AG and AT therapeutic effects as a basis for further clinical studies, and clinical trials are required before these findings can be applied to human neurological disorders.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권5호
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• pp.2124-2141
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• 2018

Recent studies have revealed the efficacy of incorporating delayed channel state information at transmit side (CSIT) in transmission scheme design. This paper focuses on transmit precoder design to maximize the ergodic sum-rate in a two-user Multiple-Input Single-Output (MISO) system with delayed and statistical CSIT. A new transmit strategy which precodes signals in all transmit slots is proposed in this paper, denoted as all time-slots precoding Alternative MAT (AAMAT). There is a common procedure in conventional delayed-CSIT based schemes, which is retransmitting the overheard interferences. Since the retransmitting signal is intended to both users, all previous schemes tend to use only one antenna. We however figure out an improvement in spectral efficiency could be realized if all antennas can be utilized. In this paper, we detail the design of the procoder which enabling all antennas and also we compute a lower bound of the ergodic sum-rate in an ideal condition. In addition, simulation results demonstrate the superiority of our proposed scheme.

• Journal of Information Science Theory and Practice
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• 제12권2호
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• pp.36-48
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• 2024

For consumers making health decisions, Wikipedia is a popular source for health information. This study investigated major factors influencing consumer satisfaction with Wikipedia medical/health articles. Using a crowdsourcing method, data were collected from 322 adults who read/edit English Wikipedia medical/health articles and reside in the US. The results showed that the presentation of information was the most influential factor. Trustworthiness was the second most important factor for consumer satisfaction with the quality of information, followed by reliability, and topic coverage. Study participants did not consider other factors such as accuracy and currency to be crucial factors. Moderating effects of the control variables such as editing experience with Wikipedia articles, gender, and age were also examined to enhance the internal validity of the study. Implications for the Wikipedia editor community and researchers, and directions of future research are presented.

• Advances in nano research
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• 제13권5호
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• pp.437-451
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• 2022

Synthesis approaches usually affect the physical and chemical properties of ferrites. This helps ferrite materials to design them for desired applications. Some of these methods are mechanical milling, ultrasonic method, micro-emulsion, co-precipitation, thermal decomposition, hydrothermal, microwave-assisted, sol-gel, etc. These methods are extensively reviewed by taking example of ZnFe₂O₄. These methods also affect the microstructure and local structure of ferrite which ultimately affect the physical and chemical properties of ferrites. Various spectroscopic techniques such as Raman spectroscopy, Fourier Transform Infrared spectroscopy, Ultra Violet-Visible spectroscopy, Mossbauer spectroscopy, extended x-ray absorption fine structure, and electron paramagnetic resonance are found helpful to reveal this information. Hence, the basic principle and the usefulness of these techniques to find out appropriate information in ZnFe₂O₄ nanoparticles is elaborated in this review.

• Tuberculosis and Respiratory Diseases
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• 제87권3호
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• pp.234-251
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• 2024

Globally, providing evidence on the economic burden of chronic obstructive pulmonary disease (COPD) is becoming essential as it assists the health authorities to efficiently allocate resources. This study aimed to summarize the literature on economic burden evidence for COPD from 1990 to 2019. This study examined the economic burden of COPD through a systematic review of studies from 1990 to 2019. A search was done in online databases, including Web of Science, PubMed/Medline, Scopus, and the Cochrane Library. After screening 12,734 studies, 43 articles that met the inclusion criteria were identified. General study information and data on direct, indirect, and intangible costs were extracted and converted to 2018 international dollars (Int$). Findings revealed that the total direct costs ranged from Int$ 52.08 (India) to Int$ 13,776.33 (Canada) across 16 studies, with drug costs rannging from Int$ 70.07 (Vietnam) to Int$ 8,706.9 (China) in 11 studies. Eight studies explored indirect costs, while one highlighted caregivers' direct costs at approximately Int$ 1,207.8 (Greece). This study underscores the limited research on COPD caregivers' economic burdens, particularly in developing countries, emphasizing the importance of increased research support, particularly in high-resource settings. This study provides information about the demographics and economic burden of COPD from 1990 to 2019. More strategies to reduce the frequency of hospital admissions and acute care services should be implemented to improve the quality of COPD patients' lives and reduce the disease's rising economic burden.

• Journal of Ecology and Environment
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• 제36권1호
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• pp.1-9
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• 2013

In South Korea, the conflict between development and conservation policy still exist among government ministries, and conventional development plan often has priority over conservation policy. Establishment of sustainable development and comprehensive management policy employing the results of ecosystem service studies are highly warranted, but researchers in South Korea are still limited and often misuse the concept of ecosystem services. Thus, we aimed to introduce the concept of Ecosystem Service (ES) and related terminologies such as Social-Ecological Systems (SESs), ecosystem function, trade-off, and human well-being in this paper. Additionally, this article reviewed and arranged key approaches in ES studies as follows: 1) field works, 2) mapping ecosystem services, 3) valuing ES, 4) quantifying trade-offs between ES and 5) understanding SESs. Based on those results, we suggest that field works for basic information have the first priority to be conducted among ES studies. Once basic information is sufficiently accumulated, researchers can perform applied ES research with accuracy. Finally, results of ES studies conducted by five approaches allow decision makers to consider both natural system and society simultaneously, and hence the results can be utilized for sustainable development and conservation policy based on ecosystem-based management.

• 정보교육학회논문지
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• 제19권4호
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• pp.533-544
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• 2015

본 연구에서는 소프트웨어 교육의 전면 시행을 앞두고 학교 급별 연계성 있는 교육과정 운영을 위한 가이드라인을 제시하고자 하였다. 이를 위하여 학생들의 수준에 맞는 교육용 프로그래밍 언어의 형태를 제시하기 위해서 해외의 사례를 살펴보았다. 해외의 사례는 현재 필수교육과정으로써 프로그래밍 과정을 운영하고 있는 나라의 교육과정을 분석하여 초-중-고등학교에 제시된 프로그래밍 언어의 유형을 살펴보고, 이를 통해 우리나라의 소프트웨어 교육 체제 구성을 위한 제언을 하고자 하였다. 해외의 사례를 살펴본 결과, 초등학교에서는 블록기반의 프로그래밍 언어를 활용하고 있고, 중학교부터는 텍스트 기반의 프로그래밍 언어를 중점적으로 사용하고 있는 것으로 나타났다.

• Molecules and Cells
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• 제38권1호
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• pp.1-13
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• 2015

Recent technical developments have transformed how neuroscientists can probe brain function. What was once thought to be difficult and perhaps impossible, stimulating a single set of long range inputs among many, is now relatively straight-forward using optogenetic approaches. This has provided an avalanche of data demonstrating causal roles for circuits in a variety of behaviors. However, despite the critical role that neuropeptide signaling plays in the regulation of behavior and physiology of the brain, there have been remarkably few studies demonstrating how peptide release is causally linked to behaviors. This is likely due to both the different time scale by which peptides act on and the modulatory nature of their actions. For example, while glutamate release can effectively transmit information between synapses in milliseconds, peptide release is potentially slower [See the excellent review by Van Den Pol on the time scales and mechanisms of release (van den Pol, 2012)] and it can only tune the existing signals via modulation. And while there have been some studies exploring mechanisms of release, it is still not as clearly known what is required for efficient peptide release. Furthermore, this analysis could be complicated by the fact that there are multiple peptides released, some of which may act in contrast. Despite these limitations, there are a number of groups making progress in this area. The goal of this review is to explore the role of peptide signaling in one specific structure, the bed nucleus of the stria terminalis, that has proven to be a fertile ground for peptide action.

• 정보교육학회논문지
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• 제23권6호
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• pp.529-542
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• 2019

4차 산업혁명의 도래로 사회가 요구하는 인재상이 변함에 따라 메이커 교육이 새로운 패러다임으로 대두되고 있으며 관련 연구 또한 증가하고 있다. 본 연구에서는 메이커 교육 관련 논문 65편을 대상으로 체계적 문헌고찰을 진행하였다. 메이커 교육을 학교 교육 현장에 적용하기 위해 고려할 요소를 중점적으로 분석하였으며 이를 통해 메이커 교육 연구가 나아가야 할 방향을 제시하고자 하였다. 분석 결과 메이커 교육 프로그램 개발 관련 논문의 1.4%만이 정규 교과 수업에서 활용 가능한 프로그램을 다루고 있는 것으로 나타났다. 또한, 활용한 메이커 교구의 대부분이 사전학습과 컴퓨터 시설을 필요로 하였다. 대부분의 프로그램이 2개 이상의 교과가 융합된 형태로 설계되었으며, 다수의 프로그램이 협동과 공유의 시간을 갖는 것으로 나타났다. 이러한 문헌고찰 결과를 바탕으로 향후 메이커 교육 연구에서는 교육 프로그램의 정규 교과과정 내 적용 방안, 학교급 별 권장 교구 및 사전 도구 교육, 학교 내 메이커스페이스의 구축, 메이커 산출물 공유 방안, 교사 연수 등에 대한 연구가 필요하다는 시사점을 제시하였다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2005년도 Proceedings of ISRS 2005
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• pp.571-574
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• 2005

In this paper, we propose an efficient image segmentation technique for large-sized monochrome images using a hybrid approach which combines threshold and region-based techniques. First, an image is partitioned into fixed-size blocks and for each block the representative intensity is determined by averaging pixel intensities within the block. Next, the neighborhood blocks that have similar characteristics with respect to a specific threshold are merged in order to form candidate regions. Finally, those candidate regions are refined to get final target object regions by merging regions considering the spatial locality and certain criteria. We have performed experiments on images selected from various domains and showed that our technique was able to extract target object regions appropriately from most images.