• Phonetics and Speech Sciences
• /
• v.16 no.1
• /
• pp.33-40
• /
• 2024

This study investigated acoustic features in spectral moment analysis, comparing accurate articulations with distortions of alveolar fricatives such as dentalization, palatalization, and lateralization. A retrospective analysis was conducted on speech samples from 61 children (mean age: 5.6±1.5 years, 19 females, 42 males) using the Assessment of Phonology & Articulation for Children (APAC) and Urimal-test of Articulation and Phonology I (U-TAP I). Spectral moment analysis was applied to 169 speech samples. The results revealed that the center of gravity of accurate articulations was higher than that of palatalization, while palatalization was lower than dentalization. The variance of dentalization was higher than that of both accurate articulations and palatalization. The skewness of dentalization was higher than that of accurate articulations, and the skewness of palatalization was higher than that of accurate articulations. The kurtosis of palatalization was higher than that of both accurate articulations and dentalization. No significant differences were observed for the position of fricatives (initial, medial) and tense type (plain, tense) across all variables of spectral moment analysis for each distortion type. This study confirmed distinct patterns in center of gravity, variance, skewness, and kurtosis depending on the type of alveolar fricative distortion. The objective values provided in this study will serve as foundational data for diagnosing alveolar fricative distortions in children with speech sound disorders.

• Journal of the Korean Society of Physical Medicine
• /
• v.19 no.1
• /
• pp.81-94
• /
• 2024

PURPOSE: This study aimed to investigate the effect of a progressive balance training program with whole-body vibration stimulation on knee joint pain, dysfunction, psychosocial status, and balance ability in individuals aged ≥ 65 years with knee osteoarthritis. METHODS: A total of 40 individuals aged ≥ 65 years with osteoarthritis of the knees participated in the study. Using a randomization program, participants were assigned to an experimental group (n = 20) or a control group (n = 20). Both groups were assigned a knee strength training program, and a progressive balance training program with whole-body vibration stimulation was assigned to the experimental group. All interventions were conducted three times a week for four weeks. Participants were evaluated for the following: pain (numeric rating scale, NRS), knee dysfunction (Korean version of the Western Ontario and McMaster Universities Arthritis Index, K-WOMAC), fall efficacy (Korean Version Falls Efficacy Scale, K-FES), quality of life (Euro Quality of life 5 Dimension, EQ-5D), and advanced balance scale score (Fullerton advanced balance scale, FAB) before and after the intervention, and the effects of the intervention were compared accordingly between groups. RESULTS: Both groups showed significant differences in the results of the NRS, K-WOMAC, K-FES, and EQ-5D assessments before and after the intervention, and there was a significant difference in the amount of change between the two groups (p < .05). There was a significant improvement in FAB in all but items FAB 8 and FAB 9 after the intervention in the experimental group. In the control group, there was a significant improvement in FAB 1, FAB 2, FAB 7, and FAB total after the intervention (p < .05). In addition, there was a significant difference in the amount of change between the two groups in all items except FAB 8 and FAB 9 (p < .05). CONCLUSION: The progressive balance training program with whole body vibration stimulation is an effective intervention method with clinical significance in improving knee joint pain, knee disability index, psychosocial level, and balance ability in adults aged ≥ 65 with osteoarthritis of the knees.

• Parasites, Hosts and Diseases
• /
• v.62 no.1
• /
• pp.42-52
• /
• 2024

Antimalarial drugs are an urgently need and crucial tool in the campaign against malaria, which can threaten public health. In this study, we examined the cytotoxicity of the 9 antimalarial compounds chemically synthesized using SKM13-2HCl. Except for SKM13-2HCl, the 5 newly synthesized compounds had a 50% cytotoxic concentration (CC₅₀) >100 μM, indicating that they would be less cytotoxic than SKM13-2HCl. Among the 5 compounds, only SAM13-2HCl outperformed SKM13-2HCl for antimalarial activity, showing a 3- and 1.3-fold greater selective index (SI) (CC₅₀/IC₅₀) than SKM13-2HCl in vitro against both chloroquine-sensitive (3D7) and chloroquine -resistant (K1) Plasmodium falciparum strains, respectively. Thus, the presence of morpholine amide may help to effectively suppress human-infectious P. falciparum parasites. However, the antimalarial activity of SAM13-2HCl was inferior to that of the SKM13-2HCl template compound in the P. berghei NK65-infected mouse model, possibly because SAM13-2HCl had a lower polarity and less efficient pharmacokinetics than SKM13-2HCl. SAM13-2HCl was more toxic in the rodent model. Consequently, SAM13-2HCl containing morpholine was selected from screening a combination of pharmacologically significant structures as being the most effective in vitro against human-infectious P. falciparum but was less efficient in vivo in a P. berghei-infected animal model when compared with SKM13-2HCl. Therefore, SAM13-2HCl containing morpholine could be considered a promising compound to treat chloroquine-resistant P. falciparum infections, although further optimization is crucial to maintain antimalarial activity while reducing toxicity in animals.

• Journal of Digital Policy
• /
• v.3 no.1
• /
• pp.1-10
• /
• 2024

The purpose of this study was to identify the predictors of self-regulated learning strategies among nursing university students. Data were collected from 212 nursing university students in G metropolitan city and K city. The SPSS WIN 23.0 version program was used for data analysis. The data were analyzed using Pearson's correlation coefficient and multiple regression. There were significant correlations between media multitasking and self-regulated learning strategies(r=.45, p<.001), learning flow and self-regulated learning strategies(r=.59, p<.001), and media multitasking and learning flow(r=.32, p<.001). Friendship satisfaction, media multitasking and learning flow explained 45% of the variance for self-regulated learning strategies. To increase the self-regulated learning strategies among nursing university students, it is necessary to develop multiple interventions that enhance friendship satisfaction, media multitasking and learning flow.

• The Journal of the Convergence on Culture Technology
• /
• v.10 no.1
• /
• pp.403-409
• /
• 2024

In this paper, the guidelines for the design of an Artificial Intelligence(AI) based Integrated Process Safety Management(PSM) system to enhance workplace safety using data from process safety reports submitted by hazardous and risky facility operators in accordance with the Occupational Safety and Health Act is proposed. The system composed of the proposed guidelines is to be implemented separately by individual facility operators and specialized process safety management agencies for single or multiple workplaces. It is structured with key components and stages, including data collection and preprocessing, expansion and segmentation, labeling, and the construction of training datasets. It enables the collection of process operation data and change approval data from various processes, allowing potential fault prediction and maintenance planning through the analysis of all data generated in workplace operations, thereby supporting decision-making during process operation. Moreover, it offers utility and effectiveness in time and cost savings, detection and prediction of various risk factors, including human errors, and continuous model improvement through the use of accurate and reliable training data and specialized datasets. Through this approach, it becomes possible to enhance workplace safety and prevent accidents.

• Journal of Pharmacopuncture
• /
• v.27 no.1
• /
• pp.14-20
• /
• 2024

Objectives: Frozen shoulder (FS) is one of the most challenging shoulder disorders for patients and clinicians. Its symptoms mainly include any combination of stiffness, nocturnal pain, and limitation of active and passive glenohumeral joint movement. Conventional treatment options for FS are physical therapy, nonsteroidal anti-inflammatory drugs, injection therapy, and arthroscopic capsular release, but adverse and limited effects continue to present problems. As a result, pharmacoacupuncture (PA) is getting attention as an alternative therapy for patients with FS. PA is a new form of acupuncture treatment in traditional Korean medicine (TKM) that is mainly used for musculoskeletal diseases. It has similarity and specificity compared to corticosteroid injection and hydrodilatation, making it a potential alternative injection therapy for FS. However, no systematic reviews investigating the utilization of PA for FS have been published. Therefore, this review aims to standardize the clinical use of PA for FS and validate its therapeutic effect. Methods: The protocol was registered in Prospero (CRD42023445708) on 18 July 2023. Until Aug. 31, 2023, seven electronic databases will be searched for randomized controlled trials of PA for FS. Authors will be contacted, and manual searches will also be performed. Two reviewers will independently screen and collect data from retrieved articles according to predefined criteria. The primary outcome will be pain intensity, and secondary outcomes will be effective rate, Constant-Murley Score, Shoulder Pain and Disability Index, range of motion, quality of life, and adverse events. Bias and quality of the included trials will be assessed using the Cochrane handbook's risk-of-bias tool for randomized trials. Meta analyses will be conducted using Review Manager V.5.3 software. GRADE will be used to evaluate the level of evidence for each outcome. Results: This systematic review and meta-analysis will be conducted following PRISMA statement. The results will be published in a peer-reviewed journal. Conclusion: This review will provide scientific evidence to support health insurance policy as well as the standardization of PA in clinical practice.

• Therapeutic Science for Rehabilitation
• /
• v.13 no.2
• /
• pp.41-51
• /
• 2024

Objective : This study aimed to assess the applicability of the Yonsei Lifestyle Profile (YLP), initially developed for adults, for adolescents and verify its reliability and validity. Methods : This study evaluated the reliability and validity of the YLP among 436 middle and high school students in South Korea. The internal consistency of this scale was analyzed using Cronbach's alpha and Spearman-Brown's coefficient. Concurrent validity was assessed using Pearson's correlation coefficient with the Korean Youth Physical Activity Questionnaire, the Korean version of the Children and Adolescents Participation Scale, and the Nutrition Quotient for Adolescents. Results : The overall internal consistency of the YLP items demonstrated high reliability, with a Cronbach's α of .811 and Spearman-Brown's coefficient of .779. Significant positive correlations were observed for physical activity (r=.555, p<.01), activity participation (r=.177, p<.01), and dietary habits (r=.633, p<.05), indicating consistent correlations with the related scales. Conclusion : This study analyzed the YLP targeting adolescents and confirmed its high reliability and significant validity in the areas of physical activity, activity participation, and dietary habits. These findings suggest that the YLP can be utilized as a reliable tool for evaluating healthy lifestyles among adolescents.

• Therapeutic Science for Rehabilitation
• /
• v.13 no.2
• /
• pp.69-84
• /
• 2024

Objective : This study aimed to categorize the lifestyles of older adults into two types - healthy and unhealthy, and use machine learning to identify the personal values that influence these lifestyles. Methods : This cross-sectional study targeting middle-aged and older adults (55 years and above) living in local communities in South Korea. Data were collected from 300 participants through online surveys. Lifestyle types were dichotomized by the Yonsei Lifestyle Profile (YLP)-Active, Balanced, Connected, and Diverse (ABCD) responses using latent profile analysis. Personal value information was collected using YLP-Values (YLP-V) and analyzed using machine learning to identify the relative importance of personal values on lifestyle types. Results : The lifestyle of older adults was categorized into healthy (48.87%) and unhealthy (51.13%). These two types showed the most significant difference in social relationship characteristics. Among the machine learning models used in this study, the support vector machine showed the highest classification performance, achieving 96% accuracy and 95% area under the receiver operating characteristic (ROC) curve. The model indicated that individuals who prioritized a healthy diet, sought health information, and engaged in hobbies or cultural activities were more likely to have a healthy lifestyle. Conclusion : This study suggests the need to encourage the expansion of social networks among older adults. Furthermore, it highlights the necessity to comprehensively intervene in individuals' perceptions and values that primarily influence lifestyle adherence.

• Progress in Medical Physics
• /
• v.34 no.4
• /
• pp.41-47
• /
• 2023

Purpose: This study aimed to dosimetrically compare the technique of three-dimensional conformal radiotherapy (3D CRT), which is a traditional prophylactic cranial irradiation method, and the intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) techniques used in the last few decades with the dynamic conformal arc therapy (DCAT) technique. Methods: The 3D CRT, VMAT, IMRT, and DCAT plans were prepared with 25 Gy in 10 fractions in a Monaco planning system. The target volume and the critical organ doses were compared. A comparison of the body V₂, V₅, and V₁₀ doses, monitor unit (MU), and beam on-time values was also performed. Results: In planned target volume of the brain (PTV_Brain), the highest D99 dose value (P<0.001) and the most homogeneous (P=0.049) dose distribution according to the heterogeneity index were obtained using the VMAT technique. In contrast, the lowest values were obtained using the 3D CRT technique in the body V₂, V₅, and V₁₀ doses. The MU values were the lowest when DCAT (P=0.001) was used. These values were 0.34% (P=0.256) lower with the 3D CRT technique, 66% (P=0.001) lower with IMRT, and 72% (P=0.001) lower with VMAT. The beam on-time values were the lowest with the 3D CRT planning (P<0.001), 3.8% (P=0.008) lower than DCAT, 65% (P=0.001) lower than VMAT planning, and 76% (P=0.001) lower than IMRT planning. Conclusions: Without sacrificing the homogeneous dose distribution and the critical organ doses in IMRTs, three to four times less treatment time, less low-dose volume, less leakage radiation, and less radiation scattering could be achieved when the DCAT technique is used similar to conventional methods. In short, DCAT, which is applicable in small target volumes, can also be successfully planned in large target volumes, such as the whole-brain.

• The Journal of Korean Academy of Sensory Integration
• /
• v.22 no.1
• /
• pp.69-84
• /
• 2024

Objective : This study aimed to provide an overview of task-oriented approaches for children with developmental coordination disorder, including its definition, diagnosis, causes, and assessment, through a literature review. Subject : Eighteen international articles published between January 2000 and September 2023 were analyzed to explore the intervention strategies of Neuromotor Task Training (NTT) and Cognitive Orientation to daily Occupational Performance (CO-OP). The objectives of the interventions mentioned in the reviewed articles were categorized according to the criteria of the Occupational Therapy Practice Framework-4 (OTPF-4). The results showed that NTT more frequently set goals in the area of client factors, while CO-OP set goals only in the area of occupation. This difference in goal setting can be explained by the strategy differences between the two interventions. Conclusion : A broader and deeper understanding of strategies for interventions with task-oriented approaches to developmental coordination disorder can increase awareness of the disorder and provide a more solid basis for evidence-based practice.