• Pediatric Infection and Vaccine
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• v.29 no.2
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• pp.70-76
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• 2022

Coronavirus disease 2019 (COVID-19) in patients with underlying diseases, is associated with high infection and mortality rates, which may result in acute respiratory distress syndrome and death. Mucopolysaccharidosis (MPS) type II is a progressive metabolic disorder that stems from cellular accumulation of the glycosaminoglycans, heparan, and dermatan sulfate. Upper and lower airway obstruction and restrictive pulmonary diseases are common complaints of patients with MPS, and respiratory infections of bacterial or viral origin could result in fatal outcomes. We report a case of COVID-19 in a 16-year-old adolescent with MPS type II, who had been treated with idursulfase since 5 years of age. Prior to infection, the patient's clinical history included developmental delays, abdominal distension, snoring, and facial dysmorphism. His primary complaints at the time of admission included rhinorrhea, cough, and sputum without fever or increased oxygen demand. His heart rate, respiratory rate, and oxygen saturation were within the normal biological reference intervals, and chest radiography revealed no signs of pneumonia. Consequently, supportive therapy and quarantine were recommended. The patient experienced an uneventful course of COVID-19 despite underlying MPS type II, which may be the result of an unfavorable host cell environment and changes in expression patterns of proteins involved in interactions with viral proteins. Moreover, elevated serum heparan sulfate in patients with MPS may compete with cell surface heparan sulfate, which is essential for successful interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the host cell surface, thereby protecting against intracellular penetration by SARS-CoV-2.

• Asia Marketing Journal
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• v.13 no.4
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• pp.253-264
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• 2012

A growing number of Korean companies are trying to expand their business area into global market due to saturation in the Korean domestic market. Home shopping industry arriving on mature stage is faced with less growth recently. CJ O Shopping which is a top ranked home shopping company in Korea, has been showing meaningful performances by earlier moving to global market with thorough preparations. CJ O Shopping's global marketing strategy focused on asian countries including China, India, Vietnam, and Japan is going successfully, which enables top ranked on-line retailing company in asia as well as in Korea. CJ O Shopping effectively penetrated into overseas market with both core competence based on Korean home shopping model and rigorous preliminary study on target market. Especially shoppertainment (Shopping+Entertainment) that is unique feature of globally competitive Korean home shopping created huge differentiations in target market. Also choosing the influential local partner, sharing the business goals, and building the joint venture could make stable operations, thereby easily earning of well-established awareness from target consumers. A step ahead entry of competitors and intensive localization of CJ O Shopping's core competence for arriving safe in target market were additional key factors for global marketing success. We can extract above key factors for success as implications of case study on CJ O Shopping's global marketing, and expect those factors to be spread into lots of Korean companies and utilized as successful strategies for global marketing.

• Journal of Korean Elementary Science Education
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• v.41 no.1
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• pp.44-64
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• 2022

This study explored the elementary school teachers' experiences while teaching students with low achievement in science based on the grounded theory. In-depth interviews and analysis were conducted on 13 teachers with experiences in teaching students with low achievement in science within the last three years and more than five years of field experience until the theoretical saturation of data on the teaching experiences for students with low achievement in science. The analysis results were as follows. First, the teaching experiences of elementary school teachers for underachievers in science were classified into 119 concepts, 41 subcategories, and 17 categories. Based on the paradigm model, the categories were structured and presented as causal conditions, contextual conditions, intervening conditions, action/interaction strategies and consequences based on the central phenomenon of 'difficulty in teaching students with low achievement in science'. Second, the core category of elementary school teachers' teaching underachievers in science was assumed to be 'overcoming difficulties and teaching underachievers in science'. And according to the properties and dimensions of the core category, teachers who teaching students with low achievement in science were divided into four types: 'compromising-', 'overcoming-', 'accepting-', and 'conflicting-reality type'. Third, a conditional matrix was presented to summarize and integrate the results of this study by classifying the teaching experience of elementary school teachers for underachievers in science into educational providers and educational demanders. On the basis of these findings, educational implications for teaching students with low achievement in science were discussed.

• Journal of Nutrition and Health
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• v.55 no.5
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• pp.523-532
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• 2022

Vitamin C is an important physiological antioxidant which neutralizes reactive oxygen species (ROS) and reduces the oxidative stress in the body. Although it has been associated with various diseases, few studies have reported the dose-response relationship between vitamin C intake, storage and functions in the body, including its antioxidant function. The criteria to establish the Dietary Reference Intakes for Koreans (KDRIs) for vitamin C were based on the changes in plasma concentrations and saturation of leukocytes according to intake levels and the effects on antioxidant capacity and risk of metabolic diseases. When establishing the 2020 vitamin C KDRI, while there was no change in the criteria from those of 2015, the reference values were recalculated and revised to reflect changes such as the new standard weight by age. As the number of people consuming dietary supplements has increased over the last decade, only about 10% of adults consume less than the average total vitamin C, but the proportion of adolescents and elderly who consume less than the average is high. On the other hand, as the intake of vitamin C supplements increases, the proportion of people consuming excessive vitamin C is also increasing. There is a body of opinion that it is necessary to establish a vitamin C KDRI for smokers or people with chronic diseases such as the metabolic syndrome, but these standards have not been established due to the lack of supporting scientific evidence. As a result, studies to establish vitamin C KDRI for Korean smokers and patients with the metabolic syndrome, as well as studies on the excessive intake of vitamin C due to supplementation and interactions with other nutrients, are needed.

• The Journal of Engineering Geology
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• v.33 no.3
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• pp.413-426
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• 2023

This study presents the geochemical characteristics of cave water to evaluate its origin and flow path. From June 2022 to may 2023, river water was collected at two sites (WE1 and WE2) in the Donggang River around Baengnyongdonggul Cave, and cave water was collected at four sites (WE3 to WE6) inside Baengnyongdonggul Cave. Water samples were analyzed for major dissolved components. Both river and cave waters were classified as Ca-HCO₃ type. All cave water samples were supersaturated in carbonate minerals, suggesting that carbonate minerals would precipitate within the cave. Due to differences in the source of cave water and the degree of water-rock interaction, the geochemical characteristics of water from sites where the flow of cave water is observed (WE3 and WE6) and rimstone pools (WE4 and WE5) could be clearly distinguished. The cave water at WE6 flows in from the Donggang River, then passes through WE3 and flows back out into the Donggang River. The cave water at WE4 and WE5 is supplied from precipitation, but the flow path of cave water at WE4 and WE5 is different.

• Geomechanics and Engineering
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• v.32 no.1
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• pp.111-123
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• 2023

The slope of an open cut tunnel is located above the exit of the Leijia tunnel on the Changgan high-speed railway. During the excavation of the open cut tunnel foundation pit, the slope slipped twice, a large landslide of 92500 m³ formed. The landslide body and unstable slope body not only caused the foundation pit of the open cut tunnel to be buried and the anchor piles to be damaged but also directly threatened the operational safety of the later high-speed railway. Therefore, to study the stability change in the slope of the open cut tunnel under heavy rain and excavation conditions, a 3D numerical calculation model of the slope is carried out by Midas GTS software, the deformation mechanism is analyzed, anti-sliding measures are proposed, and the effectiveness of the anti-sliding measures is analyzed according to the field monitoring results. The results show that when rainfall occurs, rainwater collects in the open cut tunnel area, resulting in a transient saturation zone on the slope on the right side of the open cut tunnel, which reduces the shear strength of the slope soil; the excavation at the slope toe reduces the anti-sliding capacity of the slope toe. Under the combined action of excavation and rainfall, when the soil above the top of the anchor pile is excavated, two potential sliding surfaces are bounded by the top of the excavation area, and the shear outlet is located at the top of the anchor pile. After the excavation of the open cut tunnel, the potential sliding surface is mainly concentrated at the lower part of the downhill area, and the shear outlet moves down to the bottom of the open cut tunnel. Based on the deformation characteristics and the failure mechanism of the landslides, comprehensive control measures, including interim emergency mitigation measures and long-term mitigation measures, are proposed. The field monitoring results further verify the accuracy of the anti-sliding mechanism analysis and the effectiveness of anti-sliding measures.

• Journal of Korean Tunnelling and Underground Space Association
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• v.25 no.2
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• pp.43-63
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• 2023

With the concentration of the population in the city center and the saturation of the structures on the ground, the development of the underground structures becomes important and the construction of an adjoining tunnel that can reduce the overall problems is respected. In addition, it is necessary to apply the reinforcement construction method for the pillar part of the adjacent tunnel that can secure stability, economy and workability of the site. In this study, the tunnel pillar reinforcement method using prestress and grouting was reviewed. There are various reinforcement methods that can compensate for the problems of the side tunnel, but as the tunnel pillar construction method using prestress and grouting is judged to be excellent in field applicability, stability and economic feasibility, theoretical and numerical analysis of the actual behavior mechanism are conducted. Numerical analysis is divided into PC stranded wire + steel pipe reinforcement grouting + prestress (Case 1), pillar part tie bolt reinforcement (Case 2), pillar part non-reinforcement (Case 3) under the same ground conditions, and the maximum value of the celling displacement, internal displacement, and member force, the stability was confirmed. Through numerical analysis, it was confirmed that Case 1 which reinforced the PC stranded wire, was the best construction method and if it is verified and supplemented through field experiments later, it will be possible to derive superior results in terms of displacement control and member force than the currently applied reinforcement method was judged.

• Journal of Service Research and Studies
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• v.12 no.4
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• pp.94-105
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• 2022

Urban Air Transportation (UAM) is a three-dimensional transport within the city using eVTOL as an alternative to the saturation of land transportation due to overcrowding in major cities around the world. Design has played its roles in various fields in the development of transport, but research on the design application of UAM, which will be commercialized soon, is insufficient. Accordingly, there is a growing need for prior research on the forecasting the future environment and the design application through phenomenon analysis. The purpose of this study is to derive mega trends through STEP analysis for UAM and present ways to apply design in the UAM field based on this. The research method was conducted in the following order. First, the theoretical background of UAM was established by analyzing prior art documents on UAM. Second, five trends in the future environment centered on UAM were derived through STEP analysis. Finally, in order to derive a design application, five experts in each design area (product, visual, video, environment, service) discussed the design application focusing on the results of STEP analysis and derived a design application plan for each design area in the UAM field. Through this study, it was found that the most frequent design area in the STEEP analysis is product design and service design, and therefore related design development is important. After analyzing UAM's information provision plan, display method, and usage process suggested in this study, it is expected that it will lead to various prior design studies related to UAM, such as customized service design, to establish an infrastructure environment for commercialization of UAM.

• Journal of the Korean Geotechnical Society
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• v.24 no.12
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• pp.103-111
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• 2008

Soils naturally contain grains of different minerals which may be dissolved under chemical or physical processes. The dissolution leads changes in microstructure of particulate media, such as an increase in local void or permeability, which affects the strength and deformation of soils. This study focuses on the small strain stiffness characteristics of vanishing mixtures, which consist of sand and salt particles at different volume fractions. Experiments are carried out in a conventional oedometer cell (Ko-loading) integrated with bender elements for the measurement of shear waves. Dissolutions of particles are implemented by saturating the mixtures at various confining stresses. Axial deformation and shear waves are recorded after each loading stage and during dissolution process. Experimental results show that after dissolution, the vertical strain and the void ratio increase, while the shear wave velocity and small strain shear modulus decrease. The decrease of the velocity results from the void ratio increase and particle contact decrease. The process monitoring during dissolution of the particles shows that the vertical strain dramatically increases at the beginning of the saturation process and converges after vanishing process finishes, and that the shear wave velocity decreases at the beginning and increases due to the particle reorientation. Specimens prepared by sand and salt particles are proved to be able to provide a valuable insight in macro structural behaviors of the vanishings mixtures.

• Korean Journal of Environmental Biology
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• v.40 no.3
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• pp.352-362
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• 2022

Photosynthesis and respiration of seagrasses are mainly controlled by water temperature. In this study, the photosynthetic physiology and respiratory changes of the Asian surfgrass Phyllospadix japonicus, which is mainly distributed on the eastern and southern coasts of Korea, were investigated in response to changing water temperature (5, 10, 15, 20, 25, and 30℃) by conducting mesocosm experiments. Photosynthetic parameters (maximum photosynthetic rate, P_max; compensation irradiance, I_c; and saturation irradiance, I_k) and respiration rate of surfgrass increased with rising water temperature, whereas photosynthetic efficiency (α) was fairly constant among the water temperature conditions. The P_max and I_k dramatically decreased under the highest water temperature condition (30℃), whereas the I_c and respiration rate increased continuously with the increasing water temperature. Ratios of maximum photosynthetic rates to respiration rates (P_max : R) were highest at 5℃ and declined markedly at higher temperatures with the lowest ratio at 30℃. The minimum requirement of H_sat (the daily period of irradiance-saturated photosynthesis) of P. japonicus was 2.5 hours at 5℃ and 10.6 hours at 30℃ for the positive carbon balance. Because longer H_sat was required for the positive carbon balance of P. japonicus under the increased water temperature, the rising water temperature should have negatively affected the growth, distribution, and survival of P. japonicus on the coast of Korea. Since the temperature in the temperate coastal waters is rising gradually due to global warming, the results of this study could provide insights into surfgrass responses to future severe sea warming and light attenuation.